Clinical trials: Corneal Disease
Keratoconus
Feasibility Study of the Vedera KXS for Treatment of Keratoconus
The objective of this investigation is to evaluate the feasibility, safety and efficacy of the Vedera KXS for the reduction or elimination of myopia and astigmatism in patients with keratoconus, who are no longer able to achieve…
- Trial name
- NCT01069848
- Testing
- Vedera KXS
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Glaukos Corporation
Keratoconus
Fourier Transform of Videokeratography Data: Clinical Usefulness in Moderate and Frome Fruste Keratoconus
Primary objective of this study was evaluate the diagnostic capacity of fourier analysis of keratometric data in differentiating moderate KC and FFK from healthy corneas.
- Trial name
- FFTKC (NCT02617368)
- Where
- Greece
- Volunteers
- 185 people
- Sponsor
- Democritus University of Thrace
Corneal Ectasia Disorders Including Keratoconus
The Effects of Corneal Collagen Cross-linking
The corneal collagen cross-linking treatment has been used with increasing success to treat corneal dystrophies such as "keratoconus." Recent advances have allowed different techniques for performing this cross-linking treatment.
- Trial name
- NCT01708538
- Testing
- CXL
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rush Eye Associates
Myopia, Myopic Astigmatism
Laser In-situ Keratomileusis With Crosslinking Compared to Conventional LASIK in Patients With High Myopia
The objectives of this study are to evaluate the safety and efficacy of a treatment regimen for high myopia and myopic astigmatism: LASIK followed by crosslinking performed with the KXL Crosslinking-System and VibeX Xtra…
- Conditions
- Myopia, Myopic Astigmatism, Crosslinking, Corneal Ectasia
- Trial name
- NCT03913338
- Testing
- LasikXtra, LASIK
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Clinic Frankfurt
Myopia
Corneal Endothelial Cell Injury Induced by Mitomycin-C
our study will investigate the effecacy of Mitomycin-C in TransEpi single step photorefractive keratectomy (PRK) and alcohol assisted PRK
- Trial name
- NCT05548478
- Testing
- Transepithelial PRK/MMC, Alcohol-Assisted PRK/MMC
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
Ocular Inflammation, Infection Associated Blepharitis
Antibiotic Steroid Combination Compared With Individual Administration in the in the Treatment of Ocular Inflammation and Infection
To evaluate the efficacy and safety of fixed combination of azithromycin 1.5% + 0.5% Loteprednol eye drops for the treatment of ocular inflammation and infection associated bacterial blepharitis and / or keratitis and / or…
- Conditions
- Ocular Inflammation, Infection Associated Blepharitis, Keratitis, Conjunctivitis, Bacterial
- Trial name
- NCT01721694
- Testing
- azithromycin 1.5% + Loteprednol 0,5% (separately)
- Where
- Brazil
- Sponsor
- Adapt Produtos Oftalmológicos Ltda.
Keratoconus
Astigmatism in Keratoconus Patients
Keratoconus is a bilateral (but usually asymmetrical) non-inflammatory progressive thinning process of the cornea. It manifests as characteristic cone-like ectasia of the cornea associated with irregular stromal thinning…
- Trial name
- NCT03450213
- Testing
- Pentacam
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Retinal Diseases
Measuring Corneal Cells With Specular Microscopy
Assess changes in the corneal cell count using Specular Microscopy following tretments with Anti-VEGF injections
- Trial name
- NCT01792154
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Retina Institute of Hawaii
Keratoconus
Comparison of Penetrating Keratoplasty and Deep Lamellar Keratoplasty With the Big Bubble Technique for Keratoconus
it is a randomized clinical trial to compare deep lamellar keratoplasty (DLK) Using big bubble technique and Penetrating Keratoplasty (PK) in patients with keratoconus
- Trial name
- NCT00371202
- Testing
- keratoplasty
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Corneal Dystrophy
Microsurgical Robot-assisted Corneal Transplant
Full-thickness corneal grafting (transfixing keratoplasty) is a tissue graft described at the beginning of the 20th century, which has remained technically unchanged for several decades.
- Trial name
- GRACE (NCT06844123)
- Testing
- Robot-assisted keratoplasty
- Where
- France
- Volunteers
- 10 people
- Sponsor
- CHU de Reims
Cataract
Zeiss® IOLMaster 700 Corneal Topography Module Comparison With Schwind's Sirius Corneal Topography®
In order to determine the intraocular lens to be implanted during cataract surgery, keratometry and axial length must be measured in preoperative. The axial length is obtained by ocular ultrasound mode B.
- Trial name
- VIMECT (NCT05414773)
- Testing
- measurement of axial length and keratometry by sonographers with a topographic module
- Volunteers
- 100 people
- Sponsor
- Edouard KOCH
Keratoconus
Central Versus Peripheral Air Injection for DALK (Deep Anterior Lamellar Keratoplasty)
Different techniques of deep anterior lamellar keratoplasty (DALK) have been introduced to create a uniform recipient bed, thereby reducing complications, such as interface irregularity and opacification encountered with…
- Trial name
- NCT02485951
- Testing
- Central air injection, Peripheral air injection
- Where
- Iran
- Volunteers
- 49 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Keratoconus
Intacs for Keratoconus
To study the effects Intacs intracorneal ring segments(Addition Technology, Inc) insertion in the treatment of keratoconus
- Trial name
- NCT00347230
- Testing
- Intacs intracorneal ring insertion for the treatment of keratoconus
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Keratoconus, Keratoconus, Unspecified, Bilateral
Evaluation of Tomographic and Genetic Aspects of Keratoconus Patients Compared to Sounds Corneas
Evaluation of tomographic (Pentacam) parameters and genetic parameters of Visual System Homeobox 1 (VSX1), Superoxide Dismutase (SOD1), Tissue Inhibitors of Metalloproteinases (TIMP3) genes of keratoconus patients diagnosed by…
- Trial name
- NCT03071302
- Testing
- EVALUATION OF VSX1, SOD1, and TIMP3 genes
- Where
- Brazil
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Sao Jose do Rio Preto Medical School
Cataract With Pre-existing Regular Corneal Astigmatism
Influence of Implantation Technique on Rotational Stability of a Frosted-Haptic Toric Intraocular Lens: A Prospective Contralateral-Eye Study
This prospective, randomized contralateral-eye study evaluates whether the implantation technique influences the rotational stability and refractive outcomes of the TECNIS Eyhance™ Toric II intraocular lens (IOL) during cataract…
- Trial name
- NCT07768722
- Testing
- OVD-assisted Implantation, BSS-assisted hydroimplantation
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Neurotrophic Keratitis, Neurotrophic Keratopathy
Open-label Trial to Evaluate Efficacy and Safety of rhNGF on Corneal Thickness Via AS-OCT in Neurotrophic Keratitis
Primary Objective: To assess the efficacy of cenegermin-bkbj (20 mcg/mL) ophthalmic solution on overall corneal thickness via AS-OCT in patients with stage 3 neurotrophic keratitis with respect to change from baseline at weeks 4…
- Conditions
- Neurotrophic Keratitis, Neurotrophic Keratopathy, Corneal Ulcer
- Trial name
- IMAGO (NCT06411145)
- Testing
- OXERVATE® 0.002%
- Sponsor
- Dompé Farmaceutici S.p.A
Cornea; Ectasia, Refractive Errors
Corneal Elastography and Patient Specific Modeling
The goal of this research is to develop measurement tools and simulation technology for characterizing and predicting individual responses to corneal treatments and for advancing understanding of corneal ectasia risk factors.
- Conditions
- Cornea; Ectasia, Refractive Errors, Keratoconus
- Trial name
- NCT03030755
- Testing
- Optical coherence tomography
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Trachoma
App-based Versus Slide-based Inter-grader Agreement (IGA) Test for Trachoma Graders
Trachomatous inflammation-follicular (TF) is diagnosed by looking for clinical signs of infection of everted eyelids (conjunctivae) of children.
- Trial name
- NCT04002726
- Testing
- Inter-grader agreement (IGA) app
- Where
- Tanzania
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Persistent Corneal Epithelial Defects
Efficacy and Safety Study of Nexagon for Persistent Corneal Epithelial Defects
The purpose of this study is to evaluate the efficacy and safety of Nexagon® in subjects with persistent corneal epithelial defects (PED) resulting from corneal epithelial debridement during diabetic vitrectomy surgery, HSV…
- Trial name
- NTX-PED-001 (NCT01165450)
- Testing
- Nexagon, Vehicle only
- Volunteers
- 2 people
- Sponsor
- University of California, San Francisco
Deep Learning, Corneal Disease
Artificial Intelligence for Screening of Multiple Corneal Diseases
This study developed a deep learning algorithm based on anterior segment images and prospectively validated its ability to identify corneal diseases.The effectiveness and accuracy of this algorithm was evaluated by sensitivity…
- Conditions
- Deep Learning, Corneal Disease, Screening
- Trial name
- NCT06211218
- Testing
- Cornea diseases diagnosed by artificial intelligence algorithm
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Tianjin Eye Hospital
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