Clinical trials: Deep Brain Stimulation
Deep Brain Stimulation, PARKINSON DISEASE (Disorder)
Cortical Network Modulation by Subthalamic Nucleus DBS
Deep brain stimulation of the subthalamic nucleus (STN DBS) in Parkinson's disease (PD) can provide substantial motor benefit yet can also produce unwanted mood and cognitive side effects.
- Trial name
- NCT04922411
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Dystonia, Pediatric
Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia
The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children.
- Conditions
- Dystonia, Pediatric, Deep Brain Stimulation, Motor Development
- Trial name
- NCT07325175
- Testing
- DBS
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Refractory Epilepsy, Deep Brain Stimulation
Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection.
- Trial name
- NCT05493722
- Testing
- Physician-Selected Settings Stimulation, Optimized Settings Stimulation, DBS Setting Optimization
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Parkinson's Disease (PD), Deep Brain Stimulation
Coordinated Reset Deep Brain Stimulation for Parkinson's Disease
Deep brain stimulation (DBS) is a surgical implant procedure for the treatment of Parkinson's Disease (PD) utilizing medical devices approved by the FDA.
- Trial name
- CR DBS PD (NCT07340073)
- Testing
- DBS
- Volunteers
- 24 people
- Sponsor
- University of Minnesota
Deep Brain Stimulation, Parkinson Disease
Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study
The objective of this research study is to understand how Deep Brain Stimulation (DBS) targeting the subthalamic nucleus (STN) affects cognitive networks in the brain, potentially leading to cognitive decline in patients with…
- Trial name
- NCT06960096
- Testing
- DBS combined with fMRI
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Parkinson Disease, Deep Brain Stimulation
Effect of Physical Activity on the Course of Parkinson's Disease in Patients With Bilateral DBS-STN Stimulation.
Parkinson's disease is a common, progressive neurodegenerative disorder. The degeneration of dopaminergic neurons is associated with characteristic clinical symptoms such as tremor, rigidity, slowness of movement (bradykinesia)…
- Conditions
- Parkinson Disease, Deep Brain Stimulation, PD - Parkinson's Disease, PD
- Trial name
- EPA-DBS (NCT07838636)
- Testing
- Physiotherapy, Education about physiotherapy
- Where
- Poland
- Volunteers
- 102 people
- Sponsor
- Medical University of Warsaw
Parkinson's Disease (PD), Deep Brain Stimulation
A Study of Buntanetap in Participants With PD
This study will examine the long-term safety of buntanetap in participants with PD. This will be a 36-month open-label safety study. This study will be conducted with two cohorts.
- Trial name
- NCT07284784
- Testing
- buntanetap/posiphen
- Where
- 27 sites in United States
- Volunteers
- 500 people
- Sponsor
- Annovis Bio Inc.
Pathology Requiring Deep Brain Stimulation Therapy
Determination of Biomarkers of the Effectiveness of Deep Brain Stimulation by Direct Electrophysiological Recordings of Brain Activity in a Cognitive Context - LFP-DBS 2024
Deep brain stimulation (DBS) is a therapeutic approach aimed at applying high-frequency, low-intensity electrical stimulation using electrodes implanted in subcortical structures and connected subcutaneously to a stimulator…
- Trial name
- LFP-DBS 2024 (NCT06813300)
- Testing
- Electrophysiological recordings
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier St Anne
PARKINSON DISEASE (Disorder), Deep Brain Stimulation
Anesthesia and Postoperative Delirium in Parkinson DBS
Parkinson's disease (PD) is the second most common neurodegenerative disorder, with a rising incidence due to global aging. Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is a core therapeutic modality for motor…
- Conditions
- PARKINSON DISEASE (Disorder), Deep Brain Stimulation, Postoperative Delirium
- Trial name
- POD-DBS-PD (NCT07792265)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Tiantan Hospital
Deep Brain Stimulation
Efficacy and Safety of Combo-stim Deep Brain Stimulation for Treatment-refractory Mental Disorders
This is a multi-center, single arm, prospective, open-label, extendable study for the efficacy and safety of combo-stim deep brain stimulation for treatment-refractory mental disorders (obsessive-compulsive disorder…
- Trial name
- NCT06112067
- Testing
- deep brain stimulation
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai Mental Health Center
Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder
Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease
The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in…
- Conditions
- Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Deep Brain Stimulation, Mild Alzheimer's Disease
- Trial name
- LIFUP-MCIAD (NCT05417555)
- Testing
- Low-Intensity Focused Ultrasound Pulsation (LIFUP)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Los Angeles
Parkinson's Disease (PD), Essential Tremor
LIFUS For Neurological Disorders
Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation.
- Conditions
- Parkinson's Disease (PD), Essential Tremor, Orthostatic Tremor, Dystonia
- Trial name
- NCT07417280
- Testing
- LIFUS
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Freezing of Gait Symptoms in Parkinson's Disease, Deep Brain Stimulation
Imaging Biomarkers of FOG Response to DBS
For this study, the investigators are recruiting 54 individuals with Parkinson's Disease and Freezing of Gait (FOG) who are planning to undergo Deep Brain Stimulation (DBS).
- Trial name
- NCT06951906
- Testing
- fMRI
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Medical University of South Carolina
Parkinson's Disease, Deep Brain Stimulation
Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS
This study is focused on people with Parkinson's disease who already have deep brain stimulation devices. The goal is to understand how aerobic exercise, specifically forced vs voluntary cycling, affects movement, thinking, and…
- Trial name
- NCT07442747
- Testing
- Exercise
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- The Cleveland Clinic
Deep Brain Stimulation
Evaluation of Advanced Imaging and Visualization for Clinical Deep Brain Stimulation
The objective of this project is to evaluate next generation visualization tools and surgical targeting models for clinical deep brain stimulation (DBS).
- Trial name
- NCT06191874
- Testing
- Standard-of-care (SOC) surgery plan, HoloDBS hypothetical surgery plan
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Duke University
Deep Brain Stimulation, PARKINSON DISEASE (Disorder)
Investigating the Increased Risk of Falls in Individuals With Parkinson's Disease Treated With Deep Brain Stimulation
The purpose of this pilot study is to assess changes in thinking and movement after deep brain stimulator implantation. The study will also examine whether these changes are related to the risk of falls.
- Trial name
- NCT07725315
- Testing
- DBS as part of standard of care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Treatment Resistant Depression, Undergoing Deep Brain Stimulation (DBS) Surgery
Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant Depression
Treatment resistant depression remains a major problem for individuals and society. Surgical procedures may provide relief for some of these patients.
- Trial name
- NCT03952962
- Testing
- Abbott Laboratories Infinity™ implantable deep brain stimulation system
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Nader Pouratian
Parkinson Disease, Deep Brain Stimulation
Safety and Tolerability of Patterned Stimulation for DBS in the Home Setting
The primary objective of the proposed pilot study is to assess the safety and tolerability of active patterned Deep Brain Stimulation (pDBS) when administered in a home setting for patients with Parkinson's disease (PD) who have…
- Trial name
- NCT07410598
- Testing
- Biphasic deep brain stimulation, Conventional deep brain stimulation, Theta burst deep brain stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Florida
Parkinson Disease, Gait Disorders, Neurologic
Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease
The purpose of this study is to assess how alternating-frequency Deep Brain Stimulation (DBS) works to improve postural instability and gait, while also treating other motor symptoms of Parkinson Disease (PD).
- Conditions
- Parkinson Disease, Gait Disorders, Neurologic, Disease Progression, Subthalamic Nucleus
- Trial name
- ENGAGE-PD (NCT05022147)
- Testing
- High-Frequency-Only Stimulation, Low-Frequency-Only Stimulation, Alternating, 50 sec High-Frequency, 10 sec Low-Frequency Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- James Liao
Deep Brain Stimulation, Parkinson's Disease (PD)
Testing of an Interface for Synchronizing tACS-DBS With a Phase-locked-loop
The investigators aim to test an interface to phase-lock transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS) for future studies investigating the effects of different time-lags between DBS and…
- Trial name
- NCT07139093
- Testing
- DBS-coupled tACS
- Where
- Germany
- Volunteers
- 2 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf