Clinical trials: Delivery Uterine
Postpartum Hemorrhage, Twin
Oxytocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With Twin Pregnancy
Postpartum hemorrhage (PPH) due to uterine atony is a major cause of maternal morbidity and mortality. Uterotonic drugs are used to improve the muscle tone of the uterus after birth and these are effective at reducing the…
- Trial name
- NCT04025658
- Testing
- Oxytocin
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Thin Endometrium, Infertility Female
Effectiveness of Intrauterine Growth Hormone Administration as an add-on Therapy to Conventional Hormone Therapy Compared to Placebo in Patients With Thin Endometrium Undergoing Frozen Thawed Embryo Transfer
The purpose of this clinical trial is to see if intrauterine growth hormone infusions can help subjects reach a suitable endometrial thickness in patients who are resistant to routine hormonal therapy for embryo transfer in the…
- Conditions
- Thin Endometrium, Infertility Female, Infertility
- Trial name
- NCT06379659
- Testing
- Growh hormone
- Where
- Iran
- Volunteers
- 54 people
- Sponsor
- Isfahan University of Medical Sciences
Pregnancy Related, Immune-mediated Diseases
Impact of In Utero Exposure to Immunomodulatory Drugs on Neonatal Immune System Development
What is this project about? This project aims to better understand how the immune system develops in babies whose mothers received immunomodulatory treatments during pregnancy.
- Trial name
- NEWbornIMMPACT (NCT07033663)
- Testing
- Monoclonal antibody
- Where
- 3 sites in Spain
- Volunteers
- 90 people
- Sponsor
- Fundació Sant Joan de Déu
Preeclampsia, Preterm Birth
Prediction of Preeclampsia and Other Pregnancy Complications Following Combined Iterative Screening
Preterm birth (PTB), preeclampsia (PE), fetal growth restriction (FGR) and intra-uterine fetal death (IUFD) constitutes the main causes of perinatal morbidity and mortality and are called "Great Obstetrical Syndromes".
- Conditions
- Preeclampsia, Preterm Birth, Fetal Growth Restriction, Intra Uterine Fetal Death
- Trial name
- PREDICTION2 (NCT03067298)
- Where
- Canada
- Volunteers
- 805 people, healthy volunteers welcome
- Sponsor
- Emmanuel Bujold
Diabetes, Gestational, Glucose Metabolism Disorders
Gestational Diabetes Mellitus and Neurodevelopment in Newborns
The purpose of this study is to evaluate the feasibility of using a quantitative EEG method to evaluate neurodevelopment in newborns and to evaluate whether subtle neurodevelopmental deficits can be detected in newborns from…
- Trial name
- NCT02779452
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Cesarean Delivery, Postpartum Hemorrhage (PPH)
Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery
The goal of this clinical trial is to learn whether applying topical tranexamic acid (TXA) directly to the uterine incision during cesarean delivery can reduce surgical bleeding compared to placebo.
- Conditions
- Cesarean Delivery, Postpartum Hemorrhage (PPH), Intraoperative Blood Loss, Hemostasis
- Trial name
- NCT07362992
- Testing
- Tranexamic Acid (Topical)
- Where
- 4 sites in Israel
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Infertility, Endometrial Peristalsis
Endometrial Peristalsis and Pregnancy Outcomes in Hormone Replacement Therapy (HRT) - Frozen Embryo Transfer (FET) Cycles
Endometrial peristalsis may influence embryo implantation and pregnancy outcomes, but its role during hormone replacement therapy (HRT)-prepared frozen embryo transfer (FET) cycles remains unclear.
- Conditions
- Infertility, Endometrial Peristalsis, Uterine Contraction, Endometrial Waves
- Trial name
- CONCO (NCT07675213)
- Testing
- Endometrial peristalsis and hormone measurements
- Where
- Vietnam
- Volunteers
- 442 people
- Sponsor
- Mỹ Đức Hospital
Preterm Birth, Cervical Insufficiency
Bed Rest With a Short Cervix on Preterm Birth
Maternal AR has long been used to prevent PTB. However, definitions of AR vary widely, ranging from complete bed rest to partial limitation of physical activity for one or more hours daily.
- Conditions
- Preterm Birth, Cervical Insufficiency, Bed Rest, Pregnancy Complications
- Trial name
- BEWISE (NCT07577388)
- Testing
- Activity Restriction, No Activity Restriction
- Volunteers
- 6,000 people
- Sponsor
- Julie Glavind
Postpartum Hemorrhage
TRAnexamic Acid for Preventing Postpartum Hemorrhage Following a Cesarean Delivery
The aim is to assess the impact of tranexamic acid (TXA) for preventing postpartum hemorrhage (PPH) following a cesarean section (CS).
- Trial name
- TRAAP2 (NCT03431805)
- Testing
- Tranexamic Acid Injectable Solution, Sodium Chloride 0.9%
- Where
- 26 sites in France
- Volunteers
- 4,574 people
- Sponsor
- University Hospital, Bordeaux
Brain Cancer, Head and Neck Cancer
A Simple Walking Program to Enhance Concurrent Chemoradiotherapy Delivery
By utilizing fitness trackers, this study aims to demonstrate that a simple walking program improves patients' ability to tolerate curative concurrent chemoradiotherapy without treatment interruption.
- Conditions
- Brain Cancer, Head and Neck Cancer, Lung Cancer, Gastrointestinal Cancer
- Trial name
- NCT03115398
- Testing
- Pedometer-based Walking Program
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Montefiore Medical Center
Postpartum Hemorrhage, Vaginal Delivery
Reducing Postpartum Hemorrhage After Vaginal Delivery
Postpartum hemorrhage is the primary cause threatening the life safety of pregnant women in the world and China, and also the main cause of hysterectomy for women giving birth.
- Trial name
- NCT05501106
- Testing
- Integrated Improvement strategies
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University Third Hospital
Post Partum Hemorrhage
Carbetocin Versus Syntometrine in Obese Women Undergoing Elective Cesarean
to compare effectiveness and tolerability of carbetocin versus syntometrine in prevention of Postpartum hemorrhage after cesarean section
- Trial name
- NCT03693599
- Testing
- carbetocin, Syntometrine
- Where
- Egypt
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Weight Gain, Disorder of Bone Density and Structure, Unspecified
Drug Exposure and Depot Medroxyprogesterone Acetate (DMPA) in Adolescent Subjects
The investigators are doing this study to look at how different doses of the Depot medroxyprogesterone acetate (DMPA) shot effect weight gain and bone mineral density in teens.
- Conditions
- Weight Gain, Disorder of Bone Density and Structure, Unspecified, Uterine Bleeding
- Trial name
- NCT01461824
- Testing
- Depot medroxyprogesterone acetate (DMPA)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Postpartum Hemorrhage
A Study of Self-administered Misoprostol to Prevent Bleeding After Childbirth in the Community (MamaMiso)
Postpartum hemorrhage (PPH) is a major cause of maternal death in the developing world. An important strategy in the prevention of deaths is the use of uterotonic drugs for PPH prophylaxis.
- Trial name
- NCT01510574
- Testing
- Misoprostol
- Where
- 4 sites in Uganda
- Volunteers
- 749 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Venous Thromboembolism, Postpartum Period
The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The goal of the PARTUM trial is to determine if taking low-dose aspirin daily for 6 weeks after delivery is similar (non-inferior) to usual care low-molecular-weight heparin injections to prevent venous thromboembolism (VTE…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin, Low Molecular Weight Heparin
- Trial name
- NCT06494878
- Testing
- Aspirin, Low-molecular-weight heparin
- Where
- 12 sites in Belgium, Canada and 5 more
- Volunteers
- 8,805 people
- Sponsor
- University of Calgary
Infertility, Fertility Disorders
Live Birth Rate After Sperm Selection Using ZyMōt Multi (850µL) Device for Intra Uterine Insemination
This single centre interventional pilot randomized control study intends to compare two methods of sperm preparation for couples referred for Intra Uterine Insemination (IUI) procedure.
- Trial name
- FERTINSEM (NCT06144268)
- Testing
- ZyMōt Multi (850µL), Density Gradient Centrifugation
- Where
- Belgium
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Cesarean Section Complications, Fertility Disorders
Uterine Inflammatory Characteristics
Data regarding fertility following niche repair is limited. It has been reported that a niche can reduce the chances of embryo implantation and may lead to spontaneous miscarriages if the implantation is close to or in the niche.
- Trial name
- NCT04747418
- Testing
- Diagnostic Hysteroscopy, Trans-vaginal ultrasound
- Where
- Israel
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Placenta Previa, Post Partum Hemorrhage
Glove-loaded Foley's Catheter Tamponade for Cesarean Section for Placenta Previa
Objective: To investigate the effect of A glove-loaded Foley's catheter tamponade versus stepwise uterine devascularization on blood loss during cesarean section (CS) in patients with complete placenta previa.
- Trial name
- NCT03570723
- Testing
- A glove-loaded Foley's catheter tamponade, stepwise uterine devascularization
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Aswan University Hospital
Severe Postpartum Haemorrhage
A Research Study to See How Safe is Eptacog Alfa When Used to Stop Heavy Bleeding in Women After Giving Birth in India
This study will look at how safe is the medicine eptacog alfa when used in women in India for stopping heavy bleeding after giving birth.
- Trial name
- NCT07157423
- Testing
- Eptacog alfa (NovoSeven)
- Where
- 14 sites in India
- Volunteers
- 64 people
- Sponsor
- Novo Nordisk A/S
Uterine Contraction, Labor Complication
Oral Calcium Supplementation in Labor
The goal of this clinical trial is to learn if oral calcium carbonate can improve uterine contractions and labor outcomes in term pregnancies. It will also evaluate the safety of calcium carbonate when used during labor.
- Conditions
- Uterine Contraction, Labor Complication, Labor Active Dilated Cm, Labor Dystocia
- Trial name
- NCT07056062
- Testing
- Calcium carbonate
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Arrowhead Regional Medical Center