Clinical trials: Depigmentation
Hermansky-Pudlak Syndrome (HPS), Pulmonary Fibrosis
Pilot Study of a Multi-Drug Regimen for Severe Pulmonary Fibrosis in Hermansky-Pudlak Syndrome
This study will examine whether five drugs (pravastatin, Losartan, Zileuton, N-acetylcysteine and erythromycin) used together can slow the course of pulmonary fibrosis (scarring of the lung tissue) in patients with…
- Conditions
- Hermansky-Pudlak Syndrome (HPS), Pulmonary Fibrosis, Oculocutaneous Albinism, Platelet Storage Pool Deficiency
- Trial name
- NCT00467831
- Testing
- Losartan, Zileuton, N-Acetylcysteine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Vitiligo
Topical Ruxolitinib for Face and Neck Vitiligo of Adult Chinese Patients Refractory to Topical Tacrolimus
This trial is a prospective, open-label, single-center, split face randomized controlled study comparing 1.5% topical Ruxolitinib cream twice daily (BD) to aqueous cream in treating non-segmental vitiligo (NSV) of the face and…
- Trial name
- RCT (NCT06719024)
- Testing
- Ruxolitinib Cream 1.5%, Aqueous cream
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Hospital Authority, Hong Kong
Vitiligo
Improved Phototherapy in Patients With Vitiligo
Vitiligo is a common acquired depigmentation skin and mucosal disease in dermatology, with or without white hair. Vitiligo with white hair is difficult to treat.
- Trial name
- NCT05836441
- Testing
- Exposure to white patches, Exposure to edge of white patches and normal skin around white patches
- Where
- China
- Volunteers
- 110 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Chronic Heart Failure, Old Myocardial Infarction
Japanese OMI Treatment With Kit-positive Cells for Enhanced Regeneration
The purpose of this study is to determine the safety and effectiveness of intracoronary infusion of autologous cardiac stem cells in patients with ischemic cardiomyopathy.
- Trial name
- JOKER (NCT03351400)
- Testing
- Stem cells administered to participants
- Where
- Japan
- Volunteers
- 6 people
- Sponsor
- Sakakibara Heart Institute
Vitiligo, Vitiligo, Generalized
Oral Vitamin D Supplementation Combined With Phototherapy as a Treatment for Vitiligo
A randomized clinical trial that treats vitiligo patients with oral vitamin D and Narrow-Band Ultraviolet B (NB-UVB) phototherapy (intervention group); or placebo and NB-UVB phototherapy (control group).
- Conditions
- Vitiligo, Vitiligo, Generalized, Autoimmune, Autoimmune Diseases
- Trial name
- NCT04872257
- Testing
- Oral Vitamin D, NB-UVB Phototherapy
- Where
- Mexico
- Volunteers
- 26 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Vitiligo
Oral Mini Pulse Dexamethasone in Pediatric Vitiligo
The goal of this clinical trial is to learn if oral mini pulse (OMP) dexamethasone works to treat active vitiligo in children and also learn about the safety of this drug within this age group the main questions it aims to answer…
- Trial name
- NCT07353801
- Testing
- Dexamethasone (0.1 mg/kg)
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Cairo University
Gingival Pigmentation
Gingival Depigmentation Using Diode Laser 940nm Versus 980nm
is study aimed to evaluate the effectiveness of two diode lasers of different wave lengths 940nm and 980nm for the treatment of physiologic gingival melanin hyperpigmentation.
- Trial name
- NCT06167148
- Testing
- Biolase Epic X 940nm wavelength Diode laser, Doctor smile simpler 980nm wavelength Diode laser
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Nourhan M.Aly
Vitiligo
Microneedling Combined With Topical Crisaborole 2 % Ointment in Treatment of Vitiligo.
The goal of this clinical trial is to learn if topical crisaborole ointment works to treat vitiligo. It will also learn about the safety of the drug.
- Trial name
- NCT07088276
- Testing
- microneedling with topical crisaborole
- Volunteers
- 20 people
- Sponsor
- Tanta University
Upper Cross Syndrome
Comparative Effects of Global Postural Re-education and NASM-based Corrective Exercises in Patients With Upper Cross Syndrome (UCS)
The goal of this clinical trial is to learn the comparative effects of Global postural re-education (GPR) and National Academy of Sports Medicine (NASM) based corrective exercises in participants with upper cross syndrome (UCS).
