Clinical trials: Cornea
Infectious Keratitis
Investigation of the Microbiome of the Cornea in Microbial Keratitis
Design: Prospective observational diagnostic study and methods-comparison. Aims: The overall aim of the project is to better define the pathogenic microorganisms in patients with microbial keratitis (MK) through a better…
- Trial name
- STOICA (NCT04030403)
- Where
- United Kingdom
- Volunteers
- 219 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
CORNEAL EDEMA
Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema
The Hyper-CL™ lenses are indicated for therapeutic use as a bandage to protect the corneal surface and to relieve corneal pain in the treatment of acute or chronic ocular pathologies, such as bullous keratopathy, corneal…
- Trial name
- NCT02660151
- Testing
- Hyper-CL™ lens, Regular soft contact lens, Salt solution
- Where
- 4 sites in Israel, Poland
- Volunteers
- 68 people
- Sponsor
- Eye-yon Medical
Keratoconus
Astigmatism in Keratoconus Patients
Keratoconus is a bilateral (but usually asymmetrical) non-inflammatory progressive thinning process of the cornea. It manifests as characteristic cone-like ectasia of the cornea associated with irregular stromal thinning…
- Trial name
- NCT03450213
- Testing
- Pentacam
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cornea
Influence of Silicone Hydrogel Contact Lens Neophyte Wear on Corneal Sensitivity
Soft contact lenses can affect the ocular surface and sometimes cause intolerance. The aim of this study is to measure corneal sensitivity using the Swiss Liquid Jet aesthesiometer at baseline, after one and after six weeks, in…
- Trial name
- CSCL (NCT05745220)
- Testing
- Device: silicone hydrogel contact lens
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Daniela Nosch
Corneal Disease
Automated Lamellar Keratectomy in Symptomatic Patients With Bullous Keratopathy
To relieve pain in patients with symptomatic bullous keratopathy (BK) until keratoplasty and in patients without visual prediction.
- Trial name
- ALKSBK (NCT00654888)
- Testing
- ALK (automated lamellar keratectomy), Mitomycin
- Volunteers
- 28 people
- Sponsor
- Federal University of São Paulo
Keratoconus, High Myopia
Anterior Segment and Corneal Parameters in Keratoconus and High Myopic Astigmatism Using Schiempflug Imaging
The purpose of this study was to compare Scheimpflug corneal tomography findings in keratoconus and high myopic astigmatic eyes, as well as to establish the parameters distinguishing keratoconus from high myopic astigmatism.
- Trial name
- NCT06739018
- Testing
- pentacam scheimpflug tomography
- Where
- 2 sites in Egypt
- Volunteers
- 66 people
- Sponsor
- Assiut University
Corneal Abrasion
Short Term Topical Tetracaine is Safe and Highly Efficacious for the Treatment of Pain Caused by Corneal Abrasions
The objective of this study was to show that patients with corneal abrasions would experience more pain relief with short term topical tetracaine than placebo, have similar complication rates, and take less hydrocodone for…
- Trial name
- NCT04187417
- Testing
- topical tetracaine hydrochloride 1%
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- INTEGRIS Southwest Medical Center
Keratoconus, Corneal Ectasia
Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia
Corneal collagen crosslinking (CXL) has been demonstrated as an effective method of reducing progression of both keratoconus and corneal ectasia after surgery, as well as possibly decreasing the steepness of the cornea in these…
- Trial name
- NCT04905108
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Cornea and Laser Eye Institute
Corneal Abrasion
The Debridement To Treat The Traumatic Corneal Abrasion
Patients who signed informed consent to participate in the study will receive corneal epithelial deplasia. The patient was instructed to follow up closely in the following year, and the recurrence of the patient was collected…
- Trial name
- NCT05534217
- Testing
- corneal debridement of corneal abrasion
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Corneal Edema
A Safety and Efficacy Study of Corneal Injection for Endothelial Dysfunction Using Human Corneal Endothelial Cell Therapy in Subjects With Corneal Edema Secondary to Endothelial Dysfunction
The purpose of this study is to assess the safety of a fixed dose of human corneal endothelial cells when administered with varying concentrations of Rho kinase inhibitor (Y-27632) in patients with corneal edema secondary to…
- Trial name
- Escalon (NCT05309135)
- Testing
- HCEC-1
- Where
- El Salvador
- Volunteers
- 22 people
- Sponsor
- Aurion Biotech
Keratoconus
A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus Patients
This randomized clinical trial will assess corneal astigmatism and visual outcomes in participants who have undergone corneal transplantation for keratoconus with ex vivo cross-linked donor corneal tissue versus participants who…
- Trial name
- EVOKE (NCT04584125)
- Testing
- Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% with UV light, Riboflavin 5'-phosphate in 20% dextran ophthalmic solution) 0.146% without UV light
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Joseph B. Ciolino, MD
Corneal Neovascularization
Effectiveness and Safety of Topical Ranibizumab for Treatment of Corneal Neovascularization (NV)
The purpose of this study is to determine the effectiveness and safety of ranibizumab (Lucentis) in treatment of corneal neovascularization.
- Trial name
- NCT00681889
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Reza Dana, MD
Corneal Ulcer, Neurotrophic Corneal Ulcer
Topical Insulin in Neurotrophic Keratopathy After Diabetic Vitrectomy
Various treatment options have been proposed in managing NK such as preservative-free lubrication (PF-L), withdrawal of epitheliotoxic medication, prophylactic antibiotics, applying of bandage contact lenses, using…
- Conditions
- Corneal Ulcer, Neurotrophic Corneal Ulcer, Diabetes Mellitus
- Trial name
- NCT05940376
- Testing
- rapid acting insulin
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Keratoconus
Myofibroblastic Transformation Secondary to Epithelial-stromal Interactions in the Keratoconus
Keratoconus is characterized by a thinning of the cornea, which causes a decrease in visual acuity due to astigmatism. Publications suggest that keratoconus is linked to chronic inflammation (increase in pro-inflammatory…
- Trial name
- MYKE (NCT03990740)
- Testing
- Corneal sampling
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Keratoconus
Transepithelial Customized Cross-linking
Customized remodeled vision (CuRV) is a new corneal cross-linking protocol for keratoconus, combining a transepithelial approach with customized energy application.
- Trial name
- NCT04820608
- Testing
- Cross-linking
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Ophthalmica Eye Institute
Keratoconus, Keratoconus, Unstable
Corneal Biomechanical Analysis Using Brillouin Microscopy
The objective of this study is to measure the Brillouin biomechanical properties in keratoconic corneas and characterize biomechanical alterations that occur after corneal procedures that inherently strengthen or weaken the…
- Conditions
- Keratoconus, Keratoconus, Unstable, Keratoconus, Stable
- Trial name
- NCT04598932
- Testing
- Brillouin microscopy
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- The Cleveland Clinic
Progressive Keratoconus
Efficacy and Safety ofCACXL in the Treatment of Keratoconus With Thin Corneas
The aim of this study is to detect the safety and effectiveness of contact lens assisted corneal cross linking in managing progressive keratoconus with thin corneas CACXL was done for 40 eyes of 30 of keratoconic patients…
- Trial name
- CACXL (NCT04504578)
- Testing
- contact lens assisted corneal cross linking
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Kasr El Aini Hospital
Fuchs Dystrophy, Cataract
The Evaluation of Balanced Salt Solution During Cataract Surgery
This study aims to identify if the use of BSS PLUS® Sterile Intraocular Irrigating Solution as an irrigation solution leads to improved corneal outcomes vs BSS® Sterile Irrigating Solution in more compromised corneas.
- Trial name
- NCT05853978
- Testing
- BSS Plus, BSS
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Adam Fedyk, MD, FACS
Corneal Opacity
OCT-guided LALAK in Children
The primary goal of the trial is to determine if laser-assisted lamellar anterior keratoplasty (LALAK) will reduce the risks of post-operative complications such as adhesions, glaucoma and cataract that are associated with…
- Trial name
- LALAK (NCT01579643)
- Testing
- OCT guided laser-assisted lamellar anterior keratoplasty (LALAK), Penetrating Keratoplasty (KP)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Oregon Health and Science University
Corneal Opacity
The Use of MMC During PRK and Its Effect on Postoperative Topical Steroid Requirements
1. Purpose To evaluate the use of mitomycin-C (MMC) as an intraoperative adjunct during photorefractive keratectomy (PRK), its effect on postoperative healing and its ability to reduce the postoperative topical steroid course…
- Trial name
- NCT02030990
- Testing
- Mitomycin-C, Fluorometholone 1% topical ocular steroid
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego