Clinical trials: Coronary Bifurcation Lesion, open to volunteers
Coronary Artery Disease (non-left Main), Coronary Bifurcation Lesion
The European Bifurcation Club Randomized Trial of Stepwise Provisional Stenting Versus Drug Coated Balloon Therapy for Non-left Main True Coronary Bifurcations
Clinical outcomes are worse in patients with coronary artery bifurcation lesions, even if commonly encountered in clinical practice.
- Trial name
- EBC DCB (NCT06822322)
- Testing
- Percutaneous Coronary Angioplasty, Stepwise Provisional Stent Strategy, Drug Coated Balloon Strategy
- Volunteers
- 750 people
- Sponsor
- Ceric Sàrl
Coronary Artery Disease, Coronary Stenosis
Reverse T-stenting and Minimal Protrusion With External Minicrush for Treatment of Complex Coronary Bifurcation
The Reverse T-stenting And Minimal Protrusion (Reverse TAP) is an up-front 2-stent technique that treats complex coronary bifurcation.
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Coronary Disease
- Trial name
- T-REX (NCT05782738)
- Testing
- Percutaneous Coronary Intervention
- Where
- 5 sites in Italy
- Volunteers
- 361 people
- Sponsor
- San Luigi Gonzaga Hospital
Coronary Artery Disease, Ischemic Heart Disease
Comparison of PROVISIONal 1-stent Strategy with DEB Versus Planned 2-stent Strategy in Coronary Bifurcation Lesions.
[The Purpose of the Clinical Study] The purpose of this randomized comparison study is to compare the 1-stent strategy with a drug-eluting balloon and the 2-stent strategy in patients with non-LM coronary true-bifurcation…
- Trial name
- PROVISIONDEB (NCT06002932)
- Testing
- Procedure: planed 2-stent strategy, Procedure: provisional 1-stent plus DEB strategy
- Where
- South Korea
- Volunteers
- 750 people
- Sponsor
- Saint Vincent's Hospital, Korea
Coronary Bifurcation Lesions, Death
Mini-Crush Or Controlled Balloon-Crush For True Coronary Bifurcation Lesions
The mini-crush technique is one of the leading 2-stent techniques frequently applied by interventional cardiologists to treat complex bifurcation lesions.
- Conditions
- Coronary Bifurcation Lesions, Death, Myocardial Infarction (MI), Stent Thrombosis
- Trial name
- NCT06880978
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Coronary Bifurcation Lesion, Coronary Artery Disease (CAD)
Crossover vs Accurate Ostial PCI for Medina 0.0.1 and 0.1.0 Left Main Bifurcation Lesions
Coronary artery disease is a leading cause of mortality and morbidity globally. The left coronary artery system is critically important due to its supply of a large area of myocardium.
- Conditions
- Coronary Bifurcation Lesion, Coronary Artery Disease (CAD), Left Main Coronary Artery Stenosis
- Trial name
- NCT07596706
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital
Coronary Artery Disease
Simple Crossover Versus Side Branch Opening in Patients With Non-Left Main Bifurcation Lesion
Hypothesis: Simple crossover strategy would be non-inferior to SB opening strategy in the risk of target lesion failure (TLF) in patients with angiographically compromised SB (visually SB stenosis ≥50%) after provisional MV…
- Trial name
- CROSS-COBIS (NCT05705362)
- Testing
- Simple Crossover, Side branch opening
- Volunteers
- 1,000 people
- Sponsor
- Keimyung University Dongsan Medical Center
Coronary Artery Disease (CAD), Percutaneous Coronary Intervention (PCI)
Minicrush Versus Culotte Stenting in Complex Coronary Bifurcation Lesions:The Multicenter T-REX II Registry
Percutaneous coronary intervention (PCI) of complex coronary bifurcation lesions frequently requires an upfront two-stent strategy.
- Conditions
- Coronary Artery Disease (CAD), Percutaneous Coronary Intervention (PCI), Bifurcation Coronary Artery Disease
- Trial name
- NCT07849335
- Testing
- Percutaneous Coronary Intervention with Minicrush
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- San Luigi Gonzaga Hospital
Coronary Artery Disease, DCB
DCB vs. DES in Bifurcation Coronary Lesions
This is an investigator-driven prospective, multicentric, international, randomized clinical study, in an open-label randomized fashion, where patients with bifurcation coronary artery disease (Medina: 111,101,011,001) in vessels…
- Trial name
- PICCOLETO V (NCT06551662)
- Testing
- Paclitaxel drug-coated balloons, Sirolimus drug-coated balloons, New generation drug-eluting stent
- Where
- 17 sites in Italy, Poland and 2 more
- Volunteers
- 321 people
- Sponsor
- Fondazione Ricerca e Innovazione Cardiovascolare ETS
Coronary Bifurcation Lesion
International Bifurcation Study
The IBS registry is an observational, multi-center, real-world registry of stenting in coronary bifurcation lesions that will collect information on procedures and outcomes from various participating centers.
- Trial name
- IBS (NCT03450577)
- Testing
- PCI of bifurcation lesions
- Where
- Russia
- Volunteers
- 5,000 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Safety Issues, Efficacy, Self
Lower Silesia Culotte Bifurcation Registry (LSCBR).
The study aimed to evaluate the outcomes of bifurcation PCI using two techniques (Culotte vs. DK-Culotte) using data from a retrospective analysis.
