Clinical trials: Consciousness Disorders, open to volunteers
Stellate Ganglion Block, Prolonged Disorders of Consciousness
Stellate Ganglion Block on Postoperative Sleep Status in Patients With Prolonged Disorders of Consciousness
This is a prospective, single-centre, single-arm, self-controlled, exploratory pilot study. The goal of this clinical trial is to learn about the effect of preoperative administration of stellate ganglion block on postoperative…
- Conditions
- Stellate Ganglion Block, Prolonged Disorders of Consciousness, Sleep
- Trial name
- NCT07274683
- Testing
- stellate ganglion block with 0.5% ropivacaine
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Beijing Tiantan Hospital
Disorders of Consciousness
Spontaneous Eye Blinking in Disorders of Consciousness
Differential diagnosis between Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS) is complicated due to severe cognitive and/or sensorimotor deficits in these patients.
- Trial name
- Blink-DoC (NCT06323031)
- Where
- 8 sites in Belgium, Germany and 2 more
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Traumatic Brain Injury, Severe Traumatic Brain Injury
Vagus Nerve Stimulation in Patients in Comatose State
Some patients with severe traumatic brain injury cannot respond at the bedside, yet about 1 in 4 may be aware but unable to show it - a hidden state called cognitive motor dissociation.
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Disorders of Consciousness Due to Severe Brain Injury, Coma, Traumatic
- Trial name
- NCT07719595
- Testing
- Dual-Site Transcutaneous Auricular Nerve Stimulation (taVNS + taTNS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sima Mofakham
Bradycardia, Syncope, Vasovagal
Comparison of Focal Cryoablation vs. Radiofrequency Cardioneuroablation for Bradyarrhythmias
Bradyarrhythmias are conditions where the heart beats too slowly, causing symptoms like dizziness, fainting, and fatigue. In some patients, these slow heart rhythms are caused by overactivity of the vagus nerve (the part of the…
- Conditions
- Bradycardia, Syncope, Vasovagal, Sick Sinus Syndrome, Atrioventricular Block
- Trial name
- CRYO-CNA vs RF (NCT07671898)
- Testing
- Focal Cryoablation, Radiofrequency Catheter Ablation
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Disorder of Consciousness, Acquired Brain Injury
Describing the Effect of Familiar Song on Arousal and Awareness for Children With Disorders of Consciousness (DoC)
The goal of this clinical trial is to compare the effect of live music therapy and recorded music on recovery of consciousness in children aged 1 to 18 years who have a disorder of consciousness (DoC) after a severe brain injury.
- Trial name
- SongDoC (NCT07209657)
- Testing
- Live Music Therapy, Recorded Music
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Murdoch Childrens Research Institute
Disorders of Consciousness
REstoring CONsciousness With NEurostimulation of the Central Thalamus: The RECONNECT Study
The RE-CONNECT study is an early feasibility study to establish the safety, feasibility, and efficacy of two central thalamic deep brain stimulation targets in patients with chronic disorders of consciousness.
- Trial name
- NCT07228286
- Testing
- Deep brain stimulation (DBS) electrode implantation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Samuel Snider, MD
Critical Illness, Mechanical Ventilation
Analysis of Weaning of Analgosedation and Kinetics of Emergence in Critically Ill Patients
The goal of this prospective multicenter observational study is to characterize early trajectories of consciousness recovery following the first valid structured awakening trial in mechanically ventilated critically ill adults, a…
- Conditions
- Critical Illness, Mechanical Ventilation, Weaning Invasive Mechanical Ventilation, Sedation and Analgesia
- Trial name
- AWAKE-ICU (NCT07710066)
- Testing
- Structured Awakening Evaluation (SAE)
- Volunteers
- 500 people
- Sponsor
- Patricia Rodriguez Villamizar
Disorder of Consciousness
Neurorehabilitation in Patients With Disorders of Consciousness: Multidimensional Ambispective Study on the Impact of Single and Combined Approaches
Disorders of consciousness (DOC), such as the vegetative state/unresponsive wakefulness syndrome (VS/UWS) and the minimally conscious state (MCS), represent severe clinical conditions arising from acquired brain injury (ABI)…
- Trial name
- NCT07385508
- Testing
- Multidisciplinary neurorehabilitation
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Coma, Electrographic Status Epilepticus
Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2)
The goal of this comparative effectiveness trial is to study electrographic status epilepticus (ESE) treatment in comatose patients after cardiac arrest.
- Trial name
- TELSTAR-2 (NCT06549426)
- Testing
- anti-seizure medication + sedative agent(s)
- Where
- 21 sites in Belgium, Netherlands
- Volunteers
- 150 people
- Sponsor
- University of Twente
Brain Death, Respiration, Artificial
Miniature In-line Respirator
This first-in-human pilot study will test an investigational miniature breathing device called the Hope inVent. The device is a small, single-use, in-line respirator that connects to a breathing tube and uses compressed oxygen to…
- Trial name
- NCT07768215
- Testing
- Hope inVent
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Sexual Health, Sexual Dysfunction, Physiological
The PANHIS Study: Sexual Health in Spanish-Speaking Adults - A Cross-Sectional Online Survey
This cross-sectional observational study uses an online survey to describe the epidemiology of sexual health, sexual behaviour and sexual function in Spanish-speaking adults, and to estimate the prevalence and phenomenology of…
- Conditions
- Sexual Health, Sexual Dysfunction, Physiological, Sexual Dysfunctions, Psychological, Dyspareunia
- Trial name
- PANHIS (NCT07746297)
- Where
- 2 sites in Spain
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Menoclinica by Palacios
Traumatic Brain Injury, Intracerebral Haemorrhage
The EBC Recovery Study
The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up…
- Conditions
- Traumatic Brain Injury, Intracerebral Haemorrhage, Subarachnoid Haemorrhagic Stroke
- Trial name
- NCT04712591
- Testing
- Auditory stimuli
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Miami
Disorders of Consciousness
Advancing Assessment for Disorders of Consciousness
Over the past two decades, major progress has been made in detecting, predicting and promoting recovery of consciousness in patients with disorders of consciousness (DOC) caused by severe brain injuries.
- Trial name
- AADOC (NCT07180589)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xuanwu Hospital, Beijing
Focal Seizure, Epilepsy
Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures
This is a clinical research study for an investigational drug called RAP-219 in adult participants with focal seizures. This study is being conducted to determine if RAP-219 is safe and effective in reducing focal seizure…
- Conditions
- Focal Seizure, Epilepsy, Focal Epilepsy
- Trial name
- FOCUS 2 (NCT07594119)
- Testing
- RAP-219
- Where
- 14 sites in United States, Australia
- Volunteers
- 312 people
- Sponsor
- Rapport Therapeutics Inc.
Depression Chronic, Depressed
Evaluation of Dalia Solution For Depressed Patient
The goal of this superiority clinical investigation, prospective, multicenter, controlled, randomized, open-label is to evaluate the clinical impact of the Dalia medical telemonitoring device on the management of depressive…
- Conditions
- Depression Chronic, Depressed, Depressed Mood, Depression and Quality of Life
- Trial name
- DaliaMonitorin (NCT07211984)
- Testing
- Dalia Monitoring, Conventional healthcare
- Where
- France
- Volunteers
- 644 people
- Sponsor
- Dalia Care
Syncope, Vasovagal, Blood, Injection, Injury Type Phobia
Impact of Blood Phobia on Fainting Susceptibility
The primary purpose of this study is to characterize cardiovascular autonomic function to emotional stimuli (blood-injection-injury phobia [needle phobia]) during an orthostatic (upright) challenge in individuals with and without…
- Trial name
- NCT06336031
- Testing
- blood-injection-injury (BII) phobia stimuli, neutral stimuli
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Atrial Fibrillation (AF), Atrial Flutter
Head-to-Head (H2H) Comparison of Ambulatory Cardiac ECG Monitors in Japan
The goal of this clinical trial is to compare the yield of clinically actionable arrhythmias through the end of indicated wear duration in Zio monitor and Heartnote patch ECG devices.
- Conditions
- Atrial Fibrillation (AF), Atrial Flutter, Supraventricular Tachycardia (SVT), Ventricular Tachycardia (VT)
- Trial name
- Japan H2H (NCT07870837)
- Testing
- Application of ambulatory cardiac monitor
- Where
- 4 sites in Japan
- Volunteers
- 130 people
- Sponsor
- iRhythm Technologies, Inc.
Coma, Heart Arrest
Predictive Outcome in Comatose Patients
Evaluating the prognosis of comatose patients after cardiac arrest (CA) in the intensive care unit (ICU) remains challenging. It requires a multimodal approach combining standardized clinical examination, serum biomarkers…
- Conditions
- Coma, Heart Arrest, Cardiopulmonary Resuscitation
- Trial name
- PRECOM (NCT05321459)
- Testing
- Neurological prognosis
- Where
- 7 sites in France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Disorder of Consciousness
Electroacupuncture at Jing-Well Points for Chronic Disorders of Consciousness: A Randomized Controlled Study With Multimodal Assessment
Disorder of consciousness (DOC) is a common complication of severe central nervous system injury. It is defined as prolonged DOC when lasting more than 28 days.
- Trial name
- NCT07551076
- Testing
- Electrostimulation at the Twelve Hand Jing-Well Points
- Volunteers
- 66 people
- Sponsor
- The Third People's Hospital of Huizhou
Severe Spontaneous Intracranial Hemorrhage, Long-term Antiplatelet Treatment
China Research for Severe Spontaneous Intracerebral Hemorrhage（CRISIH）
Background: Although emergency surgery may reduce mortality in patients with severe spontaneous intracerebral hemorrhage (SSICH), the effectiveness and safety of surgical treatment among SSICH patients receiving long-term oral…
- Conditions
- Severe Spontaneous Intracranial Hemorrhage, Long-term Antiplatelet Treatment, Emergency Surgery, Complications
- Trial name
- NCT05975398
- Testing
- Emergency neurosurgery, Conservative treatment
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital