Clinical trials: Complications Surgical
Recurrent Vulvar Cancer, Persistent Vulvar Cancer
Pembrolizumab Combination With Lenvatinib in Pts With Recurrent,Persistent,Metastatic or Locally Advanced Vulvar Cancer Not Amenable to Curative Surgery or Radiotherapy
Evaluation of efficacy and safety of pembrolizumab in combination with lenvatinib in patients with recurrent, persistent, metastatic or locally advanced vulva cancer.
- Conditions
- Recurrent Vulvar Cancer, Persistent Vulvar Cancer, Metastatic Vulva Cancer, Locally Advanced Vulvar Cancer
- Trial name
- PIERCE (NCT05903833)
- Testing
- Pembrolizumab, Lenvatinib
- Where
- 15 sites in Germany
- Volunteers
- 42 people
- Sponsor
- AGO Research GmbH
Postoperative Pain
Comparison of Paravertebral Versus Epidural Block for Post-thoracotomy Pain Control
This is a randomized, assessor-blinded, non-inferiority clinical trial comparing continuous thoracic paravertebral block (BPV) versus continuous thoracic epidural block (BPD) for postoperative pain control in adult patients…
- Trial name
- NCT07763249
- Testing
- Continuous Thoracic Paravertebral Block, Continuous Thoracic Epidural Block
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Obesity, Lumbar Spine Surgery
WoundVac in Obese Patients Undergoing Lumbar Surgery
This is an open label, randomized clinical trial of Closed-Incision Negative-Pressure Therapy to decrease post-operative wound complications in patients with BMI ≥35kg/m2 after posterior lumbar spine surgery.
- Trial name
- NCT03688438
- Testing
- Closed-Incision Negative-Pressure Therapy
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Norton Leatherman Spine Center
Central Venous Catheterization
Comparison of the Proximal Approach and Distal Approach of Axillary Vein Catheterization Under Ultrasound Guidance
Ultrasound-guided axillary vein catheterization can be performed via the proximal or distal approach of the axillary vein. The aim of our study is to compare the first puncture success rate and safety between the two approaches…
- Trial name
- NCT03395691
- Testing
- The distal approach, The proximal approach
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Shanghai Zhongshan Hospital
Stress Urinary Incontinence
Urethral Length Measurement in Women Undergoing Suburethral Sling Operative Procedure
This is a prospective, non-randomized, observational, multicenter study in which urethral length is measured in women with surgically-correctable stress urinary incontinence who undergo a suburethral sling operative procedure.
- Trial name
- NCT01660438
- Where
- 3 sites in Germany, Poland and 1 more
- Volunteers
- 188 people
- Sponsor
- Cantonal Hospital, Frauenfeld
Postoperative Pain, Patient Controlled Analgesia
Monitoring Postoperative Patient-controlled Analgesia (PCA)
The introduction of Acute Pain Service (APS), 1985, specialized pain management could be offered to the inpatient care. An example of this is patient-controlled analgesia (PCA), which is a technique that is used mostly after…
- Conditions
- Postoperative Pain, Patient Controlled Analgesia, Surgery, Nurse-Patient Relations
- Trial name
- NCT03697278
- Testing
- Smith medical CADDsolis
- Where
- 2 sites in Sweden
- Volunteers
- 90 people
- Sponsor
- Pether Jildenstal
Surgery, Perioperative Complication
BRAIN-targeted Goal-directed Therapy in High-risk Patients undeRgOing Major electIve SurgEry: the BRAIN-PROMISE Study
The aim of the study is to further understand whether the use of non-invasive monitoring NIRS (Near Infrared Spectroscopy) is useful in reducing postoperative complications in high-risk patients undergoing elective surgery.
- Trial name
- BRAINPROMISE (NCT04266574)
- Testing
- Near Infrared Spectroscopy (NIRS), Standard Care
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Clinico Humanitas
Myocardial Ischemic Reperfusion Injury, End Stage Heart Disease
Remote Ischemic Preconditioning With Postconditioning in Heart Transplantation Surgery
The purpose of this study is to determine whether remote ischemic preconditioning with postconditioning (RIPC+RIPostC) reduces myocardial injury and improves clinical outcomes in heart transplantation surgery.
- Conditions
- Myocardial Ischemic Reperfusion Injury, End Stage Heart Disease, Heart Failure, Cardiomyopathy
- Trial name
- NCT02149316
- Testing
- RIPC+RIPostC, control
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Postoperative Pain
Enhanced Recovery After Surgery (ERAS) in Live Donor Kidney Transplant Recipients
The goal of this interventional study is to learn if an Enhanced Recovery After Surgery (ERAS) protocol works to reduce the need for narcotic pain medications in live donor kidney transplant recipients.
- Trial name
- NCT06997016
- Testing
- pre-operative carbohydrate drink, Acetaminophen, Gabapentin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Baylor Research Institute
Pain, Chronic Post-Surgical
PERIoperative Holistic RIsk Factor SCreening in the Prevention of Persistent Pain
Assessment and management for improved wellbeing after elective surgery (PERISCOP³E-Care) Diagnostic assessment tool evaluation and cut-off determination for participation in a transmural perioperative care program
- Trial name
- PERISCOPEcare (NCT05526976)
- Testing
- PERISCOPE-care
- Where
- 2 sites in Belgium
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Surgery--Complications
Association of the Arteriovenous Difference in Carbon Dioxide and Its Relation to the Difference in Arteriovenous Oxygen Content With the Occurrence of Postoperative Complication
Intra-operative hemodynamic management in high-risk surgery is a priority for the anesthesiologist. The current strategy is based on the continuous measurement of cardiac output and its maximization by vascular filling has many…
- Trial name
- CARBODAV (NCT03914976)
- Testing
- patient having to undergo a high risk programmed digestive surgery
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Hospices Civils de Lyon
Postoperative Atelectasis, Postoperative Pulmonary Complications
HFNC for Postoperative Atelectasis After Laparoscopic Surgery
Pneumoperitoneum and Trendelenburg positioning during laparoscopic surgery promote atelectasis development, which has been reported in up to 90% of patients under general anesthesia and increases the risk of postoperative…
- Trial name
- NCT07676760
- Testing
- High-Flow Nasal Cannula (HFNC), Conventional Oxygen Therapy
- Volunteers
- 90 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Surgical Site Infections
PVP Iodine vs Chlorhexidine in Alcohol for Disinfection of the Surgical Site
Prospective cluster-randomized multicenter cross-over trial to prove non-inferiority of PI compared to CHX in preoperative skin antisepsis
- Trial name
- PICASSo (NCT03685604)
- Testing
- CHX disinfection, PI Disinfection
- Where
- 3 sites in Switzerland
- Volunteers
- 3,321 people
- Sponsor
- University Hospital, Basel, Switzerland
Delirium, Postoperative
Effect of Percutaneous Acupoint Electrical Stimulation on Delirium
This study is a multicenter, prospective, randomized controlled clinical trial that aims to observe the impact of Transcutaneous Electrical Acupoint Stimulation (TEAS) on plasma TK/MMP3 in a randomized controlled setting.
- Trial name
- NCT06360549
- Testing
- Transcutaneous Electrical Acupoint Stimulation
- Where
- 2 sites in China
- Volunteers
- 238 people
- Sponsor
- Qin Zhang
Low Anterior Resection Syndrome (LARS)
Evaluating the Optimal Timing of Trans-Anal Irrigation for Low Anterior Resection Syndrome Post-rectal Cancer Surgery
This study aims to evaluate the optimal timing of trans-anal irrigation (TAI) for participants with low anterior resection syndrome (LARS) who have undergone surgery for rectal cancer.
- Trial name
- EARLY-TAI (NCT07696689)
- Testing
- Water-based transanal irrigation system
- Volunteers
- 250 people
- Sponsor
- Simona Ascanelli
Perioperative Inflammatory Response, Postoperative Pain
Suprazygomatic Maxillary Nerve Block Effect on Systemic Inflammatory Response in Cleft Palate Surgeries
the aim is to determine the value of adding bilateral supra zygomatic maxillary nerve block to general anesthesia in attenuating the systemic inflammatory response in paediatrics.
- Trial name
- NCT05495750
- Testing
- Bupivacaine 0.25% Injectable Solution
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Alaa Mohamed Abdel Salam Ibrahim Soliman
Postoperative Pain, Acute, Anaesthetic
Analgesic Effect of Intraoperative Intravenous S-Ketamine During Total Knee Arthroplasty Surgery
Severe acute pain after total knee arthroplasty surgery has multiple implications for hospitals and patients, monopolising resources and affecting the quality of life.
- Trial name
- NCT05289050
- Testing
- sodium chloride (NaCl; 0.9%), S-ketamine
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Ling Dong
Kidney Stone, Benign Prostatic Hyperplasia
Utilization of a Web-Based Application to Improve Patient Health Literacy and Reduce Clinic Visit Times in Holmium Laser Enucleation of the Prostate (HoLEP) Procedures and Kidney Stone Surgery
The investigator and research team plan to investigate whether patients who receive access to WellPrept website will report greater confidence and understanding of their medical condition, have shorter clinic visit times, and…
- Trial name
- NCT07580391
- Testing
- WellPrept, Standard Care
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Pain, Postoperative
Effect of Preincisional Bupivakain Infiltration on Postoperative Narcotic Medication Requirement
Postoperative pain and use of narcotic analgesics after laparoscopic bariatric surgeries are problems that need to be solved in terms of patient comfort.
- Trial name
- NCT03071991
- Testing
- study group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Umraniye Education and Research Hospital
Pain, Postoperative, Pain, Chest
Ideal Initial Bolus and Infusion Rate for Erector Spinae Plane Block Catheters
This study would like to identify the best starting dose and infusion rate for nerve blocks and nerve catheters related to the erector spinae plane block that can improve functional status and pain control on cardiac surgery…
- Trial name
- NCT03961048
- Testing
- Ropivacaine 0.2%-Sodium Chloride 0.9% Injectable Solution bilaterally, Ropivacaine 0.2%-Sodium Chloride 0.9% Injectable Solution unilaterally
- Where
- United States
- Sponsor
- Virginia Commonwealth University
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