Clinical trials: Corneal Defect
Persistent Corneal Epithelial Defect
A Study of the KIO-201 (Ocular Bandage Gel) for Improving Persistent Corneal Epithelial Defects
The objective of this study is to evaluate the safety and effectiveness of topical KIO-201 in patients with persistent corneal epithelial defects (PED). KIO-201 will be administered six (6) times per day while awake for 4 weeks.
- Trial name
- NCT05436288
- Testing
- KIO-201, a Crosslinked Thiolated Carboxymethyl Hyaluronic Acid 0.75% (CMHA-S)
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Kiora Pharmaceuticals, Inc.
Mesenchymal Stromal Cells, Cornea
Safety of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease
This study is a longitudinal assessment using a classic dose-escalation study design to assess the safety and maximal tolerated dose (MTD) of topical MSC Secretome eye drops.
- Conditions
- Mesenchymal Stromal Cells, Cornea, Corneal Defect, Corneal Epithelium Defect
- Trial name
- MSC Secretome (NCT05204329)
- Testing
- MSC Secretome Eye Drops
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Illinois at Chicago
Corneal Epithelium Defect
GenTeal in Perioperative Treatment of Laser Assisted in Situ Keratomileusis LASIK Patients
GenTeal gel is an artificial tear gel used to lubricate the surface of the eye. This study will evaluate the effect of GenTeal gel on comfort following LASIK surgery.
- Trial name
- NCT00598689
- Testing
- 0.3% hypromellose
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Augusta University
Limbal Stem Cell Deficiency
Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft
The main aim of the study is to determine the safety and feasibility of a cultivated autologous limbal epithelial cell (CALEC) transplantation in the treatment of limbal stem cell deficiency.
- Trial name
- CALEC (NCT02592330)
- Testing
- Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Corneal Epithelial Defect, Diabetic Retinopathy
Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries
Ophthalmology ,cornea Autologous serum has long been known to be effective to promote corneal epithelial wound healing in a variety of ocular surface disorders.
- Conditions
- Corneal Epithelial Defect, Diabetic Retinopathy, Penetrating Keratoplasty
- Trial name
- NCT01075347
- Testing
- autologous serum, Non-autologous serum
- Where
- Taiwan
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Corneal Persistent Epithelial Defect
NEXAGON for the Treatment of Corneal Persistent Epithelial Defects Following Severe Ocular Injuries
This study will enroll participants with a non-infected, corneal persistent epithelial defect (PED) resulting from an ocular chemical and/or thermal ocular injury which is non-responsive or refractory to current standard of care…
- Trial name
- EXPEDE (NCT04081103)
- Testing
- Nexagon® (lufepirsen) High Dose Concentration, Nexagon® (lufepirsen) Low Dose Concentration, Vehicle
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Glaukos Corporation
Keratoconus
Performance and Safety Assessment of T4020 in Managing Corneal Epithelial Defect Following Epi-off Accelerated Crosslinking
The purpose of this study is to assess the performance and safety of T4020 versus saline solution.
- Trial name
- NCT02979054
- Testing
- T4020
- Where
- 4 sites in Bulgaria, France and 2 more
- Volunteers
- 157 people
- Sponsor
- Laboratoires Thea
Persistent Corneal Epithelial Defects
Efficacy and Safety Study of Nexagon for Persistent Corneal Epithelial Defects
The purpose of this study is to evaluate the efficacy and safety of Nexagon® in subjects with persistent corneal epithelial defects (PED) resulting from corneal epithelial debridement during diabetic vitrectomy surgery, HSV…
- Trial name
- NTX-PED-001 (NCT01165450)
- Testing
- Nexagon, Vehicle only
- Volunteers
- 2 people
- Sponsor
- University of California, San Francisco
Postoperative Ocular Pain After PRK Surgery
Study of SAF312 as an Eye Drop for Treatment of Eye Pain Following Photorefractive Keratectomy (PRK) Surgery
The purpose of this study is to determine if SAF312 eye drops have an adequate safety and efficacy profile to justify further clinical development for the treatment of ocular pain associated with corneal epithelial defect such as…
- Trial name
- NCT02961062
- Testing
- SAF312
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals