Clinical trials: Curcumin
Bioavailability
Enhanced Absorption of curQ+ or Liposomal Curcumin Formulations Versus 95% Curcumin Powder in Healthy Subjects
This study is intended to evaluate how significantly a proprietary curcumin formulation (curQ+® or liposomal curcumin) results in greater GI absorption compared to 95% curcumin extract over a 6-hour time period following a single…
- Trial name
- NCT06177483
- Testing
- 95% curcumin extract powder, curQ+ curcumin formulation, liposomal curcumin formulation
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- ESM Technologies, LLC
Healthy
A Comparative Pharmacokinetic Study to Evaluate the Ability of a New Formulation to Enhance Curcuminoids Bioavailability
The rhizome of Curcuma longa (turmeric) is commonly used as a spice and for its medicinal properties traditionally in Asian countries.
- Trial name
- TURBIO (NCT03621865)
- Testing
- TG, STE, NOV
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Givaudan France Naturals
Healthy Volunteer
Single Oral Dose Comparative Bioavailability Study of Investigational Product in Healthy Human Subjects Under Fasting Conditions.
The sponsor has developed new curcuminoid formulations with the expectation of enhanced bioavailability compared to existing benchmark products.
- Trial name
- NCT07141368
- Testing
- Curcumin Dispersome formulation, Non-formulated Curcumin, Benchmark Formulation 1 - Turmipure Gold™
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Exercise-induced Muscle Soreness, Exercise-induced Joint Pain
Effects of Eggshell Membrane and Curcumin Extract Supplementation, Separately or Combined, on Recovery From Intense Exercise
Eggshell membrane and Curcumin supplementation prior to intense exercise may reduce inflammation, muscle and joint pain, and promote recovery.
- Conditions
- Exercise-induced Muscle Soreness, Exercise-induced Joint Pain, Exercise-induced Joint Stiffness, Exercise-induced Cartilage Turnover
- Trial name
- NCT07766720
- Testing
- NEM® brand eggshell membrane powder, curQ+® brand highly absorbable curcumin, NEM® plus curQ+® combination
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ESM Technologies, LLC
Mild Cognitive Impairment
Effect of Nutritional Supplementation With Turmeric on the Cognitive Performance of Subjects With Metabolic Syndrome
The EPICURO study aims to demonstrate the beneficial effects of a 6-month dietary supplementation with an improved bioavailable turmeric (MERIVA®) on inflammatory, oxidative and metabolic parameters together with cognitive…
- Trial name
- EPICURO (NCT04705220)
- Testing
- MERIVA® Tablets
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- Indena S.p.A
Depression
RCT of Adjunctive Curcumin and the Meru Health Program
This is a randomized controlled trial (RCT) to compare the Meru Health Program plus adjunctive curcumin (MHP-CUR) versus Meru Health Program only (MHP-ONLY) for adults with depression.
- Trial name
- NCT04744545
- Testing
- Meru Health Program, Curcumin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meru Health, Inc.
Glioblastoma
Study of Liposomal Curcumin in Combination With RT and TMZ in Patients With Newly Diagnosed High-Grade Gliomas
The objective of this study is to assess the tolerability, safety, and efficacy of Liposomal Curcumin (LC) in combination with radiotherapy (RT) and Temozolomide (TMZ) in patients with newly diagnosed High-Grade Gliomas (HGG).
- Trial name
- NCT05768919
- Testing
- Treatment Period 1, Treatment Period 2, Treatment Period 3
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- SignPath Pharma, Inc.
Healthy
A Study to Evaluate the Effect of Turmeric in Healthy Participants
Turmeric is recognized as a bioactive compound with potential benefits for human health. This study compares the pharmacokinetic profile of the Turmeric test product to a comparator.
- Trial name
- NCT05535231
- Testing
- Turmeric test product, Turmeric comparator
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Gaia Herbs Inc.
Uveitis
Assessment of the Anti-inflammatory Effects of Norflo Oro in Acute Relapses of HLA-B27 Associated Autoimmune Uveitis
The purpose of this study is to explore the efficacy of Norflo Oro in the treatment of relapsing autoimmune uveitis (RAU), measured as a long term reduction of the frequency and the severity of relapses, in patients with HLA-B27…
- Trial name
- NCT03584724
- Testing
- Norflo Oro
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Eye Pharma
Drug Safety
Evaluation of Liposomal Curcumin in Healthy Volunteers
Aim of the present study is: To evaluate the safety and tolerability of increasing doses of intravenous liposomal Curcumin in healthy subjects by means of adverse events, vital signs and safety laboratory assessments.
- Trial name
- NCT01403545
- Testing
- Liposomal Curcumin
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- SignPath Pharma, Inc.
Knee Osteoarthritis
Exploratory Non Comparative Study to Evaluate the Efficacy of Highly Bioavailable Curcumin (Flexofytol) in Patients With Knee Osteoarthritis
The purpose of this study is to evaluate the efficacy of bio-optimized curcumin(Flexofytol) during a 90-days period in knee ostearthritis patients on the serum levels of specific biomarkers of osteoarthritis and on the evaluation…
- Trial name
- NCT01909037
- Testing
- Flexofytol (bio-optimized curcumin)
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Tilman S.A.
Joint, Joint Diseases
Flexy3 Supplementation and Joint Health
The prevalence of osteoarthritis (OA) of the knee, hip, and hand has been estimated at 20% to 30% in the adult population (Neogi and Zhang, 2012).
- Trial name
- NCT07349264
- Testing
- Flexy3 Supplement (OriactivTM, Flexy3, Malaysia)
- Where
- Malaysia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NXTVSION SDN. BHD.
Hand Joint Discomfort
Evaluation of Flexofytol® PLUS in Hand Joint Chronic Dyscomfort.
The purpose of this study is to evaluate the effect of curcuminoids and Boswellia serrata extracts combination (Flexofytol PLUS) in support to standard treatments during a 12-weeks period on hand pain on people with chronic hand…
- Trial name
- NCT05089318
- Testing
- Flexofytol PLUS
- Where
- 2 sites in Belgium
- Volunteers
- 239 people
- Sponsor
- Tilman S.A.
Multiple Sclerosis
Dietary Supplement of Curcumin in Subjects With Active Relapsing Multiple Sclerosis Treated With Subcutaneous Interferon Beta 1a
This is a prospective, monocentric, double blind, placebo controlled, two arm study. Curcumin is derived from the rhizomes of the plant Curcuma longa (common name, turmeric) belonging to the Zingiberaceae family found in South…
- Trial name
- CONTAIN (NCT01514370)
- Testing
- IFN beta 1a 44 mcg TIW, Curcumin
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Healthy
A Study to Compare the Pharmacokinetic Profile of a Proprietary Curcumin Forumulation to a Comparator Curcumin Product
This study is investigating the pharmacokinetic profile (i.e. the way the product is processed by the body) of a proprietary curcumin formulation compared to an unformulated curcumin product.
- Trial name
- 15PCHB (NCT02474953)
- Testing
- Proprietary Curcumin Formulation, Unformulated Comparator Curcumin Product
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- KGK Science Inc.
Patients w/Advanced Cancer That Failed Std of Care Therapy
A Phase IB Dose Escalation Study of Lipocurc in Patients With Cancer
This is a single center in patient/outpatient, uncontrolled dose escalating study in cancer patients to evaluate the safety, tolerability and pharmacokinetic (PK) profiles of body surface area adjusted doses of liposomal curcumin…
- Trial name
- NCT02138955
- Testing
- Liposomeal curcumin
- Where
- 2 sites in Austria
- Volunteers
- 30 people
- Sponsor
- SignPath Pharma, Inc.
Healthy
Bioavailability of Curcuminoids From Turmipure Gold® in Different Food Matrices
The goal of this clinical trial is to learn about the extent to which turmeric compounds in different food matrices becomes available to the body in healthy volunteers.
- Trial name
- NCT06300021
- Testing
- TPG capsule, TPG ready to drink, TPG dairy analog
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Givaudan France Naturals
Healthy
Longvida Curcumin Human Pharmacokinetics Study
The primary objective of the study is to characterize the curcumin metabolites of 2 different capsule formulations of curcumin relative to unformulated Curcuma longa extract of Rhizomes including assessing relative…
- Trial name
- CRC (NCT03289507)
- Testing
- Treatment1, Treatment2, Treatment3
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Alcohol Hangover
A Crossover Exploratory Study of NatureU Cheers Friends Curcumin on Acute Alcohol Hangover Symptoms
This was a single-center, open-label, exploratory crossover study evaluating acute hangover symptoms after use of NatureU Cheers Friends Curcumin compared with an active comparator product in healthy adult men.
- Trial name
- NUZY (NCT07585825)
- Testing
- NatureU Cheers Friends Curcumin, Herbsense Hangover Relief Tablet
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- OmniSolutions Laboratory Holdings Limited
Bioavailability
Theracurmin vs Curcumin Bioavailability Study
A randomized, open-label, cross-over, single administration study to compare bioavailability of curcumin in health adults
- Trial name
- NCT04028739
- Testing
- curmin
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Handok Inc.