Clinical trials: Corneal Defect
Corneal Defect
Evaluate the Tolerance, Safety and Pharmacokinetics of Germinal Peptide Eye Drops in Healthy Volunteers
Phase I Clinical Trial to Evaluate the Tolerance, Safety and Pharmacokinetics of Germinal Peptide Eye Drops in Healthy Volunteers.
- Trial name
- NCT03662971
- Testing
- Germinal peptide eye drops
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Persistent Epithelial Defect
Autologous Platelet-rich Plasma in the Treatment of Persistent Epithelial Defects
Persistent epithelial defects (PED) are corneal ulcers that do not heal within the first two weeks of treatment with artificial tears or ocular lubricant ointment.
- Trial name
- NCT03653650
- Testing
- PRP plus BCL, BCL plus PFL, Eye patch plus ocular lubricant ointment
- Where
- Mexico
- Volunteers
- 54 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Persistent Corneal Epithelial Defect
A Study of the KIO-201 (Ocular Bandage Gel) for Improving Persistent Corneal Epithelial Defects
The objective of this study is to evaluate the safety and effectiveness of topical KIO-201 in patients with persistent corneal epithelial defects (PED). KIO-201 will be administered six (6) times per day while awake for 4 weeks.
- Trial name
- NCT05436288
- Testing
- KIO-201, a Crosslinked Thiolated Carboxymethyl Hyaluronic Acid 0.75% (CMHA-S)
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Kiora Pharmaceuticals, Inc.
Mesenchymal Stromal Cells, Cornea
Safety of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease
This study is a longitudinal assessment using a classic dose-escalation study design to assess the safety and maximal tolerated dose (MTD) of topical MSC Secretome eye drops.
- Conditions
- Mesenchymal Stromal Cells, Cornea, Corneal Defect, Corneal Epithelium Defect
- Trial name
- MSC Secretome (NCT05204329)
- Testing
- MSC Secretome Eye Drops
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Illinois at Chicago
Ophthalmology, Photorefractive Keratectomy ("PRK")
Ocular Bandage Gel (OBG) Pivotal Trial in Patients Undergoing Photorefractive Keratectomy ("PRK")
Prospective, randomized, masked (reading center), controlled pivotal study of Ocular Bandage Gel (OBG) vs. a bandage contact lens (BCL) in subjects who have undergone bilateral photorefractive keratectomy (PRK).
- Conditions
- Ophthalmology, Photorefractive Keratectomy ("PRK"), Laser Assisted Surgery, Refractive Surgery
- Trial name
- NCT03938883
- Testing
- Ocular Bandage Gel (OBG), Bandage Contact Lens (BCL)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Eyegate Pharmaceuticals, Inc.
Corneal Defect
Evaluating the Efficacy and Safety of ZKY001 Eye Drops in the Treatment of Corneal Epithelial Defects
The subjects of this study were patients who underwent corneal endothelial transplantation,who were randomly divided into 3 groups, 2 groups (0.002% and 0.004% ZKY001 eye drops) and 1 placebo control group.
- Trial name
- NCT04228926
- Testing
- ZKY001 eye drops 0.3g:0.006mg, ZKY001 eye drops 0.3g:0.012mg, ZKY001 simulated eye drops
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Corneal Epithelial Defect
To Evaluate the Efficacy and Safety of ZKY001 Eye Drops in the Treatment of Corneal Epithelial Defects Caused by Neurotrophic Keratitis
An investigator-initiated single-center, randomized, double-blind, placebo-controlled clinical study .The main purpose is to evaluate the effectiveness of ZKY001 eye drops in treating corneal epithelial defects caused by…
- Trial name
- NCT07120308
- Testing
- ZKY001 eye drops
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Corneal Defect
The Germinal Peptide Eye Drops in Healthy Volunteers in a Clinical Study
The subjects of this study were healthy subjects, who were given medicine in a single dose group: 0.004%.
- Trial name
- NCT03967548
- Testing
- Germinal peptide eye drops
- Where
- China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Corneal Epithelial Defect
The Role of Umbilical Cord Serum Therapy on Improvement of Corneal Epithelial Defect Following Diabetic Vitrectomy
80 diabetic patients underwent vitrectomy and had no history of Eye herpes infection, Refractive surgery, Autoimmune disease, Immune deficiency will be randomized into two groups (double blind)to evaluate the role of umbilical…
- Trial name
- NCT01168375
- Testing
- conventional therapy plus umbilical cord serum eye drop, conventional therapy
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Neurotrophic Keratitis
A Study Comparing KB801 Verse Placebo in Patients With Stage 2 or 3 Neurotrophic Keratitis
The Sponsor is developing KB801, a replication-defective, non-integrating herpes simplex virus type 1 (HSV-1)-derived vector engineered to deliver functional full-length human nerve growth factor (NGF) to the corneas of people…
- Trial name
- EMERALD-1 (NCT06999733)
- Testing
- KB801
- Where
- 9 sites in United States
- Volunteers
- 60 people
- Sponsor
- Krystal Biotech, Inc.
Fuchs' Endothelial Dystrophy, Pseudophakic Bullous Keratopathy
The Effect Of Preoperative Parameters On Success After DMEK Surgery
The aim of this study is to evaluate the effect of preoperative parameters on surgical results in Descemet Membrane Endothelial Keratoplasty (DMEK) surgery.
- Conditions
- Fuchs' Endothelial Dystrophy, Pseudophakic Bullous Keratopathy, Descemet's Membrane; Defect, Herpetic Keratitis
- Trial name
- NCT04420429
- Testing
- Descemet membrane endothelial keratoplasty (DMEK)
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Beyoglu Eye Research and Education Hospital
Corneal Epithelial Defect
ZKY001 Eye Drops in the Treatment of Corneal Epithelial Defects in a Phase Ⅱ Clinical Trial
A multicenter, randomized, double-blind, placebo-controlled clinical trial was designed. The study included two experimental groups (low-dose ZKY001 eye drops group and medium-dose ZKY001 eye drops group) and a placebo control…
- Trial name
- NCT06213727
- Testing
- lowe-dose ZKY001 eye drops, Medium-dose ZKY001 eye drops, ZKY001 simulated eye drops
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Persistent Epithelial Defect
A Study to Investigate the Safety and Clinical Effect of Nexagon® to Treat Persistent Epithelial Defects
The purpose of this study is to evaluate the efficacy and safety of Nexagon® in subjects with Persistent Epithelial Defects (PED) originally caused by chemical burns.
- Trial name
- NCT00821561
- Testing
- Nexagon®, Nexagon® vehicle
- Volunteers
- 90 people
- Sponsor
- OcuNexus Therapeutics, Inc.
Cataract, Lens Opacities
Feasibility Investigation of Biometry and Tomography Measurements in a Heterogeneous Patient Cohort
The planned clinical investigation will be conducted to acquire raw data for the development of the algorithm. The data acquisition is intended to obtain first impressions of the potential performance of the changed hardware and…
- Conditions
- Cataract, Lens Opacities, Artificial Lens Implant, Corneal Astigmatism
- Trial name
- BioBase (NCT05458661)
- Testing
- Clinical Prototype BioBase (SN 07 and SN 08)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec AG
Corneal Epithelium Defect
GenTeal in Perioperative Treatment of Laser Assisted in Situ Keratomileusis LASIK Patients
GenTeal gel is an artificial tear gel used to lubricate the surface of the eye. This study will evaluate the effect of GenTeal gel on comfort following LASIK surgery.
- Trial name
- NCT00598689
- Testing
- 0.3% hypromellose
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Augusta University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Limbal Stem Cell Deficiency
Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft
The main aim of the study is to determine the safety and feasibility of a cultivated autologous limbal epithelial cell (CALEC) transplantation in the treatment of limbal stem cell deficiency.
- Trial name
- CALEC (NCT02592330)
- Testing
- Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Persistent Corneal Epithelial Defect
Trial to Evaluate Safety and Efficacy of KPI-012 Ophthalmic Solution in Participants With PCED
The primary objective of the study is to investigate the safety and efficacy of KPI-012 compared to vehicle in participants who have a documented clinical diagnosis of PCED.
- Trial name
- CHASE (NCT05727878)
- Testing
- KPI-012, KPI-012 Vehicle
- Where
- 46 sites in United States, Argentina and 1 more
- Volunteers
- 103 people
- Sponsor
- Combangio, Inc
Corneal Ulcer, Persistent Corneal Epithelial Defect
Use of a Biological Lens of Amniotic Membrane (LV-Visio-AMTRIX) in the Treatment of Trophic Ulcers
The purpose of this open, multicenter pilot trial is to assess the impact of the use of an amniotic membrane on the healing of a persistent epithelial lesion or of a corneal ulcer.
- Trial name
- NCT05172349
- Testing
- LV-Visio-AMTRIX
- Sponsor
- TBF Genie Tissulaire
Corneal Diseases
Phase I Clinical Study of ZKY001 Eye Drops in the Treatment of Corneal Epithelial Defect
One dose group of 0.004% was used.
- Trial name
- NCT07132437
- Testing
- ZKY001 EYE DROPS
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.