Clinical trials: Dental Pulp Necroses
Pulp Necrosis, Periapical Lesion
Success Rate of Single Versus Two Visit Regenerative Treatment Protocol in Non Vital Mature Anterior Teeth
This study evaluates success rate of non vital mature anterior teeth with periapical lesion treated by regenerative endodontic protocol in single visit versus two visit technique.
- Conditions
- Pulp Necrosis, Periapical Lesion, Anterior Teeth
- Trial name
- NCT03717337
- Testing
- Single visit pulp regeneration, Two visit pulp regeneration
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Necrotic Pulp, Postoperative Pain
Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy
The aim of the current study is to compare a newly introduced material which is a combination of triple mix antibiotics paste and anti-hyperlipidemia drug simvastatin, the new material is named 3MIX-TATIN \& will be compared to…
- Trial name
- 3-mixtatin (NCT03084601)
- Testing
- Calcium Hydroxide, Iodoform, paste, 3-mixtatin
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mahmoud M Saadoon
Necrotic Pulp
Comparative Evaluation of the Regenerative Capacity of Two Platelet Concentrates
Injectable platelet-rich fibrin (I-PRF) is a flowable blood concentrate that is entirely natural and allows ease of access and flow within the root canal. It was first developed in 2014 by modifying the centrifugation parameters.
- Trial name
- NCT03698188
- Testing
- Injectable platelet-rich fibrin, Platelet-rich plasma
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Necrotic Pulp, Single Root Teeth
Clinical Assessment of 3 Differant Obturation Sealers on Postoprative Pain and Swelling
aim of the study will be conducted to compare the effect of MTA fill apex sealer and endo sequence bioceramic sealer in obturation on the intenisty of postoperative pain and the incidence of post operative swelling in patient…
- Trial name
- NCT05419752
- Testing
- bioceramic sealer, MTA, resin sealer
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulp Necroses
Histopathological Evaluation of the Periodontal Ligament Subjected to Laser Ablation.
Laser Ablation therapy (LA) using an 810nm diode laser and Indocyanine Green (ICG) solution, which efficiently absorbs laser energy and increases the effectiveness of tissue removal.
- Trial name
- NCT06173648
- Testing
- Laser and ICG solution.
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- CAO Group, Inc.
Necrotic Pulp, Primary Teeth
Clinical and Radiographic Evaluation of Zinc Oxide Modified 3Mixtatin Versus Zical in Root Canal Treatment of Necrotic Primary Molars.
Primary molars with necrotic pulp or abscess are common unfortunate event faced in pediatric dentistry .The traditional treatment is either pulpectomy or extraction.
- Trial name
- NCT06752889
- Testing
- Group( 1): Control Group (pulpectomy using zic oxide eugenol based sealer Zical):, Group ( 2) Experimental group modified 3-MIX-TATIN):
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Necrotic Pulp, Apical Periodontitis
Effect of Diclofenac Sodium Versus Calcium Hydroxide as Intracanal Medication on the Intensity of Postoperative Pain, Bacterial Load Reduction and MMP-9 Levels in Patients With Necrotic Pulp.
the aim of this study is to compare the effect of using Diclofenac Sodium Versus Calcium Hydroxide as Intracanal medication on intensity of postoperative pain, bacterial load reduction after root canal preparation and periapical…
- Trial name
- NCT05582421
- Testing
- Diclofenac Sodium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Necrotic Pulp
Evaluation of Pain Relief and Bacterial Reduction After Using Calcium Hydroxide With Mesoporous Silica Nanoparticles as an Intracanal Medicament in Necrotic Mandibular Molars: A Randomized Controlled Clinical Trial
This study compares how well different root canal medications reduce pain and bacteria after treatment of lower molar teeth with necrotic pulp.
- Trial name
- NCT07327996
- Testing
- Calcium Hydroxide Intracanal medication, mesoporous silica nanoparticles paste, Calcium Hydroxide + mesoporous silica nanoparticles
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Pulp Necroses
Laser Activated Irrigation Versus Passive Ultrasonic Irrigation
assessment of bacterial reduction and post-operative pain following Laser activated irrigation using sodium hypochlorite and a 980 nm diode laser device as an adjunct to conventional root canal treatment, and comparing it with…
- Trial name
- NCT04035083
- Testing
- Laser activated irrigation, Passive ultrasonic irrigation
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulp Necrosis, Postoperative Pain
Evaluation of Post-operative Pain and Bacterial Load Reduction After Application of Three Intra-canal Medications (Cocoa Husk Versus Calcium Hydroxide With and Without Cocoa) in Necrotic Mandibular First Molar.
The study will aim to evaluate the postoperative pain and bacterial load after application of two intracanal medications in mandibular first molar teeth with necrotic pulp.
- Trial name
- NCT07790796
- Testing
- Root canal treatment with intracanal medication by calcium hydroxide for one week., Root canal treatment with intracanal medication by cocoa husk for one week, Root canal treatment with intracanal medication by calcium hydroxide with cocoa husk for one week.
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Pulp Necrosis
Evaluation of Biodentine and Mineral Trioxide Aggregate in Revascularization of Non Vital Immature Anterior Teeth
the object of this study is to evaluate clinically and radiographically the effect of using Biodentine and Mineral Trioxide Aggregate as coronal plug materials in revascularization of non-vital immature teeth
- Trial name
- NCT03589560
- Testing
- Biodentine, Mineral Trioxide Aggregate
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Root Canal Therapy
Apical Size and Root Canal Treatment Success Trial (AS-RCT Trial)
This study is looking into two different ways to perform a root canal treatment. The study will look at differences and compare the two different treatment options over a 2-year period.More specifically, this study evaluates a…
- Trial name
- AS-RCT (NCT03053037)
- Testing
- final apical size instrumentation
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Washington
Photochemotherapy Reaction, Dental Pulp Necrosis
Antimicrobial Photodynamic Therapy Associated With the Conventional Endodontic Treatment: A Clinical and Microbiological Study
Microorganisms play a critical role in the etiology and pathogenesis of apical periodontitis. Enterococcus faecalis and Candida sp. are frequently associated with persistent infections.
- Conditions
- Photochemotherapy Reaction, Dental Pulp Necrosis, Polymerase Chain Reaction, Infection
- Trial name
- NCT03212729
- Testing
- ANTIMICROBIAL PHOTODYNAMIC THERAPY, Conventional endodontic treatment
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Necrotic Pulp
Effect of Etidronate in Sodium Hypochlorite Versus Sodium Hypochlorite on the Intensity of Postoperative Pain
To compare the effect of using Etidronate in sodium hypochlorite versus sodium hypochlorite irrigating solution on: Postoperative pain in patients with necrotic pulp.
- Trial name
- NCT04035330
- Testing
- etidronate in sodium hypochlorite, sodium hypochlorite
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulp Necrosis
Photo-Activated Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth
This study aims to compare regenerative endodontics for necrotic young permanent anterior teeth using oral photo-activated disinfection versus triple antibiotic paste in terms of: 1.
- Trial name
- NCT03763110
- Testing
- Photo Activated Disinfection, antibiotic paste
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Necrotic Pulp
Incidence of Post-Operative Pain After Single Visit Root Canal Treatment in Necrotic Teeth Using Two Different Rotary Systems (Protaper Nex t& Neolix File)
this prospective in vivo randomized clinical is to evaluate the post operative pain (incidence ,degree and duration) with multiple full rotation file (protaper next ®) and single full rotation file (Neolix®) in treating maxillary…
- Trial name
- NCT03059290
- Testing
- neolix file
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Necrotic Pulp
Efficacy of Guedes-Pinto Paste and CTZ Paste in the Non-instrumental Endodontic Treatment of Primary Teeth
The maintenance of the deciduous tooth until its physiological exfoliation occurs is one of the main objectives of pediatric dentistry.
- Trial name
- NCT04587089
- Testing
- Irrigation, Filling with Guedes-Pinto Paste, Filling with CTZ Paste
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Necrotic Pulp, Acute Apical Periodontitis of Pulpal Origin
Clinical Efficacy of Novel Jasminum-based Calcium Hydroxide Medicament
A triple-blind, parallel group, randomized trial with an allocation ratio of 1:1. Participants randomly allocated into two groups A and B.
- Trial name
- NCT06653608
- Testing
- Nano-reinforced calcium hydroxide medicament, Calcium hydroxide without nanoparicles
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Necrotic Pulp
Rosmarinus Officinalis Versus 2.5%Sodium Hypochlorite as Root Canal Irrigants
To measure the Effect of Rosmarinus Officinalis versus 2.5%Sodium Hypochlorite as Root canal Irrigants on the Intensity of post-operative pain and Bacterial Reduction in asymptomatic necrotic Mandibular premolars.
- Trial name
- NCT05289843
- Testing
- Rosmarinus Officinallis
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulp Necroses, Periapical Lesion
Magnetic Resonance Imaging (MRI) of Pulp Regeneration
The present study was conducted to test whether pulp-like tissue can be regenerated in mature teeth with closed apex? And whether the size of the apical diameter affects the success of REPs? And whether Magnetic resonance imaging…
- Conditions
- Pulp Necroses, Periapical Lesion, Regeneration
- Trial name
- NCT03804450
- Testing
- Regenerative endodontic procedures (REPs)
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Alexandria University