Clinical trials: Corneal Crosslinking
Keratoconus
Transepithelial Corneal Collagen Crosslinking in Eyes With Progressive Keratoconus
Keratoconus is a corneal ectatic disease responsible for a loss of visual acuity when the steepening increases. Corneal collagen crosslinking (CXL) is a procedure that appears to halt or slow down the progression and avoid the…
- Trial name
- TE-CXL (NCT03584243)
- Testing
- A crosslinking with oxygen treatment
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Toulouse
Ectasia
Corneal Collagen Cross-Linking for Ectasia (CXL)
Prospective, randomized multicenter study to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes with ectasia after refractive surgery.
- Trial name
- CXL (NCT00674661)
- Testing
- riboflavin ophthalmic solution, UVA Irradiation
- Where
- 10 sites in United States
- Volunteers
- 130 people
- Sponsor
- Glaukos Corporation
Keratoconus, Ectasia Corneal
Comparison of Standard vs. Accelerated Corneal Crosslinking
The study objective is to compare accelerated and standard corneal crosslinking for treatment of progressive keratoconus or corneal ectasia.
- Trial name
- NCT03922542
- Testing
- riboflavin 0.1%
- Where
- United States
- Volunteers
- 508 people
- Sponsor
- Price Vision Group
Presbyopia
Quantitative Refractive Crosslinking in Presbyopia Aged Patients
An 'on-eye' UV delivery system for corneal crosslinking can be used safely and effectively to help free presbyopic patients from the need for reading glasses.
- Trial name
- NCT07137767
- Testing
- Quantitative refractive crosslinking
- Where
- 2 sites in Brazil, Dominican Republic
- Volunteers
- 25 people
- Sponsor
- TECLens, Inc.
Keratoconus
Tobacco Smoking Among Crosslinked-keratoconus Patients
Certain studies reported that cigarette by-products may make the cornea more rigid, suggesting that it could lead to "natural" CXL of collagen fibers, hence a protective effect for KC.
- Trial name
- TOBACOLINK (NCT03462355)
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Keratoconus, Ectasia
Cross-linking of Corneal Collagen (CXL) With Ultraviolet-A in Asymmetric Corneas
The purpose of this study is to evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional…
- Conditions
- Keratoconus, Ectasia, Degeneration
- Trial name
- NCT01189864
- Testing
- Ciprofloxicin or Vigamox or other., Nonsteroidal (Acular, Acuvail, Voltaren Xibrom, etc), Steroid (FML, Pred Forte, Flarex, etc.)
- Where
- 16 sites in United States
- Volunteers
- 3,493 people
- Sponsor
- Cxlusa
Keratoconus
McNeel Eye Center Corneal Crosslinking Study
This study will investigate the effectiveness in treating keratoconus, pellucid marginal degeneration and post LASIK iatrogenic ectasia utilizing fluence rates and treatment times of Corneal Cross Linking other than the original…
- Trial name
- NCT02921009
- Testing
- Crosslinking using UV light of two different fluence rates
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McNeel Eye Center
Keratoconus
The Effect of Mitomycin C on Corneal Haze and Scarring After Corneal Crosslinking in Keratoconus Patients
Corneal crosslinking (Crosslinking, CXL) is a treatment offered for the stabilization of early corneal ectatic disorders such as keratoconus.
- Trial name
- NCT04811924
- Testing
- Application of 0.02% MMC over 60 seconds post corneal crosslinking., Corneal crosslinking without the application of 0.02% MMC
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Keratoconus, Corneal Crosslinking
Photorefractive Intrastromal Crosslinking (PiXL) for the Treatment of Progressive Keratoconus
The purpose of this study is to evaluate the efficacy, safety and postoperative ocular discomfort by comparing individually customized Photorefractive intrastromal crosslinking (PiXL) for progressive Keratoconus.
- Conditions
- Keratoconus, Corneal Crosslinking, Corneal Biomechanics, Corneal Densitometry
- Trial name
- NCT03990506
- Testing
- Epi-on PiXL, Epi-Off PiXL
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Umeå University
Keratoconus, Corneal Ectasia
Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/Methylcellulose
This study is being conducted to evaluate the safety and efficacy of isotonic riboflavin for corneal collagen crosslinking for keratoconus and corneal ectasia.
