Clinical trials: Delirium Prevention
Delirium in Old Age
Quality Contract: Prevention of Postoperative Delirium in the Care of Older Patients (QV-POD-2)
The project "QV-POD-2" is a prolongation based on "QV-POD-1", which was a quality contract program of the IQTIG - Institute for Quality and Transparency in Health Care.
- Trial name
- NCT04355195
- Where
- 2 sites in Germany
- Volunteers
- 18,100 people
- Sponsor
- Charite University, Berlin, Germany
Delirium
Digital Rehabilitation Environment Augmenting Medical System
D.R.E.A.M.S. will assess an immersive digital reality-augmenting system in reducing the occurrence of cognitive, behavioral, and emotional consequences of critical illness and environmental exposures that are risk factors for the…
- Trial name
- DREAMS (NCT03385993)
- Testing
- Technology based guided meditation and relaxation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Postoperative Delirium, Aging Disorder
Non-pharmacological Prevention of Postoperative Delirium by Occupational Therapy Teams
In the world, 230 million surgeries are performed every year and US data indicates that more than a third of patients who undergo surgery are older than 65 years, in which between 10 and 70% develop postoperative delirium (POD).
- Trial name
- PREPODOT (NCT03704090)
- Testing
- Occupational therapy intervention, Standard non-pharmacological prevention intervention
- Where
- Chile
- Volunteers
- 160 people
- Sponsor
- University of Chile
Neurological Conditions
DELirium, Incidence, preVEntion and pRogression During Acute Intensive Neurological -Neurosurgical Rehabilitation
In this longitudinal cohort study the incidence of delirium is assessed for all patients being admitted to the acute intensive neurological-neurosurgical rehabilitation over 3 years.
- Trial name
- DeliVeriNN (NCT07070310)
- Where
- Germany
- Volunteers
- 210 people
- Sponsor
- Heart Centre Rotenburg
Postoperative Delirium
EPO for Postop Delirium in Elderly Patients
Postoperative delirium is a common complication after surgery. The underlying pathophysiology of this complication is unclear, however neuroinflammation and oxidative stress secondary to surgery had shown to be the cause of…
- Trial name
- NCT06178835
- Testing
- Erythropoietin, normal saline
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Yonsei University
Delirium
A Multidisciplinary Delirium Prevention Strategy Involving Psychiatry in the ICU
Delirium affects up to 80% of intensive care unit (ICU) patients and is associated with longer hospital stays, increased morbidity and mortality, and increased costs.
- Trial name
- ICU (NCT03550495)
- Testing
- psychiatry involvement
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Southern California
Central Nervous System Diseases
Impact Dexmedetomidine on Postoperative Delirium in Patients After Intracranial Operation for Brain Tumor
Postoperative delirium is one of the most common serious complications after major surgery and is associated with undesirable consequences.
- Trial name
- NCT04494828
- Testing
- Dexmedetomidine, Normal saline group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Delirium in Old Age, Anesthesia; Adverse Effect
Postoperative Dexmedetomidine in Prevention of Postoperative Delirium
The goal of this clinical trial is to learn how postoperative infusion of dexmedetomidine would influence postoperative delirium in elderly patients undergoing lung surgery. The main questions it aims to answer are : 1.
- Trial name
- NCT06382961
- Testing
- Dexmedetomidine injection, Sufentanil injection
- Where
- China
- Volunteers
- 287 people
- Sponsor
- Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.
Mechanically Ventilated Patients
Prevention of Delirium in Intensive Care by Melatonin
This is a double-blind, randomized, placebo-controlled, Phase 2b/3 two-part adaptive clinical trial. The trial is designed to investigate the pharmacokinetics and the efficacy of multiple dosing regimens of melatonin and to…
- Trial name
- DEMEL (NCT03524937)
- Testing
- MELATONIN (HIGH DOSE), MELATONIN (LOW DOSE)
- Where
- France
- Volunteers
- 355 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Delirium
Using Eye Mask and Earplugs on Prevention of Delirium
This research is planned as a randomized controlled experimental study to examine the effect of using eye mask and earplugs in preventing delirium with evidence-based nonpharmacological nursing interventions in intensive care…
- Trial name
- NCT05000476
- Testing
- eye mask and earplugs, Nurse Education and Environmental Regulation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Baskent University
Delirium in Old Age
Software-guided Cognitive Stimulation to Prevents Delirium
This study is a pilot randomized controlled trial, comparing a group of older patients with standardized non-pharmacological delirium prevention plus a basic tablet versus a group with standardized non-pharmacological delirium…
- Trial name
- Prevedel (NCT03573843)
- Testing
- Prevention software
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- University of Chile
Postoperative Delirium
Prevention of Postoperative Delirium After Acute Surgery
The aim of this trial is to evaluate the implementation and effect of an evidence based, multicomponent intervention on postoperative delirium, when fast implemented throughout the patients stay in hospital before, during and…
- Trial name
- POD-CARE (NCT04857125)
- Testing
- Patient interventions, Staff education
- Where
- Denmark
- Volunteers
- 476 people
- Sponsor
- Bispebjerg Hospital
Delirium
Efficacy of Melatonin in Decreasing the Incidence of Delirium in End of Life Patients
The purpose of this study is to determine if melatonin administration to end-of-life patients is effective in preventing the development of delirium compared with those who do not receive this treatment.
- Trial name
- NCT02536417
- Testing
- Melatonin, Sugar pill
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Fraser Health
Delirium
Melatonin for Delirium Prophylaxis
Delirium is a common complication of illness especially among the elderly with serious sequelae including increased mortality, morbidity and length of stay.
- Trial name
- NCT02282241
- Testing
- Melatonin
- Where
- Canada
- Sponsor
- University of British Columbia
Behavior Problem
Effects of Esketamine on Postoperative Behavioral Changes in Children Undergoing Tonsillectomy and/or Adenoidectomy
The goal of this clinical trial is to learn the effect of intravenous esketamine in postoperative negative behavior changes in children compared to placebo (a look-alike substance that contains no drug).
- Trial name
- NCT06579937
- Testing
- Esketamine hydrochloride, normal saline
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Fujian Provincial Hospital
Intensive Care Unit Delirium, Postoperative Delirium
Role of Natural Light in the Prevention of Delirium After Cardiac Surgery: a Prospective Observational Study With Historical Control
Postoperative delirium is a common complication that usually occurs acutely within the first 24 hours after surgery and resolves within 72 hours; it is common in all medical areas and particularly affects patients over the age of…
- Conditions
- Intensive Care Unit Delirium, Postoperative Delirium, Cardiac Surgery
- Trial name
- iWOnDer (NCT05936944)
- Testing
- Exposure to totally artificial lighting
- Where
- Italy
- Volunteers
- 448 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Emergence Delirium
Emergence Agitation of Sevoflurane in Pediatric
Low dose nalbuphine versus dexmedetomidine on prevention of emergence agitation in children
- Trial name
- NCT06830564
- Testing
- we will give the patient 0.1 mg nalbuphine 15 min before the end of the procedure, we will give the patient 0.5 mg dexmedetomidine 15 min before the end of the procedure
- Where
- Egypt
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Hematopoietic Stem Cell Transplantation, Delirium
High Dose Intravenous Thiamine for the Prevention of Delirium in Allogeneic Hematopoietic Stem Cell Transplantation
Purpose: To conduct a randomized controlled pilot study investigating the use of high dose intravenous (IV) thiamine to prevent delirium and mitigate the long-term effects of delirium, including health-related quality of life…
- Conditions
- Hematopoietic Stem Cell Transplantation, Delirium, Thiamine Deficiency
- Trial name
- NCT03263442
- Testing
- Thiamine, Normal saline
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Delirium
Melatonin Supplementation for Delirium Prevention in Acutely Hospitalized Elderly
122 people over 70 who were admitted to hospital were enrolled to the study. Half got .5 mg a night of melatonin, half got a placebo.
- Trial name
- NCT00873379
- Testing
- melatonin
- Where
- Canada
- Volunteers
- 122 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Emergence Delirium
Ketofol Versus Dexmedetomidine for Prevention of Emergence Delirium in Pediatric Patients Undergoing Squint Surgeries
The aim of the study is to compare the effectiveness of ketofol for the prevention of emergence delirium in pediatric patients undergoing squint surgery, in comparison to dexmedetomidine.
- Trial name
- NCT06545890
- Testing
- Ketamine, Dexmedetomidine
- Where
- 2 sites in Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University