Clinical trials: Coronary Artery Disease Risk High
Coronary Artery Disease, Stable Angina Pectoris
A Comparative Evaluation of the Extent of Neointima Formation at 1 Month and 2 Months After Implantation Using OCT
The objective of this study is a comparative evaluation of BuMA Supreme™ stent and of Xience V/Prime stent in terms of the extent of neointima formation at 1 or 2 months after implanting in relatively high bleeding risk patients…
- Conditions
- Coronary Artery Disease, Stable Angina Pectoris, Unstable Angina Pectoris
- Trial name
- NCT02747329
- Testing
- BuMA Supreme™ stent, Xience V/Prime stent
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Sino Medical Sciences Technology Inc.
Chronic Total Occlusion of Coronary Artery, Angina Pectoris
Invest-CTO PCI Trial
Following unsuccessful CTO crossing a CTO modification procedure is sometimes performed. CTO PCI registries where plaque modification has been performed in some patients, report this to be safe, and associated with higher success…
- Conditions
- Chronic Total Occlusion of Coronary Artery, Angina Pectoris, Quality of Life, PROM
- Trial name
- NCT04774913
- Testing
- Chronic total occlusion(CTO) percutaneous coronary intervention (PCI)
- Where
- 5 sites in United States, Norway and 1 more
- Volunteers
- 200 people
- Sponsor
- Haukeland University Hospital
Fibromuscular Dysplasia, Early Onset CAD
CAUSE Trial: Patient Specific-Cellular Characterization of Fibromuscular Dysplasia and High-Risk Atherosclerotic Endothelium
The purpose of this project is to see if heritable alterations in the function, biology and vascular repair capacity of vascular cells make a major contribution to the burden of coronary artery disease (CAD), fibromuscular…
- Trial name
- NCT01808729
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Coronary Artery Disease, Acute Coronary Syndrome
Bioresorbable Polymer-Coated EES in Patients at High Bleeding Risk Undergoing PCI Followed by 1-Month DAPT
Objective: To evaluate the safety of bioresorbable polymer-coated everolimus-eluting Synergy® stent followed by 1-month dual antiplatelet therapy in patients at high-bleeding risk.
- Trial name
- POEM (NCT03112707)
- Testing
- Aspirin, P2Y12 inhibitor
- Where
- Italy
- Volunteers
- 1,023 people
- Sponsor
- Humanitas Hospital, Italy
Coronary Artery Disease
Comparison of Scoring Balloon and Conventional Balloon Predilation Before Drug Coated Balloon for de Novo Lesion in Patients With High Bleeding Risk
This study is designed to investigate whether scoring balloon (non-slip element, NSE) predilation compared to non-compliant (NC) balloon predilation for de novo lesion in patients with high bleeding risk and planning to receive…
- Trial name
- PREPARE-NSE (NCT03817801)
- Testing
- NSE balloon, NC balloon
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease
ESCALATion of Medical Therapy Following Multimodality Plaque Evaluation in High-risk Chronic Coronary Syndromes
ESCALATE will provide a thorough investigation of how anti-inflammatory therapy, with low-dose colchicine, affects patients with stable coronary artery disease.
- Trial name
- ESCALATE (NCT06469528)
- Testing
- Colchicine 0.5 MG
- Volunteers
- 50 people
- Sponsor
- King's College Hospital NHS Trust
Coronary Artery Disease
PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm
This purpose of this trial is to demonstrate 30 day safety and effectiveness outcomes of the KARDION CORY P4 System in subjects who require hemodynamic support during a high-risk PCI procedure.
- Trial name
- NCT06445608
- Testing
- Percutaneous Mechanical Circulatory Support
- Where
- 18 sites in United States
- Volunteers
- 310 people
- Sponsor
- Kardion Inc
Primary Angioplasty
Evaluation of Feasibility of Radial Access for Primary Angioplasty and to Assess it in High Risk Subgroups
Primary percutaneous coronary intervention is the preferred treatment for patients with ST-segment acute coronary syndrome. The radial access is an established approach, associated with a reduction in vascular access related…
- Trial name
- NCT03488407
- Volunteers
- 315 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Coronary Artery Disease (CAD), Artificial Intelligence Algorithms
AI Facial Analysis Algorithm to Screening Coronary Artery Disease in High-Risk Community Population
This study aims to evaluate the effectiveness of this facial image-based AI algorithm for screening CAD in high-risk community populations (specifically individuals with diabetes, hypertension, or aged over 65).
- Conditions
- Coronary Artery Disease (CAD), Artificial Intelligence Algorithms, Face, Screening
- Trial name
- NCT07277686
- Testing
- No Intervention
- Where
- 3 sites in China
- Volunteers
- 1,392 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Coronary Syndrome, Interventional Cardiology
Ticagrelor With Low-dose Versus Regular Aspirin in Patients With Acute Coronary Syndrome (ACS) at High-Risk for Ischemia After Percutaneous Coronary Intervention
The present study is aimed to compare the safety and efficacy of Ticagrelor with low-dose Aspirin versus standard dual anti-platelet therapy (DAPT) in patients with acute coronary syndrome (ACS) at high risk for ischemic events…
- Trial name
- LD-ASPIRIN (NCT04240834)
- Testing
- Aspirin, Ticagrelor
- Where
- China
- Volunteers
- 1,220 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Coronary Artery Disease, Heart Failure With Reduced Ejection Fraction
STRATegy SUccesS in High-Risk PCI With Impella CP: Evaluation of Hemodynamic Protection in Complex PCI
STRATUS-PCI is a pilot clinical trial that compares two ways of running a small heart pump called Impella CP during a high-risk procedure to open blocked heart arteries (percutaneous coronary intervention, or PCI) in patients…
- Trial name
- STRATUS-PCI (NCT07588399)
- Testing
- Impella CP
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Rayyan Hemetsberger
Acute Coronary Syndrome, Lipoproteinemia
Influence of Pelacarsen on Patients After Myocardial Infarction With High Lp(a) Values (PEMILA)
The aim of study is to examine the relationship between lipid subfractions, inflammation and structural-functional properties of the arterial wall in patients after myocardial infarction with high lipoprotein (a) (Lp (a)) levels…
- Conditions
- Acute Coronary Syndrome, Lipoproteinemia, Inflammation, Genetic Polymorphisms
- Trial name
- NCT04993664
- Testing
- Pelacarsen (TQJ230)
- Where
- Slovenia
- Sponsor
- University Medical Centre Ljubljana
Myocardial Infarction
Reduced Antithrombotic Strategy for High Bleeding Risk Patients With Myocardial Infarction
Rationale: Heart attacks are a major cause of death and result from coronary blood clots that require acute coronary intervention and antithrombotic drugs to restore blood flow and prevent new heart attacks.
- Trial name
- Dan-DAPT (NCT05262803)
- Testing
- CYP2C19*2/*3, Shorter DAPT duration
- Where
- 6 sites in Denmark
- Volunteers
- 2,808 people
- Sponsor
- Rikke Sorensen
Renovascular Hypertension, Renovascular Hypertension With Renal Failure
Effects of Percutaneous Transluminal Renal Angioplasty of Atherosclerotic Renal Artery Stenosis in High-Risk Patients.
The goal of this clinical trial is to investigate whether percutaneous transluminal renal angioplasty (PTRA) with stent placement of atherosclerotic renal artery stenosis is beneficial in high-risk patients selected according to…
- Conditions
- Renovascular Hypertension, Renovascular Hypertension With Renal Failure, Heart Failure, Renal Artery Stenosis Atherosclerotic
- Trial name
- DAN-PTRAII (NCT05834803)
- Testing
- Optimal medical therapy (OMT), Catheter-based angiography, Measurement of translesional pressure gradients
- Where
- 3 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
High Risk PCI, Coronary Arterial Disease (CAD)
Prospective Evaluation for Receiving SynFlow 3.0 Interventional Circulatory Support in High-risk PCI: A Randomized Controlled Trial
This study is conducted to compare the effectiveness of a new percutaneous mechanical circulatory support device called SynFlow 3.0 with VA-ECMO in high-risk percutaneous coronary intervetnion(PCI) patients.
- Trial name
- PERSIST Ⅲ (NCT06853470)
- Testing
- VA-ECMO circulatory support, SynFlow 3.0 circulatory support, percutaneous coronary intervention
- Where
- China
- Volunteers
- 222 people
- Sponsor
- ForQaly Medical (Shanghai) Co., Ltd
Coronary Artery Disease
Identification for High Risk of Coronary Heart Disease Based on Quantitative Analysis of Fundus Vessels and Metabolic Molecules
This ambidirectional observational cohort study builds upon and expands an existing coronary artery disease (CAD) cohort based on retinal fundus imaging (ChiCTR2200066429).
- Trial name
- NCT07773064
- Where
- 3 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Hospital
High-risk Percutaneous Coronary Intervention, Heart Disease, Coronary
VITALYST Early Feasibility Study in High-Risk PCI Patients (VITALYST EFS)
The VITALYST Early Feasibility study (EFS) is designed to evaluate the feasibility and safety of the VITALYST System in subjects undergoing elective high-risk percutaneous coronary intervention (HR-PCI).
- Trial name
- VITALYST EFS (NCT06132568)
- Testing
- VITALYST System
- Where
- 5 sites in United States, Sweden
- Volunteers
- 15 people
- Sponsor
- Boston Scientific Corporation
Perioperative Myocardial Infarction, Perioperative Myocardial Injury
Monitoring of Vital Signs for Phenotyping of Perioperative Myocardial Infarction/Injury After Noncardiac Surgery
The goal of this observational prospective cohort study is to learn about the pathophysiology of perioperative myocardial infarction/injury in high-risk patients undergoing major non-cardiac surgery.
- Trial name
- PMI-VITAL (NCT05866874)
- Where
- Switzerland
- Volunteers
- 875 people
- Sponsor
- University Hospital, Basel, Switzerland
Coronary Artery Bypass Graft Surgery, Myocardial Ischemia
A Safety and Efficacy Study to Confirm the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG
The purpose of this study is to determine the effect of MC-1 on the combined incidence of cardiovascular death and nonfatal myocardial infarction (MI) up to and including 30 days following coronary artery bypass graft (CABG)…
- Conditions
- Coronary Artery Bypass Graft Surgery, Myocardial Ischemia, Reperfusion Injury
- Trial name
- NCT00402506
- Testing
- (MC-1) Pyridoxal 5'-phosphate
- Where
- 2 sites in United States, Canada
- Volunteers
- 3,000 people
- Sponsor
- Medicure
Diabetes Mellitus, Hypertension
Improved Cardiovascular Risk Reduction to Enhance Rural Primary Care
The trial will examine whether a centralized Prevention Health \& Cardiovascular Risk Service (PHCVRS) run by clinical pharmacists at the University of Iowa can be implemented in primary care offices and whether it can improve…
- Conditions
- Diabetes Mellitus, Hypertension, Coronary Artery Disease, Atrial Fibrillation
- Trial name
- ICARE (NCT01983813)
- Testing
- PHCVRS Intervention, Personal Health Record
- Where
- 12 sites in United States
- Volunteers
- 302 people
- Sponsor
- Korey Kennelty