Clinical trials: Confocal Laser Endomicroscopy
Gastrointestinal Post Acute COVID-19 Syndrome
The Clinical Significance of Gut Permeability in Gastrointestinal Post Acute COVID-19 Syndrome
Severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) and the associated coronavirus disease 2019 (COVID-19) have been spreading all around the world for past 3 years.
- Trial name
- NCT05612087
- Testing
- Confocal laser endomicroscopy
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Frozen Sections, Indocyanine Green (ICG)
A PROSPECTIVE, SINGLE-CENTERED, ASSESSOR-BLINDED STUDY TO EVALUATE THE CLINICAL EFFICACY OF THE PROPOSED CELL/TISSUE HISTOPATHOLOGY PROCESSOR CCELL (CONFOCAL FLUORESCENCE ENDOMICROSCOPY) FOR INTRAOPERATIVE DIAGNOSIS IN BRAIN TUMORS
The primary objective of this single-center study is to demonstrate the performance of cCeLL, used in real time, compared to frozen section analysis.
- Conditions
- Frozen Sections, Indocyanine Green (ICG), Brain Tumor
- Trial name
- NCT07254845
- Testing
- cCeLL In vivo, Indocyanine Green
- Volunteers
- 30 people
- Sponsor
- VPIX Medical
Lung Carcinoma
Needle-Based Confocal Laser Endomicroscopy for Diagnosis of Lung Cancer in Patients With Peripheral Pulmonary Nodules
This clinical trial compares the addition of needle-based confocal laser endomicroscopy (nCLE) and fluorescein to endobronchial ultrasound-guided transbronchial needle aspiration (EBUS TBNA) with EBUS TBNA alone for the diagnosis…
- Trial name
- NCT05556525
- Testing
- Fluorescein, Image-Guided Needle Confocal Laser Endomicroscopy, Ultrasound-Guided Transbronchial Needle Aspiration
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Atrophic Gastritis
Grading Atrophic Gastritis by Confocal Laser Endomicroscopy Probe (p-CLE)
Atrophic gastritis (AG) is a chronic disease, associated to gastric adenocarcinoma moreover if severity AG is present. Sydney system classified AG as mild, moderate and severe, but with moderate interobserver agreement, due to…
- Trial name
- NCT02351154
- Testing
- Cellvizio Viewer software
- Where
- Ecuador
- Volunteers
- 30 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Undifferentiated Gastric Cancer
Role of Probe-based Confocal Laser Endomicroscopy Targeted Biopsy in the Molecular Study of Undifferentiated Gastric Cancer
The purpose of this study is to conduct a study on genetic pathology, obtaining of pure cancer tissues is mandatory. Although the endoscopy with biopsy has been a gold standard for diagnosing gastric cancer, percentage of cancer…
- Trial name
- NCT02799420
- Testing
- GastroFlex UHD, Cellvizio; Mauna Kea Technologies, Paris, France, white light endoscopy (WLE)
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Yonsei University
Peripheral Pulmonary Lesions (PPLs)
CLE vs. ROSE for Ex Vivo Lung Biopsy Assessment
The goal of this observational study is to evaluate the diagnostic efficacy of Confocal Laser Endomicroscopy (CLE) compared to Rapid On-Site Evaluation (ROSE) for ex vivo lung biopsy specimens obtained via bronchoscopy.
- Trial name
- NCT07725510
- Testing
- Ex Vivo Confocal Laser Endomicroscopy (CLE) Imaging and Interpretation, Rapid On-Site Evaluation (ROSE) Imaging and Interpretation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guangzhou Medical University
Pancreatic Cysts
Confocal Endomicroscopy of Pancreatic InVivo
Confocal laser endomicroscopy (CLE) is a novel and highly promising imaging method for that allows in vivo imaging of the mucosal layer at resolution of approximately 1 micron.
- Trial name
- NCT01035008
- Testing
- Endoscopic Ultrasound (EUS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Irritable Bowel Syndrome
Confocal Laser Endomicroscopy, IBS and Stress
After standard endomicroscopy with fluorescein to investigate for dysplasia in Barrett's esophagus the endoscope will be forwarded into the 2nd part of the duodenum.
- Trial name
- NCT02316132
- Testing
- Stress, Control
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Irritable Bowel Syndrome, Inflammatory Bowel Disease
Assessment of Small Intestinal Bowel Epithelial Gaps in Irritable Bowel Syndrome
The study aims to: 1. Determine whether the density of epithelial gaps in terminal ileum of patients with irritable bowel syndrome (IBS) is different from that in inflammatory bowel disease (IBD) patients and normal controls by…
- Trial name
- NCT01632488
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Shandong University
Esophageal Neoplasms, Artificial Intelligence
Automatic Diagnosis of Early Esophageal Squamous Neoplasia Using pCLE With AI
Detection and differentiation of esophageal squamous neoplasia (ESN) are of value in improving patient outcomes. Probe-based confocal laser endomicroscopy (pCLE) can diagnose ESN accurately.However this requires much experience…
- Conditions
- Esophageal Neoplasms, Artificial Intelligence, Confocal Laser Endomicroscopy
- Trial name
- NCT04136236
- Testing
- The diagnosis of Artificial Intelligence and endoscopist
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Shandong University
Interstitial Lung Diseases
Confocal Laser Endomicroscopy and Optical Coherence Tomography for Diagnosing ILD.
Often, assessing a classifying diagnosis in patients with interstitial lung disease provides a diagnostic challenge. Currently HRCT, endoscopic or surgical video assisted thoracoscopic surgery(VATS) assessment including lung…
- Trial name
- NCT02689102
- Testing
- Probe based optical techniques
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Intestinal Metaplasia of Gastric Mucosa, Confocal Laser Endomicroscopy
Artificial Intelligence Confocal Laser Endomicroscopy for Real-time Assessment of Gastric Cancer Risk.
Current national guidelines recommend the use of OLGIM score to evaluate the risk of gastric cancer in patients, and close gastroscopic monitoring should be performed after OLGIM grade III/IV.
- Trial name
- NCT05459428
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shandong University
Pleural Carcinomatosis
Probe Based Confocal Laser Endomicroscopy During Thoracoscopy for Pleural Malignancies Diagnosis.
Probe based confocal laser endomicroscopy (pCLE) is a new optical endoscopic technique, generating fluorescent light emission from the tissue of interest and allowing in vivo live imaging at a cellular level ("optical biopsies").
- Trial name
- NCT03805971
- Testing
- Study of the pleural cavity with a confocal laser endomicroscope.
- Where
- Belgium
- Volunteers
- 65 people
- Sponsor
- University of Liege
Bladder Neoplasm, Urothelial Carcinoma
Confocal Laser Endomicroscopy in the Lower Urinary Tract
Rationale: Cystoscopy and cytology, the current 'gold standard' for detection and follow-up of primary and recurrent bladder cancer have some limitations.
- Trial name
- NCT03013894
- Where
- Netherlands
- Volunteers
- 73 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Gastric Cancer, Intestinal Metaplasia
New Classification of Stomach Using Probe-based Confocal Laser Endomicroscopy
The aim of the present study was to propose a new pCLE classification of gastric pit patterns and vessel architecture, and to assess the accuracy and interobserver agreement of this new pCLE classification system in the stomach.
- Conditions
- Gastric Cancer, Intestinal Metaplasia, Atrophic Gastritis, Inflammation
- Trial name
- NCT01896310
- Testing
- probe-based confocal laser endomicroscopy
- Where
- China
- Volunteers
- 272 people
- Sponsor
- Shandong University
Stomach Neoplasms, Precancerous Conditions
Detection of Early Gastric Cancers Using Confocal Laser Endomicroscopy
The purpose of this study is to determine whether endomicroscopy can improve the detection of Early Gastric Cancers (EGC).
- Trial name
- CLE (NCT00851305)
- Testing
- Endomicroscope (Pentax, Tokyo, Japan), Gastroscopes (Pentax, Tokyo, Japan)
- Where
- China
- Volunteers
- 1,786 people
- Sponsor
- Shandong University
Ulcerative Colitis, Artificial Intelligence
Automatic Evaluation of Inflammation Activity in Ulcerative Colitis Using pCLE With Artificial Intelligence
Probe-based confocal laser endomicroscopy (pCLE) is an endoscopic technique that enables to evaluate the inflammation activity of ulcerative colitis with excellent correlation with histopathology.
- Conditions
- Ulcerative Colitis, Artificial Intelligence, Confocal Laser Endomicroscopy
- Trial name
- NCT04131530
- Testing
- The diagnosis of Artificial Intelligence and endoscopist
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shandong University
Intestinal Metaplasia, Intestinal Dysplasia
Comparison Between Probe-based Confocal Laser Endomicroscopy, White-light Endoscopy and Virtual Chromoendoscopy
The investigators hypothesis that 1. clinical applicability and overall diagnostic sensitivity and specificity of pCLE for diagnosing gastric preneoplastic and neoplastic lesions is acceptable 2.
- Trial name
- pCLE-GCEP (NCT01398579)
- Testing
- Gastroscopy
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- National University Hospital, Singapore
Flow Determination
Real-time Observation of Microcirculatory Hemodynamics in Gastric Intestinal Metaplasia by Confocal Laser Endomicroscopy
The morphologic change of microvessels has the clinical value to distinguish cancerous from non-cancerous mucosa. The aim of this study was to observe gastric mucosa microcirculatory hemodynamic changes real-time using pCLE…
- Trial name
- NCT02595151
- Testing
- CLE
- Where
- China
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Shandong University
Non Small Cell Lung Cancer
Real-Time Imaging to Improve Lung Cancer Diagnosis : Comparing Confocal Laser Endomicroscopy (CLE) With Standard Biopsy for Quicker and Safer Detection of Non-Small Cell Lung Cancer
The goal of this observational study is to evaluate whether confocal laser endomicroscopy (CLE) can improve the real-time diagnosis of non-small cell lung cancer (NSCLC) in patients undergoing bronchoscopic biopsy for suspected…
- Trial name
- SCORACLE (NCT07538947)
- Testing
- bronchoscopic navigation with CLE
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Central Hospital, Nancy, France