Clinical trials: Deprescribing
Dementia
Deprescribing Intervention Among Nursing Home Residents With Major Neurocognitive Disorders
Canadians with neurocognitive disorders often are admitted to nursing homes when their disease reaches an advanced stage. At the end of their life, they may encounter adverse symptoms related to medications they no longer need…
- Trial name
- OptimaMedLTC (NCT05155748)
- Testing
- Continuous education and knowledge exchange
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Dre Edeltraut Kröger
Inappropriate Dose of Drug Administered, Pain, Chronic
Trial Applying Policy to Eliminate or Reduce Inappropriate Narcotics in the General-population
To assess the effectiveness of a government-led population-based opioid intervention on discontinuation of opioid medication in community-dwelling adults with chronic non-cancer pain.
- Conditions
- Inappropriate Dose of Drug Administered, Pain, Chronic, Health Behavior
- Trial name
- TAPERING (NCT03400384)
- Testing
- Direct-to-consumer educational brochure
- Where
- Canada
- Volunteers
- 4,255 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Benign Prostatic Hyperplasia
Ceasing Alpha-blockers Early After Resection of the Prostate (The CLEAR Trial)
After surgery for benign prostatic hyperplasia (BPH) that physically removes the prostatic transition zone (such as TURP or laser enucleation), many men are routinely sent home with a 2- to 4-week prescription of an alpha-blocker…
- Trial name
- CLEAR (NCT07846579)
- Testing
- Tamsulosin hydrochloride 0.2 mg
- Volunteers
- 400 people
- Sponsor
- Shanghai East Hospital
Chronic Pain, Central Sensitisation
Clinical Trial on Deprescribing Associated With a Psychoeducational Program Using Virtual Reality for Patients With Chronic Pain and Central Sensitization
This clinical trial evaluates the effectiveness of the REDOCVR program, an interdisciplinary, psychoeducational intervention designed to support deprescribing of chronic pain medications in primary care.
- Conditions
- Chronic Pain, Central Sensitisation, Opioid-Related Disorders, Patient Empowerment
- Trial name
- REDOCVR_AC (NCT06964360)
- Testing
- REDOCVR Psychoeducational Program, Standard Educational Materials
- Where
- 4 sites in Spain
- Volunteers
- 174 people
- Sponsor
- Badalona Serveis Assistencials
Geriatric Patients
Attitudes and Beliefs Related to Benzodiazepine Deprescribing
The use of benzodiazepines in older adults is associated with an increased risk of adverse effects due to age-related physiological changes.
- Trial name
- BENZ-AC (NCT07474532)
- Testing
- Patient rPATD Benzo questionnaire, Geriatrician rPATD Benzo questionnaire
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Hospices Civils de Lyon
Proton Pump Inhibitors, Deprescribing
RAK-PRIDE: Optimizing Proton Pump Inhibitor Use Through Education and Intervention
The goal of this study is to determine if a pharmacist-led educational intervention can reduce the inappropriate use of proton pump inhibitors (PPIs) among adult patients (≥18 years) with potentially inappropriate PPI…
- Conditions
- Proton Pump Inhibitors, Deprescribing, Inappropriate Use
- Trial name
- NCT06858384
- Testing
- Control (Standard treatment), Pharmacist-Led Educational Intervention
- Where
- United Arab Emirates
- Volunteers
- 479 people
- Sponsor
- RAK Medical and Health Sciences University
Deprescribing Anticholinergic and Sedative Medications, Physical Function
Impact in Older Adults of Reducing Anticholinergic and Sedative Rx Burden on Physical Function Measured by Wearables
Medications with sedative or anticholinergic effects such as antidepressants, benzodiazepines, or opioids have been associated with impaired cognitive and physical function.
- Trial name
- NCT05735379
- Testing
- Deprescribing anticholinergic and sedative mediications
- Where
- Canada
- Volunteers
- 182 people
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Benzodiazepines Deprescribing
Benzodiazepines Deprescribing in Nursing Homes: Intervention Feasibility
The goal of this feasibility study is to evaluate the feasibility of a complex intervention towards benzodiazepines and Z-drugs deprescribing in older adults living in the Belgian nursing home setting.
- Trial name
- END-IT NH (NCT05929443)
- Testing
- END-IT intervention for nursing homes
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Université Catholique de Louvain
Fall in Nursing Home, Medication Therapy Management
Nursing Home Team-Care Deprescribing Study
This is a multi-centre study in Singapore nursing homes, investigating the factors that affecting deprescribing, and if a team-care based deprescribing standard practice gives superior health and pharmacoeconomic outcomes over…
- Trial name
- NCT02863341
- Testing
- Team-care deprescribing with deprescribing guide
- Where
- Singapore
- Volunteers
- 295 people
- Sponsor
- Tan Tock Seng Hospital
Poly Pharmacy, Frail Elderly
Applying a Multidisciplinary Intervention for Drug Adequacy in an Intermediate Care Hospital (AMIDA-ICH)
The goal of this clinical trial is to learn if a multi-professional (conducted by geriatricians, clinical pharmacists, nurses) medication revision, centered on patients' goals and characteristics, can improve treatment adequacy…
- Trial name
- AMIDA-ICH (NCT07015112)
- Testing
- Patient-centered multidisciplinary treatment review
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Parc Sanitari Pere Virgili
Heart Failure, Heart Failure, Diastolic
Impact of Beta-blockers on Physical Function in HFpEF
The purpose of this study is to understand the impact of beta-blockers on physical function in older adults with heart failure. We will achieve this objective by conducting N-of-1 trials.
