Clinical trials: Craniotomy
Metabolic Acidosis, Antiepileptic Drugs
The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy Operations
The relationship of developing metabolic acidosis with antiepleptic drugs in craniotomy operations
- Conditions
- Metabolic Acidosis, Antiepileptic Drugs, Craniotomy, Anesthesia Management
- Trial name
- NCT05940935
- Testing
- Arterial Blood Gas Base Deficit
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Trakya University
Brain Tumor, Brain Metastases
Re-craniotomy and Complications After Elective Neurosurgery
This study is a prospective cohort study to find the incidence of re-craniotomy and predictive factors. The secondary outcomes are to find the incidence of major non-neurological complications and predictive factors.
- Conditions
- Brain Tumor, Brain Metastases, Brain Cancer, Brain Neoplasms
- Trial name
- NCT03910556
- Testing
- Propofol
- Volunteers
- 439 people
- Sponsor
- Chiang Mai University
Craniotomy
Post Market Study of Tutopatch In Craniotomy
This is a post market prospective, multi-center study of up to 75 participants at approximately 8 clinical study sites. The objective of the study is to evaluate safety by assessing incidence of device and/or procedure related…
- Trial name
- NCT07118020
- Where
- 2 sites in Austria, Spain
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- RTI Surgical
Epidural Hematoma, Brain Herniation
Prospective Randomized Evaluation of Decompressive Ipsilateral Craniectomy for Traumatic Acute Epidural Hematoma
Although craniotomy provides a more complete evacuation of the acute epidural hematoma, there are insufficient data to support specific surgical treatment method.
- Conditions
- Epidural Hematoma, Brain Herniation, Decompressive Craniectomy, Craniotomy
- Trial name
- PREDICT-AEDH (NCT04261673)
- Testing
- Decompressive Craniectomy, Craniotomy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- RenJi Hospital
Pain, Supratentorial Brain Tumor
Effects of Pre-emptive Scalp Infiltration With Ketorolac and Ropivacaine for Post-craniotomy Pain
The PAINLESS study is a single-center, prospective, randomized, open-label, blinded-endpoint (PROBE) controlled clinical study to compare the efficacy and safety of pre-emptive scalp infiltration with ropivacaine plus ketorolac…
- Trial name
- NCT04141319
- Testing
- Ketorolac, Ropivacaine, Epinephrine
- Volunteers
- 100 people
- Sponsor
- Beijing Tiantan Hospital
Meningioma
Magnesium and Intraoperative Blood Loss in Meningioma Surgery
Meningioma is the most common central nervous system tumor and craniotomy with tumor removal was associated with moderate blood loss and blood transfusion.
- Trial name
- NCT03558516
- Testing
- Magnesium group, Normal saline group
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Supratentorial Neoplasms
Comparison of Efficacy and Safety of the Postoperative Analgesia Methods
An optimal analgesic therapy is very important for postoperative recovery. In recent years, several studies showed that the prevalence of the moderate to severe pain after craniotomy ranged from 69 to 87% of patients.
- Trial name
- NCT02929147
- Testing
- Morphine, Dexketoprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Awake Craniotomy for Brain Tumour Surgery
Patient-controlled Versus Anesthesiologist-controlled Propofol-remifentanil in Awake Craniotomy
Awake craniotomy for removal of brain tumour is performed because the tumour may be located close to areas of the brain that control specific functions such as movement or speech.
- Trial name
- NCT00992940
- Testing
- Patient-Controlled Sedation/Analgesia, Anesthetist-Controlled Sedation/Analgesia
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Cerebral Arterial Disease, Cerebral Aneurysm
Esmolol Infusion in Patients Undergoing Craniotomy
Anesthesia techniques that minimize anesthetic requirements and their effects may be beneficial. Esmolol, a short acting hyperselective β-adrenergic blocker is effective in blunting adrenergic response to several perioperative…
- Trial name
- NCT02455440
- Testing
- Esmolol, Propofol and sevoflurane
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- George Papanicolaou Hospital
Demyelinating Diseases
Oligodendrocyte Progenitor Cell Culture From Human Brain
Recent developments in the understanding of stem- and progenitor cell differentiation raises hopes that brain damage in chronic neurological diseases may become repaired by systemic or focal transplantation of such cells.
- Trial name
- NCT00283023
- Testing
- Oligodendrocyte progenitor cell culture/craniotomy
- Where
- Thailand
- Volunteers
- 5 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Craniotomy
Craniofacial Surgery Perioperative Registry
Craniofacial reconstruction procedures are undertaken in young children to improve appearance, prevent functional disturbances, and enhance psychosocial development.
- Trial name
- NCT00658242
- Where
- United States
- Volunteers
- 249 people
- Sponsor
- Children's Hospital of Philadelphia
Scalp Block
Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients"
The goal of this clinical trial is to learn if an ultrasound-guided scalp block can improve intraoperative hemodynamic stability and provide better postoperative pain relief in adult patients undergoing elective supratentorial…
- Trial name
- NCT07496632
- Testing
- Surgical site infiltration with plain bupivacaine, Scalp block with plain bupivacaine
- Where
- Bangladesh
- Volunteers
- 72 people
- Sponsor
- Bangladesh Medical University
Electroencephalography, Craniotomy Surgery
Evaluation of Response to Pain From Skull Pin Fixation in Craniotomies
The goal of this observational study is to investigate the relationship between the response to skull pin fixation pain and the analysis of blood pressure, heart rate, and brain wave activity in adults undergoing brain surgery.
- Conditions
- Electroencephalography, Craniotomy Surgery, Pain Management
- Trial name
- NCT06811701
- Testing
- Scalp nerve block, Opioid Anesthetics, Local Anesthetic Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Aneurysm Cerebral
Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy
This study is looking at how taking aspirin regularly affects bleeding during and after brain surgery. Specifically, it focuses on patients who are having elective surgery to clip a brain aneurysm.
- Trial name
- ASPRIN (NCT07086183)
- Testing
- Observation
- Where
- 3 sites in United States, Italy and 1 more
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Pain
Safety Study of Analgesia After Craniotomy Surgery With End Tidal (ET) Carbon Dioxide (CO2) Monitoring
This research is being done to compare two methods of giving fentanyl, a narcotic often given to patients following brain surgery and determine if one method has more side effects than the other.
- Trial name
- NCT01327677
- Testing
- Fentanyl
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Johns Hopkins University
Pain, Postoperative Children
Pre-emptive Infiltration of the Scalp with Diprospan Plus Ropivacaine for Pain After Craniotomy in Children
At present, pediatric postoperative analgesia has not been fully understood and controlled, particularly craniotomy surgery. On the one hand, professional evaluation of postoperative pain for young children is difficult; on the…
- Trial name
- NCT06321354
- Testing
- The diprospan plus ropivacaine group, The ropivacaine group
- Where
- 2 sites in China
- Volunteers
- 108 people
- Sponsor
- Beijing Tiantan Hospital
Brain Tumor
Behavioral Health Evaluation and Intervention Program for Patients Undergoing Craniotomy
This is a single center non-randomized, single-arm feasibility trial of the implementation of virtual behavioral health counseling sessions alongside standard-of-care treatment.
- Trial name
- NCT05789862
- Testing
- Counseling Sessions, Quality of Life Questionnaires
- Sponsor
- University of California, San Francisco
Brain Tumor
Intraoperative Optical Imaging of Brain Function
The goal of this proposal is to test the performance of a novel optical imaging system for real-time quantitative imaging of brain function through multiple hemodynamic measures during neurosurgery.
- Trial name
- NCT00632437
- Testing
- Speckle-Contrast Imaging
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Craniotomy
Comparison of Epinephrine-lidocaine Solution and Dexmedetomidine -Lidocaine Solution
Scalp infiltration with Epinephrine- containing lidocaine solution is common method for craniotomy but it may result in transient but significant hypotension in patients undergoing neurosurgery.
- Trial name
- NCT01606969
- Testing
- scalp infiltration solution
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Yonsei University
Postoperative Pain
Flurbiprofen Axetil as an Adjuvant to Pre-emptive Scalp Infiltration
Post-craniotomy pain remains a major challenge in patient care following neurosurgery.Flurbiprofen axetil (FA), as an injectable nonselective cyclooxygenase inhibitor, is a widely prescribed NSAID for postoperative pain.
- Trial name
- NCT05624359
- Testing
- FA plus ropivacaine, ropivacaine alone
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Beijing Tiantan Hospital