Clinical trials: Complicated Pleural Effusion/ Empyema
Pleural Infection Bacterial, Pleural Infections
Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema
The goal of this clinical trial is to find out if giving certain medications once a day works just as well as giving them twice a day to treat infections around the lungs (called pleural infections).
- Conditions
- Pleural Infection Bacterial, Pleural Infections, Pleural Infections and Inflammations, Empyema, Pleural
- Trial name
- ONLY ONCE (NCT07095361)
- Testing
- Fibrinolytic once daily, Fibrinolytic twice daily, DNA degradation once daily
- Where
- 11 sites in United States
- Volunteers
- 270 people
- Sponsor
- University of North Carolina, Chapel Hill
Empyema, Pleural Effusion
Alteplase for Treatment of Empyema and Complicated Parapneumonic Effusion
The purpose of this study is to assess the benefit to patients with empyema or complicated parapneumonic effusion (CPE) using a daily versus twice daily Alteplase regimen of two different dose strategies compared with saline…
- Trial name
- NCT00103766
- Testing
- Alteplase
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- O'Brien, Jeana D., MD, FACP, FCCP
Complicated Pleural Effusion/ Empyema
Efficacy of Fibrinolytic Agents in Complicated Pleural Effusion
Intrapleural administration of fibrinolytic therapy, urokinase in parapneumonic effusion and empyema has been shown to decrease the need for surgical intervention and length of hospital stay.
- Trial name
- NCT03716375
- Testing
- Intrapleural Medications
- Volunteers
- 80 people
- Sponsor
- Beijing Children's Hospital
Pleural Empyema
Dornase Alfa and Urokinase for Kids With Pleural Empyema
The purpose of this study is to determine whether intrapleural treatment with Dornase alfa plus Urokinase improves clinical outcome compared to Urokinase alone in children with complicated parapneumonic effusions
- Trial name
- DUKE (NCT00502632)
- Testing
- Urokinase and Dornase alfa, Urokinase
- Where
- 3 sites in Italy
- Volunteers
- 94 people
- Sponsor
- Azienda Ospedaliera di Padova
Parapneumonic Effusion, Empyema, Pleural
Treatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs Decortication
This study aims to standardize the treatment of pleural space (parapneumonic) infections by comparing the difference in outcomes between 2 methods of treatment: early VATS (Video Assisted Thorascopic Surgery) decortication versus…
- Conditions
- Parapneumonic Effusion, Empyema, Pleural, Coagulopathy
- Trial name
- NCT03583931
- Testing
- VATS Decortication, Fibrinolytic Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Denver Health and Hospital Authority
Complicated Parapneumonic Effusion, Empyema, Pleural
Flush, Lyse, Operate
The goal of this observational study is to learn if saline results in improvement for patients with infection of their plerual space.
- Trial name
- FLO (NCT07592520)
- Testing
- Intrapleural Saline with possible escalation to intraplerual alteplase and dornase.
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Empyema, Pleural, Pleural Infection
Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas
Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest drains can get blocked by the drainage fluid and material.
- Trial name
- RELIEF (NCT06427538)
- Testing
- Saline Flush
- Where
- 5 sites in United States
- Volunteers
- 96 people
- Sponsor
- Vanderbilt University Medical Center
Complicated Parapneumonic Effusion, Pleural Empyema
Early Medical Thoracoscopy Versus Simple Chest Tube Drainage in Complicated Parapneumonic Effusion and Pleural Empyema
Multicenter, randomized controlled study to compare early mini-invasive thoracoscopy to simple chest tube drainage in complicated parapneumonic effusions or pleural empyema. 100 patients will be recruited.
- Trial name
- NCT00234208
- Testing
- Medical thoracoscopy, Simple chest tube drainage
- Where
- 5 sites in Greece, Italy and 1 more
- Volunteers
- 2 people
- Sponsor
- University Hospital, Basel, Switzerland
Empyema, Pleural, Pleural Effusion
Efficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and Empyema
1. Objectives: Main objective: To evaluate the efficacy and safety of intrapleural alteplase vs urokinase in patients with complex complicated parapneumonic pleural effusion and empyema.
- Conditions
- Empyema, Pleural, Pleural Effusion, Pleural Diseases
- Trial name
- NCT01246453
- Testing
- Intrapleurally Alteplase vs Intrapleurally Urokinase
- Where
- 2 sites in Spain
- Volunteers
- 204 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Pleural Effusion Associated With Pulmonary Infection, Bacterial Pleural Effusion Other Than Tuberculosis
Efficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/Empyemas
The purpose of this study is to document the efficacy and safety of intrapleural instillation of Activase vs Placebo in the management of complicated pleural effusions and empyemas
- Trial name
- CPE (NCT00468104)
- Testing
- Alteplase
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Midwest Pulmonary and Critical Care
Pleural Infection
Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic Effusion
The purpose of this study is to see if there is any benefit in adding saline irrigation through a chest tube to the standard course of treatment for people diagnosed or suspected of having a pleural space infection.
- Trial name
- NCT06434324
- Testing
- Saline Irrigation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Complicated Pleural Effusion/ Empyema
Effectiveness and Safety of Sodium Bicarbonate Pleural Lavage in the Treatment of Complex Pleural Effusion
The goal of this clinical trial is to evaluate the safety and efficacy of sodium bicarbonate pleural lavage in treating complex pleural effusion in adult.
- Trial name
- SAPLIC (NCT06734481)
- Testing
- Sodium bicarbonate pleural lavage, Saline pleural lavage
- Where
- China
- Volunteers
- 260 people
- Sponsor
- First Affiliated Hospital of Ningbo University