Clinical trials: Cornea; Ectasia
Keratoconus, Ectasia
Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2)
To evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional cross-links within or…
- Conditions
- Keratoconus, Ectasia, Degeneration
- Trial name
- NCT01097447
- Where
- 5 sites in United States
- Volunteers
- 2,619 people
- Sponsor
- Cxlusa
Keratoconus, Corneal Ectasia
Clinical and Structural Outcome of Conventional Versus Accelerated Corneal Collagen Cross-linking (CXL).
Compare different corneal parameters and visual outcome of corneal collagen cross-linking (CXL) with conventional versus accelerated ultraviolet-A irradiation using riboflavin with hydroxypropyl methylcellulose.
- Trial name
- CXL (NCT02883478)
- Testing
- UV-X 1000 (3 mW/cm²), UV-X 2000 (9 mW/cm²), riboflavin with hydroxypropyl methylcellulose
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Keratoconus, Ectasia
Collagen Cross-Linking for Keratoconus/Ectasia With and Without Intacs
This study will determine the efficacy of collagen cross linking for progressive keratoconus and ectasia after lasik. It will try and determine which is a more effective treatment: collagen cross linking alone or collagen cross…
- Trial name
- NCT01081561
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Yaron S. Rabinowitz M.D.
Keratoconus, Pellucid Marginal Degeneration
T-Cat Laser & Cross-linking for Keratoconus
The purpose of this study is to determine whether excimer laser corneal surface ablation (T-Cat) can be safely combined with simultaneous corneal collagen cross-linking treatment to produce an improved and stable corneal profile…
- Trial name
- T-Cat (NCT00777322)
- Testing
- Excimer laser ablation, and collagen cross-linking
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Corneal Ectasia, Keratoconus
Safety and Effectiveness of the PXL-Platinum 330 System
To evaluate the safety and effectiveness of the PXL Platinum 330 system for performing corneal cross-linking (CXL) for the treatment of ectatic disorders.
- Conditions
- Corneal Ectasia, Keratoconus, Pellucid Marginal Corneal Degeneration
- Trial name
- NCT04401865
- Testing
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Colorado Eye Consultants/Cornea Consultants of Colorado
Keratoconus
INTACS (Intrastromal Corneal Ring Segments) For Corneal Ectasia
To join established study put on by Addition Technologies, Inc. in the surgical implantation of asymmetrical INTACS segments to treat myopia and astigmatism in patients with keratoconus.
- Trial name
- INTACS (NCT02512432)
- Testing
- INTACS
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Keratoconus, Ectasia
Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia
This prospective, randomized study is being conducted to evaluate the safety and effectiveness of corneal cross-linking (CXL) in patients with keratoconus or post-refractive ectasia (post-LASIK or PRK) utilizing two techniques…
- Trial name
- CXL (NCT03080077)
- Testing
- Ricrolin+, Epi-Off
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Keratoconus, Pellucid Marginal Degeneration
Corneal Cross Linking and Topography Guided Excimer Laser Treatment
Topography guided laser treatment enables the surgeon to correct higher order aberrations in corneas with irregular astigmatism.
- Trial name
- NCT01682993
- Testing
- Topography guided Excimer Laser treatment and Corneal Cross Linking, Corneal Cross Linking
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Corneal Ectasia
Three Different Cross-linking Protocols for Treatment of Pediatric Keratoconus
comparison between standard cross-linking protocol and accelerated and transepithelial cross-linking
- Trial name
- NCT05691335
- Testing
- Standard CXL, Accelerated CXL, Transepithelial CXL
- Where
- Egypt
- Volunteers
- 97 people
- Sponsor
- Sohag University
Corneal Ectasia
Riboflavin-UVA Induced Collagen Crosslinking Treatment for Corneal Ectasia
This is a hospital-based interventional prospective study. Patients with clinical keratoconus or LASIK keratectasia presenting to the Singapore National Eye Centre who meet the eligibility criteria are recruited for this study.
- Trial name
- NCT01123057
- Testing
- riboflavin-induced collagen cross-linking treatment, Riboflavin-UVA induced collagen cross-linking treatment for corneal ectasia
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore National Eye Centre
Corneal Ectasia of Both Eyes
Collagen Cross-linking Clinical and Oct Study
1. Assessment of corneal changes in AS-OCT after collagen cross-linking (corneal thickness and demarcation line). 2. Assessment of the effect of collagen cross-linking on best-corrected visual acuity
- Trial name
- NCT05717517
- Testing
- anterior segment oct
- Volunteers
- 100 people
- Sponsor
- Assiut University
Keratoconus, Post-Laser Retinal Condition
Investigator Initiated, Prospective Study of Xenia Corneal Lenticule
Cornea ectatic conditions such as keratoconus and post-LASIK (Laser In situ Keratomileusis) ectasia are disorders of the eye that are notorious for its uncontrolled progression over time, leading to loss of vision.
- Trial name
- NCT04741230
- Testing
- Gebauer Lenticule
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Keratoconus, Corneal Ectasia
Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia
Corneal collagen crosslinking (CXL) has been proposed as an effective method of reducing progression of both keratoconus and corneal ectasia after surgery, as well as possibly decreasing the steepness of the cornea in these…
- Trial name
- NCT01464268
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Cornea and Laser Eye Institute
Keratoconus
Treatment of Keratoconus Using Collagen Cross-Linking
The purpose of this study is to determine the effectiveness of collagen cross-linking in the cornea in halting the progression and possibly partially reversing the effects of keratoconus.
- Trial name
- NCT00841386
- Testing
- Riboflavin-5-phosphate
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Keratoconus, Corneal Ectasia
Safety and Preliminary Efficacy of IVMED-80 Eye Drops in Keratoconus Patients
We investigated the use of a copper sulfate eye drop (IVMED-80) for the treatment of keratoconus. Preliminary laboratory data shows that the addition of copper sulfate increase crosslinking of the structural proteins of the…
- Trial name
- NCT05241145
- Testing
- IVMED-80
- Where
- Mexico
- Volunteers
- 38 people
- Sponsor
- iVeena Delivery Systems, Inc.
Corneal Ectasia Disorders Including Keratoconus
The Effects of Corneal Collagen Cross-linking
The corneal collagen cross-linking treatment has been used with increasing success to treat corneal dystrophies such as "keratoconus." Recent advances have allowed different techniques for performing this cross-linking treatment.
- Trial name
- NCT01708538
- Testing
- CXL
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rush Eye Associates
Keratoconus
Photorefractive Keratectomy and Corneal Cross-linking in Keratoconus
Evaluation of the safety and efficacy of surface ablation followed by Collagen Cross-linking in patients with keratoconus
- Trial name
- NCT02189447
- Testing
- Simultaneous Photorefractive Keratectomy and Collagen Cross-linking in patients with keratoconus
- Volunteers
- 44 people
- Sponsor
- The Eye Center and The Eye Foundation for Research in Ophthalmology
Myopia, Myopic Astigmatism
Laser In-situ Keratomileusis With Crosslinking Compared to Conventional LASIK in Patients With High Myopia
The objectives of this study are to evaluate the safety and efficacy of a treatment regimen for high myopia and myopic astigmatism: LASIK followed by crosslinking performed with the KXL Crosslinking-System and VibeX Xtra…
- Conditions
- Myopia, Myopic Astigmatism, Crosslinking, Corneal Ectasia
- Trial name
- NCT03913338
- Testing
- LasikXtra, LASIK
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Clinic Frankfurt
Progressive Keratoconus, Corneal Ectasia
Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia
Prospective, randomized, single site study to determine the safety and effectiveness of performing corneal collagen cross-linking (CCCL)using riboflavin and UVA light in eyes with corneal ectasia or progressive keratoconus.
- Trial name
- CL (NCT00567671)
- Testing
- Corneal collagen
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Emory University
Keratoconus, Artificial Intelligence, Support Vector Machine
Efficiency of an Algorithm Derived From Corneal Tomography Parameters to Distinguish Highly Susceptible Corneas to Ectasia From Healthy
The objective of this study was to identify and build an algorithm through an imaging process using a support vector machine (SVM) with the tomography variables of cases with, KC, highly susceptible corneas to ectasia (HSCE), and…
- Trial name
- NCT04313387
- Testing
- Corneal tomography multivariate index derived from a support vector machine (CTMVI).
- Volunteers
- 588 people
- Sponsor
- Gildasio Castello de Almeida Junior