- Trial name
- CXL (NCT04897503)
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Keratoconus, Corneal Ectasia
Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia
Corneal collagen crosslinking (CXL) has been demonstrated as an effective method of reducing progression of both keratoconus and corneal ectasia after surgery, as well as possibly decreasing the steepness of the cornea in these…
- Trial name
- NCT04905108
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Keratoconus, Post-Refractive Ectasia
Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia
The purpose of this study is to evaluate the effectiveness of using riboflavin and UV light to treat progressive keratoconus or post-refractive corneal ectasia.
- Trial name
- NCT01143389
- Testing
- Riboflavin, UVX light
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Price Vision Group
Corneal Epithelial Wound
Safety and Effectiveness of OBG vs.a Bandage Contact Lens for Large Corneal Epithelial Defects in Patients Post-PRK.
This is a prospective, randomized (Reading Center), masked, controlled study in up to 45 subjects who have undergone bilateral PRK with epithelial removal using alcohol in a 9.0 mm well or trephine at the time of surgery to…
- Trial name
- NCT03163641
- Testing
- Acuvue Oasys, Ocular Bandage Gel
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Eyegate Pharmaceuticals, Inc.
Corneal Transplantation
Pretreatment to Promote Graft Survival After Subsequent High-risk Corneal Transplantation [CrossCornealVision]
The trial evaluates the effect of corneal crosslinking as pre-treatment before corneal transplantation. The goal is to improve graft survival by reducing pathological vessels through pre-treatment.
- Trial name
- NCT05870566
- Testing
- Corneal Crosslinking
- Where
- 7 sites in Germany
- Volunteers
- 110 people
- Sponsor
- Claus Cursiefen
Keratoconus
Performance and Safety Assessment of T4020 in Managing Corneal Epithelial Defect Following Epi-off Accelerated Crosslinking
The purpose of this study is to assess the performance and safety of T4020 versus saline solution.
- Trial name
- NCT02979054
- Testing
- T4020
- Where
- 4 sites in Bulgaria, France and 2 more
- Volunteers
- 157 people
- Sponsor
- Laboratoires Thea
Corneal Transplant, Corneal Crosslinking
A Prospective Clinical Trial Designed to Evaluate the Repeatability and Reproducibility of the Intelon BOSS(tm) System
This is a prospective, open-label, single-site clinical trial designed to evaluate the repeatability and reproducibility of biomechanical imaging by the updated version of the BOSS device.
- Conditions
- Corneal Transplant, Corneal Crosslinking, Healthy Eyes
- Trial name
- NCT05423041
- Testing
- BOSS Imaging
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Intelon Optics, Inc
Tomography, Corneal Biomechanics
Long-term Safety and Effectiveness of LASIK-Xtra Compared to Conventional LASIK
Laser in situ keratomileusis (LASIK) is a widely used procedure for the correction of myopia and myopic astigmatism. Despite its high effectiveness and the general safety of the procedure, long-term safety and effectiveness…
- Conditions
- Tomography, Corneal Biomechanics, Manifest Ref, Endothelial Cells
- Trial name
- Xtra Lasik (NCT06857032)
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Clinic Frankfurt
Pain
Pain Management in Corneal Collagen Crosslinking for Keratoconus
This is a prospective, randomized, single blind study. Patients enrolled in the study were randomly assigned to a ketorolac or a gabapentin group for pain control.
- Trial name
- NCT02867176
- Testing
- Gabapentin, Ketorolac
- Volunteers
- 25 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Infective Keratitis
The Role of Adjuvant Corneal Crosslinking in the Management of Infective Keratitis
This was a prospective, single centre, randomised controlled study to evaluate the clinical effectiveness of corneal collagen crosslinking as an adjuvant to antimicrobial therapy.
- Trial name
- NCT06967376
- Testing
- Corneal Collagen Cross-Linking Solutions, Topical Antimicrobial/Antifungal Medications
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Research Institute of Ophthalmology, Egypt
Keratoconus, Corneal Ectasia
Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia
This randomized study compares 2 variations of corneal crosslinking for treatment of keratoconus or corneal ectasia.
- Trial name
- NCT07841470
- Testing
- Riboflavin 0.1% ophthalmic solution and pulsed light, Riboflavin 0.1% ophthalmic solution and non-pulsed light
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Price Vision Group