Clinical trials: Cumulus Cell
Infertility
Aurora Test for ART Donor Patients (AURORA-Donor)
This is a randomized observational study. The main aim is to determine potential oocyte competence predictive mRNA expression profiles in the cumulus cells isolated form individual oocytes.
- Trial name
- NCT06280677
- Testing
- AURORA-Donor
- Where
- Spain
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Fertiga, Belgium
Unrecognized Condition
The Effect of Melatonin Supplementation on Cumulus Cells and IVF Outcomes
This study investigates the effects of melatonin supplementation on cumulus cell gene expression and in vitro fertilization (IVF) outcomes in women over 35 years old.
- Trial name
- NCT06546774
- Testing
- Melatonin
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Infertility
Tachykinin and Kisspeptin Expression in Human Granulosa and Cumulus Cells
The purpose of this project is to study the presence of expression differences - at RNA and protein level - of different members of the tachykinin family and kisspeptin and their receptors, between fertile women and infertile…
- Trial name
- NCT02877992
- Testing
- Ovarian puncture
- Where
- 2 sites in Spain
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Vida Recoletas Sevilla
Infertility
Single-center Prospective Cumulus Cell Test Study in rFSH Patients
Performing an additional non-invasive oocyte diagnostic test based on cumulus cell gene expression could improve the outcome of the ART cycle for rFSH stimulated patients
- Trial name
- NCT03663868
- Testing
- CC-Test
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Dehydroepiandrosterone, DHEAS
Effects of Dehydroepiandrosterone Supplementation on Cumulus Cells Gene Expression Under Controlled Ovarian Hyper-stimulation in Patients With Diminished Ovarian Reserve
Diminished ovarian reserve (DOR) is one the challenge in the field of artificial reproductive technology (ART) while there is still no effective resolution of this disorder.
- Conditions
- Dehydroepiandrosterone, DHEAS, Gene Expression of Cumulus Cells., Ovarian Hyper-stimulation Protocol.
- Trial name
- NCT02150330
- Testing
- Dehydroepiandrosterone (DHEAS)
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Pregnancy
Single-center Prospective Cumulus Cell Test Study
Performing an additional non-invasive oocyte diagnostic test based on cumulus cell gene expression could improve the outcome of the ART cycle
- Trial name
- CC-Test (NCT03659786)
- Testing
- CC-Test
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility
Gene Expression in Cumulus Cells to Predict Pregnancy
The purpose of this study is to determine the performance of a genetic assay, GemART, in cumulus cells predictive of embryo viability, and pregnancy success in women undergoing in vitro fertilization (IVF).
- Trial name
- NCT01732900
- Testing
- Morphology, GemART assay
- Where
- 4 sites in United States
- Volunteers
- 133 people
- Sponsor
- Gema Diagnostics
Infertility
Mitochondrial Activity of Cumulus Cells From the Cumulus-oocyte Complex and Oocyte Competence
The need for non-invasive biomarkers of oocyte competency has become urgent as women increasingly delay attempts at childbearing.
- Trial name
- NCT02793752
- Testing
- Age
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Main Line Fertility Center
Telomere Length
Telomere Length in Human Polar Body and Telomere Length in Cumulus Cells: A Clinical Validation Study
To investigate whether telomere length (TL) of the first Polar body (PB) correlates with TL in Cumulus cells (CC)
- Trial name
- NCT04577560
- Testing
- First polar body biopsy in MII oocytes, PGT-A blastocyst
- Where
- United Arab Emirates
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Low Responder
Oxidative Stress-related Gene Expression in Cumulus Cells Among Low Responders
In Vitro Fertilization is considered one of effective treatment for infertile couple. However, some women do not have adequate response to controlled ovarian hyperstimulation, resulting in low response which defined as less than…
- Trial name
- NCT03155438
- Testing
- Oxidative stress-related gene expression (RNA expression), oocyte competence biomarkers
- Where
- Thailand
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Pregnancy
Multicenter Prospective Cumulus Cell Test Study
Performing an additional non invasive oocyte diagnostic test based on cumulus gene expression could improve the outcome of the ART cycle.
- Trial name
- MC_CC-Test (NCT02962466)
- Testing
- CC-Test
- Where
- 2 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
PCOS (Polycystic Ovary Syndrome), Cumulus Cell
Transcriptomic Profiling of Cumulus Cells From CAPA-IVM
Capacitation in vitro maturation (CAPA-IVM) has improved oocyte maturation and resulted in live births. Because cumulus cells (CCs) communicate bidirectionally with the oocyte, their transcriptomic profile may serve as a…
- Conditions
- PCOS (Polycystic Ovary Syndrome), Cumulus Cell, Capacitation IVM, Transcriptomic Profiling
- Trial name
- NCT07197255
- Where
- Vietnam
- Volunteers
- 10 people
- Sponsor
- Mỹ Đức Hospital
IVF/ICSI, Frozen Embryo Transfer
Cumulus Cell Mitochondrial Activity as a Non-invasive Marker of Embryo Quality (FLIM)
This study aims to test the extent of association of FLIM parameters of cumulus cells with clinical outcomes (clinical pregnancy, ongoing pregnancy at 12 weeks, and live birth) of the embryos that result from the enclosed oocytes.
- Conditions
- IVF/ICSI, Frozen Embryo Transfer, Cumulus Cell, Fluorescence Lifetime Imaging Microscopy
- Trial name
- NCT05332769
- Testing
- FLIM parameters
- Where
- Vietnam
- Volunteers
- 200 people
- Sponsor
- Mỹ Đức Hospital
Unrecognized Condition
Effects of LH and FSH on Metabolic Regulation in Cumulus Cells
The combined use of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) has improved IVF pregnancy rates in infertile women aged 35-40, but its mechanisms remain unclear.
- Trial name
- NCT06803199
- Testing
- FSH and LH, FSH
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Female Infertility Due to Diminished Ovarian Reserve
Alpha-Lipoic Acid Supplementation and IVF Outcomes in Women of Advanced Maternal Age
Female fertility declines with advancing age, largely because of deteriorating oocyte quality driven by mitochondrial dysfunction and oxidative stress within the ovarian microenvironment.
- Trial name
- NCT07685431
- Testing
- Alpha-Lipoic Acid (ALA)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Increased Oocyte Death, in Vitro Maturation
GREM1, HAS2 and PTGS2 Gene Expression Following the in Vitro Maturation (IVM)
Poor ovarian reserve (POR) is an adverse prognostic factor for In-Vitro Fertilization (IVF) success. Numerous established data showed low live birth rates per IVF cycle; 6 to 10%, including the usage of In-Vitro Maturation (IVM).
- Conditions
- Increased Oocyte Death, in Vitro Maturation, GREM1 Gene Mutation, Cumulus Cell
- Trial name
- NCT06315777
- Testing
- cumulus cell oocytes complex (COC) among women with poor ovarian reserve
- Where
- Malaysia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Infertility
Aurora Test for Patients Treated With Recombinant Gonadotropins
This is an observational study. The main aim is to determine the expression of potential biomarker genes in the cumulus cells isolated from individual oocytes in two patient cohorts: recombinant human Follicle Stimulating…
- Trial name
- AURORA-REC (NCT04710264)
- Testing
- AURORA-Rec
- Where
- Belgium
- Volunteers
- 137 people
- Sponsor
- Fertiga, Belgium
OVARIAN STIMULATION, Telomere Length
Does Recombinant FSH (rFSH, i.g. Gonal F®) as Compared to Human Menopausal Gonadotrophin (hMG) Affect Telomere Length of Cumulus Cells During Antral Follicle Growth and Impact Blastocyst Status?
Gonal-F® (follitropin alfa) is a recombinant FSH without LH activity, while Menopur® contains both LH and hCG. The MEGASET trial compared Menopur® and Gonal-F® in GnRH antagonist cycles with SET, showing similar efficacy.
- Conditions
- OVARIAN STIMULATION, Telomere Length, Telomere Length, Mean Leukocyte
- Trial name
- rFSH and hMG (NCT06732843)
- Where
- United Arab Emirates
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Endometriosis
Endometriosis Impact on Oocyte Quality
The aim of this study is to evaluate the impact of endometriosis on folliculogenesis and oocyte quality. To do so, a metabolomic approach will be conducted in order to analyze the follicular fluid.
- Trial name
- EndOvo (NCT03241329)
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infertility
Effect of Ovarian Stimulation With r-hLH/r-hFSH,r-hFSH and hMG in Reducing Apoptosis Rate in Cumulus Cells of Patients Undergoing ICSI
HP-hMG, recombinant FSH (r-hFSH) and a combination of r-hFSH/r-hLH, are commonly used for ovarian stimulation in infertile women undergoing IVF/ICSI treatments.
- Trial name
- NCT01872247
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- Centro di Biologia della Riproduzione, Palermo, Italy