Alcohol HangoverNUZYNCT07585825
A Crossover Exploratory Study of NatureU Cheers Friends Curcumin on Acute Alcohol Hangover Symptoms
A study testing NatureU Cheers Friends Curcumin and Herbsense Hangover Relief Tablet in people with Alcohol Hangover, run by OmniSolutions Laboratory Holdings Limited at 1 site in China.
Trial summary
This was a single-center, open-label, exploratory crossover study evaluating acute hangover symptoms after use of NatureU Cheers Friends Curcumin compared with an active comparator product in healthy adult men. Participants completed two independent test-food sessions separated by at least 48 hours. Read more about this study
- Who is it for?
- Ages 20 to 48 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Alcohol Hangover
- What is being tested?
- NatureU Cheers Friends Curcumin and Herbsense Hangover Relief Tablet
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 12 participants
- Where
- 1 siteChina
- Study dates
- 20 Jun 2024to 25 Jun 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 48 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Signed informed consent before the study and understood the study content, procedures, and possible adverse reactions.
- Healthy adult man aged 20 to 48 years, inclusive.
- Normal social drinking lifestyle and no alcohol dependence.
- Aspartate aminotransferase and alanine aminotransferase values within two standard deviations of the normal range.
- Able to maintain normal healthy routines during the study.
- Able to avoid other interfering supplements for 2 weeks before and during the study.
- Abstained from alcohol for 24 hours before the study.
- Abstained from caffeinated beverages, including coffee, tea, and energy drinks, for 12 hours before the study.
Who cannot join
- Known allergy or hypersensitivity to product ingredients, including magnolia bark, milk thistle extract, turmeric, or alcohol.
- History of multiple drug or food allergies.
- Acute or chronic inflammatory disease, including influenza A, within the previous month.
- Hypertension.
- Participation in any other clinical trial within 1 month before first use of the study product.
- Clinically significant gastrointestinal, renal, hepatic, neurologic, hematologic, endocrine, oncologic, pulmonary, immune, psychiatric, cardiovascular, cerebrovascular, or metabolic disease within the previous 6 months.
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- Acute illness or concomitant medication use from screening to first use of the study product.
- Surgery within the previous 3 months.
- Blood donation or major blood loss greater than 450 mL within the previous 3 months.
- Difficulty swallowing.
- Use of prescription or non-prescription medications affecting nutritional supplements or alcohol metabolism.
- Any other factor judged by the investigator to make participation inappropriate.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Single-Center, Open-Label, Crossover Exploratory Study of NatureU Cheers Friends Curcumin on Acute Alcohol Hangover Symptoms in Healthy Adult Men
This was a single-center, open-label, exploratory crossover study evaluating acute hangover symptoms after use of NatureU Cheers Friends Curcumin compared with an active comparator product in healthy adult men. Participants completed two independent test-food sessions separated by at least 48 hours. Sixteen participants were recruited, 12 were screened and enrolled, and 12 were included in the effectiveness analysis. In the control session, participants took Herbsense hangover relief tablets 30 minutes before alcohol intake. In the NatureU Cheers Friends Curcumin session, participants took NatureU Cheers Friends Curcumin 30 minutes before alcohol intake. The main outcome was the Acute Hangover Scale (AHS) assessed the morning after each test session. Safety was monitored during the test procedures.
Read the detailed description
The study was designed as an exploratory human evaluation of a functional food product intended to support post-alcohol hangover relief. Eligible healthy adult male participants completed two independent test-food sessions under researcher supervision. Screening was performed on June 19, 2024, and eligible participants were enrolled on June 20, 2024. Test sessions were held on June 20 and June 23, 2024, each followed by a next-morning questionnaire; data collection was completed on June 25, 2024. Participants were instructed not to drink alcohol for 24 hours before each test day and not to eat during the 3 hours before testing. On each test day, participants arrived at the study center at approximately 18:00, completed check-in and baseline assessments including blood pressure, pulse rate, and breath alcohol measurement, and received the assigned test product at approximately 18:30. At approximately 19:00, participants consumed 100 mL of commercially available 52% Chinese baijiu within 10-15 minutes and consumed a standardized meal within 30 minutes. Blood pressure and pulse rate were measured 30, 60, and 120 minutes after alcohol intake. Participants completed the Acute Hangover Scale the next morning after waking. The study was open-label and exploratory, with no masking. Analyses compared AHS scores after NatureU Cheers Friends Curcumin with scores after the comparator product.
- Conditions
- Alcohol Hangover
- Being tested
- NatureU Cheers Friends Curcumin, Herbsense Hangover Relief Tablet
- Keywords
- NatureU Cheers Friends Curcumin, hangover, acute hangover scale, functional food, magnolia bark; milk thistle; turmeric
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
NatureU Cheers Friends CurcuminDietary supplement
NatureU Cheers Friends Curcumin is an oral functional food product containing magnolia bark extract, milk thistle extract, high-concentration turmeric, and related ingredients. Participants took three tablets 30 minutes before alcohol intake.
Herbsense Hangover Relief TabletDietary supplement
The comparator product was Herbsense hangover relief tablet. Participants took two tablets 30 minutes before alcohol intake during the comparator session.
| Study group | Role | What they receive |
|---|---|---|
| NatureU Cheers Friends Curcumin | Experimental | Participants received NatureU Cheers Friends Curcumin, three tablets orally 30 minutes before alcohol intake. Receives: Dietary Supplement: NatureU Cheers Friends Curcumin |
| Herbsense Hangover Relief Tablet | Active comparator | Participants received Herbsense hangover relief tablets, two tablets orally 30 minutes before alcohol intake. Receives: Dietary Supplement: Herbsense Hangover Relief Tablet |
What is being measured
The primary outcome is the main question the study is designed to answer.
Difference in Acute Hangover Scale Total Score Between NatureU Cheers Friends Curcumin and Comparator Product
The Acute Hangover Scale includes nine items scored from 0 to 7, with higher scores indicating more severe hangover symptoms. The primary endpoint was the difference in total AHS score after NatureU Cheers Friends Curcumin compared with the comparator product.
Measured: 12 hours after alcohol intake in each test-food session
Secondary outcomes (1)
Difference in Individual Acute Hangover Scale Item Scores Between NatureU Cheers Friends Curcumin and Comparator Product
Individual AHS item scores included hangover, thirst, fatigue, headache, dizziness, appetite loss, stomachache, nausea, and heart racing. Each item was scored from 0 to 7, with higher scores indicating more severe symptoms.
Measured: 12 hours after alcohol intake in each test-food session
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 May 2026
- Study start20 Jun 2024
- Primary completion25 Jun 2024
- Study completion25 Jun 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alcohol HangoverStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Model description
- Participants completed two independent test-food sessions, one with the comparator product and one with NatureU Cheers Friends Curcumin, separated by at least 48 hours.
- Masking
- None (open label)
- Enrolment
- 12 participants (actual)
Sponsor and investigators
- Lead sponsor
- OmniSolutions Laboratory Holdings Limited
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Luke Law, Dr, Study director, OmniSolutions Laboratory Holdings Limited
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07585825
- Sponsor's protocol ID
- 2024060001
- Other IDs
- 2024060001
- Acronym
- NUZY
- Status last verified
- Oct 2026
- First submitted
- 30 Apr 2026
- Last updated
- 15 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared due to privacy protection and ethical considerations.
Study at a glance
From the registry record, last updated by the sponsor on 15 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Single-Center, Open-Label, Crossover Exploratory Study of NatureU Cheers Friends Curcumin on Acute Alcohol Hangover Symptoms in Healthy Adult Men
- ClinicalTrials.gov ID
- NCT07585825
- Acronym / sponsor ID
- NUZY / 2024060001
- Conditions
- Alcohol Hangover
- Keywords
- NatureU Cheers Friends Curcumin, hangover, acute hangover scale, functional food, magnolia bark; milk thistle; turmeric
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 12 participants (actual)
- Lead sponsor
- OmniSolutions Laboratory Holdings LimitedIndustry (pharma, biotech, devices)
- Study start
- 20 Jun 2024 (actual)
- Primary completion
- 25 Jun 2024 (actual)
- Study completion
- 25 Jun 2024 (actual)
- First posted
- 14 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This was a single-center, open-label, exploratory crossover study evaluating acute hangover symptoms after use of NatureU Cheers Friends Curcumin compared with an active comparator product in healthy adult men. Participants completed two independent test-food sessions separated by at least 48 hours. Sixteen participants were recruited, 12 were screened and enrolled, and 12 were included in the effectiveness analysis. In the control session, participants took Herbsense hangover relief tablets 30 minutes before alcohol intake. In the NatureU Cheers Friends Curcumin session, participants took NatureU Cheers Friends Curcumin 30 minutes before alcohol intake. The main outcome was the Acute Hangover Scale (AHS) assessed the morning after each test session. Safety was monitored during the test procedures.
Detailed description
The study was designed as an exploratory human evaluation of a functional food product intended to support post-alcohol hangover relief. Eligible healthy adult male participants completed two independent test-food sessions under researcher supervision. Screening was performed on June 19, 2024, and eligible participants were enrolled on June 20, 2024. Test sessions were held on June 20 and June 23, 2024, each followed by a next-morning questionnaire; data collection was completed on June 25, 2024. Participants were instructed not to drink alcohol for 24 hours before each test day and not to eat during the 3 hours before testing. On each test day, participants arrived at the study center at approximately 18:00, completed check-in and baseline assessments including blood pressure, pulse rate, and breath alcohol measurement, and received the assigned test product at approximately 18:30. At approximately 19:00, participants consumed 100 mL of commercially available 52% Chinese baijiu within 10-15 minutes and consumed a standardized meal within 30 minutes. Blood pressure and pulse rate were measured 30, 60, and 120 minutes after alcohol intake. Participants completed the Acute Hangover Scale the next morning after waking. The study was open-label and exploratory, with no masking. Analyses compared AHS scores after NatureU Cheers Friends Curcumin with scores after the comparator product.
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants completed two independent test-food sessions, one with the comparator product and one with NatureU Cheers Friends Curcumin, separated by at least 48 hours.
| Arm | Type | Receives |
|---|---|---|
| NatureU Cheers Friends Curcumin | Experimental | Dietary Supplement: NatureU Cheers Friends CurcuminParticipants received NatureU Cheers Friends Curcumin, three tablets orally 30 minutes before alcohol intake. |
| Herbsense Hangover Relief Tablet | Active comparator | Dietary Supplement: Herbsense Hangover Relief TabletParticipants received Herbsense hangover relief tablets, two tablets orally 30 minutes before alcohol intake. |
Who may qualify
- Ages
- 20 to 48 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (8 listed)
- Signed informed consent before the study and understood the study content, procedures, and possible adverse reactions.
- Healthy adult man aged 20 to 48 years, inclusive.
- Normal social drinking lifestyle and no alcohol dependence.
- Aspartate aminotransferase and alanine aminotransferase values within two standard deviations of the normal range.
- Able to maintain normal healthy routines during the study.
Key exclusion criteria (12 listed)
- Known allergy or hypersensitivity to product ingredients, including magnolia bark, milk thistle extract, turmeric, or alcohol.
- History of multiple drug or food allergies.
- Acute or chronic inflammatory disease, including influenza A, within the previous month.
- Hypertension.
- Participation in any other clinical trial within 1 month before first use of the study product.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| NatureU Cheers Friends CurcuminNatureU Cheers Friends Curcumin is an oral functional food product containing magnolia bark extract, milk thistle extract, high-concentration turmeric, and related ingredients. Participants took three tablets 30 minutes before alcohol intake. | Dietary supplement | NatureU Cheers Friends Curcumin |
| Herbsense Hangover Relief TabletThe comparator product was Herbsense hangover relief tablet. Participants took two tablets 30 minutes before alcohol intake during the comparator session. | Dietary supplement | Herbsense Hangover Relief Tablet |
Primary outcome
Difference in Acute Hangover Scale Total Score Between NatureU Cheers Friends Curcumin and Comparator Product
Time frame: 12 hours after alcohol intake in each test-food session
The Acute Hangover Scale includes nine items scored from 0 to 7, with higher scores indicating more severe hangover symptoms. The primary endpoint was the difference in total AHS score after NatureU Cheers Friends Curcumin compared with the comparator product.
1 secondary outcome
Difference in Individual Acute Hangover Scale Item Scores Between NatureU Cheers Friends Curcumin and Comparator Product
Time frame: 12 hours after alcohol intake in each test-food session
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Oct 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared due to privacy protection and ethical considerations.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Luke Law, Dr study director
OmniSolutions Laboratory Holdings Limited
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing NatureU Cheers Friends Curcumin and Herbsense Hangover Relief Tablet in people with Alcohol Hangover, run by OmniSolutions Laboratory Holdings Limited at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Difference in Acute Hangover Scale Total Score Between NatureU Cheers Friends Curcumin and Comparator Product (time frame: 12 hours after alcohol intake in each test-food session). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Oct 2026.