Clinical trials: Coronary Artery Calcification
Coronary Artery Disease
Feasibility of Orbital Atherectomy System in Calcified Bifurcation Lesion
ORBID-OA is a single-center, observational study in 30 patients with stable coronary artery disease. The aim of the study is to analyze the outcomes of main vessel stenting on side branch in calcified bifurcation lesion and…
- Trial name
- ORBID-OA (NCT03058510)
- Testing
- Frequency domain optical coherence tomography
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Coronary Artery Calcification
Toe-brachial Index and Coronary Calcification in Type 1 and 2 Diabetes
Diabetes is not a coronary risk equivalent, despite cardiovascular disease is the most common cause of death in diabetes. So, to identify diabetic patients at high cardiovascular risk is necessary.
- Trial name
- ACCoDiab (NCT03920683)
- Testing
- Data collection
- Where
- France
- Volunteers
- 707 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Diseases
ASpirin Use and stAtin Strategy for Primary Prevention in Severe Coronary Calcium Score on Computed Tomography
The primary objective of the ASA-3C trial is to evaluate the role of aspirin and high-intensity statin therapy, respectively, in individuals with severe coronary calcification (coronary calcium score ≥300) to prevent…
- Trial name
- ASA-3C (NCT06676280)
- Testing
- Aspirin, High-intensity statin, Guideline-directed statin therapy
- Where
- 32 sites in South Korea
- Volunteers
- 5,000 people
- Sponsor
- Jung-min Ahn
Calcified Coronary Artery Disease (Grade 3)
A ComparIson of Strategies to PrepAre SeveRely CALCified Coronary Lesions
The objective of this prospective, multicenter, randomized, open-label trial is to evaluate the completeness of stent expansion following a strategy of lesion preparation with either a Super High-Pressure NC PTCA Balloon (OPN NC)…
- Trial name
- ISAR-CALC (NCT03487432)
- Testing
- Super High-Pressure NC PTCA Balloon (OPN NC), Scoring PTCA Balloon (NSE Alpha)
- Where
- 5 sites in Germany, Switzerland
- Volunteers
- 74 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Kidney Diseases, Coronary Artery Calcification
Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients
Vessel calcification is a recognised cardiovascular morbidity risk factor in patients with chronic kidney disease (CKD). Recent reports indicate a significant role of Matrix Gla-protein (MGP) in decreasing calcification…
- Trial name
- CACSK2 (NCT01101698)
- Testing
- Vitamin K2+10μg cholecalciferol, Vitamin D
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lodz
Coronary Artery Disease
Study to Evaluate the Association of Testosterone Levels With Coronary Artery Calcification
Coronary artery calcification (CAC) is a pandemic condition in elderly patients with coronary artery disease (CAD) and associated with worse prognosis.
- Trial name
- NCT02310659
- Testing
- No intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhejiang University
Coronary Artery Bypass Graft, Chronic Kidney Disease
Evaluation of the Bone Mineral Density and Muscle Mass in Patients Post Coronary Artery Bypass Graft Surgery With Chronic Kidney Disease
The purposes of this study are: (1) to compare the body composition, physical activity, physical function, and quality of life between patients with and without CKD after CABG; and (2) to analyze the relationships among body…
- Trial name
- NCT01932008
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Coronary Arterial Disease (CAD), Calcific Coronary Arteriosclerosis
Evaluation of Calcified Coronary Lesion Preparation With the Naviscore Scoring Balloon
The purpose of this clinical study is to evaluate the effectiveness and safety of a specialized medical device, the Naviscore scoring balloon, in preparing calcified coronary artery narrowings before the implantation of a…
- Trial name
- MILOU (NCT07650578)
- Testing
- Scoring Balloon PTCA Catheter, Non-Compliant (NC) Angioplasty Balloon
- Where
- 14 sites in Belgium, Luxembourg and 2 more
- Volunteers
- 200 people
- Sponsor
- University of Mons
Type 1 Diabetes, Coronary Artery Calcification
Cardiovascular Risk Stratification in Young People With Type 1 Diabetes
The aim of the study is to compare ESC recommendations on cardiovascular (CV) risk stratification with the achievement of a CAC (Coronary Artery Calcification).
- Trial name
- CACD1 (NCT05283538)
- Testing
- Coronary Artery Calcification Realization
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Poitiers University Hospital
Coronary Artery Disease, Myocardial Infarction
Disrupt CAD IV With the Shockwave Coronary IVL System
The study design is a prospective, multicenter, single-arm study to evaluate the safety and effectiveness of the Shockwave Medical Coronary Intravascular Lithotripsy (IVL) System in de novo, calcified, stenotic coronary arteries…
- Trial name
- NCT04151628
- Testing
- Lithotripsy
- Where
- 8 sites in Japan
- Volunteers
- 72 people
- Sponsor
- Shockwave Medical, Inc.
Coronary Artery Disease
The Prospective Segeberg Registry for Rotational Atherectomy in Coronary Lesion/s
A Prospective Follow-up Assessment in Bad Segeberg with Patients undergoing a Rotational Atherectomy in Coronary Lesion/s
- Trial name
- NCT04011527
- Testing
- Rotational Atherectomy in Coronary Lesion/s
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- Segeberger Kliniken GmbH
Coronary Artery Disease
Evaluation of Coronary Artery Calcification Using Gated Stationary Chest Tomosynthesis
The purpose of this study is to propose a new method for evaluating coronary artery calcium scores (CACS) in individuals with coronary artery disease.
- Trial name
- NCT03169062
- Testing
- Gated Stationary Chest Tomosynthesis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Kidney Disease, Coronary Arteries Calcifications
CXCR2 Leucocyte Expression Level as a Predictive Factor of Coronary Artery Calcification Progression in Advanced Chronic Kidney Disease Patients
Chronic kidney disease (CKD) is associated with the development of coronary arteries calcifications (CAC) and increased cardiovascular mortality.
- Conditions
- Chronic Kidney Disease, Coronary Arteries Calcifications, CXCR2 Expression
- Trial name
- MACXCALCIF (NCT07811505)
- Testing
- Thoracic CT, Blood samples
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Vascular Calcification
Comparison of RA-IVL and RA-SHP in Calcified Coronary Lesions
Study Design Prospective, multicenter, single-blind, randomized controlled trial Hypothesis In patients with severely calcified coronary lesions undergoing rotational atherectomy (Rota), post-rotational lesion optimization using…
- Trial name
- CRUSH-CALC (NCT07279987)
- Testing
- Super High-Pressure Non-Compliant Balloon, Intravascular Lithotripsy System
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Lin Zhao
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Cardiovascular Disease (CVD)
Cardiovascular Risk Assessment and Coronary Calcium Score in Thai MASLD Patients
Metabolic dysfunction-associated steatotic liver disease (MASLD) is common in Thailand and is strongly linked to metabolic risk factors such as obesity, diabetes, hypertension, and dyslipidemia.
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Cardiovascular Disease (CVD), Coronary Artery Calcification
- Trial name
- MASLD-CAC (NCT07865936)
- Where
- Thailand
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Watcharasak Chotiyaputta
Coronary Artery Disease
AI-Based CT Analysis of Coronary Plaque Evolution
This retrospective, multicenter, observational study will evaluate an artificial intelligence-based system for quantitative assessment and risk stratification of coronary atherosclerotic plaque.
- Trial name
- AI-CT-PLAQUE (NCT07886996)
- Where
- 5 sites in China
- Volunteers
- 326 people
- Sponsor
- Zhejiang Hospital
Coronary Artery Calcification, Coronary Artery Disease
MAP-Calcification: MicroRNAs as Potential Biomarkers for Coronary Artery Calcification
Coronary artery disease (CAD) remains the leading cause of mortality in the UK with an estimated 80,000 fatalities in 2010. Coronary artery calcification (CAC) is associated with atherosclerotic plaque burden and cardiovascular…
- Conditions
- Coronary Artery Calcification, Coronary Artery Disease, Osteoporosis, Osteopenia
- Trial name
- NCT01992848
- Testing
- Venous blood sampling, 4-day food diary, 1 week UV dosimeter
- Where
- 2 sites in United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Surrey
Coronary Artery Disease
Comparison of DCB and DES for Severe Calcification of de Novo Lesion in Elderly CHD
The goal of this clinical trial was to compare the effectiveness of drug balloons versus drug-coated stents in calcified lesions in elderly coronary artery disease.
- Trial name
- NCT05750771
- Testing
- DES, DCB
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Coronary Heart Disease
A Cohort Study of PCI Strategies for Severely Calcified Lesions of Complex Coronary Arteries in the Elderly
The aim of this observational study is to compare the prognostic outcomes of various PCI strategies in elderly patients with complex coronary calcified lesions.
- Trial name
- PSSCCE (NCT06168422)
- Testing
- DES, DCB
- Where
- China
- Volunteers
- 2,100 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Coronary Artery Disease, Calcification
Rotablation vs Intravascular Lithotripsy in Calcified Coronary Lesions
Prospective, 1:1 randomized, controlled, multicenter trial to assess effectiveness and safety of Intravascular Lithotripsy (IVL) compared to Rotational Atherectomy (RA) treatment in calcified coronary lesions
- Trial name
- DECALCIFY (NCT04960319)
- Testing
- Intravascular Lithotripsy
- Volunteers
- 100 people
- Sponsor
- Medical Care Center Prof. Mathey, Prof. Schofer, Ltd.