Clinical trials: DNA Strand Breaks
DNA Damage, DNA Strand Breaks
Comparison of Two Different Sperm Processing Methods and Their Effects on Sperm DNA Fragmentation and Embryo Development
The goal of this clinical trial is to learn if the LensHooke CA0 device lowers DNA fragmentation in sperm samples compared to a gradient/swim-up technique. The main questions it aims to answer are: 1.
- Conditions
- DNA Damage, DNA Strand Breaks, Sperm DNA Fragmentation
- Trial name
- NCT06990841
- Testing
- sperm separation device
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Richard Kordus, PhD, HCLD (ABB)
Reactive Hyperemia, Micro RNA
Effect on Markers of Cardiovascular, Reproductive and Cancer Risk From Firefighting Training
Epidemiological studies based on Danish registries have observed that Danish male firefighters have more cardiovascular disease, infertility diagnose and a trend to increased risk of cancer than other Danish employed males.
- Conditions
- Reactive Hyperemia, Micro RNA, Heart Rate Variability, DNA Strand Breaks
- Trial name
- BIOBRAND3 (NCT05753254)
- Testing
- Firefighting training exercises with no fire, Firefighting training exercises under wood fire, Firefighting training exercises under gas fire
- Where
- 2 sites in Denmark
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Research Centre for the Working Environment, Denmark
HNSCC, DNA Damage
Predictive Biomarkers for Response to Nivolumab in Head and Neck Squamous Cell Carcinoma
Nivolumab is FDA-approved for the treatment of patients with recurrent/metastatic Head and Neck Squamous Cell Carcinoma (HNSCC). HNSCC whose disease has progressed within 6 months after platinum-based chemotherapy.
- Conditions
- HNSCC, DNA Damage, DNA Double Strand Break
- Trial name
- NCT03652142
- Testing
- Biomarker Research, Nivolumab
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Attikon Hospital
Spermatogenesis and Semen Disorders, DNA Double Strand Break
Effects of Procyanidine on Semen Parameters and DNA Fragmentation Index During Cryopreservation of Abnormal Human Semen Samples
Cryopreservation is the storage of biological material at subzero temperatures at which biochemical processes of cell metabolism and the biochemical reactions that lead to cell death are slowed, interrupted or stopped.Many…
- Trial name
- NCT03451682
- Testing
- procyanidine
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Aristotle University Of Thessaloniki
Spermatogenesis and Semen Disorders, DNA Double Strand Break
In Vitro Effects of Procyanidine on Semen Parameter and DFI
Proanthocyanidins are a class of polyphenols found in a variety of plants that have antioxidant activity in vitro, which is stronger than vitamin C or vitamin E.
- Trial name
- NCT03414164
- Testing
- procyanidine
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Aristotle University Of Thessaloniki