Clinical trials: Concussion, Brain, open to volunteers
Concussion
Telehealth Specialty Concussion Treatment for Youth
Specialty concussion care can help youth recover more quickly but many youth face barriers to accessing concussion specialists. A care delivery model whereby concussion specialists are available to co-manage injuries with primary…
- Trial name
- SPEEDYRecovery (NCT07736534)
- Testing
- Specialist and Pediatrician Co-Management for Early and Effective Concussion Care Delivery to Hasten Your Recovery (SPEEDY Recovery)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Rhode Island
Traumatic Brain Injury, Post-Concussive Symptoms
Long-Term Outcomes Following HBOT
This study is designed to better understand the long-term effects of hyperbaric oxygen therapy (HBOT). Our goal is to determine whether improvements after treatment are maintained over time and whether additional benefits appear…
- Conditions
- Traumatic Brain Injury, Post-Concussive Symptoms, Post-Traumatic Stress Disorder
- Trial name
- NCT07732374
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Summit Hyperbarics and Wellness
Healthy
Naturally Produced Cannabinoids for Neuroprotection From Concussion
The goal of this double-blind, placebo-controlled, cross over study is to learn about the neuroprotective properties of a broad-spectrum cannabinoid formulation in normal healthy adults engaged in elite contact sport competition.
- Trial name
- NCT07715864
- Testing
- Broad spectrum cannabinoid formulation
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Regina
Concussion Post Syndrome, Concussion
Effect of Vestibular Rehabilitation on Gait, Balance, and Coordination in Post Concussion Combat Athletes
This randomized controlled trial aims to evaluate the effectiveness of vestibular rehabilitation in improving gait and balance among post-concussion combat athletes aged 18-25 years.
- Trial name
- NCT07717528
- Testing
- Vestibular Rehabilitation Program, Conventional Post-Concussion Rehabilitation
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder
Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History
This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS)…
- Conditions
- Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Amnestic Mild Cognitive Impairment, Mild Traumatic Brain Injury
- Trial name
- PATH (NCT05446584)
- Testing
- High Definition Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Texas Southwestern Medical Center
Traumatic Brain Injury, Insomnia
CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and…
- Conditions
- Traumatic Brain Injury, Insomnia, Depression, Post-traumatic Stress
- Trial name
- NCT05663034
- Testing
- Mindfulness-based treatment for insomnia (MBTI), Cognitive behavioral therapy for insomnia (CBT-I)
- Where
- 5 sites in United States
- Volunteers
- 360 people
- Sponsor
- Johns Hopkins University
Brain Concussion, Mild Traumatic Brain Injury
Rehabilitation, Education, and SElf-management for Adolescents After Mild Traumatic Brain Injury
Concussion or mild traumatic brain injury (mTBI) is a major public health concern. Most adolescents will recover from mTBI without complication; however, a sizeable minority experience symptoms that last more than one most…
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Concussion
- Trial name
- RESET (NCT07698015)
- Testing
- Mindfulness-based intervention, Health Education
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Molly Cairncross
Concussion, Brain, Mild Traumatic Brain Injury
Risk Stratification in Children With Concussion
This project will measure concussion symptoms, biological markers, and academic and social factors across the first year postconcussion to develop a model that enables early identification of and symptom management for children…
- Trial name
- RSiCC (NCT05825027)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Duke University
TBI (Traumatic Brain Injury), Implementation Research
Emergency Department Implementation of the i-STAT Alinity Traumatic Brain Injury Whole Blood Test
The objective of this study is to identify determinants for implementing the i-STAT Alinity whole blood traumatic brain injury (TBI) test for its Food and Drug Administration (FDA)-indicated use and to evaluate other potential…
- Trial name
- EDI (NCT07373509)
- Testing
- i-STAT Alinity TBI test
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- Shawn Eagle
Concussion, Mild, Mild Traumatic Brain Injury (mTBI)
Acceptance and Commitment Therapy Integrated Vestibular Rehabilitation (ACTIVE) RCT
The primary objective of this multi-site randomized clinical trial (RCT) is to compare Acceptance and Commitment Therapy Integrated Rehabilitation (ACT) with usual care rehabilitation (CONTROL) in 250 individuals with…
- Conditions
- Concussion, Mild, Mild Traumatic Brain Injury (mTBI), Psychological Health
- Trial name
- NCT06819904
- Testing
- Acceptance and Commitment Therapy Integrated Rehabilitation (ACT), Usual Care Rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Pittsburgh
Mild Traumatic Brain Injury
Multicenter Early Intervention Study in Adults With Complaints After Mild Traumatic Brain Injury
Rationale: In the Netherlands, traumatic brain injury (TBI) is one of the most frequent neurological diseases and one of the leading causes of disability.
- Trial name
- BRAIN-RESET (NCT07341074)
- Testing
- Treatment by physical- and/or occupational therapist, Psychoeducation via telephonic counselling
- Where
- Netherlands
- Volunteers
- 655 people
- Sponsor
- University Medical Center Groningen
Traumatic Brain Injury
University of Pittsburgh Brain Health Initiative
This project will define the prevalence of brain health (i.e., normal cognitive, neuromotor, behavioral function) in living professional football retirees and group-matched controls through a comprehensive assessment of clinical…
- Trial name
- BHI (NCT04708613)
- Testing
- Cognitive/Neuropsychological Testing, Vestibular/Ocular-Motor Testing, Sleep Evaluation
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- David Okonkwo, MD, PhD
Concussion, Brain
Creatine Supplementation in Concussion Recovery
The proposed study aims to compare concussion recovery in those supplementing creatine and those not supplementing creatine. Specific aim 1: To compare number of days until asymptomatic between those taking creatine vs.
- Trial name
- CSCR (NCT06208813)
- Testing
- Creatine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- San Diego State University
Concussion (Diagnosis), Concussion, Mild Traumatic Brain Injury
Multidimensional Sleep Health Intervention to Optimize Concussion Recovery
Following adolescent concussion, poor sleep health is common and relates to the development of persisting post-concussion symptoms, and uninjured adolescents (independent of concussion) also commonly experience sleep…
- Conditions
- Concussion (Diagnosis), Concussion, Mild Traumatic Brain Injury, Treatment, Sleep Health
- Trial name
- SCORE (NCT07082218)
- Testing
- Sleep Intervention
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Colorado, Denver
Olfactory Disorder, Smell Disorder
Olfactory Training in Various Populations
To date, there is no validated pharmacotherapy for olfactory disorders. Interestingly, olfactory training - the intentional exposure to odorants for the purposes of retraining the sense of smell - has shown success with as many…
- Conditions
- Olfactory Disorder, Smell Disorder, Traumatic Brain Injury, Concussion, Brain
- Trial name
- NCT06115291
- Testing
- Smell Test
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Kansas Medical Center
Mild Traumatic Brain Injury, Alexithymia
Clinical Trial Comparing the Efficacy of Two Teletherapy Programs at Improving Psychological Health in People With Brain Injury
The purpose of the study is to test two different training programs to find out which is better at helping people with a concussion or mild TBI (mTBI) improve their emotional health and well-being.
- Trial name
- NCT07436754
- Testing
- Program 1, Program 2
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Hackensack Meridian Health
Concussion, Mild, Photophobia
Use of Tinted Contact Lenses for Concussion-Related Light Sensitivity
The purpose of this study is to gather pilot data on the effectiveness of daily disposable tinted contact lenses in reducing photophobia (light sensitivity) following a concussion, with the goal of facilitating the return to work…
- Conditions
- Concussion, Mild, Photophobia, Contact Lens
- Trial name
- NCT07223086
- Testing
- Narrow band (tinted) contact lenses, broad band (clear) contact lenses
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Concussion (Diagnosis)
Nature as Medicine for the Healing Brain: Utilization of a Nature-based Exposure Intervention for Decreasing Concussion Recovery Timeline and Symptom Load
The overall goal of this research is to provide pilot data that informs and drives a larger scale research project, incorporating multiple contemporary measurement modalities, to understand the utility and pathological mechanisms…
- Trial name
- NCT07642739
- Testing
- Nature-based Guided Awareness Group, Standard Guided Awareness Group
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Penn State University
REM Sleep Behavior Disorder, Concussion, Brain
The COSP-RBD Study: Concussions and Contact Sports in RBD vs Controls
The goal of this observational study is to investigate concussions and contact sports practices in REM sleep behaviour disorder (RBD).
- Trial name
- COSP-RBD (NCT06270290)
- Testing
- Exposure to contact sports or history of concussions
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Concussion, Brain, Mild Traumatic Brain Injury
REhabilitation of MEMory Symptoms After BRain Concussion
Persistent memory symptoms after concussion are common, and likely perpetuated by unhelpful illness beliefs and coping behaviors.
- Trial name
- REMEMBR (NCT06956417)
- Testing
- Cognitive behavioral therapy, Cognitive rehabilitation
- Where
- 8 sites in Canada
- Volunteers
- 184 people
- Sponsor
- University of British Columbia