- Conditions
- Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure
- Trial name
- NCT04767061
- Testing
- Beta blockers
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Weill Medical College of Cornell University
Respiratory Tract Diseases
Impact of Pharmacist Led Multidisciplinary Deprescribing Strategy in Patients With Respiratory Tract Infections
This prospective, open-label, randomized controlled trial will evaluate the impact of a pharmacist-led multidisciplinary deprescribing strategy on azithromycin use in clinically stable adults aged 18-65 years with respiratory…
- Trial name
- RCT (NCT07849491)
- Testing
- Pharmacist-Led Azithromycin Deprescribing Intervention
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Xi'an Jiaotong University
Deprescription, Benzodiazepine (BZD) and Related Drugs
Multimodal Educative Data Feedback for Deprescribing BZD and Related Drugs in Outpatients: a Cluster RCT
Benzodiazepine (BZD) and related drugs are sedative anxiolytics and hypnotics that should be avoided especially in people aged 65 years and older, given the high risk of falling, fracture, dependence, respiratory depression and…
- Trial name
- NCT05859555
- Testing
- Thematic quality circles - Deprescription
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Réseau de soins Delta
Polypharmacy
Deprescribing in a Long Term Care Facility
This study will develop, implement and evaluate a deprescribing initiative at a Canadian Long Term Care (LTC) Facility. Residents currently undergo an annual medication review as part of the clinical pharmacy services provided in…
- Trial name
- NCT03091153
- Testing
- Medication Review
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- Memorial University of Newfoundland
Dementia, Behavior
Deprescribing Antipsychotics in Long-Term Care
Aggressive behaviours in long-term care (LTC) is a difficult health care issue to manage. One method that has been over-used is the prescription of antipsychotics for the behaviours and psychological symptoms of dementia (BPSD).
- Trial name
- NCT02958800
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- McMaster University
suspensión Completa Del Tratamiento Con Benzodicepinas, Disminución Del Consumo Benzodiacepinas
Evaluation of the Effectiveness of a Psychoeducational Intervention on Benzodiazepine Use in the Population Over 64 Years Old in Primary Care
The goal of this pragmatic, multicenter, randomized controlled trial is to determine whether a multidisciplinary psychoeducational intervention combined with therapeutic exercise is more effective than a minimal educational…
- Trial name
- BENZOS-AP (NCT06950567)
- Testing
- psycho-educational intervention and therapeutic activity, Control
- Where
- Spain
- Volunteers
- 122 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Deprescribing, Multi-disciplinary
Efficacy and Feasibility of De-prescribing Rounds in a Singapore Rehabilitative Hospital- a Pilot Randomized Controlled Trial
This open-labelled randomized control trial will be conducted in a Singapore Rehabilitation Hospital to investigate the efficacy, cost-reduction, safety and feasibility of a weekly deprescribing multi-disciplinary inpatient…
- Conditions
- Deprescribing, Multi-disciplinary, Rounds
- Trial name
- NCT03713112
- Testing
- Weekly MDT deprescribing rounds for certain drugs
- Where
- Singapore
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Bright Vision Hospital
Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms
Deprescribing Tamsulosin in Older Men
This is a pilot 12-week randomized, placebo-controlled N-of-1 deprescribing trial among older men receiving chronic tamsulosin therapy for lower urinary tract symptoms attributed to benign prostatic hyperplasia.
- Trial name
- PERSONAL (NCT05415748)
- Testing
- Tamsulosin
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of California, San Francisco
Frailty, Deprescription
Understanding Benzodiazepine and Non-benzodiazepine Sedative Use
Inappropriate medication use among the elderly ranges from 11% to 62% and is a major concern for patient safety. Benzodiazepines account for approximately 20 to 25% of inappropriate medications prescribed to the elderly, thus…
- Conditions
- Frailty, Deprescription, Aged
- Trial name
- NCT02833272
- Testing
- EMPOWER Educational Brochure
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Polypharmacy, Deprescription
Reducing Post-discharge Potentially Inappropriate Medications Among Older Adults
Potentially inappropriate medications (PIMs) can lead to adverse drug events (ADEs) among older adults and especially those classified as frail. ADEs are responsible for nearly 27,000 hospital admissions in Canada annually.
- Conditions
- Polypharmacy, Deprescription, Aged
- Trial name
- MedSafer (NCT02918058)
- Testing
- MedSafer
- Where
- Canada
- Volunteers
- 924 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre