Clinical trials: Cornea
Corneal Perforation, Corneal Stromal Lenticule,Sandwich Technique
A Novel Sandwich Technique of Minimally Invasive Keratoplasty for Corneal Perforation
The goal of this type of study to describe a new sandwich technique of minimally invasive keratoplasty (STMIK) by using SMILE-extracted lenticules for treatment corneal perforation and effectiveness.
- Trial name
- STMIK (NCT06233409)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Keratoconus
Reliability of Topography Measurements in Keratoconus
The purpose of this study is to assess the reliability and repeatability of the parameters obtained using the Galilei dual-scheimpflug corneal topographer for monitoring progression in eyes with keratoconus.
- Trial name
- NCT03511495
- Testing
- Galilei Corneal Topographer
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Keratoconus
The Possible Role of Thyroxine in Keratoconus Development
Keratoconus (KC) is a corneal ectatic disorders, with incidence rate 1 per 50,000 among the population. Hormonal imbalances may be associated with KC as it affects the corneal metabolism.
- Trial name
- NCT03637673
- Testing
- No intervention
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Alexandria University
Dry Eye Syndromes, Keratoconjunctivitis Sicca
Efficacy and Safety Study of ATs in Patients With Dry Eye Syndrome
The purpose of this study is to determine whether artificial tears are safe and effective in the treatment of Dry Eye Syndrome.
- Trial name
- NCT00788229
- Testing
- AT01, AT02, AT03
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Dhp Korea Co., Ltd.
Fuchs Endothelial Corneal Dysfunction, Open Angle Glaucoma (OAG)
A Study to Assess Brillouin Hydration Mapping for the Evaluation of Ocular Tissues and Diseases
The overall goal of this study is to develop Brillouin microscope as a novel tool for measuring biomechanical and hydration properties of human tissues in vivo.
- Conditions
- Fuchs Endothelial Corneal Dysfunction, Open Angle Glaucoma (OAG), Dry Eye Disease (DED), Keratoconus
- Trial name
- NCT07780890
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Adenoviral Keratoconjunctivitis
Treatment of Corneal Infiltrates Secondary to Epidemic Keratoconjunctivitis
Purpose: To compare efficiency and tolerance between topical 0.5% cyclosporine A and fluorometholone in patients with subepithelial corneal infiltrates (SEIs).
- Trial name
- NCT04376970
- Testing
- FLUCON®, Cyclosporine A eye drops 0.5%
- Where
- Tunisia
- Volunteers
- 51 people
- Sponsor
- Military Hospital of Tunis
Cornea, Refraction Error
Corneal Topography and High Order Aberrations in Regular Contraceptive Pills
Effect of regular usage of contraceptive pills on corneal topography and corneal high-order aberrations
- Trial name
- NCT07693673
- Testing
- Hormonal Contraception, Combined Oral Contraceptive (COC)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Elshimaa A.Mateen
Ectasia
Corneal Collagen Cross-Linking for Ectasia (CXL)
Prospective, randomized multicenter study to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes with ectasia after refractive surgery.
- Trial name
- CXL (NCT00674661)
- Testing
- riboflavin ophthalmic solution, UVA Irradiation
- Where
- 10 sites in United States
- Volunteers
- 130 people
- Sponsor
- Glaukos Corporation
Keratoconus, Corneal Ectasia
Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia
Corneal collagen crosslinking (CXL) has been proposed as an effective method of reducing progression of both keratoconus and corneal ectasia after surgery, as well as possibly decreasing the steepness of the cornea in these…
- Trial name
- NCT01464268
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Cornea and Laser Eye Institute
Keratoconus, Corneal Ectasia
Outcomes of CTAK Surgery
Measuring quality of vision and quality of life outcomes using a validated questionnaire in participants undergoing CTAK surgery for corneal ectasia
- Trial name
- CTAK (NCT07474870)
- Testing
- Questionnaire and Physical Exam
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Corneal Endothelial Dystrophy, Corneal Edema
Loteprednol Etabonate 0.25% for Prevention of Cornea Transplant Rejection
The purpose of this study is to assess off-label use of loteprednol etabonate 0.25% ophthalmic suspension (Eysuvis) for prevention of immunologic rejection in the first year after Descemet membrane endothelial keratoplasty…
- Trial name
- NCT05136443
- Testing
- loteprednol etabonate 0.25% ophthalmic suspension
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Price Vision Group
Hereditary Corneal Dystrophy, Keratoconus
Autologous Adipose-Derived Adult Stem Cell Transplantation for Corneal Diseases
Transplantation of cellularized human cornea impregnated and populated by mesenchymal stem cells derived from the patient's adipose tissue.
- Trial name
- A-ADAS-CT-CD (NCT02932852)
- Testing
- Lipoaspiration, Transplantation
- Where
- Lebanon
- Volunteers
- 12 people
- Sponsor
- Vissum, Instituto Oftalmológico de Alicante
Fuchs Dystrophy, Cataract
The Evaluation of Balanced Salt Solution During Cataract Surgery
This study aims to identify if the use of BSS PLUS® Sterile Intraocular Irrigating Solution as an irrigation solution leads to improved corneal outcomes vs BSS® Sterile Irrigating Solution in more compromised corneas.
- Trial name
- NCT05853978
- Testing
- BSS Plus, BSS
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Adam Fedyk, MD, FACS
Keratoconus
Comparative Analysis of the Visual Performance After TICL Implantation in Patients With Stable Keratoconus
To report on 4-year postoperative safety, efficacy, stability and predictability outcomes(to evaluate the visual, refractive, contrast sensitivity, defocus curve and aberrometric data preoperation, and compare with a similar…
- Trial name
- TICL (NCT02833649)
- Testing
- Toric Implantable collamer Lens
- Where
- Iran
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Eye Diseases
Development of an IT Tool Able to Identify Ocular Conditions
The aim of the study is to use machine learning to develop an IT tool able to differentiate between eye conditions analysing corneal biomechanical data.
- Trial name
- NCT05973617
- Testing
- Measurement of corneal biomechanical properties
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aston University
Trachoma
Azithromycin in Control of Trachoma II
Trachoma is the world's leading cause of preventable blindness. This disease, caused by Chlamydia trachomatis, is endemic in many parts of the developing world.
- Trial name
- NCT00286026
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Corneal Ulcer, Eye Infections, Fungal
The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo
The purpose of this study is to determine if the addition of oral voriconazole to topical treatment regimens results in lower rates of perforation in severe fungal corneal ulcers.
- Trial name
- MUTTII (NCT00997035)
- Testing
- Voriconazole
- Where
- 7 sites in United States, India and 1 more
- Volunteers
- 240 people
- Sponsor
- University of California, San Francisco
Bullous Keratopathy, Corneal Erosion
Air Optix® Night and Day® Aqua Therapeutic Wear
The purpose of this study is to support the safety and performance assessment of Air Optix Night and Day Aqua (AONDA) soft contact lenses for therapeutic use in accordance with updated EU Medical Device Regulation (MDR)…
- Conditions
- Bullous Keratopathy, Corneal Erosion, Entropion, Corneal Edema
- Trial name
- NCT05956535
- Testing
- Lotrafilcon A contact lenses, Balafilcon A contact lenses
- Where
- 3 sites in United States
- Volunteers
- 168 people
- Sponsor
- Alcon Research
Keratoconus
Epi-on CuRV and Epi-off aCXL Protocols in the Management of Keratoconus
This study investigates the effectiveness and safety of two different corneal cross-linking (CXL) protocols for the management of progressive keratoconus: the accelerated epithelium-off technique (aCXL) and the topography-guided…
- Trial name
- CuRVaCXL (NCT07173907)
- Testing
- CuRV CXL, Accelerated CXL Procedure (aCXL)
- Volunteers
- 135 people
- Sponsor
- Gemini Eye Clinic
Junctional Epidermolysis Bullosa, Epidermolysis Bullosa (EB)
Pilot Study of ELK-003 Eye Drops for Treating Ocular Manifestations of Epidermolysis Bullosa
This study consists of two phases: an Observational Phase to evaluate the natural history of ocular manifestations in subjects with Dystrophic and Junctional Epidermolysis Bullosa, followed by a Treatment Phase to assess the…
- Conditions
- Junctional Epidermolysis Bullosa, Epidermolysis Bullosa (EB), Dystrophic Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa
- Trial name
- GOTAS-ELK-EB (NCT06713434)
- Testing
- ELK-003 (Standarized Amniotic Fluid Secretome Eye Drops)
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Fundación DEBRA Chile, Niños Piel de Cristal