Clinical trials: Crohn's
Crohn's Disease
STA-5326 in Crohn's Disease Patients
The purpose of this study is to determine the safety and tolerability of STA-5326 given once daily or twice daily to Crohn's Disease patients with moderate disease.
- Trial name
- NCT00088062
- Testing
- STA-5326
- Where
- 18 sites in United States
- Volunteers
- 48 people
- Sponsor
- Synta Pharmaceuticals Corp.
Crohn's Disease
The ImageKids Study: Developing the pMEDIC and the PICMI
The overall objectives of this study are to develop two indices capable of measuring intestinal damage, and, separately, inflammatory disease activity in Pediatric Crohn's disease by means of Magnetic Resonance Imaging with…
- Trial name
- NCT01881490
- Testing
- MRE
- Where
- Israel
- Volunteers
- 240 people
- Sponsor
- Shaare Zedek Medical Center
Crohn's Disease
Vitd and Barrier Function in IBD
Increased Intestinal Permeability is detectable in clinically active Crohn's disease, in stable Crohn's disease and is predictive of clinical relapse.
- Trial name
- VIP (NCT01792388)
- Testing
- Vitamin D, Soya Bean oil
- Where
- 2 sites in Ireland
- Volunteers
- 30 people
- Sponsor
- University of Dublin, Trinity College
Crohn Disease (CD)
AI-Assisted MRE for Intestinal Fibrosis in Crohn's Disease
Intestinal fibrotic strictures represent a severe complication of Crohn's disease (CD), affecting over half of the patients. Despite the continuous emergence of novel medications, effective treatment options remain scarce.
- Trial name
- NCT06858553
- Where
- 5 sites in China
- Volunteers
- 234 people
- Sponsor
- Minhu Chen
Crohn's Enteritis, Crohn Disease
Impact of a Physical Activity Program on Bone Mineral Density in Children and Adolescents With Chronic Inflammatory Bowel Disease
Muscle and physical activity play an important role in in growth, development and bone health in healthy children, especially during puberty.
- Conditions
- Crohn's Enteritis, Crohn Disease, Ulcerative Colitis, Chronic; Colitis (Noninfective)
- Trial name
- PROPHYSICOS (NCT03774329)
- Testing
- Usual care, adapted physical activity
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Lille
Crohn Disease
TRansmural hEaliNg Definition in CroHn's Disease (TRENCH 1)
Multicenter prospective cross-sectional study of CD patients, its aim is the construction of an objective and reproducible system for evaluation of Transmural healing in Crohn's Disease (CD).
- Trial name
- TRENCH 1 (NCT05903066)
- Testing
- Magnetic Resonance Enterography (MRE)
- Where
- 18 sites in Belgium, France
- Volunteers
- 210 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Inflammatory Bowel Disease, Crohn's Disease
The Impact of 6MP Metabolite Levels on Infliximab Pharmacokinetics and Anti-infliximab Antibodies in Crohn's Disease
In this research proposal, the investigators will focus on methods to optimize the therapeutic response to anti-TNF antibodies, by determining a correlation of 6-mp metabolite levels with IFX trough levels, anti-IFX antibody…
- Trial name
- NCT02453607
- Testing
- Infliximab, thiopurine
- Where
- Canada
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Ernest Seidman
Crohn's Disease
Dose Ranging Study Comparing the Efficacy, Safety and Pharmacokinetics of Intravenous Infusions of ABT-874 vs Placebo in Subjects With Active Crohn's Disease
To compare the efficacy, safety and pharmacokinetics of ABT-874 to placebo in subjects who have moderately to severely active Crohn's Disease.
- Trial name
- NCT00562887
- Testing
- ABT-874
- Where
- 61 sites in United States, Australia and 5 more
- Volunteers
- 246 people
- Sponsor
- Abbott
Crohn Disease
Impact of Infliximab in Fistulizing Crohn's Disease on Health Care Resources (Study P04204)(TERMINATED)
A multi-centre retrospective review of fistulizing Crohn's disease (CD) patient charts will capture data to measure health care resource utilization associated with the use of Infliximab for treatment of CD.
- Trial name
- NCT00705471
- Testing
- Infliximab
- Volunteers
- 42 people
- Sponsor
- Merck Sharp & Dohme LLC
Crohn Disease
A Study of LY4395089 and Mirikizumab (LY3074828) Given Together and Mirikizumab (Alone) in Adults With Crohn's Disease
The main purpose of this study is to see how the safety and efficacy of a farnesoid X receptor (FXR) agonist (LY4395089), given together with mirikizumab compares with mirikizumab (alone) in adults with moderately to severely…
- Trial name
- NCT07483099
- Testing
- LY4395089, Mirikizumab - Intravenous (IV), Mirikizumab - Subcutaneous (SC)
- Where
- 70 sites in United States, Belgium and 8 more
- Volunteers
- 60 people
- Sponsor
- Eli Lilly and Company
Crohn's Disease, IBD
Precision Crohn's Disease Management Utilizing Predictive Protein Panels (ENvISION)
Crohn's disease and ulcerative colitis affect about 1.6 to 3 million people in the United States with many of those being young children and adolescents.
- Trial name
- ENvISION (NCT04131504)
- Testing
- Infliximab, Adalimumab
- Where
- 4 sites in United States
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Ulcerative Colitis, Crohn's Disease
An Open-label Study of Vedolizumab (MLN0002) in Participants With Ulcerative Colitis and Crohn's Disease
The purpose of this multicenter, open-label study is to collect data on the occurrence of important clinical safety events resulting from chronic vedolizumab (MLN0002) administration.
- Trial name
- GEMINI LTS (NCT00790933)
- Testing
- Vedolizumab
- Where
- 41 sites in United States, Australia and 8 more
- Volunteers
- 2,243 people
- Sponsor
- Takeda
Inflammatory Bowel Diseases
Evaluation of the Clinical and Immunological Impact of Two Therapeutic Strategies in Chronic Inflammatory Diseases
This study evaluates 2 therapeutic strategies (increase infliximab dose or add an immunosuppressant) in patients with inflammatory bowel disease in loss of response to infliximab.
- Trial name
- STAMP (NCT03370601)
- Testing
- Infliximab, Mercaptopurine, Azathioprine
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Lille
Crohn's Disease
The MOTOR-CD Trial
Both single-balloon enteroscopy (SBE) and novel motorized spiral enteroscopy (NMSE) are effective techniques for small bowel endoscopy in suspected Crohn's disease (CD).
- Trial name
- NCT05363930
- Testing
- Novel motorized spiral enteroscopy, Single balloon enteroscopy
- Where
- India
- Volunteers
- 128 people
- Sponsor
- Asian Institute of Gastroenterology, India
Ulcerative Colitis, Crohn's Disease
Adherence to Mesalamine Profile for Patients With Inflammatory Bowel Disease
Hypothesis: Mesalamine is commonly used to induce and maintain remission in patients with Inflammatory Bowel Disease (IBD). Behavioral and psycho-social barriers to mesalamine adherence exist in patients with IBD.
- Trial name
- NCT01349504
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Beth Israel Deaconess Medical Center
Inflammatory Bowel Diseases
Butyrate in Pediatric Inflammatory Bowel Disease
The first prospective randomised placebo-controlled study in the IBD pediatric population was conducted to evaluate the effectiveness of oral sodium butyrate as add-on therapy in IBD.
- Trial name
- NCT05456763
- Testing
- sodium butyrate
- Volunteers
- 100 people
- Sponsor
- Centre of Postgraduate Medical Education
Crohn's Disease
Phase 1 Study of Safety and Biological Effects of C326, an Inhibitor of IL-6, in Crohn's Disease
The purpose of this study is to determine whether C326, a new inhibitor of IL-6, is safe in patients with Crohn's disease.
- Trial name
- NCT00353756
- Testing
- C326, IL-6 Inhibitory Avimer protein
- Where
- 2 sites in Australia
- Volunteers
- 52 people
- Sponsor
- Avidia
Crohn's Disease, Ulcerative Colitis
Quality of Life in Pediatric Inflammatory Bowel Disease
Measurement of the quality of life (QoL) of children and adolescents with inflammatory bowel diseases (IBD) has had little attention, despite the importance of understanding key factors affecting QoL, especially for measuring the…
- Trial name
- NCT00061737
- Where
- 6 sites in United States
- Volunteers
- 350 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Crohn Disease, Ulcerative Colitis
Evaluation of the Safety, Tolerability, and Efficacy of MDGN-002 in Adults With Moderate to Severe Active Crohn's Disease or Ulcerative Colitis
This is a Phase 1b, open-label, dose-escalation, signal-finding, multi-center study. The study will evaluate the safety, tolerability, pharmacokinetics and short-term efficacy of MDGN-002 in adults with moderate to severe, active…
- Trial name
- NCT03169894
- Testing
- MDGN-002
- Where
- 13 sites in United States
- Volunteers
- 8 people
- Sponsor
- Avalo Therapeutics, Inc.
Inflammatory Bowel Disease, Crohn's Disease
A Trial of Yoga in Pediatric Inflammatory Bowel Disease
IBD adds additional stressors as a chronic disease that has unpredictable and sometimes embarrassing symptoms to the normal challenges that teenagers face.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT03338894
- Testing
- Yoga
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Atlantic Health System
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