Clinical trials: Cytoreductive Surgery
Malignant Tumor
Effect of Intraoperative Dexmedetomidine on Development of Acute Kidney Injury
To investigate the renal protective effect of dexmedetomidine in patients undergoing cytoreduction and hyperthermic intraperitoneal chemotherapy
- Trial name
- NCT02641938
- Testing
- Dexmedetomidine, Normal Saline
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Gangnam Severance Hospital
Cytoreductive Surgery, Grade 3 Endometrial Endometrioid Adenocarcinoma
PET/MRI in Endometrial Cancer
This study is investigating if positron emission tomography (PET)/Magnetic resonance imaging (MRI) is more effective than the currently used imaging modalities (computed tomography [CT], or PET/CT) for high-risk endometrial…
- Conditions
- Cytoreductive Surgery, Grade 3 Endometrial Endometrioid Adenocarcinoma, High Grade Serous Carcinoma, Endometrial Undifferentiated Carcinoma
- Trial name
- NCT05390021
- Testing
- PET/MRI with radiotracer ([18F]- fluorodeoxyglucose) and a gadolinium-based contrast agent
- Sponsor
- Massachusetts General Hospital
Kidney Cancer
Sunitinib Before or After Surgery in Treating Patients With Metastatic Kidney Cancer
RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00626509
- Testing
- sunitinib malate, adjuvant therapy, neoadjuvant therapy
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Gruppo Italiano Carcinoma Renale
Ovarian Cancer, Low Anterior Resection Syndrome
Assessment of Quality of Life After Low Anterior Resection During Cytoreductive Surgery for Advanced Ovarian Cancer
This study aims to evaluate the incidence of low anterior resection syndrome and quality of life after cytoreductive surgery for advanced ovarian cancer patients.
- Conditions
- Ovarian Cancer, Low Anterior Resection Syndrome, Quality of Life
- Trial name
- LAPSODY (NCT05431530)
- Testing
- Cytoreductive surgery
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Seoul National University Hospital
Relapsed/Refractory, B-cell Acute Lymphocytic Leukemia
Phase Ib/II Study Assessing the Clinical Activity and Safety of Brexucabtagene Autoleucel as a Consolidation in Patients With Relapsed/Refractory (R/R) and Newly Diagnosed B-cell Acute Lymphocytic Leukemia (ALL) Post Cytoreduction With Mini-HCVD-inotuzumab-blinatumomab/HCVAD-inotuzumab-blinatumomab
To learn about the safety of giving the drug brexucabtagene autoleucel to participants with relapsed/refractory B-cell ALL after treatment with inotuzumab ozogamicin, blinatumomab, and either hyper-CVAD or mini-hyper-CVD.
- Trial name
- NCT06287229
- Testing
- Blinatumomab, Inotuzumab Ozogamicin, Hyper-CVAD
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- M.D. Anderson Cancer Center
Peritoneal Carcinomatosis
Single-photon Emission Computed Tomography (SPECT) to Predict Peritoneal Chemotherapy
SPECT was performed in 51 patients after cytoreductive surgery in combination with intraperitoneal chemotherapy. The detected volume was compared to the number of subsequent sequential postoperative intraperitoneal chemotherapy…
- Trial name
- NCT00997633
- Where
- Sweden
- Volunteers
- 51 people
- Sponsor
- Uppsala University
Thymic Epithelial Tumor
Intrathoracic Chemotherapy for TETs With Pleural Spread or Recurrence
Hyperthermic intrathoracic chemotherapy (HITOC) offers an additional treatment option for malignant pleural tumors after surgical cytoreduction.
- Trial name
- CHOICE (NCT05446935)
- Testing
- HITOC
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Shanghai Zhongshan Hospital
Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma
Heated Mitomycin and Cisplatin During Surgery in Treating Patients With Stomach or Gastroesophageal Cancer
This phase II trial studies how well heated mitomycin and cisplatin during surgery work in treating patients with stomach or gastroesophageal cancer.
- Conditions
- Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Peritoneal Carcinomatosis
- Trial name
- NCT02891447
- Testing
- Cisplatin, Hyperthermic Intraperitoneal Chemotherapy, Mitomycin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Peritoneal Cancer, Chemotherapy-Induced Change
Study of Plasma Tumor-promoting Factors and Immune Function After Laparotomy, Cytoreductive Surgery and HIPEC vs. PIPAC in Patients With Peritoneal Metastasis
The general goal of this study is to investigate the effect of treatment on serum concentrations of proteins known to impact angiogenesis or tumor growth and establishment in patients with peritoneal metastasis of various origin.
- Trial name
- IMMUNOPAC (NCT04122885)
- Testing
- PIPAC with oxaliplatin, Cytoreductive surgery and Hyperthermic IntraPeritoneal Chemotherapy
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Tuebingen
Recurrent Ovarian Carcinoma
Secondary Interval Cytoreductive Surgery in Platinum-sensitive Recurrent Epithelial Ovarian Cancer
About 80% of advanced ovarian cancer patients recurred in 2-3 years. Secondary cytoreduction benefits selected patients who have high chance of complete resection.
- Trial name
- SCENIC (NCT06292286)
- Testing
- Carboplatin or cisplatin, Paclitaxel, gemcitabine or liposomal doxorubicin with or without bevacizumab or biosimilar, Bevacizumab or biosimilar
- Where
- Hong Kong
- Volunteers
- 18 people
- Sponsor
- The University of Hong Kong
Colorectal Peritoneal Carcinomatosis
Cytoreduction and Intraperitoneal Chemotherapy Versus Systemic Chemotherapy in Colorectal Peritoneal Carcinomatosis
The purpose of this study is to see if there is a difference in survival between two different treatment strategies for colorectal peritoneal surface disease.
- Trial name
- NCT01524094
- Testing
- Systemic chemotherapy alone (oxaliplatin, 5-fluorouracil, isovorin), Cytoreductive surgery (CRS) plus postoperative intraperitoneal chemotherapy (5-fluorouracil, isovorin)
- Where
- Sweden
- Volunteers
- 49 people
- Sponsor
- Uppsala University
Ovarian Neoplasms, Fallopian Tube Neoplasms
OVCA-NAC-P2: Study of Chemotherapy Followed by Cytoreductive Surgery for Ovarian, Tubal and Peritoneal Cancers: JCOG0206
A feasibility study of neoadjuvant chemotherapy (NAC) followed by interval cytoreductive surgery (ICS) and postoperative chemotherapy for stage III/IV mullerian carcinomas such as ovarian, tubal and peritoneal carcinomas.
- Conditions
- Ovarian Neoplasms, Fallopian Tube Neoplasms, Peritoneal Neoplasms
- Trial name
- NCT00112086
- Testing
- Neoadjuvant chemotherapy (Paclitaxel and Carboplatin)
- Where
- Japan
- Volunteers
- 56 people
- Sponsor
- Japan Clinical Oncology Group
Colon Cancer
The Influence of Perioperative Administration of Dexmedetomidine on Inflammation Response and Postoperative Outcomes in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Cytoreductive Surgery; Double Blind Randomized Controlled Trial
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) has been reported to be an effective treatment approach for peritoneal cancer, however, the stress response to HIPEC is major neuroendocrine and…
- Trial name
- NCT03370588
- Testing
- dexmedetomidine, Normal saline
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
Pseudomyxoma Peritonei, Appendiceal Neoplasms
Antibiotic Treatment and Long-term Outcomes of Patients With Pseudomyxoma Peritonei of Appendiceal Origin
The purpose of this study is to determine the impact of antibiotic therapy on the disease progression and overall survival of patients with Pseudomyxoma Peritonei (PMP).
- Trial name
- NCT02387203
- Testing
- PrevPac (Prevacid, Amoxicillin, Clarithromycin)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mercy Medical Center
Colorectal Cancer Metastatic, Peritoneal (Metastatic) Cancer
Lubiprostone Combined With Maintenance Therapy for Prevention of Postoperative Recurrence in Peritoneal Metastatic Colorectal Cancer
The goal of this phase II randomized controlled clinical trial is to evaluate whether adding lubiprostone to standard postoperative maintenance therapy can delay disease progression and recurrence in adult patients with…
- Conditions
- Colorectal Cancer Metastatic, Peritoneal (Metastatic) Cancer, Peritoneal Metastasis, Colorectal Cancer (CRC)
- Trial name
- NCT07405736
- Testing
- maintenance therapy plus lubiprostone, maintenance therapy
- Volunteers
- 124 people
- Sponsor
- Sun Yat-sen University
Ovarian Cancer, Epithelial
Two Therapeutic Strategies in First-line in Patients With Epithelial Advanced Ovarian Cancer
CHIMOVIP is a study to determine the best therapeutic strategy in patient with ovarian advanced cancer.
- Trial name
- CHIMOVIP (NCT03025477)
- Testing
- CC0 - Carboplatin (IV) - Paclitaxel (IV), CC0 - Cisplatin (IP) - Epirubicin (IV), CC>0 - Carboplatin (IV)- Paclitaxel (IV)
- Where
- 7 sites in France
- Volunteers
- 84 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Peritoneal Carcinomatosis
Peritoneal Carcinomatosis Extent Evaluation: Radiologic, Laparoscopic and Pathologic.
pathologically proved ovarian cancer patients that underwent contrast enhanced abdomino-pelvic CT and diagnostic laparoscopy before cytoreductive surgery (CRS) will be included in the study.
- Trial name
- NCT03798132
- Testing
- laparoscopy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Shimaa Abdalla Ahmed
Hyperthermia, Colorectal Neoplasms
Impact of an Optimised Monitored Anesthesia on the Patients' Recovery After Cytoreduction Surgery Plus HIPEC
The objective of our PILOT study is to evaluate the impact of a controlled (monitored) randomized anesthesia during cytoreductive surgery with HIPEC to oxaliplatin in order to treat adenocarcinomas of colorectal origin.
- Conditions
- Hyperthermia, Colorectal Neoplasms, Oxaliplatin
- Trial name
- CHIPNOL (NCT04104334)
- Testing
- Remifentanil infusion, desflurane titration and fluid infusion will be guided by NOL index, BIS index and Flotrac EV1000 system respectively, Remifentanil infusion and desflurane titration will be guided by anesthesia usual practices
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Cytoreductive Surgery
Cytoreductive Surgery in Platinum-resistant Recurrent Ovarian Cancer
This novel study was specifically designed for platinum-resistant recurrent ovarian cancers with PFI<6 months and aimed to compare prognosis of patients who received cytoreductive surgery followed by chemotherapy versus…
- Trial name
- NCT05633199
- Testing
- cytoreductive surgery
- Where
- 2 sites in China
- Volunteers
- 140 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Epithelial Ovarian Cancer
Microscopic Peritoneal Metastases After Complete Macroscopic Cytoreductive Surgery for Epithelial Ovarian Cancer
The objective of the cytoreductive surgery carried out for the management of ovarian cancers is to obtain a complete macroscopic cytoreduction. This means that all visible peritoneal metastases must be resected.
- Trial name
- MicroPCI (NCT03754569)
- Testing
- Peritoneal biopsies after complete macroscopic cytoreduction
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris