Clinical trials: Critical Illness Recovery
Mental Disorders, Severe
Feasibility and Acceptability of an Intervention to Support People With Severe Mental Illness in South Africa
Despite commendable progress in developing mental health systems in low-and-middle income countries, critical gaps remain, particularly the development of community-based systems of support for people living with severe mental…
- Trial name
- MhINT Recovery (NCT07339462)
- Testing
- Multilevel psychosocial support for people living with severe mental illness and their caregivers
- Where
- South Africa
- Volunteers
- 86 people
- Sponsor
- University of KwaZulu
Adults With Cardiopulmonary Disease at Risk of Prolonged Weaning From Mechanical Ventilation
Neurally Adjusted Ventilatory Assist in Adults at Risk of Delayed Weaning From Mechanical Ventilation
Many patients admitted to intensive care have heart or lung problems. Patients with these conditions often require longer durations of support from breathing machines.
- Trial name
- RESTUS (NCT01826890)
- Testing
- NAVA Technology
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- King's College Hospital NHS Trust
Critical Illness, Circadian Dysregulation
Effect of Sleep on the Recovery of Patients Admitted to the ICU
The investigators plan to create several sleep/circadian rhythm friendly rooms within the medical intensive care unit to determine if decreasing sleep fragmentation effects recovery in patients hospitalized in the ICU.
- Conditions
- Critical Illness, Circadian Dysregulation, Delirium
- Trial name
- NCT04111900
- Testing
- Sleep/Circadian Friendly
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Rush University Medical Center
Funcional Status, Return to Work
Machine Learning Model for Predicting Recovery After Critical Illness
This study aims to develop and test an artificial intelligence (AI) model to predict long-term functional status and return to work after critical illness.
- Conditions
- Funcional Status, Return to Work, Predictive Learning Models
- Trial name
- NCT07616388
- Testing
- No interventions were performed.
- Where
- Brazil
- Volunteers
- 2,016 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acute Kidney Injury
Dynamic Change of Doppler-based Renal Resistive Index in Predicting Renal Recovery
The goal of this observational study is to observe the correlation between dynamic changes in the Doppler-based renal resistive index (RI) and the occurrence of persistent acute kidney injury (AKI) in critically ill patients.
- Trial name
- DRRRI (NCT05866250)
- Testing
- Doppler-based renal resistive index
- Where
- 7 sites in China
- Volunteers
- 467 people
- Sponsor
- The First Hospital of Jilin University
Hypernatremia
Prospective Data Analysis of the Development of Hypernatremia in Intensive Care Unit
Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay.
- Trial name
- HYPNIC (NCT03752450)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Critical Illness, Mechanical Ventilation
Analysis of Weaning of Analgosedation and Kinetics of Emergence in Critically Ill Patients
The goal of this prospective multicenter observational study is to characterize early trajectories of consciousness recovery following the first valid structured awakening trial in mechanically ventilated critically ill adults, a…
- Conditions
- Critical Illness, Mechanical Ventilation, Weaning Invasive Mechanical Ventilation, Sedation and Analgesia
- Trial name
- AWAKE-ICU (NCT07710066)
- Testing
- Structured Awakening Evaluation (SAE)
- Volunteers
- 500 people
- Sponsor
- Patricia Rodriguez Villamizar
Critical Illness, Sepsis
MICU Recovery Clinic
Summary: Emerging data demonstrate long-term morbidity and mortality in those who survive critical illness. However, there is no data regarding long-term follow-up for ICU survivors.
- Conditions
- Critical Illness, Sepsis, Respiratory Failure, ARDS
- Trial name
- NCT02560129
- Testing
- Questionnaires, Physical and Cognitive Function
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Wake Forest University Health Sciences
Aortic Diseases, Intensive Care Unit Syndrome
Muscle Recovery Following Aortic Surgery Induced ICUAW.
To identify determinants of 'good and bad recovery' from ICUAW and build knowledge around the timing of these processes. Also, the investigators want to discover the effects of ICUAW on physical function and HRQoL following…
- Conditions
- Aortic Diseases, Intensive Care Unit Syndrome, Intensive Care Neuropathy, Intensive Care (ICU) Myopathy
- Trial name
- VARIANCE (NCT03714399)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Barts & The London NHS Trust
Post-Intensive Care Syndrome (PICS), Critical Illness Recovery
Integrated Rehabilitation in HDU for Post-Intensive Care SyndromeLiberation in Patients With PICS
Post-intensive care syndrome (PICS) is characterized by persistent physical, cognitive, and psychological impairments among survivors of critical illness.
- Conditions
- Post-Intensive Care Syndrome (PICS), Critical Illness Recovery, Mechanical Ventilation
- Trial name
- NCT07521540
- Testing
- Integrated Multidisciplinary Rehabilitation
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Hongying Jiang, MD
Critical Illness
Enhanced Recovery After Intensive Care (ERIC)
The primary objective of the multi-center stepped-wedge cluster-randomized controlled trial ERIC is to evaluate the effects of a multi-component telemedicine-based intervention delivered by the ICU on the adherence to quality…
- Trial name
- NCT03671447
- Testing
- ICU Usual Care, Tele-ICU
- Where
- 13 sites in Germany
- Volunteers
- 1,463 people
- Sponsor
- Charite University, Berlin, Germany
Recovery From Critical Illness
Rehabilitating Muscle After Intensive Care
The study will examine the effect of amino acid supplements and enhanced physiotherapy on physical recovery following critical illness in intensive care.
- Trial name
- REMAIC (NCT01063738)
- Testing
- Amino acid supplement, PEPSE, Intensive Care Unit (ICU) Recovery Manual
- Where
- 2 sites in United Kingdom
- Volunteers
- 93 people
- Sponsor
- St Helens & Knowsley Teaching Hospitals NHS Trust
Critically Ill
TEAM: A Trial of Early Activity and Mobility in ICU
Patients in the intensive care unit (ICU) traditionally receive bed rest as part of their care. They develop muscle weaknesses even after only a few days of mechanical ventilation that may prolong their time in ICU and in…
- Trial name
- TEAM-RCT (NCT01927510)
- Testing
- Early mobilisation
- Where
- 5 sites in Australia, New Zealand
- Volunteers
- 50 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Heart Failure and Chronic Kidney Disease Post-ICU
Dapagliflozin for Cardio-renal Protection After ICU Discharge
Several millions of patients are admitted to ICUs in Europe or USA each year. We and others, have shown that patients discharged from intensive care units (ICU) have a high incidence of cardiovascular and/or renal events and high…
- Trial name
- DAPA-ICU (NCT07025629)
- Testing
- Dapagliflozin 10 MG Oral Tablet [Farxiga]
- Where
- 2 sites in France
- Volunteers
- 600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Illness, Oliguria
Performance of Diuretic Stress Test in Predicting Short Term Renal Recovery in Oliguric Critically-ill Patients Recovery in the Short Term
Acute kidney injury (AKI) is a common disorder and associated with high morbidity and mortality. However, distinguishing transient AKI from persistent AKI may help in individualizing treatment and limit short and long term…
- Trial name
- NCT02800135
- Testing
- Furosemide
- Where
- 4 sites in France
- Volunteers
- 93 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Acute Respiratory Failure, Critical Illness
Muscle Ultrasound Signifies Condition Upgrade Leading Approach to Recovery
Examination of serial muscle ultrasounds and muscle sampling within the population of ICU patients who require mechanical ventilation for acute respiratory failure, will lead to the ability of investigators to link specific…
- Trial name
- MUSCULAR (NCT02014285)
- Testing
- Muscle Ultrasound and Muscle Sample
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Wake Forest University Health Sciences
Critical Illness, COVID-19 Pneumonia
Acute Kidney Injury in Coronavirus Disease-19 (COVID-19) Patients Admitted to the Intensive Care Unit (ICU)
The aim of this study is to evaluate the rate and outcomes of COVID-19 associated acute kidney injury (AKI) and use of kidney replacement therapy (KRT) in critically ill COVID-19 patients in ICUs in several large hospitals in…
- Conditions
- Critical Illness, COVID-19 Pneumonia, Acute Kidney Injury
- Trial name
- COVID-AKI-B (NCT04997915)
- Testing
- Observational study exploring the epidemiology and outcomes of AKI in critical COVID-19 patients admitted to the ICU
- Where
- 9 sites in Belgium
- Volunteers
- 1,286 people
- Sponsor
- University Hospital, Ghent
Psychotic Disorders, Schizophrenia
Critical Time Intervention-Peer Support
There is increasing awareness of the importance of providing mental health services and support that promote a recovery-oriented and human rights-based approach.
- Conditions
- Psychotic Disorders, Schizophrenia, Bipolar Disorder, Schizo Affective Disorder
- Trial name
- CTI-PS (NCT05945277)
- Testing
- Critical Time Intervention - Peer Support
- Where
- 3 sites in Portugal
- Volunteers
- 60 people
- Sponsor
- Lisbon Institute of Global Mental Health - LIGMH
Disorder of Consciousness, Unresponsive Wakefulness Syndrome
Auditory Processing in DOC Patients
This prospective observational study investigates whether electroencephalography (EEG) can improve the differentiation between unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) in patients with severe…
- Conditions
- Disorder of Consciousness, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- AUD-DOC (NCT07455682)
- Testing
- Coma Recovery Scale-Revised (CRS-R), Electroencephalography (EEG)
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Post Intensive Care Syndrome (PICS)
Post Intensive Care Accelerometery to Study and Support Recovery Outcomes
The primary purpose of this study is to find out whether a wrist-worn activity monitor can help healthcare professionals understand how people recover after they leave the intensive care unit (ICU), where they were cared for when…
- Trial name
- PICASSO (NCT07466446)
- Where
- 3 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh