Clinical trials: Cough Hypersensitivity Syndrome
Cough
An Investigation Into the Mechanism of Inhalation Cough Challenge
Despite its commonplace use in respiratory medicine the mechanism whereby inhalation challenge with a variety of mild acid aerosols produces a dose related and predictable cough is unknown.
- Trial name
- NCT02039999
- Testing
- Nebulised citric acid in serial dilutions, Nebulised ATP solution in serial dilutions, Nebulised TRPA1 agonist solution in serial dilutions
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Delirium, Confusion
Improving Safety of Diagnosis and Therapy in the Inpatient Setting
To improve the safety of diagnosis and therapy for a set of conditions and undifferentiated symptoms for hospitalized patients, the investigators will employ a set of methods and tools from the disciplines of systems engineering…
- Conditions
- Delirium, Confusion, Mental Status Change, Back Pain
- Trial name
- PSLL2-0 (NCT04393909)
- Testing
- Diagnostic Uncertainty Educational Curriculum, Diagnostic Timeout, Patient Diagnostic (Dx) Questionnaire
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Brigham and Women's Hospital
Chronic Cough (CC), Asthma
The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges
The inhalation of adenosine 5'-triphosphate (ATP) to evoke cough (ATP cough challenge) is becoming increasingly used as a tool to measure cough hypersensitivity in patients with chronic cough.
- Trial name
- NCT07085975
- Testing
- Adenosine 5'-triphosphate
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cough, Refractory Chronic Cough
A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough
The FORTITUDE trial will provide head-to-head evidence on the benefits and harms of two commonly prescribed neuromodulators (low-dose morphine and pregabalin), the effectiveness of a virtual cough control therapy, exploratory…
- Conditions
- Cough, Refractory Chronic Cough, Unexplained Chronic Cough, Cough Hypersensitivity Syndrome
- Trial name
- FORTITUDE (NCT07288528)
- Testing
- Morphine Sulphate, Morphine Sulphate + Cough Control Therapy, Pregabalin
- Where
- 5 sites in Canada
- Volunteers
- 124 people
- Sponsor
- McMaster University
Cough
Cough Desensitization Therapy: Pilot 2
The purpose of this study is to investigate a modified behavioral treatment for chronic cough due to cough hypersensitivity syndrome (CHS).
- Trial name
- CDTPilot2 (NCT05226299)
- Testing
- Supra-threshold and progressive doses of diluted capsaicin via a dosimeter-controlled nebulizer, Saline
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Montana
Chronic Cough
Feasibility, Acceptability, and Safety Trial of Brief, Breath Control-Focused Acceptance and Commitment Therapy in Adults With Chronic Cough
This study is a prospective, single-center, single-arm pilot trial. The primary research question is whether brief, breath control-focused Acceptance and Commitment Therapy (ACT) is feasible, acceptable, and safe in adults with…
- Trial name
- FAST-COUGH (NCT07566117)
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Cough, Larynx
The Efficacy of Capsaicin Sensitivity Testing in Patients With Irritable Larynx Syndrome
Irritable larynx syndrome (ILS) is a hyperkinetic laryngeal dysfunction that is characterized by a persistent cough, voice changes, or breathing difficulties, which are often triggered by an irritant.
- Trial name
- NCT02065128
- Testing
- Capsaicin cough challenge test
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acne Vulgaris, Allergic Rhinitis
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use
The specific aim of this proposed pilot study is to compare two standardized processes (paper and electronic) to deliver a customized MedlinePlus health information prescription.
- Conditions
- Acne Vulgaris, Allergic Rhinitis, Anxiety, Asthma
- Trial name
- NCT01050465
- Testing
- health information prescription
- Volunteers
- 907 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Cough
Cough Desensitization Therapy for Cough Hypersensitivity Syndrome
The purpose of this study is to investigate a modified behavioral treatment for chronic cough due to cough hypersensitivity syndrome (CHS).
- Trial name
- NCT04256733
- Testing
- Supra-threshold and progressive doses of diluted capsaicin via a Koko Digidoser nebulizer, Sub-threshold doses of diluted capsiacin via a KoKo Digidoser nebulizer
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Montana
Postoperative Cough, Cough Hypersensitivity Syndrome
Effects of Energy Versus Mechanical Surgical Devices on Postoperative Cough
Numerous current studies have indicated that transecting the pulmonary plexus nerve as a routine step in radical lung cancer surgery is an independent risk factor for cough hypersensitivity (CH).
- Trial name
- ENERGY-COUGH (NCT07524712)
- Testing
- Energy Device Vagus Nerve Transection, Mechanical Vagus Nerve Transection
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Tongji Hospital
Refractory Chronic Cough
Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough
This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with refractory chronic cough (RCC)
- Trial name
- MACS-1 (NCT05110144)
- Testing
- Duloxetine 30 MG, Duloxetine 60 MG, Amitriptyline 25 MG
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Chronic Cough (CC), Refractory Chronic Cough
Mechanisms of Change in Behavioral Cough Suppression Therapy for Refractory Chronic Cough
This study is testing new ways to help people who have chronic cough that has not improved with typical treatments. One approach is called behavioral cough suppression (BCS) therapy, which teaches people techniques to stop…
- Conditions
- Chronic Cough (CC), Refractory Chronic Cough, Unexplained Chronic Cough
- Trial name
- CoughLESS (NCT06960759)
- Testing
- BCS+inactive, BCS+active
- Where
- 3 sites in United States
- Volunteers
- 135 people
- Sponsor
- University of Montana
Cough
Influence on Cough and Airway Symptoms by Oral Capsaicin
Study objectives To establish whether an oral intake of Capsicum oleoresin; capsaicinoids expressed as 0.4 mg capsaicin (C18H27N03; Mw: 305.4) in each capsule (from chili extract) can desensitise the cough reflex and improve…
- Trial name
- NCT04125563
- Testing
- Capsicum Oleoresin
- Where
- Sweden
- Volunteers
- 55 people
- Sponsor
- Vastra Gotaland Region
Cough, Cough Variant Asthma
MCT and Capsaicin Provocation Challenge in Diagnosis of Chronic Cough
The aim of the study is to assess the prevalence of bronchial hyperresponsiveness (BHR) in non-smoking adults with chronic cough and the prevalence of BHR in patients with upper airway cough syndrome (UACS) and gastroesophageal…
- Conditions
- Cough, Cough Variant Asthma, Upper-Airway Cough Syndrome, GERD
- Trial name
- NCT03363698
- Testing
- Cough variant asthma treatment
- Where
- Poland
- Volunteers
- 55 people
- Sponsor
- Medical University of Warsaw