Clinical trials: Degenerative Lumbar Canal Stenosis
Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease
Effect of Pre-existing Adjacent Segment Degeneration on Long-term Effectiveness After Lumbar Fusion Surgery
This is a prospective single-center study. Patients requiring posterior lumbar interbody fusion (PLIF) for lumbar degenerative disease are prospectively enrolled and followed.
- Conditions
- Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease, Degeneration Spine
- Trial name
- NCT04467944
- Testing
- Pre-existing degenerative factors at adjacent segment
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Peking University Third Hospital
Spinal Canal Stenosis, Spondylolisthesis
Adaptix RCT Evaluating Adaptix™ Versus PEEK Cages
The purpose of this randomized controlled trial is to assess and compare radiographic and clinical outcomes in patients who are to undergo combined interbody/posterolateral lumbar fusion procedures, supplemented with pedicle…
- Conditions
- Spinal Canal Stenosis, Spondylolisthesis, Osteophyte, Bony Growth Formation
- Trial name
- NCT05182489
- Testing
- Medtronic Adaptix™ titanium implants, Medtronic CAPSTONE® PEEK cage
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Spinal Stenosis Lumbar, Spinal Canal Stenosis
Degenerative Lumbar Stenosis Conservative Treatment
The trial aims to compare the effectiveness of three methods of conservative treatment of degenerative lumbar spine stenosis (DLSS): GOLDIC autologous serum epidural injections, steroid epidural injections and manual therapy.
- Trial name
- GOLDSTEN (NCT04492774)
- Testing
- Goldic serum, Steroid injections, Manual therapy
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Sutherland Medical Center
Degenerative Lumbar Canal Stenosis
Comparison Between The Results of Open and Microsurgical Decompression in Degenerative Spinal Canal Stenosis in Lumbar Spine
To compare the outcomes of open and microsururgical decompression in degenerative spinal stenosis in lumbar spine
- Trial name
- NCT06722859
- Testing
- Open surgical decompression in degenerative lumbar canal stenosis, Microsurgical decompression
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Assiut University
Lumbar Spinal Stenosis
Minimal Invasive Surgery Versus Interlaminar Decompression in Lumbar Canal Stenosis
Conventional open surgery has been shown to be an effective procedure for LCS decompression. Minimally invasive surgery (MIS) through tubular retractors is a recently introduced alternative procedure for decompression of LCS.
- Trial name
- NCT05147064
- Testing
- minimally invasive surgery, conventional open surgery
- Volunteers
- 40 people
- Sponsor
- Assiut University
Lower Back Pain of Disc Origin, Joint Facet Syndrome
Long-Term Evaluation of the Performance and Safety of the IntraSPINE® Interlaminar Implant in the Treatment of Lumbar Degenerative Disc Disease
This is an observational study designed as an extension of a prospective study conducted between 2012 and 2017. Patients who were originally enrolled in the initial study are being recontacted for follow-up assessment, including…
- Conditions
- Lower Back Pain of Disc Origin, Joint Facet Syndrome, Lumbar Canal Stenosis, Spinal Disease
- Trial name
- IntraLT (NCT07790328)
- Testing
- IntraSPINE
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Cousin Biotech
Low Back Pain, Lumbar Spinal Stenosis
Improvement of Low Back Pain After Decompression in Patients with Degenerative Spinal Canal Stenosis
Degenerative lumbar spine disease is a leading cause of disability in the world; it encompasses conditions such as spondylolisthesis, disc degeneration, and lumbar spinal stenosis.
- Trial name
- NCT05791422
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Assiut University
Degenerative Lumbar Spinal Stenosis
Segmental Decompression Versus Wide Decompression With Fixation for Degenerative Lumbar Canal Stenosis
The purpose of this study is to compare two different surgical techniques for treating degenerative lumbar canal stenosis, a condition where the lower spinal canal narrows and puts pressure on the spinal nerves.
- Trial name
- NCT07542054
- Testing
- Segmental Decompression, Wide Decompression with Fixation
- Volunteers
- 56 people
- Sponsor
- Assiut University
Degenerative Spine, Degeneration of Lumbar Intervertebral Disc
Percutaneous Trans-facet Spine Fixation
Percutaneous Trans-facet Fixation Massoud-Goel Technique and Theory for Treatment of Degenerative Spine
- Conditions
- Degenerative Spine, Degeneration of Lumbar Intervertebral Disc, Degenerative Cervical Disc Disease, Ligamentum Flavum Hypertrophy
- Trial name
- Massoud-Goel (NCT07001969)
- Testing
- Massoud-Goel Technique and Theory, Percutaneous Trans-facet Fixation for Treatment of Degenerative Spine
- Where
- Egypt
- Volunteers
- 77 people
- Sponsor
- Mahmoud Massoud
Lumbar Spondylolisthesis Involving L4-L5
Survivorship of Decompression Alone Vs Decomp With Fusion in DLS and LCS
There has been a long-standing controversy on the operative treatment of Degenerative Lumbar Spondylolisthesis (DLS) with Lumbar Canal Stenosis (LCS), especially whether the addition of fusion to decompression is necessary.
- Trial name
- NCT05386381
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Chronic Low-back Pain, Herniated Disc
LISA Post Market Clinical Follow-Up Study: Documentation of Clinical Outcomes After Surgery With LISA Implant
The study is a post-market surveillance study of the Lumbar Implant for Stiffness Augmentation (LISA), a medical device, which is used to treat low-back pain that accompanies degenerative lesions of grades II, III, and IV…
- Conditions
- Chronic Low-back Pain, Herniated Disc, Degenerative Disc Disease, Lumbar Canal Stenosis
- Trial name
- LISA-PMCF (NCT04631133)
- Testing
- Lumbar Implant for Stiffness Augmentation (LISA)
- Where
- 5 sites in Denmark, France and 1 more
- Volunteers
- 136 people
- Sponsor
- BACKBONE
Spinal Stenosis Lumbar Canal With Neurogenic Claudication (Diagnosis)
Comparison of Open and Minimally Invasive Surgical Techniques in the Treatment of Degenerative One-level Stenosis of Lumbar Spine
The purpose of this study is to evaluate the clinical and radiological results of surgical treatment of one-level central stenosis of the lumbar spine using traditional open approach (PLIF) and a minimally invasive procedure (MIS…
- Trial name
- NCT03748277
- Testing
- Decompression, PLIF, MIS TLIF
- Where
- Russia
- Volunteers
- 132 people
- Sponsor
- Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
Lumbar Spinal Stenosis
Endoscopic Versus Conventional Lumbar Decompression for Lumbar Canal Stenosis
This is a randomized controlled trial comparing interlaminar uniportal endoscopic bilateral lumbar decompression with conventional open laminectomy in patients with degenerative lumbar canal stenosis.
- Trial name
- ENDOLSS (NCT07562035)
- Testing
- Interlaminar Uniportal Endoscopic Lumbar Decompression, Open Lumbar Laminectomy
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Ain Shams University
Low Back Pain, Herniation, Disc
Non-surgical Spinal Decompression Therapy and Outcomes
This project will determine the clinical utility of non-surgical spine decompression for chronic low back pain (LBP). LBP is one of the highest incidence medical conditions that contributes to disability, decreased activities of…
- Conditions
- Low Back Pain, Herniation, Disc, Sciatic Radiculopathy, Intervertebral Disc Stenosis of Neural Canal
- Trial name
- RESTORE (NCT06525896)
- Testing
- NSSD
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of South Florida
Degenerative Lumbar Spinal Stenosis, Degenerative Spondylolisthesis
Instability in the Lumbar Spine of Patients With Age Related Changes and Narrowing of the Spinal Canal (Spinal Stenosis)
Age related changes in the lumbar spine can lead to narrowing of the spinal canal (spinal stenosis) causing leg and back pain. Spinal stenosis can be associated with a misalignment of the spine caused by forward slippage of a…
- Trial name
- NCT04406987
- Testing
- decompression, fusion
- Where
- Denmark
- Volunteers
- 235 people
- Sponsor
- Spine Centre of Southern Denmark
Lumbar Canal Stenosis
Anterior Discectomy Surgery With Arthrodesis in Degenerative Spinal Canal sténoses. (ICASC)
Single-center retrospective study to characterize changes in the functional capacity of patients (change in Oswestry Desability Index (ODI)) undergoing anterior approach surgery for the management of symptomatic lumbar spinal…
- Trial name
- ICASC (NCT06555887)
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Brest
Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease
Preventive Effect of Limited Decompression on Adjacent Segment Following Posterior Lumbar Interbody Fusion
This is a prospective single-center study. Patients requiring posterior lumbar interbody fusion (PLIF) for degenerative disease are prospectively enrolled and followed.
- Conditions
- Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease, Degeneration Spine
- Trial name
- NCT04469387
- Testing
- Limited decompressions at adjacent segment with asymptomatic pre-existing spinal canal stenosis, Responsible segments fused
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Lumbar Disc Disease, Low Back Pain
Clinical and MRI Findings in Lumbar Disc Disease
Low back pain related to lumbar disc disease is a very common condition. Doctors frequently use Magnetic Resonance Imaging (MRI) to look at the spine and diagnose these problems.
- Conditions
- Lumbar Disc Disease, Low Back Pain, Lumbar Disc Herniation, Lumbosacral Radiculopathy
- Trial name
- NCT07516613
- Volunteers
- 96 people
- Sponsor
- Assiut University