Clinical trials: Connective Tissue
Cancer of the Skin
Role of microRNA in the Development of Cutaneous Squamous Cell Carcinoma
The aim of this study is to analyze the differential expression of the miR transcriptome in the distinctive stages of the development of cutaneous squamous cell carcinoma (C-SCC).
- Trial name
- NCT01143311
- Testing
- Arm A
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
SLE - Systemic Lupus Erythematosus
Safety and Efficacy Study of CC312 for Moderate to Severe SLE
This study is a randomized, double-blind, placebo-controlled Phase I clinical trial featuring single and multiple ascending doses.
- Trial name
- NCT07177911
- Testing
- CC312
- Where
- China
- Volunteers
- 32 people
- Sponsor
- CytoCares Inc
Sarcoma, Bone Tumor
Cost-effectiveness Evaluation of the Use of a Patient Specific Instrument for Surgical Resection of Malignant Bone Tumor Within the Pelvis Versus the Conventional Surgical Treatment
Primitive malignant bone tumor or mixt tumor (compounded of soft tissues and bone) is a rare pathology particularly within the pelvis, the sacrum or the hip (between 25 and 80 new cases in France per year).
- Trial name
- MARGIC (NCT02544711)
- Testing
- Patient specific instrument, Conventional surgical treatment
- Where
- 8 sites in France
- Volunteers
- 88 people
- Sponsor
- Nantes University Hospital
Porphyria, Acute Intermittent
Clinical Research on Acute Intermittent Porphyria and the Use of Carbohydrate-Rich Diet as a Treatment
The main aim of this clinical trial is to learn about the effect of carbohydrate-rich diet as a treatment for AIP (acute intermittent porphyria).
- Trial name
- NCT06273644
- Testing
- Carbohydrates
- Where
- 3 sites in Norway, Sweden
- Volunteers
- 50 people
- Sponsor
- Nordlandssykehuset HF
Actinic Keratosis, Imipramine
The Effect of Topical Imipramine on Photodynamic Therapy-Mediated Immunosuppression on Forearms or Face on US Veterans
The purpose of this study is to test the use of topical imipramine in combination with topical photodynamic therapy's (PDT) effect on the effectiveness and pain immunosuppression following treatment.
- Conditions
- Actinic Keratosis, Imipramine, Photodynamic Therapy
- Trial name
- NCT06778434
- Testing
- Imipramine, Control Vehicle
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development
Breast Cancer, Non-small Cell Lung Cancer
BostonGene and Exigent Genomic INsight Study
The BEGIN Study by BostonGene and Exigent Genomic INsight evaluates the efficacy of comprehensive molecular testing in advanced cancer patients.
- Conditions
- Breast Cancer, Non-small Cell Lung Cancer, Melanoma, Sarcoma
- Trial name
- BEGIN (NCT06272864)
- Where
- 7 sites in United States
- Volunteers
- 400 people
- Sponsor
- BostonGene
Rheumatoid Arthritis
Comparison of Combination Disease Modifying Antirheumatic Drugs With Methotrexate Therapy in Early Rheumatoid Arthritis
This study will be conducted to find out how well a patient of rheumatoid arthritis (RA) will respond to disease-modifying antirheumatic drugs (DMARDs).
- Trial name
- NCT02644499
- Testing
- Methotrexate, Leflunomide, Hydroxychloroquine
- Where
- India
- Volunteers
- 186 people
- Sponsor
- Jawaharlal Institute of Postgraduate Medical Education & Research
Pain Syndrome, Dizziness
Postoperative Analgesia Between Paravertebral Block and Epidural Block in Esophageal Surgery
Prevention of postoperative pain is essential for the recovery of esophageal surgery. Epidural analgesia is a traditional and standard perioperative pain management for these patients.
- Conditions
- Pain Syndrome, Dizziness, Vomiting, Itching
- Trial name
- NCT06704698
- Testing
- Liposomal bupivacaine, Bupivacaine Hydrochloride
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Zhejiang Cancer Hospital
Breast Cancer
Longitudinal Assessment of Arthralgia and Related Symptoms in Breast Cancer Patients Receiving Aromatase Inhibitors
The goal of this research study is to learn more about what it is like for patients with breast cancer to receive treatment with the drug anastrozole.
- Trial name
- NCT00738998
- Testing
- Questionnaire, Phone Calls
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- M.D. Anderson Cancer Center
Ovarian Cancer, Breast Cancer
A Study of Serum Folate Levels in Patients Treated With Olaparib
This is a study investigating folate deficiency (lack of folic acid in the blood) in patients who take the drug olaparib to treat their advanced ovarian or breast cancer.
- Conditions
- Ovarian Cancer, Breast Cancer, Folic Acid Deficiency
- Trial name
- NCT04024254
- Testing
- Folic Acid Tablet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rush University Medical Center
Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Triple-Negative Breast Carcinoma
Rintatolimod, Celecoxib and Interferon Alpha 2b With Pembrolizumab For the Treatment of Patients With Metastatic or Unresectable Triple Negative Breast Cancer
This phase I/IIa trial tests the safety, side effects, and best dose of chemokine modulation therapy (CKM) (rintatolimod, celecoxib, and interferon alpha 2b) in combination with pembrolizumab for the treatment of patients with…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Triple-Negative Breast Carcinoma, Unresectable Triple-Negative Breast Carcinoma
- Trial name
- NCT05756166
- Testing
- Biopsy, Biospecimen Collection, Celecoxib
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Roswell Park Cancer Institute
Sarcoma, Soft Tissue Sarcoma
Cathepsin Activatable Fluorescent Probe
Real-time detection of cancer cells during surgical removal of a tumor is important. Currently when tissue is removed at the time of surgery, the removed tissue goes to pathology when the margins (edges of the tissue) are…
- Conditions
- Sarcoma, Soft Tissue Sarcoma, Breast Cancer
- Trial name
- LUM015 (NCT01626066)
- Testing
- LUM015
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- David Kirsch
Sarcoma
Novel Biochemical and Molecular Determinants for Soft Tissue Sarcoma
The purpose of this study is to study normal and sarcoma cells. To study these cells we need to have human tissue. You will be having or have already had a procedure to remove tissue. We would like to use some of this tissue.
- Trial name
- NCT00579566
- Testing
- Specimen protocol
- Where
- 7 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Diabetic Foot Ulcer
PHASE 1, OPEN-LABEL SAFETY STUDY OF UMBILICAL CORD LINING MESENCHYMAL STEM CELLS (CORLICYTE®) TO HEAL CHRONIC DIABETIC FOOT ULCERS
Study Objective: The objective of this Phase 1 open-label study is to establish the safety and tolerability of Corlicyte mesenchymal stem cells (MSCs) in the treatment of patients with chronic diabetic foot ulcers (DFUs).
- Trial name
- NCT04104451
- Testing
- Corlicyte
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Acne Vulgaris
Risk Minimisation Study for Diane-35 and Its Generics
The study will be an observational, cross-sectional study of knowledge, understanding, and self-reported behavior among a sample of physicians with recent experience in prescribing Diane-35 or its generics in a total of five…
- Trial name
- NCT02410031
- Testing
- Cyproterone acetate 2mg/ethinylestradiol 35 μg (Diane-35)
- Where
- 5 sites in Austria, Czechia and 3 more
- Volunteers
- 759 people
- Sponsor
- Bayer
Lupus Nephritis
Comparison between2 Drugs in Lupus Nephritis
The aim of this work is to study the effect and side effects of the cyclophosphamide versus mycophenolate in lupus nephritis
- Trial name
- NCT04424602
- Testing
- cyclo phosphamide, mycophenolate
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Carcinoma, Intraductal, Noninfiltrating, Recurrence, Local Neoplasm
Trial of Low Dose Tamoxifen in Women With Breast Intraepithelial Neoplasia - Long Term Follow-up
The aim of the study is to evaluate whether tamoxifen at a low dose of 5mg/d reduces in the long term the incidence of invasive breast cancer and ductal carcinoma in situ, DCIS (DIN 1c, 2, 3) of the breast, in woman operated for…
- Conditions
- Carcinoma, Intraductal, Noninfiltrating, Recurrence, Local Neoplasm, Breast Neoplasms, Atypical Hyperplasia
- Trial name
- TAM-01 (NCT01357772)
- Testing
- Tamoxifen
- Where
- 14 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Andrea DeCensi
Cervical Cancer, Genital Warts
Study of an Investigational Vaccine in Pre-Adolescents and Adolescents (Gardasil)(V501-016)
The primary purpose of the study is to determine if an investigational vaccine Gardasil (V501) with 4 components will provide an immune response and will be well tolerated in pre-adolescents and adolescents.
- Trial name
- NCT00092495
- Testing
- V501, Gardasil, human papillomavirus (type 6, 11, 16, 18) recombinant vaccine
- Volunteers
- 3,055 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Giant Cell Arteritis (GCA)
The VGR GCA Cohort: Ultrasound, Biopsy and Biomarkers - Novel Methods for Diagnosis, Monitoring and Prognosis in Giant Cell Arteritis.
Giant cell arteritis (GCA) is the most common vasculitis in the elderly and is usually treated with long-term corticosteroid therapy. Many patients experience relapses and treatment-related side effects.
- Trial name
- NCT07246577
- Where
- Sweden
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Chronic Inflammatory Disorder, Arthritis, Rheumatoid
A Relative Bioavailability and Food Effect Study of New Formulations
The purpose of this trial is to assess the effect of 3 formulations on the relative bioavailability of LY3009104. Participants will receive single dose of LY3009104 on 4 separate occasions with and without food.
- Trial name
- NCT01398475
- Testing
- LY3009104
- Where
- Singapore
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company