Clinical trials: Delirium in Old Age
Delirium in Old Age
Correlation of Perioperative Brain Metabolites With Postoperative Delirium in Elderly Oral Craniomaxillofacial Surgery Patients
In view of the increasingly severe aging situation in China, the perioperative brain health of elderly patients has received increasing attention.
- Trial name
- NCT05694091
- Testing
- Collecting clinical data, blood gas data, Magnetic Resonance Spectroscopy (MRS) data and blood,urine, and feces sample
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Post-operative Cognitive Decline, Post-operative Delirium
Cardiac Surgery Neuroprotection Study in Elders
The goal of this study is to determine the potential ability of intranasal insulin to prevent post-operative cognitive decline and post-operative delirium in an elderly cardiac surgery population.
- Trial name
- CNS-Elders (NCT01561378)
- Testing
- Aspart insulin, Normal saline, Intranasal mucosal atomizer device
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Albert Einstein College of Medicine
Postoperative Delirium (POD), Prostate Cancer
A Phase II Clinical Two-Stage Study of Transcranial Magnetic Stimulation in Preventing Postoperative Delirium in Elderly Patients After Urological Surgery
Cases were included based on the inclusion and exclusion criteria, and induction, maintenance, and recovery were conducted in accordance with the standard protocol for general anesthesia.
- Conditions
- Postoperative Delirium (POD), Prostate Cancer, Kidney Tumor
- Trial name
- NCT07480044
- Testing
- Transcranial Magnetic Stimulation Device
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Zhejiang University
Delirium
Quetiapine in Prevention of Delirium
The aim is to study the effectiveness of Quetiapine in preventing delirium in the elderly patients with multiple risks for delirium.
- Trial name
- NCT05793632
- Testing
- Quetiapine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Post-Operative Confusion
Braindex Cerebral Tissue Oxygen Saturation (SctO2) Measurement Algorithm Assessment and Improvement
The objective of this clinical trial is to optimize Braindex brain tissue oxygen saturation (SctO2) measurement algorithm compared to a mixed reference value of jugular venous and systemic arterial saturation, during proven…
- Trial name
- POC-SctO2 (NCT05897060)
- Testing
- Venus Jugular O2 Saturation optical fiber
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Braindex
Delirium in Old Age
Predicting Delirium by Attentional Dysfunction
Rationale: Delirium is a common complication that occurs in various medical conditions. Validated models predicting delirium in individual patients are scarce and existing models tend to focus on demographic characteristics and…
- Trial name
- RAPID (NCT03988179)
- Testing
- The Cholinesterase Inhibitor Prognosticator (ChIP) application for iPad
- Volunteers
- 172 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Postoperative Delirium, Sarcopenia
Effect of Preoperative Sarcopenia on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Surgery
The goal of this observational study is to compare Incidence of postoperative delirium in Sarcopenic and non-sarcopenic elderly patients undergoing gastrointestinal surgery.
- Conditions
- Postoperative Delirium, Sarcopenia, Gastrointestinal Surgery, Anesthesia
- Trial name
- NCT05847296
- Where
- China
- Volunteers
- 334 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Delirium in Old Age, Anesthesia; Adverse Effect
Postoperative Dexmedetomidine in Prevention of Postoperative Delirium
The goal of this clinical trial is to learn how postoperative infusion of dexmedetomidine would influence postoperative delirium in elderly patients undergoing lung surgery. The main questions it aims to answer are : 1.
- Trial name
- NCT06382961
- Testing
- Dexmedetomidine injection, Sufentanil injection
- Where
- China
- Volunteers
- 287 people
- Sponsor
- Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.
Postoperative Delirium
Dexmetomedine for Post Operative Delirium in Elderly Patients Undergoing Elective Total Knee Replacement Under Spinal Anesthesia
Postoperative delirium is a geriatric syndrome occurring after anesthesia and surgery which manifests as acute alterations in mental status, involving changes in cognition, attention, and levels of consciousness that tend to…
- Trial name
- NCT05707741
- Testing
- dexmetomedine infusion
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Delirium
The Effect of Melatonin on Postoperative Delirium in Elderly ICU Patients
Delirium in older patients is associated with increased mortality and health care costs. And delirium is frequent in intensive care unit (ICU).
- Trial name
- NCT02588742
- Testing
- Melatonin
- Where
- South Korea
- Volunteers
- 3 people
- Sponsor
- Yonsei University
Postoperative Delirium, Postoperative Cognitive Dysfunction
fMRI Connectivity in Fracture Hip Patients
The long-term goal of this study is to evaluate cognitive function preoperatively and develop techniques of intervention in the perioperative period which would optimize brain function and functional recovery following surgery.
- Trial name
- NCT02997930
- Testing
- fMRI, Montreal Cognitive Assessment (MoCA), Digital Clock Drawing Test Command and Copy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Florida
Femoral Neck Fractures, Postoperative Complications
Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty
Hip fractures incidence grows rapidly with the aging of the population. After indicated surgical treatment, hip fracture patients experience high rates of postoperative complications, postoperative delirium (PD), postoperative…
- Conditions
- Femoral Neck Fractures, Postoperative Complications, Inflammatory Response, Postoperative Delirium
- Trial name
- NCT01934049
- Testing
- hip arthroplasty, Total Intravenous Anesthesia and Peripheral nerve blocks
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Delirium in Old Age, Anaesthetic
Impact of Propofol Versus Sevoflurane on Incidence of Postoperative Delirium in Elderly Patients After Spine Surgery
Postoperative delirium in older adults is a common and costly complication after surgery. Propofol and sevoflurane are commonly used anesthetics to maintain sedation during spine surgery, and have different sedative and…
- Trial name
- NCT05158998
- Testing
- propofol infusion, sevoflurane inhalation
- Where
- 2 sites in China
- Volunteers
- 298 people
- Sponsor
- Qianfoshan Hospital
Avitaminosis, Delirium, Dementia, Amnestic, Cognitive Disorders
Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly
Low cobalamin (vitamin B12) levels are frequent in the elderly. Most often they reflect a mild metabolic abnormality without clinical symptoms (subclinical cobalamin deficiency).
- Trial name
- NCT00212147
- Testing
- General anesthesia with nitrous oxide, General anesthesia without nitrous oxide
- Where
- 2 sites in United States
- Volunteers
- 444 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cohort Studies
The Impact of Preoperative Depression on Postoperative Delirium in Elderly Chinese Patients: A Retrospective Multicenter Observational Study
This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of preoperative depression on the incidence of postoperative delirium among elderly Chinese patients…
- Trial name
- NCT07744282
- Volunteers
- 8,000 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Delirium
The Comparison of Incidence and Risk Factors of Postoperative Delirium in Elderly Patients After Lower Extremity Surgery
The aim of this study is to compare the risk factors and the incidence of delirium following orthopedic surgery under the general or regional anesthesia in elderly patients.
- Trial name
- NCT02360982
- Testing
- propofol and esmeron(rokuronyum), marcaine and fentanyl
- Volunteers
- 120 people
- Sponsor
- Cukurova University
Hearing Loss, Hearing Loss, Age-Related
Sight and Hearing Investigation Into Effects on Delirium
The goal of this observational study is to learn about sensory loss in hospital patients with delirium. The main questions it aims to answer are: Are hearing and vision loss related to increased risk of having delirium? Do…
- Conditions
- Hearing Loss, Hearing Loss, Age-Related, Hearing Disability, Delirium
- Trial name
- SHIELD (NCT06176625)
- Testing
- Communication Signage, Amplifier Use
- Where
- United States
- Volunteers
- 1,543 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Postoperative Delirium (POD)
Perioperative Dezocine Administration and Postoperative Delirium in Elderly Cardiac Surgery Patients
Postoperative delirium (POD) is a common complication in elderly patients undergoing cardiac surgery and is associated with prolonged hospitalization, increased morbidity, and poor recovery.
- Trial name
- NCT07768150
- Testing
- Dezocine, Normal Saline (NS)
- Where
- 2 sites in China
- Volunteers
- 640 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Delirium
Impact of Impaired Cerebral Autoregulation on Postoperative Delirium in Elderly Patients Undergoing Spine Surgery
Delirium (confusion) after surgery is common and associated with a longer hospitl stay and increased hopsital cost. There is very little information available about how often delirium occurs and the complications associated with…
- Trial name
- NCT01574950
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Johns Hopkins University
Delirium
Rivastigmine in the Management of Delirium
The aim of this study is to evaluate the efficacy of an anticholinesterase treatment in patients aged 75 and over, hospitalized with delirium.
- Trial name
- confuriv (NCT01487317)
- Testing
- Rivastigmine transdermal patch
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris