Clinical trials: Conjunctival Diseases
Keratoconjunctivitis Sicca (KCS)
Intra-Nasal Mechanical Stimulation (INMEST) as a Treatment of Keratoconjunctivitis Sicca (Dry Eye Syndrome)
The purpose of the study is to evaluate how treatment with Intra-Nasal Mechanical Stimulation (INMEST) in the nasal cavity in patients with Keratoconjunctivitis sicca can relieve these symtoms.
- Trial name
- NCT03418259
- Testing
- KCS Medical Device
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Karolinska Institutet
Seasonal Allergic Rhinitis
Efficacy and Safety of Sublingual Tablets of Grass Pollen Allergen Extract
The objective of this study is to assess the effect of grass pollen extract SLIT tablets on the Rhinoconjunctivitis Total Symptom Score (RTSS) of the six rhinoconjunctivitis symptoms in response to grass pollen challenge after…
- Trial name
- NCT00619827
- Testing
- 300 IR grass pollen allergen extract tablet
- Where
- Austria
- Volunteers
- 89 people
- Sponsor
- Stallergenes Greer
Pterygium of Conjunctiva and Cornea
Vertical Split Conjunctival Autograft in Double-head Pterygia
15 eyes of 15 patients with primary double-headed pterygia that underwent vertical split conjunctival autograft pterygium surgery were retrospectively reviewed. All patients had primary double-headed pterygia.
- Trial name
- NCT03507283
- Testing
- Double head pterygia excision and repair
- Volunteers
- 15 people
- Sponsor
- Benha University
Allergic Conjunctivitis
A Long-term Study of DE-114 Ophthalmic Solution in Patients With Allergic Conjunctivitis
Safety and efficacy of DE-114 ophthalmic solution will be evaluated in patients with allergic conjunctivitis, in an open-label, multicenter study.
- Trial name
- NCT01363713
- Testing
- DE-114 ophthalmic solution
- Where
- Japan
- Volunteers
- 130 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Probiotic, Ocular Surface Disease
Efficacy and Safety of Oral Probiotics on Ocular Symptoms and Gut Microbiome of Children with Vernal Keratoconjunctivitis
The primary goal of this study is to determine the effects of oral probiotics on the severity of ocular symptoms and the alterations of the gut microbiome of children (4-18 years old) with vernal keratoconjunctivitis.
- Conditions
- Probiotic, Ocular Surface Disease, Ocular Diseases, Ocular Dryness
- Trial name
- NCT06793514
- Testing
- Probiotic
- Volunteers
- 32 people
- Sponsor
- Mohsen Pourazizi
Dry Eye Syndrome
Pilot Study to Clinical Evaluate Device Prototypes in Dry Eye Patients
The study will assess the safety, tolerability and feasibility of Lacrima investigational medical device to treat dry eye patients
- Trial name
- NCT01957670
- Testing
- Lacrima medical Prototypes
- Where
- Israel
- Sponsor
- Lacrima Medical LTD
Trachoma, Chlamydia
Tripartite International Research for the Elimination of Trachoma
Mass antimicrobial administrations have been remarkably successful in reducing the prevalence of the ocular strains of Chlamydia that cause trachoma.
- Trial name
- TIRET (NCT01202331)
- Testing
- mass treatment with oral azithromycin
- Where
- Ethiopia
- Volunteers
- 29,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Seasonal Allergic Conjunctivitis
Ketotifen Ophthalmic Solution With Emedastine in Patients With Seasonal Allergic Conjunctivitis
Medications available for the treatment of seasonal allergic conjunctivitis include antihistamines. These medicines block the release of histamine, a substance in the body that is released when an allergic reaction occurs.
- Trial name
- NCT00133627
- Testing
- Ketotifen
- Where
- China
- Volunteers
- 229 people
- Sponsor
- Novartis
Diabetic Retinopathy, Macular Edema
20- Versus 23- Gauge System for Pars Plana Vitrectomy
The aim of the present study is to compare the functional and clinical differences and advantages between a standard operating system and a newly developed even smaller system for pars plana vitrectomy.
- Conditions
- Diabetic Retinopathy, Macular Edema, Postoperative Complications, Vitreous Hemorrhage
- Trial name
- NCT00411970
- Testing
- 20- and 23 gauge vitreoretinal surgery systems
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Allergic Rhinitis, Conjunctivitis
Efficacy of the Anti-Bet v 1 Monoclonal Antibodies (Given Subcutaneously) to Reduce Allergic Rhinitis and Conjunctivitis Symptoms and Skin Test Reactivity Upon Exposure to Birch Allergen in Adult Participants
Primary objective: To assess the efficacy of a single dose of the anti- Bet v 1 monoclonal antibodies (mAb(s ) in the reduction of allergic nasal symptoms during an out-of-season birch allergen environmental exposure unit (EEU)…
- Trial name
- NCT05430919
- Testing
- REGN5713, REGN5714, REGN5715
- Where
- 3 sites in Canada
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Allergic Rhinitis, Conjunctivitis
Study to Assess the Efficacy of Anti-Bet v 1 Monoclonal Antibodies in Adults to Reduce Symptoms of Seasonal Allergic Rhinitis
The primary objective is to assess the reduction of allergic symptoms as measured by combined symptom and medication score (CSMS) during birch pollen season after a single dose of REGN5713-5714-5715 versus placebo.