- Trial name
- NCT07528248
- Testing
- Global Postural Re-education, NASM-based Corrective exercises
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Rehana Hayat
Vitiligo
A Study to Evaluate the Efficacy of Microneedling as a Stand-alone Treatment for Vitiligo
This is a study that is being conducted in order to assess the efficacy of microneedling as a stand-alone treatment for vitiligo.
- Trial name
- NCT05053022
- Testing
- Skinpen Precision System
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Crown Laboratories, Inc.
Acceptance of Visible Chronic Dermatological Disease, Disease Acceptance
Measure of Acceptance of chRonic Visible sKin conditionS
The objective of this protocol is to validate 4 scales for evaluating the acceptance of visible chronic dermatological diseases (port wine stains, alopecia areata, vitiligo, hyperpigmentation...) with a large number of patients…
- Conditions
- Acceptance of Visible Chronic Dermatological Disease, Disease Acceptance, Psychological Well-Being, Social Segregation
- Trial name
- MARKS (NCT06103903)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Tours
Myelofibrosis, Gaucher Disease
Clinical and Pathophysiological Investigations Into Erdheim Chester Disease
Background: Erdheim Chester Disease (ECD) is a very rare disease in which abnormal white blood cells start growing and affect the bones, kidneys, skin, and brain.
- Conditions
- Myelofibrosis, Gaucher Disease, Pulmonary Fibrosis, Hermansky-Pudlak Syndrome (HPS)
- Trial name
- NCT01417520
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Vitiligo, Healthy
The Gut and Skin Microbiome in Vitiligo Disease Progression
Investigators plan to perform a pilot study that aims to characterize the microbiome of human vitiligo patients with both active and stable disease and compare this to the microbiome of age and sex matched controls.
- Trial name
- NCT03577327
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Vitiligo
Interest of the Dermabrasion by Laser Erbium in the Treatment of the Vitiligo
The treatment of vitiligo remains disappointing especially in some localization such as bony prominences and extremities. The association of UVB and topical steroids has been proven to be synergistic but the results are still…
- Trial name
- NCT01087216
- Testing
- Group Laser = Arm A, Bras B : The group control
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Psoriasis, Alopecia Areata
Development and EValuation of an Online Intervention to Reduce Self-Stigma in People With Visible Chronic Skin disEases
This project aims to develop and evaluate an online intervention to prevent and/or reduce self-stigma in German patients with visible chronic skin diseases.
- Conditions
- Psoriasis, Alopecia Areata, Hidradenitis Suppurativa, Vitiligo
- Trial name
- DEVISE (NCT06324695)
- Testing
- HautKompass
- Where
- 12 sites in Germany
- Volunteers
- 298 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Vitiligo
Determining the Tolerance of Depigmented Skin to Targeted Phototherapy Using UVB in Patients With Vitiligo
The purpose of this study is to determine if vitiligo patients develop tolerance to ultraviolet light therapy, a type of treatment available for vitiligo.
- Trial name
- NCT00367224
- Testing
- 6 to 9 ultraviolet B treatments, Skin biopsies
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Vitiligo
Evaluation of Serum and Tissue Cathepsin L in Non-segmental Vitiligo Patients
Introduction Vitiligo is an autoimmune disease of the skin that targets pigment producing melanocytes and results in patches of depigmentation that are visible as white spots (Frisoli et al., 2020) Vitiligo is a relatively common…
- Trial name
- NCT06261073
- Testing
- blood sample and tissue biopsy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sohag University
Vitiligo
Evaluation of the Efficacy and the Cutaneous Acceptability of a Dermocosmetic Product in the Repigmentation of Vitiligo
Study in proof of concept; Double blind study; Comparative study, versus placebo in intra-individual Three parallel groups testing different dosages / combinations of treatments Randomized.
- Trial name
- NCT04171427
- Testing
- Lithium liposome
- Where
- Tunisia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Laboratoire Dermatologique ACM
Vitiligo
Effect of Early Systemic Stabilization Therapy on Recent Onset Vitiligo
Vitiligo is a distressing disorder of depigmentation. In spite of multiple successful therapeutic regimens, disease relapse remains a challenge to patients and physicians.
- Trial name
- NCT05037981
- Volunteers
- 25 people
- Sponsor
- Cairo University
Vitiligo
T Central Memory Cells in Early Localized Non-Segmental Vitiligo
Assessing the level of circulating TCMs (cluster of differentiation (CD) 8+, CD3+,C- chemokine receptor (CCR)7, cluster of differentiation 45 receptor (CD45R) cells) in early localized vitiligo cases prior to treatment and after…
- Trial name
- NCT05706636
- Testing
- oral mini pulse, Topical cream, targeted phototherapy
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University