- Trial name
- LSCBR (NCT06284057)
- Testing
- Bifurcation PCI with two stent technique Culotte Technique or Double Kiss (DK) Culotte
- Where
- 2 sites in Poland
- Volunteers
- 400 people
- Sponsor
- Miedziowe Centrum Zdrowia SA
Coronary Bifurcation Lesion
LATAM Bif Registry
The LATAM Bif Registy is an international and prospective registry of percutaneous coronary interventions (PCI) in coronary bifurcation lesions.
- Trial name
- NCT04471883
- Testing
- Percutaneous coronary interventions
- Volunteers
- 5,000 people
- Sponsor
- LATAM Bifurcation Club
Coronary Bifurcation Lesion
Efficacy and Safety of Sirolimus-Coated Spiral Balloon for Coronary Bifurcation Lesions
This is a multicenter, prospective randomized controlled study to evaluate the safety and effectiveness of Sirolimus-coated spiral balloon (SuperFlow®) versus Paclitaxel-coated balloon (Bingo™) in the treatment of coronary…
- Trial name
- NCT06618248
- Testing
- Sirolimus coated balloon angioplasty, Paclitaxel coated balloon angioplasty
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Dongguan TT Medical
Coronary Artery Disease, Coronary Artery Disease (Left Main)
µQFR for Branch Stenosis After Single Stent in Bifurcation Lesions
Murray-law based single-view quantitative flow ratio (µQFR) has been recommended for guiding percutaneous coronary intervention (PCI) in selective patients.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (Left Main), Obstructive Coronary Artery Disease, Stent Implantation
- Trial name
- NCT07116083
- Where
- China
- Volunteers
- 290 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease, Coronary Disease
Trial of Orbital Atherectomy Versus Standard Strategy in Calcified Bifurcation Lesions
Clinical research with medical devices indicated in accordance with the CE marking, led by researchers, multicenter, open, prospective, randomized and controlled.
- Trial name
- OraBil (NCT06736899)
- Testing
- Orbital Atherectomy System Treatment, Balloon System Treatment
- Where
- 9 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Fundación EPIC
Coronary Bifurcation Lesions
Coronary Bifurcations With Ischaemia and Flow Assessment
The coronary arteries are blood vessels that provide oxygen rich blood to the muscle of the heart. If these vessels become narrowed or blocked, this can lead to chest pain (called angina) or heart attacks.
- Trial name
- NCT06971718
- Testing
- Optical coherence tomography and pressure wire assessment of the vessel treated before and after treatment
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of East Anglia
Coronary Arterial Disease (CAD)
Efficacy and Safety of Sirolimus-coated Coronary Balloon Dilatation Catheter for De Novo Coronary Bifurcation Lesions
Evaluating the Safety and Efficacy of Sirolimus-coated Coronary Balloon Dilatation Catheter vs Paclitaxel-coated balloon catheter for the Treatment of De Novo Coronary Bifurcation Lesions
- Trial name
- NCT06822712
- Testing
- Sirolimus-coated Balloon Dilatation Catheter, Paclitaxel-coated Balloon Dilatation Catheter
- Where
- China
- Volunteers
- 250 people
- Sponsor
- BrosMed Medical Co., Ltd
Coronary Artery Disease
Smart Angioplasty Research Team-Optimal Strategy for Side Branch Stenting in Coronary Bifurcation Lesion With Drug-Coated Balloon
A prospective, multi-center, open-label, randomized controlled, superiority trial. The aim of the study is to compare clinical outcomes between upfront 2-stenting strategy versus upfront drug-coated balloon (DCB)-based hybrid…
- Trial name
- SMART-DCB (NCT07019350)
- Testing
- Upfront DCB-based hybrid strategy, Upfront 2-stenting strategy
- Where
- 3 sites in South Korea
- Volunteers
- 520 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease, Coronary Bifurcation Lesions
Progress Bifurcation Global Registry
Coronary bifurcation lesions are lesions (or blockages) that occur at or near the intersection of a major coronary artery and one of the arteries' side branches.
- Trial name
- NCT05100992
- Testing
- Percutaneous Coronary Interbention
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- Minneapolis Heart Institute Foundation
Coronary Artery Disease, Coronary Bifurcation Lesion
Bifurcation PCI With a Hybrid Strategy With Drug Eluting Balloons Versus a Stepwise Provisional Two-stent Strategy
The optimal treatment of coronary bifurcation lesions is complex and remains subject of current research. There is ongoing debate about the optimal strategy for bifurcations with upfront two-stent strategy or provisional…
- Trial name
- Hybrid DEB (NCT05731687)
- Testing
- Hybrid DEB approach with drug-eluting balloon, Two-stent strategy
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Cathreine BV
Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention (PCI)
Double Kissing-crush vs Controlled Balloon-crush Techniques For Complex Coronary Bfurcation Lesions
The Crush technique for coronary bifurcation lesions has evolved significantly since its introduction to the literature by Colombo et al. in 2003, with several iterations, including double kissing balloon inflation.
- Conditions
- Coronary Arterial Disease (CAD), Percutaneous Coronary Intervention (PCI), Bifurcation Coronary Disease
- Trial name
- NCT06931574
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Istanbul Mehmet Akif Ersoy Educational and Training Hospital