- Trial name
- NCT04709575
- Testing
- REGN5713, REGN5714, REGN5715
- Where
- 37 sites in United States, Belgium and 3 more
- Volunteers
- 353 people
- Sponsor
- Regeneron Pharmaceuticals
Keratoconjunctivitis, Vernal
Study of the Clinical and Biological Efficacity of NAAXIA SINE® in Vernal Keratoconjunctivitis
To assess the clinical and biological efficacity of preservative free NAAGA eyes drops in vernal keratoconjunctivitis
- Trial name
- NCT00357019
- Testing
- N-acetyl-aspartyl-glutamate (NAAXIA Sine)
- Sponsor
- Laboratoires Thea
Keratoconjunctivitis Sicca, Sjogren's Syndrome
Treatment of Dry Eye Syndrome With Cyclosporin A Eye Drops
This study will examine whether cyclosporin A eye drops alleviate dry eye syndrome, a disorder of tear deficiency or excessive tear evaporation. The condition damages the surface of the eye and causes discomfort.
- Trial name
- NCT00001731
- Testing
- Cyclosporin A
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Eye Institute (NEI)
Keratoconjunctivitis Sicca
A Clinical Study to Assess the Safety and Efficacy of an Ophthalmic Solution (SkQ1) in the Treatment of Dry Eye Syndrome (DES)
The purpose of this study is to evaluate whether SkQ1 ophthalmic solutions are safe and effective compared to placebo for the treatment of the signs and symptoms of dry eye syndrome.
- Trial name
- NCT02121301
- Testing
- Low Dose 0.155µg/mL SkQ1 ophthalmic solution, High Dose 1.55µg/mL SkQ1 ophthalmic solution
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Mitotech, SA
Pterygium
Alcohol 20% for Separation of Pterygium and Comparison of Different Wound Closure Methods
Purpose of this study is to evaluate efficiency and safety of Alcohol 20% for peeling pterygium and to compare 3 different methods of operative wound closure: Bare sclera, Sliding flap, Amniotic membrane + biological glue
- Trial name
- NCT00704977
- Testing
- pterygium surgery using alcohol 20% for tissue separation and bare sclera as wound closure technique
- Where
- 2 sites in Israel
- Volunteers
- 150 people
- Sponsor
- Soroka University Medical Center
Dry Eye, Keratoconjunctivitis Sicca
A Randomized Study of Smile Exercise for Dry Eye
The objective of the study is to evaluate the effectiveness of laughter therapy in relieving the symptoms of dry eye disease.
- Conditions
- Dry Eye, Keratoconjunctivitis Sicca, Eye Diseases, Corneal Diseases
- Trial name
- NCT04421300
- Testing
- smile exercise, 0.1% sodium hyaluronate eye drop
- Where
- China
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Allergy, Rhinitis
Efficacy and Safety From a High-dosed Sublingual Grass Pollen Preparation
Efficacy and Safety from a high-dosed sublingual grass pollen preparation
- Conditions
- Allergy, Rhinitis, Conjunctivitis
- Trial name
- ALLEGRA6 (NCT00623701)
- Testing
- Allerslit forte
- Where
- Germany
- Volunteers
- 126 people
- Sponsor
- Allergopharma GmbH & Co. KG
Allergic Rhinitis, Allergic Conjunctivitis
Animal Allergy in Korean Pet Owners, Pet-related Industry Workers, and Laboratory Animal Reseachers
The investigators surveyed the prevalence of animal allergy and sensitization to animal allergen among participants in international symposium of Korean association for laboratory science (laboratory animal researchers) and…
- Conditions
- Allergic Rhinitis, Allergic Conjunctivitis, Urticaria, Asthma
- Trial name
- NCT03101618
- Testing
- Animal allergy, Non-animal allergy
- Where
- South Korea
- Volunteers
- 643 people, healthy volunteers welcome
- Sponsor
- Gachon University Gil Medical Center
Keratoconjunctivitis Sicca, Dry Eye Syndrome
Effects of Dry Eye Treatments on the Ocular Surface
The purpose of this study is to evaluate whether, in people with dry eye syndrome, over the counter artificial tears and the prescription eye drop, dexamethasone, change or effect the eyes response to a low humidity environment.
- Trial name
- NCT01797822
- Testing
- Dexamethasone, Artificial tear
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Rhinitis, Allergic, Seasonal, Conjunctivitis, Allergic
Immunotherapy With Depigmented and Polymerized Allergen Extract of Phleum Pratense
The objective of this trial is to evaluate the clinical effectiveness of the administration of a depigmented and polymerized allergen extract of Phleum pratense in the rhinoconjunctivitis and/or asthma of slight or moderate…
- Conditions
- Rhinitis, Allergic, Seasonal, Conjunctivitis, Allergic, Asthma
- Trial name
- NCT00501527
- Testing
- Immunotherapy with modified extract of P. pratense pollen
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Laboratorios Leti, S.L.