Clinical trials: Critically Ill
Type 2 Diabetes Treated With Insulin
Novolog vs. Fiasp Insulin in Non-critically Ill Hospitalized Patients With Type 2 Diabetes Mellitus
Hyperglycemia affects 30-40% of hospitalized patients. Despite the fact that basal/bolus insulin therapy has been demonstrated to improve glycemic control and clinical outcomes in patients, achieving good glucose control remains…
- Trial name
- In-FI (NCT04460326)
- Testing
- Insulin glargine, NovoLog, Insulin Fiasp
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Boston Medical Center
Critically Ill
24 Hour Intensivist Coverage in the Medical Intensive Care Unit
The Hospital of the University of Pennsylvania's Medical ICU (MICU) is implementing a model of 24-hour intensivist staffing in September 2011.
- Trial name
- NCT01434823
- Testing
- Nocturnal coverage
- Where
- United States
- Volunteers
- 1,609 people
- Sponsor
- University of Pennsylvania
COPD, Sepsis
Effect of Nebulized Bronchodilators on Heart Rate
The purpose of the study is to determine adverse events rates of nebulized albuterol versus levalbuterol among adult critically ill patients and determine if a differential exists in adverse events between the two drugs.
- Conditions
- COPD, Sepsis, Shock
- Trial name
- NCT01151579
- Testing
- Levalbuterol, Albuterol
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Fahim Khorfan, MD
Critical Illness, Communication Disabilities
Enhancing & Mobilizing the POtential for Wellness & Emotional Resilience Among Surrogate Decision-Makers of ICU Patients
Intensive Care Units (ICU) are stressful places where life-and-death medical decisions are made and patients' surrogate decision-makers are exposed to potentially traumatic experiences.
- Trial name
- EMPOWER (NCT03276559)
- Testing
- EMPOWER, Enhanced Usual Care
- Where
- 3 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Nutrition, Enteral
A More Physiological Feeding Process in ICU:the Intermittent Infusion With Semi-solidification of Nutrients
Malnutrition and underfeeding are major challenges in caring for critically ill patients. Continuous feeding were thought to be better tolerated by patients with the limited absorptive gut surface area or gastrointestinal…
- Trial name
- NCT03017079
- Testing
- semi-solid agent with standard enteral feeding, standard enteral feeding
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sepsis, Critical Illness
Optimizing Vancomycin Therapy in Children
The purpose of Opt Vanc is to evaluate the feasibility of Bayesian dose adaptation, based on a previously-developed population pharmacokinetic (PK) model and a single optimally timed PK sample, to predict vancomycin area under…
- Conditions
- Sepsis, Critical Illness, Infections, Drug Toxicity
- Trial name
- Opt Vanc (NCT05691309)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Children's Hospital of Philadelphia
Surgery
Validation of Noninvasive Hemoglobin, Comparison of PVI to Standard Methods, and Validation of Clinical Efficacy of ORI
The study goal is to establish the correlation of hemoglobin values determined by the noninvasive pulse oximetry-determined hemoglobin (SpHb) system with hemoglobin as measured by other validated devices.
- Trial name
- NCT02841397
- Testing
- Masimo Pulse CO-Oximeter
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Masimo Corporation
Acute Kidney Failure
Pharmacokinetics of Ertapenem in Continuous Venovenous Hemodialysis
Critically ill patients in the intensive care unit often receive continuous hemodialysis to treat their kidney failure. Ertapenem is an antibiotic often used in these patients.
- Trial name
- NCT00877370
- Testing
- ertapenem
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Michigan
Sepsis
Imipenem/Cilastatin/Relebactam PK in ECMO
Extracorporeal membrane oxygenation (ECMO) is a from of cardiopulmonary life-support for critically ill patients where blood is extracted from the vascular system and circulated by a mechanical pump while it is oxygenated and…
- Trial name
- NCT04493151
- Testing
- Imipenem, Cilastatin and Relebactam
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Joseph L. Kuti, PharmD
Delirium
The Effect of Guanfacine on Delirium in Critically Ill Patients
Delirium in patients in the intensive care unit (ICU) is a common problem associated with increased mortality and morbidity, including increased hospital and ICU length of stay, greater hospital cost, increased ventilator days…
- Trial name
- NCT04578886
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Acute Renal Failure
High Dose CVVHDF Compared to Standard Dose CVVHDF
In the last three decades, the mortality associated with acute renal failure (ARF) in the ICU has remained unchanged at greater than 50%, despite improvements in dialysis technology.
- Trial name
- CVVHDF (NCT00561431)
- Testing
- Standard dose of dialysis, High dose of dialysis
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Alabama at Birmingham
Palliative Care, Critical Illness
A Needs-focused Palliative Care Intervention for Older Adults in ICUs
The quality of intensive care unit (ICU)-based palliative care is highly variable, particularly for the 2 million older adults admitted annually to ICUs.
- Conditions
- Palliative Care, Critical Illness, Aging, Care Delivery Model
- Trial name
- PCplanner (NCT04414787)
- Testing
- PCplanner
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Duke University
Critically Ill
Enteral Versus Parenteral Glutamine Supplement
Glutamine is a major fuel for the intestinal tract and immune cells and therefore affects the intestinal permeability (IP) and infection rate at critically ill patients.
- Trial name
- NCT00875797
- Testing
- parenteral glutamine, enteral glutamine
- Where
- Slovenia
- Volunteers
- 90 people
- Sponsor
- University Medical Centre Ljubljana
Chronic Respiratory Failure, Critical Illness Myopathy
Electric Muscle Stimulation for Patients With Chronic Respiratory Failure
Background: After mechanical ventilation, 5-20% of patients with acute respiratory failure would depend on ventilator support more than 14 days because of critical-illness weakness and their underlying diseases such as heart…
- Trial name
- NCT01930643
- Testing
- EMS
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- Mackay Memorial Hospital
ICU Acquired Weakness
Diagnosing Intensive Care Unit (ICU) Acquired Weakness
The goal of this study is to develop a non-invasive test to diagnose intensive care unit (ICU) acquired weakness that can be administered to both responsive and non-responsive patients.
- Trial name
- NCT04166630
- Testing
- Clinical Electrical Stimulator
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Emory University
Craniocerebral Trauma, Intracranial Aneurysm
Hypovitaminosis D in Neurocritical Patients
Vitamin D has been shown to impact prognosis in a variety of retrospective and randomized clinical trials within an intensive care unit (ICU) environment.
- Conditions
- Craniocerebral Trauma, Intracranial Aneurysm, Brain Neoplasms, Spinal Cord Injuries
- Trial name
- NCT02881957
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- University of Utah
Circadian Rhythm Sleep Disorder, Unspecified
Feasibility Pilot of Bright Light in the Intensive Care Unit
To evaluate the feasibility of providing daytime bright light in the ICU in a pilot randomized controlled trial.
- Trial name
- NCT03568045
- Testing
- standard light, 10,000 lux bright light, 4 hours, 10,000 lux bright light, 8 hours
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Yale University
Sleep
The Effects of White Noise for Adult Patients' Sleep Quality in Intensive Care Unit.
Poor sleep quality is one of the most common problems among adult patients in the intensive care unit (ICU). The causes of sleep disturbance are complicated.
- Trial name
- NCT05785130
- Testing
- white noise
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Nutrition Disorder, Trauma
Supplemental Enteral Protein in Critical Illness
The aim of this study is too determine the effect of enteral protein supplementation on biochemical measures of inflammation and protein metabolism in critically ill surgical patients.
- Conditions
- Nutrition Disorder, Trauma, Critical Illness
- Trial name
- NCT03170401
- Testing
- Protein supplementation, Standard enteral nutrition
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Washington
Acute Respiratory Failure
Novel Arm Restraint in the Intensive Care Unit
The goal of this pilot is to evaluate a novel restraint device in 8 older mechanically ventilated patients to demonstrate that 1) the revised novel restraint prototype is safe and 2) a future randomized controlled trial (RCT) is…
- Trial name
- NCT03621475
- Testing
- Novel restraint
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Vermont