Clinical trials: Dental Pulp Necroses
Treatment, Periodontitis, Apical
Treatment of Young Permanent Teeth With Different Adjuvant Approaches
To determine microbiology assessment of infected root canal in young permanent teeth, as well as antimicrobial efficiency of different adjuvant treatment modalities including photodynamic therapy (PDT), high-power diode laser…
- Conditions
- Treatment, Periodontitis, Apical, Necrotic Pulp
- Trial name
- NCT05291195
- Testing
- Laser-device group, Essential Oil, Sodium hypochlorite group
- Where
- Serbia
- Volunteers
- 40 people
- Sponsor
- University of Belgrade
Pulp Necrosis, Apical Periodontitis
Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis
This randomized controlled clinical trial evaluates the effect of conventional metronidazole and nano-formulated metronidazole as root canal irrigants, with and without ultrasonic activation, in patients with necrotic…
- Trial name
- NCT07897591
- Testing
- Metronidazole 0.5%, Nano-formulated Metronidazole 0.5%, Sodium Hypochlorite 2.5%
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- October 6 University
Dental Pulp Necrosis, Dental Pulp Disease
Digitized Assessment for the Survival of Mature Anterior Teeth With Periapical Lesion After One Step Regenerative Approach Using Different Asepsis Maneuvers
Trial is designed to allow revascularization and tissue engineering in necrotic teeth with peripical lesion in a single visit approach.
- Conditions
- Dental Pulp Necrosis, Dental Pulp Disease, Dental Pulp; Degeneration
- Trial name
- RCT (NCT03652129)
- Testing
- Disinfection
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Pulp Necrosis
Investigation of the Effect of Low Torque and Speed on Post-Operative Pain After Root Canal Treatment
Root canal preparation is one of the most important stages in root canal treatment. Nowadays, the use of Nickel-Titanium(Ni-Ti) rotary instrument systems for root canal expansion is becoming very popular.
- Trial name
- NCT06309095
- Testing
- use of VDW Silver Endodontic motor
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Necrotic Pulp
Postoperative Pain Following Treatment of Asymptomatic Necrotic Mandibular Molars in Single Visit Using Wave-one Reciprocating Instruments Versus One-Shape Rotary Instruments
The aim of this study is to evaluate the post treatment pain after instrumentation of root canals with a single file reciprocating (Wave-One Ni Ti file, DENTSPLY Maillefer) or rotary(One Shape, Micro Mega, France) file system in…
- Trial name
- NCT03301259
- Testing
- One-shape rotationary system
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Pulp Necrosis
Pain and Microbial Reduction of Antimicrobial Corticosteroid Mixture Versus Cryotherapy in Necrotic Teeth
The aim of this study is to compare the effect of antimicrobial-corticosteroid mixture and cryotherapy as final root canal irrigating solutions on post-instrumentation pain in single-canal teeth with necrotic pulps.
- Trial name
- MIXCRYO (NCT05739682)
- Testing
- Local anaesthetic injection of 4% articaine with 1:100000 epinephrine, Tooth isolation, Access cavity preparation
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Cairo University
Periapical Diseases, Periapical Periodontitis
Postoperative Pain After Conservative Root Canal Preparation
The goal of this clinical trial is to compare the pain experienced by healthy participants after root canal treatment with small versus large root canal sizes. The main questions it aims to answer are: 1.
- Conditions
- Periapical Diseases, Periapical Periodontitis, Postoperative Pain, Pulp Necroses
- Trial name
- NCT06545773
- Testing
- Root Canal Treatment with ProTaper Next Nickel-Titanium File (PTN), Root Canal Treatment withTruNatomy Nickel-Titanium File (TN)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Necrotic Pulp
Healing Potentiality Of Blood Clot S-PRF and A-PRF in the Treatment Of Necrotic Mature Single-Rooted Teeth With Chronic Peri-Apical Periodontitis
Earlier, it was believed that successful regeneration cannot be achieved once tooth has become infected. However, recent studies suggest that regenerative endodontics may in fact be possible in teeth with pulpal necrosis and…
- Trial name
- NCT04606719
- Testing
- Advanced Platelet Rich fibrin
- Where
- Egypt
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulp Necroses
Efficacy of Combined Blood Clot and Platelet Rich Fibrin Scaffolds in Regeneration of Necrotic Immature Permanent Teeth
The aim of the present study is to assess clinically and radio-graphically the regenerative potential of immature permanent teeth with necrotic pulp using blood clot and Platelet rich fibrin scaffolds.
- Trial name
- NCT04390854
- Testing
- Blood clot scaffold, Blood clot scaffold combined with PRF
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Nourhan M.Aly
Pulp and Periapical Tissue Disease, Pulp Necroses
The Efficacy of Laser in Root Canal Disinfection
The aim of this study is to assess in vivo the efficacy of Er,Cr:YSGG/diode laser and Diode/EDTA on bacterial count in root canal treatment in an evidence-based clinical trial.
- Conditions
- Pulp and Periapical Tissue Disease, Pulp Necroses, Pulp; Granuloma
- Trial name
- NCT05964686
- Testing
- Conventional group (NaOCl/EDTA), Dual laser group (Er,Cr:YSGG/Diode):, Combined group (EDTA/Diode):
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Dental Pulp Necrosis, Periapical Diseases
Clinical and Radiographic Success of Calcium Hydroxide-Iodoform Paste Versus Modified Triple Antibiotic Paste for Necrotic Primary Molars in Children
This randomized clinical trial aims to compare the clinical and radiographic success of calcium hydroxide-iodoform paste and modified triple antibiotic paste when used for the treatment of necrotic primary molars in children…
- Conditions
- Dental Pulp Necrosis, Periapical Diseases, Dental Caries, Primary Teeth
- Trial name
- NCT07773805
- Testing
- Calcium Hydroxide, Iodoform, paste, modified triple antibiotic paste
- Volunteers
- 50 people
- Sponsor
- Cairo University
Necrotic Pulp, Apical Periodontitis
Regenerative Endodontic Treatment of Mature Necrotic Teeth With Apical Periodontitis
The aim of this prospective, randomized, controlled double-blind study is to evaluate the effectiveness of biodentine compared with MTA used as pulp space barrier on discoloration of teeth after regenerative based non-obturation…
- Trial name
- NCT04018456
- Testing
- Biodentine, White MTA
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Dental Pulp Necrosis
Postoperative Pain After Endodontic Irrigation Using 1.3% Versus 5.25% Sodium Hypochlorite
The aim of this prospective, randomized, clinical trial was to evaluate the effect of 1.3% sodium hypochlorite (NaOCl) concentration versus 5.25% NaOCl concentration on post-operative pain and medication intake in adult patients…
- Trial name
- NCT03792217
- Testing
- 1.3% NaOCl, 5.25% NaOCl
- Volunteers
- 308 people
- Sponsor
- Cairo University
Pulpal Necrosis
The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth
In cases of permanent tooth avulsion, it is widely accepted that some necrosis always occurs after avulsion injury. If the pulp tissue does not revascularize or if endodontic therapy is not performed, the pulp space can become…
- Trial name
- NCT02477358
- Testing
- Left Tooth Platelet Rich Fibrin; Right Tooth Implant Alone, Right Tooth Platelet Rich Fibrin; Left Tooth Implant Alone
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Necrotic Pulp
Effect of Apical Enlargement to Different Preparation Sizes and Tapers on Pain and Bacterial Reduction in Necrotic Pulp
The aim of this prospective randomized clinical trial is to evaluate the effect of different apical size and taper preparation (35. 04; 35. 06; 45. 04 and 45.
- Trial name
- NCT05620147
- Testing
- Root canal instrumentation EdgeFile X7 to size #35/0.06, Root canal instrumentation EdgeFile X7 to size #45/0.04, Root canal instrumentation EdgeFile X7 to size #45/0.06
- Volunteers
- 56 people
- Sponsor
- Cairo University
Irreversible Pulpitis, Apical Periodontitis
Bite Force Measurements
ABSTRACT: Acute dental pain from untreated decay often drives patients to emergency rooms (ERs), where the lack of definitive dental treatment results in nearly 75% of these patients receiving analgesics, predominantly opioids.
- Conditions
- Irreversible Pulpitis, Apical Periodontitis, Pulpal Necrosis
- Trial name
- NCT06843525
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Rutgers, The State University of New Jersey
Endodontic Treatment, Pulp Necrosis
Dexamethasone Treatment for Patients Undergoing Endodontics
This Phase IV randomized clinical trial (RCT) evaluated the efficacy of preoperative administration of a single 4 mg oral dose of dexamethasone in reducing postoperative pain and inflammation following endodontic treatment.
- Conditions
- Endodontic Treatment, Pulp Necrosis, Periapical Lesions, Postoperative Pain
- Trial name
- (DTPE-RCT) (NCT06906315)
- Testing
- Dexamethasone 4 mg, Ibuprofen group
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- University of Salamanca
Pulp Necrosis
Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste
The purpose of this study is to determine the treatment outcomes in permanent teeth with necrotic pulp and immature root development that undergo a regenerative procedure using a triple antibiotic paste (ciprofloxacin…
- Trial name
- NCT00881491
- Testing
- Double Antibiotic Paste, Triple Antibiotic Paste, Mineral Trioxide Aggregate
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pulp Necrosis, Periapical Lesion
Success Rate of Single Versus Two Visit Regenerative Treatment Protocol in Non Vital Mature Anterior Teeth
This study evaluates success rate of non vital mature anterior teeth with periapical lesion treated by regenerative endodontic protocol in single visit versus two visit technique.
- Conditions
- Pulp Necrosis, Periapical Lesion, Anterior Teeth
- Trial name
- NCT03717337
- Testing
- Single visit pulp regeneration, Two visit pulp regeneration
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Pulp Necrosis
Antimicrobial Efficacy of Four Different Irrigation Protocols
proper disinfection of root canal system before obturation is a must for long term success of endodontic treatment, therefore a proper irrigant is mandatory, therefore investigators are studying the antibacterial effects of 4…
- Trial name
- NCT03668899
- Testing
- irrigation
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University