Clinical trials: Critically Ill, open to volunteers
Documentation of Serious Illness Communication for Critically Ill Patients
Pilot Trial of Ambient Listening for Intensive Care Unit Family Meeting Summaries
The goal of this clinical trial is to learn whether ambient listening can help healthcare providers create written summaries of conversations with the families of patients in the medical intensive care unit (ICU).
- Trial name
- PALMS (NCT07915908)
- Testing
- Receipt of ambient listening-generated draft clinical note
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
Critically Ill Patients, Circulatory Shock
Capillary Refill Time Variation to Predict Oxygen Comsumption Variation After FLuid Challenge (CARTOFL)
Circulatory shock is characterized by tissue hypoxia. Although fluid resuscitation is an essential treatment in many forms of circulatory shock, its benefits are variable, and its administration carries a risk of potentially…
- Conditions
- Critically Ill Patients, Circulatory Shock, Ventilated Patients
- Trial name
- CARTOFL (NCT07837843)
- Testing
- Indirect calorimetry measurement
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Mechanical Ventilation, Critically Ill Intensive Care Unit Patients
Ketamine Sedation in the ICU (KANINE) RCT
Sedation is given to intensive care unit (ICU) patients to treat discomfort, anxiety, agitation, and to help facilitate care, particularly when they require a breathing tube.
- Trial name
- KANINE (NCT06767358)
- Testing
- ketamine hydrochloride
- Where
- 3 sites in Canada
- Volunteers
- 54 people
- Sponsor
- McMaster University
Critically-ill Patients
Immunosuppression and Intensive Care Unit-acquired Multidrug-resistant Bacteria
Antimicrobial resistance AMR is an emerging global threat to human health, and intensive care units (ICUs) are a 'hot spot' for the emergence and diffusion of multidrug-resistant (MDR) bacteria.
- Trial name
- TANGERINE (NCT06652126)
- Testing
- Microbiological examinations.
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Lille
Long-term Sedation for Mechanical Ventilation, Critically Ill Intensive Care Unit Patients
Remimazolam vs Propofol for Long-Term Sedation in Mechanically Ventilated ICU Patients
This multicenter, randomized, controlled, non-inferiority trial is designed to determine whether remimazolam is non-inferior to propofol for prolonged sedation in adult ICU patients requiring mechanical ventilation for ≥48 hours.
- Trial name
- RePro-ICU (NCT07880548)
- Testing
- Remimazolam group, Propofol group
- Where
- 21 sites in China
- Volunteers
- 274 people
- Sponsor
- Sun Yat-sen University
Cardiac Disease, Critically Ill
Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)
OPTIC is a prospective, open-label, non-randomized study of multiple medications administered to approximately 2000 children in the pediatric cardiac intensive care unit (PCICU) per routine clinical car by their treating…
- Conditions
- Cardiac Disease, Critically Ill, Children, Adult
- Trial name
- OPTIC (NCT05055830)
- Testing
- The OPTIC study is collecting PK data on children prescribed understudied drugs of interest per standard of care.
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Duke University
Cancer, Critical Care, Cancer Critically Ill
Admission, Triage, and Discharge Criteria for Oncological Patients in the Intensive Care Unit
This study will create one agreed set of rules to help doctors decide which people with cancer should be treated in an intensive care unit (ICU), and when they are well enough to leave it.
- Trial name
- ONCO-TRIAD (NCT07809490)
- Testing
- No Intervention: Observational Cohort
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Onco Critical Care Society
Critically Ill Adults Requiring Emergency Tracheal Intubation in the Intensive Care Unit
Propofol or Esketamine: Tracheal Intubation Comparison
The goal of this clinical trial is to compare how esketamine and propofol affect blood pressure in critically ill adults who need a breathing tube in an intensive care unit (ICU).
- Trial name
- POETIC (NCT07847255)
- Testing
- Esketamine, Propofol
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Probiotic, Ventilator Associated Pneumonia
Probiotic Role in Prevention of Ventilator Associated Pneumonia in Critically- Ill Children Admitted at Pediatric Intensive Care Unit
The aim of the work is to evaluate the impact of Probiotics supplementation on prevention of ventilator associated pneumonia in critically ill children admitted at Pediatric Intensive Care Unit at Tanta University Hospitals.
- Conditions
- Probiotic, Ventilator Associated Pneumonia, Critically- Ill Children
- Trial name
- NCT07848165
- Testing
- Probiotics, Standard management
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Tanta University
Feeding Intolerance, Gastrointestinal Dysfunction
FMT for Feeding Intolerance Due to Gastrointestinal Dysfunction in Critically Ill Patients
Critically ill patients admitted to the intensive care unit (ICU) frequently present with gastrointestinal dysfunction and are at elevated risk of malnutrition.
- Conditions
- Feeding Intolerance, Gastrointestinal Dysfunction, Critically Ill Intensive Care Unit Patients
- Trial name
- FMT-FIT (NCT07640633)
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Nutritional Therapy in an ICU, Critically Ill Patients Requiring Mechanical Ventilation
Will the Use of Respiratory Quotient ''RQ'' Improve Treatment Outcomes for Intensive Care Unit (ICU) Patients?
Introduction and assumptions of the research project: Patients treated in intensive care units (ICUs) require comprehensive treatment. Nutrition is an important and integral part of this therapy.
- Trial name
- RQCal (NCT07457554)
- Testing
- RQ guided nutrition, Standard Treatment (Guideline-Based)
- Where
- Poland
- Volunteers
- 236 people
- Sponsor
- Poznan University of Medical Sciences
Critically Ill Intensive Care Unit Patients
Diagnostic Accuracy of Hepatic Vein SFF Compared With TAPSE for Assessment of RV Systolic Function in Mechanically Ventilated Patients
This prospective observational diagnostic accuracy study investigates the efficacy of the hepatic vein systolic filling fraction (SFF) as a real-time, non-invasive indicator of right ventricular (RV) systolic function in…
- Trial name
- NCT07732114
- Testing
- Diagnostic accuracy of hepatic vein systolic filling fraction compared with TAPSE for assessment of right ventricular systolic function in mechanically ventilated critically ill patients
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Menoufia University
Acute Respiratory Failure, Respiratory Insufficiency
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport
The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.
- Conditions
- Acute Respiratory Failure, Respiratory Insufficiency, Respiratory Distress, Critical Illness
- Trial name
- HERMES (NCT07805603)
- Testing
- Advanced Respiratory Support During Patient Transport
- Where
- 4 sites in Colombia, Egypt and 2 more
- Volunteers
- 565 people
- Sponsor
- Medipol University
Critically Ill Patients Who Are Not Allowed to Eat Orally But Can Initiate Enteral Nutrition Within 48 Hours of ICU
Association of Biomarkers and Gastric Antral Motility Index With Feeding Intolerance in Critically Ill Patients
When the subjects are admitted to the department, the researchers will monitor potential biomarkers of gastrointestinal injury before administering enteral nutrition (a small amount of blood is drawn, serum is separated by…
- Trial name
- NCT07178626
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The First Hospital of Jilin University
Critically Ill Patients, Acid-Base Disturbance
Bicarbonate Variation Monitoring With Indirect Calorimetry
Patients admitted to the intensive care unit frequently exhibit abnormal blood bicarbonate levels. These abnormalities are associated with patient outcomes and often prompt clinicians to modify management, either diagnostically…
- Conditions
- Critically Ill Patients, Acid-Base Disturbance, Indirect Calorimetry
- Trial name
- BICAR-CC (NCT07782658)
- Testing
- Indirect calorimetry measurement
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Hospices Civils de Lyon
Critical Illness, Critically Ill Patients
Physiological Changes in Adult Intensive Care Patients Following Contact With Their Primary Caregiver
Patients admitted to intensive care units are exposed to multiple environmental and clinical factors that may affect their physiological responses.
- Trial name
- CARE-ICU (NCT07761364)
- Testing
- Standardized therapeutic physical contact
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Universidad Autonoma del Estado de Mexico
RBCs Transfusion in Critically-ill Patients
Red Blood Cell Transfusion to Optimize Extubation
In comparison with a liberal transfusion strategy (high haemoglobin threshold), a restrictive transfusion strategy leads to around 50% decrease in the total number of transfused red blood cells (RBC) units and 30% to 40% fewer…
- Trial name
- TEXT (NCT07499492)
- Testing
- Transfusion of a single unit of RBC and standard of care
- Volunteers
- 800 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critically Ill, Haemodynamic Instability
Transducer Levelling Errors in Everyday ICU Practice - A Multicentre Blinded Observational Study
Invasive pressure monitoring (arterial blood pressure via arterial catheter and central venous pressure via central venous catheter) is fundamental to clinical decision-making in intensive care.
- Trial name
- NCT07330505
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Vastra Gotaland Region
Muscle Wasting in Critically Ill
The Effect of Muscle Stimulation and Amino Acid Intake on Protein Metabolism During Critical Illness
The goal of this clinical trial is to study how whole-body electrical stimulation combined with amino acid intake affects muscle health in ventilated ICU patients.
- Trial name
- SPICE I (NCT07430969)
- Testing
- NMES, Amino acid bolus (20g), Standard enteral nutrition
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Wageningen University
Critically Ill, Intensive Care (ICU)
Factor Associated With Mortality in the ICU
ICU mortality indicates the severity of disease, healthcare quality, and the efficacy of interventions. The severity scores are tools to predict the risk of mortality in the ICU, and the APACHE II score is frequently used for…
- Conditions
- Critically Ill, Intensive Care (ICU), Intensive Care Medicine, Mortality
- Trial name
- ICUMortal (NCT07249749)
- Testing
- Exposure factors
- Where
- Colombia
- Volunteers
- 1,000 people
- Sponsor
- Hospital Departamental de Villavicencio