Clinical trials: Curcumin
Mood Disturbance
Curcumin and EGCG Supplementation to Improve Serum BDNF and Mood Disturbance
The goal of this randomized placebo controlled trial is to examine mood disturbance and serum brain derived neurotrophic factor (BDNF) in people (age 18-50) with DASS-21 subscale scores >9.
- Trial name
- NCT06531863
- Testing
- Curcumin, Epigallocatechin Gallate
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Auburn University
Periapical Diseases, Postoperative Dental Pain
Postoperative Pain in Photodynamic Therapy Using Curcumin As a Photosensitizer
In endodontics, various irrigation solutions are used to achieve antibacterial efficacy within the root canal. The antibacterial effect of curcumin-containing root canal solutions, when combined with photodynamic therapy, has…
- Conditions
- Periapical Diseases, Postoperative Dental Pain, Irrigation Solution, Photodynamic Therapy (PDT)
- Trial name
- NCT06752655
- Testing
- Curcumin with photodynamic thearpy, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Healthy Volunteer
Single Oral Dose Comparative Bioavailability Study of Investigational Product in Healthy Human Subjects Under Fasting Conditions.
The sponsor has developed new curcuminoid formulations with the expectation of enhanced bioavailability compared to existing benchmark products.
- Trial name
- NCT07141368
- Testing
- Curcumin Dispersome formulation, Non-formulated Curcumin, Benchmark Formulation 1 - Turmipure Gold™
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Alcohol Hangover
A Crossover Exploratory Study of NatureU Cheers Friends Curcumin on Acute Alcohol Hangover Symptoms
This was a single-center, open-label, exploratory crossover study evaluating acute hangover symptoms after use of NatureU Cheers Friends Curcumin compared with an active comparator product in healthy adult men.
- Trial name
- NUZY (NCT07585825)
- Testing
- NatureU Cheers Friends Curcumin, Herbsense Hangover Relief Tablet
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- OmniSolutions Laboratory Holdings Limited
Hypogonadism, Male
Single-Dose Pharmacokinetics of Oral Testosterone Undecanoate With and Without Concomitant Inhibition of UGT2B17
This study will be performed in normal men whose endogenous testosterone production has been temporarily suppressed by the administration of a single dose of 120 mg of the oral GnRH antagonist Relugolix, which is approved for the…
- Trial name
- OralT12 (NCT06312761)
- Testing
- Relugolix 120Mg Tab, Curcumin, Testosterone Undecanoate 237 MG Oral Capsule
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Washington
Interaction
Contribution of UGT2B17 to the Pharmacokinetics of Diclofenac
The purpose of this pilot study is to gather preliminary data on the (1) contribution of the understudied drug metabolizing enzyme, UDP-glucuronosyltransferase (UGT) 2B17, to the metabolism of a widely used medication…
- Trial name
- NCT06053411
- Testing
- Diclofenac, curcumin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington State University
Bioavailability of Phytonutrients
Testing the Bioavailability of Phytonutrients, Curcumin and Ursolic Acid
The primary objective of this research is to investigate the bioavailability of curcumin (CURC) and ursolic acid (UA) in a phase I clinical trial in healthy men and obtain biological material for bioavailability analysis.
- Trial name
- NCT04421716
- Testing
- Ursolic Acid, Curcumin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Exercise-induced Joint Pain, Exercise-induced Joint Stiffness
NEM® + BIOCURC® Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women
This study is intended to evaluate the combined effects of the dietary supplement NEM® brand eggshell membrane and BIOCURC® brand bioavailable curcumin versus placebo in reducing exercise-induced joint pain, stiffness \&…
- Conditions
- Exercise-induced Joint Pain, Exercise-induced Joint Stiffness, Exercise-induced Joint Cartilage Turnover
- Trial name
- NCT03769857
- Testing
- NEM® + BIOCURC®
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- ESM Technologies, LLC
Exercise Induced Muscle Damage
The Effect of Curcumin Supplementation on Recovery From Exercise-induced Muscle Damage
Recent evidence suggests that curcumin supplementation may reduce muscle inflammation, oxidative markers, and muscle damage. The most favourable dosage to elicit these ergogenic effects are yet to be established; both 750mg \&…
- Trial name
- NCT05346211
- Testing
- Curcumin
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- St Mary's University College
Irritable Bowel Syndrome
Curcumin (Tumeric) in the Treatment of Irritable Bowel Syndrome: A Randomized-Controlled Trial
Evidence exists to support low-grade inflammation as the inciting factor leading to visceral hypersensitivity and alteration in motility in irritable bowel syndrome.In the medical literature,there is ample in vitro and in vivo…
- Trial name
- CuTIBS (NCT00779493)
- Testing
- curcumin
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Healthy
A Study to Evaluate the Effect of Turmeric in Healthy Participants
Turmeric is recognized as a bioactive compound with potential benefits for human health. This study compares the pharmacokinetic profile of the Turmeric test product to a comparator.
- Trial name
- NCT05535231
- Testing
- Turmeric test product, Turmeric comparator
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Gaia Herbs Inc.
Vascular Stiffness
The Effects of Repeated Bouts of Downhill Running and Curcumin Supplementation on Arterial Stiffness During Recovery
Arterial Stiffness: As a recognized independent indicator of cardiovascular risk, maintaining low levels of arterial stiffening is important to cardiovascular health.
- Trial name
- Cur (NCT02281981)
- Testing
- Curcumin
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Prince Edward Island
Joint Pains
Anti-inflammatory Effects of Curcumin, Ginger and Piperine Supplementation in Ultra-trail Runners: a Double-blind Randomized Placebo-controlled Trial
ECUM-RUN is a randomized, double-blind, placebo-controlled phase 3 trial evaluating whether a 30-day oral supplementation with curcumin, ginger, and piperine (9-5-1 formulation) reduces exercise-induced joint pain and…
- Trial name
- ECUM-RUN (NCT07699575)
- Testing
- 9-5-1
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Candida Albicans Infection, Cigarette Smoking
Curcumin; Rose Bengal; Denture Stomatitis
Cigarette smoking in conjugation with bad oral hygiene is considered a typical predisposing factor for many oral diseases including denture stomatitis.
- Trial name
- NCT04837664
- Testing
- Curcumin, Rose Bengal, Nystatin
- Where
- Saudi Arabia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- King Saud University
Safety After Oral Intake, Pharmacokinetics After Oral Intake
Comparison of Curcumin Bioavailability
The curcuminoids curcumin, demethoxycurcumin and bisdemethoxycurcumin can be found in the rhizome of turmeric (Curcuma longa). Curcumin is widespread used for colouring foods.
- Trial name
- NCT03530436
- Testing
- Native turmeric extract, Native turmeric extract with 7-9% volatile turmeric oils, Turmeric extract plus mixture of phytochemicals
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Healthy
Pharmacokinetic Study on Three Formulations of Curcumin With Different Carriers
Curcumin is a molecule soluble in fat. It has multiple health benefits. Indeed, it has anti-inflammatory and anti-oxidant properties.
- Trial name
- NCT04382014
- Testing
- MAG fish oil + Curcumin OR Rice bran oil + Curcumin OR Curcumin extract
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Iron Deficiency (Without Anemia)
Effect of Ferrous iROn and cUrcumin sTatus on Inflammatory and Neurotrophic markErs
INTRODUCTION: Iron is a vital nutrient for many physiological processes including DNA production, oxygen transport and neuronal processes.
- Trial name
- Fe-ROUTINE (NCT04465851)
- Testing
- Ferrous Sulphate 65 mg, Curcumin, Ferrous Sulphate 18mg
- Where
- United Kingdom
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Westminster
Dental Plaque, Tooth Discoloration
aPDT for the Remediation of Dental Black Stain
In today's society cosmetic dentistry plays an important role in social relationships and in important aspects of life such as job applications and recruitment processes.
- Trial name
- NCT03483376
- Testing
- Dental prophylaxis, Antimicrobial photodynamic therapy (aPDT)
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Metabolites, Gut Microbiota
Interindividual Variation in Excretion of Curcumin
The objective of this project is to elucidate the interindividual variations in excretion of curcumin and its metabolites.
- Trial name
- NCT03746158
- Testing
- curcumin
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst