Concussion, BrainREMEMBRNCT06956417
REhabilitation of MEMory Symptoms After BRain Concussion
A study testing Cognitive behavioral therapy and Cognitive rehabilitation in people with Concussion, Brain and Mild Traumatic Brain Injury, run by University of British Columbia at 8 sites in Canada.
Trial summary
Persistent memory symptoms after concussion are common, and likely perpetuated by unhelpful illness beliefs and coping behaviors. Results from a pilot study suggested that traditional cognitive rehabilitation and a novel cognitive-behavioral therapy (CBT) protocol were both associated with improvements in subjective… Read more about this study
- Who is it for?
- Ages 18 to 59 years
- Conditions the study is for
- Concussion, Brain, Mild Traumatic Brain Injury
- What is being tested?
- Cognitive behavioral therapy and Cognitive rehabilitation
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 184 participants
- Where
- 8 sitesCanada
- Study dates
- 2 Jul 2025to 30 Apr 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 59 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Age 18-59
- Concussion diagnosis confirmed with structured interview based on American Congress of Rehabilitation Medicine diagnostic criteria
- Concussion occurred between 6 and 36 months before enrollment
- Ongoing memory concerns
- Fluent in English
- Stable access to a computer, tablet, or smartphone with internet capability
Who cannot join
- Fail performance validity testing
- Comorbid psychiatric or neurological disorder or is taking a medication that could fully account for their memory symptoms
Trial locations and contacts
8 sites in 1 country. Contact the study team or a site near you to ask about taking part.
8 sites in 1 country
Canada8 sites, 7 recruiting
- Recruiting
Calgary Brain Injury Program
Calgary, Alberta, T2N 2T9
Chantel Debert, chantel.debert@albertahealthservices.ca
Christina Campbell, christina.campbel1@ucalgary.ca
- Active, not recruiting
Integrated Adult Concussion Program at Hamilton Health Sciences
Hamilton, Ontario, L8N 3Z5
- Recruiting
Fraser Health Acquired Brain Injury and Concussion Services
Langley, British Columbia, V1M 4A6
William Panenka, will.panenka@ubc.ca
- Recruiting
360 Concussion Care Clinic
Ottawa, Ontario, K1H 7X7
Roger Zemek, 1-613-668-0360, roger.zemek@360concussioncare.com
- Recruiting
Sunnybrook Traumatic Brain Injury Clinic
Toronto, Ontario, M4N 3M5
Matthew Burke, matthew.burke@sunnybrook.ca
- Recruiting
Hull-Ellis Concussion and Research Clinic at University Health Network
Toronto, Ontario, M5G 2A2
Mark Bayley, mark.bayley@uhn.ca
Tharshini Chandra, (416) 597-3422 ext. 3645, tharshini.chandra@uhn.ca
- Recruiting
Canadian Concussion Centre at Toronto Western Hospital
Toronto, Ontario, M5T 2S8
Carmela Tartaglia, 416-603-5483, carmela.tartaglia@uhn.ca
Artee Srivastava, Artee.Srivastava@uhn.ca
- Recruiting
G.F. Strong Adult Concussion Services
Vancouver, British Columbia, V5Z 2G9
Sarah Courtice, 604-734-4113, Sarah.Courtice@vch.ca
About this study
Persistent memory symptoms after concussion are common, and likely perpetuated by unhelpful illness beliefs and coping behaviors. Results from a pilot study suggested that traditional cognitive rehabilitation and a novel cognitive-behavioral therapy (CBT) protocol were both associated with improvements in subjective memory functioning. The present study will more definitively compare the effectiveness of these interventions for improving subjective memory functioning after concussion.
Read the detailed description
The primary research aims of this study are to determine whether cognitive behavioral therapy (CBT) and cognitive compensatory strategy training (CCST) improves subjective memory functioning compared to usual care, and to compare the effectiveness of CBT and CCST. This study is a multisite three-armed randomized control trial (RCT) that will randomize adults with persistent memory symptoms following concussion to CBT, CCST, or a covert waitlist condition (2:2:1). Participants will be blinded to the other arms of the study and the study hypotheses.
- Conditions
- Concussion, Brain, Mild Traumatic Brain Injury
- Being tested
- Cognitive behavioral therapy, Cognitive rehabilitation
- Keywords
- Functional cognitive disorder
- Medical subject headings
- Brain Concussion
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cognitive behavioral therapyBehavioural
Cognitive behavioral therapy (CBT) is delivered by a psychologist over 10 individual (1:1) manualized videoconference sessions. The goal of this therapy is for participants to use their memory more normally (i.e., reduce avoidance and safety behaviors) and view memory lapses as less threatening.
Cognitive rehabilitationBehavioural
Cognitive compensatory strategy training (CCST), a traditional cognitive rehabilitation intervention, is delivered by a Occupational Therapist over 10 individual (1:1) manualized videoconference sessions. Participants optimize their use of current compensatory strategies and/or learn new ones suited to their needs and lifestyle. The goal is to minimize memory lapses in daily life.
| Study group | Role | What they receive |
|---|---|---|
| Cognitive behavioral therapy | Experimental | Not described Receives: Behavioral: Cognitive behavioral therapy |
| Cognitive rehabilitation | Active comparator | Not described Receives: Behavioral: Cognitive rehabilitation |
| Waitlist - Usual care | No intervention | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Multifactorial Memory Questionnaire-Satisfaction scale
Measures participants' concern, satisfaction, and overall appraisal of their memory ability. Participants rate their agreement with 18 statements. Total scores range from 0 to 72, with lower total scores indicating worse subjective memory functioning.
Measured: Week 20
Secondary outcomes (3)
Fear-Avoidance of Memory Loss Scale
Assesses fears and avoidance behaviors associated with memory decline. Participants rate 24 items on a 5-point scale, where the higher scores indicate greater memory concern and maladaptive coping.
Measured: Week 1 and week 20
Patient Global Impression of Change scale
Participants rate how much their memory functioning has improved or declined overall since the beginning of the study, on a single item rated on a 7-point scale where the midpoint is no change.
Measured: Week 20
Work and Social Adjustment Scale
Participants rate how much their condition interferes with their ability to carry out occupational and social activities across 5 items, on a scale from 1-7 where higher scores indicate more difficulty.
Measured: Week 1 and week 20
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 May 2025
- Study start2 Jul 2025
- Primary completion30 Apr 2028 (estimated)
- Study completion30 Apr 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Concussion, BrainStudies of the same condition, open and under way.
- More trials run by University of British ColumbiaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 184 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of British Columbia
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Noah Silverberg, University of British Columbia
- Investigators
- Noah D Silverberg, PhD, Principal investigator, University of British Columbia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06956417
- Sponsor's protocol ID
- H24-02486
- Acronym
- REMEMBR
- Status last verified
- May 2026
- First submitted
- 25 Apr 2025
- Last updated
- 2 Jun 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Rioux M, Mamman R, Byworth MT, Panenka WJ, Howard AK, Perez DL, Schmidt J, Courchesne C, LeMoult J, Heran MK, Silverberg ND. Pilot feasibility randomised controlled trial of cognitive-behavioural therapy for functional cognitive disorder after concussion. BMJ Neurol Open. 2024 Oct 11;6(2):e000666. doi: 10.1136/bmjno-2024-000666. eCollection 2024.
PubMed 39410977
Study at a glance
From the registry record, last updated by the sponsor on 2 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- REhabilitation of MEMory Symptoms After BRain Concussion
- ClinicalTrials.gov ID
- NCT06956417
- Acronym / sponsor ID
- REMEMBR / H24-02486
- Conditions
- Concussion, Brain, Mild Traumatic Brain Injury
- Keywords
- Functional cognitive disorder
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 184 participants (estimated)
- Lead sponsor
- University of British ColumbiaUniversity, hospital or other
- Study start
- 2 Jul 2025 (actual)
- Primary completion
- 30 Apr 2028 (estimated)
- Study completion
- 30 Apr 2029 (estimated)
- First posted
- 4 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Persistent memory symptoms after concussion are common, and likely perpetuated by unhelpful illness beliefs and coping behaviors. Results from a pilot study suggested that traditional cognitive rehabilitation and a novel cognitive-behavioral therapy (CBT) protocol were both associated with improvements in subjective memory functioning. The present study will more definitively compare the effectiveness of these interventions for improving subjective memory functioning after concussion.
Detailed description
The primary research aims of this study are to determine whether cognitive behavioral therapy (CBT) and cognitive compensatory strategy training (CCST) improves subjective memory functioning compared to usual care, and to compare the effectiveness of CBT and CCST. This study is a multisite three-armed randomized control trial (RCT) that will randomize adults with persistent memory symptoms following concussion to CBT, CCST, or a covert waitlist condition (2:2:1). Participants will be blinded to the other arms of the study and the study hypotheses.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Cognitive behavioral therapy | Experimental | Behavioral: Cognitive behavioral therapy |
| Cognitive rehabilitation | Active comparator | Behavioral: Cognitive rehabilitation |
| Waitlist - Usual care | No intervention | – |
Who may qualify
- Ages
- 18 to 59 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Age 18-59
- Concussion diagnosis confirmed with structured interview based on American Congress of Rehabilitation Medicine diagnostic criteria
- Concussion occurred between 6 and 36 months before enrollment
- Ongoing memory concerns
- Fluent in English
Key exclusion criteria (2 listed)
- Fail performance validity testing
- Comorbid psychiatric or neurological disorder or is taking a medication that could fully account for their memory symptoms
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cognitive behavioral therapyCognitive behavioral therapy (CBT) is delivered by a psychologist over 10 individual (1:1) manualized videoconference sessions. The goal of this therapy is for participants to use their memory more normally (i.e., reduce avoidance and safety behaviors) and view memory lapses as less threatening. | Behavioural | Cognitive behavioral therapy |
| Cognitive rehabilitationCognitive compensatory strategy training (CCST), a traditional cognitive rehabilitation intervention, is delivered by a Occupational Therapist over 10 individual (1:1) manualized videoconference sessions. Participants optimize their use of current compensatory strategies and/or learn new ones suited to their needs and lifestyle. The goal is to minimize memory lapses in daily life. | Behavioural | Cognitive rehabilitation |
Primary outcome
Multifactorial Memory Questionnaire-Satisfaction scale
Time frame: Week 20
Measures participants' concern, satisfaction, and overall appraisal of their memory ability. Participants rate their agreement with 18 statements. Total scores range from 0 to 72, with lower total scores indicating worse subjective memory functioning.
3 secondary outcomes
Fear-Avoidance of Memory Loss Scale
Time frame: Week 1 and week 20
Patient Global Impression of Change scale
Time frame: Week 20
Work and Social Adjustment Scale
Time frame: Week 1 and week 20
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Jun 2026.
- Background: PubMed 39410977Rioux M, Mamman R, Byworth MT, Panenka WJ, Howard AK, Perez DL, Schmidt J, Courchesne C, LeMoult J, Heran MK, Silverberg ND. Pilot feasibility randomised controlled trial of cognitive-behavioural therapy for functional cognitive disorder after concussion. BMJ Neurol Open. 2024 Oct 11;6(2):e000666. doi: 10.1136/bmjno-2024-000666. eCollection 2024.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Noah D Silverberg, PhD principal investigator
University of British Columbia
8 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Cognitive behavioral therapy and Cognitive rehabilitation in people with Concussion, Brain and Mild Traumatic Brain Injury, run by University of British Columbia at 8 sites in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 2 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 8 sites in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Noah D Silverberg, PhD (6047341313 ext. 2316, noah.silverberg@ubc.ca), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Multifactorial Memory Questionnaire-Satisfaction scale (time frame: Week 20). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06956417, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Jun 2026.