Clinical trials: Community-acquired Pneumonia
Bronchitis, Acute, Community-acquired Pneumonia
Multimodal Stewardship Programme to Improve Antibiotic Prescribing for Children With Lower Respiratory Tract Infections
Children with lower respiratory tract infection (LRTI) are still often prescribed antibiotics in ways that depart from national guidelines.
- Conditions
- Bronchitis, Acute, Community-acquired Pneumonia, Respiratory Tract Infections
- Trial name
- PRACTICE-LRTI (NCT07893834)
- Testing
- PRACTICE-LRTI multimodal antimicrobial stewardship programme
- Where
- Finland
- Volunteers
- 50,000 people
- Sponsor
- Tampere University
Community-acquired Pneumonia
The Optimal Antibiotic Treatment Duration for Community-acquired Pneumonia in Adults Diagnosed in General Practice in Denmark (CAP-D)
The aim of this randomised controlled trial is to identify the optimal treatment duration with phenoxymethylpenicillin for community-acquired pneumonia diagnosed in general practice.
- Trial name
- CAP-D (NCT06295120)
- Testing
- Phenoxymethylpenicillin 1.2 MIE 4 times daily
- Where
- Denmark
- Volunteers
- 307 people
- Sponsor
- Research Unit for General Practice in Aalborg
Community-acquired Pneumonia
Optimizing Care for Children Hospitalized With Community-acquired Pneumonia: Novel Diagnostics
Children are commonly hospitalized because of community-acquired pneumonia. Despite the fact that many of these children have viral disease, a majority is treated with antibiotics.
- Trial name
- PRESTO-1 (NCT06114888)
- Testing
- MeMed BV + Usual Care, Usual Care Alone
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Jeffrey Pernica
Sepsis
CLARITHROMYCIN TO PREVENT SECONDARY INFECTIONS IN PATIENTS WITH SEPSIS FOLLOWING LOWER RESPIRATORY TRACT INFECTIONS: THE CLASSIFY TRIAL
The goal of this clinical trial is to assess whether clarithromycin, given as an adjunct to standard-of-care antibiotic therapy, can reduce the risk of new infections and secondary sepsis in adult patients hospitalized with…
- Trial name
- CLASSIFY (NCT07834346)
- Testing
- clarithromycin
- Where
- 19 sites in Greece
- Volunteers
- 252 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Community Acquired Pneumonia (CAP)
Chest Radiography Versus Ultra-Low-Dose Chest Computed Tomography in Adults in the Emergency Department
Objective: To quantify and compare total staff person-time per imaging episode betweenconventional chest radiography (CXR) and ULDCT in adult emergency department patients in whom CAP is a differential diagnosis.
- Trial name
- TIME-CAP (NCT07870525)
- Testing
- ULDCT
- Where
- Denmark
- Volunteers
- 66 people
- Sponsor
- University of Southern Denmark
Pneumonia, Bacterial, Pneumonia Childhood
Discharge Stewardship in Children's Hospitals
The goal of this interventional study is to test if a discharge stewardship bundle is effective at reducing inappropriate antibiotic prescriptions at hospital discharge for children with the three common infections…
- Conditions
- Pneumonia, Bacterial, Pneumonia Childhood, Urinary Tract Infections, Soft Tissue Infections
- Trial name
- DISCO (NCT05826873)
- Testing
- Discharge antibiotic stewardship intervention
- Where
- 5 sites in United States
- Volunteers
- 1,131 people
- Sponsor
- Children's Hospital of Philadelphia
Community-acquired Pneumonia
AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia
This is an international, open-label, stratified randomized controlled trial with Bayesian adaptive stopping rules to compare the effects of therapeutic-dose heparin vs.
- Trial name
- ATTACC-CAP (NCT05848713)
- Testing
- Heparin
- Where
- 68 sites in United States, Brazil and 2 more
- Volunteers
- 4,000 people
- Sponsor
- University of Manitoba
Community-acquired Pneumonia, CAP
Inhaled Lexofloxacin vs Usual Care for Treatment of Community-Acquired Pneumonia
This trial aims to determine whether treatment with inhaled levofloxacin (an antibiotic) is equal to systemic antibiotic treatment (usual care) for patients admitted to a hospital with community-acquired pneumonia in regards to…
- Conditions
- Community-acquired Pneumonia, CAP, Community Acquired Pneumonia, Pneumonia
- Trial name
- LANDCAP 2 (NCT07843017)
- Testing
- Inhaled levofloxacin, Standard-of-care / Usual care
- Volunteers
- 460 people
- Sponsor
- Copenhagen Respiratory Research
Community-acquired Pneumonia
Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams
The purpose of this study is to compare effectiveness and safety of Azithromycin versus Doxycycline in adult patients hospitalized with community acquired pneumonia (CAP) treated with Beta-lactams.
- Trial name
- AD-CAP (NCT07164131)
- Testing
- Doxycycline, Azithromycin
- Where
- 5 sites in United States
- Volunteers
- 1,120 people
- Sponsor
- Mayo Clinic
Community-acquired Pneumonia, Community-Acquired Infections
Noninvasive Support Methods for Acute Respiratory Failure of Community-acquired Pneumonia
This randomized controlled trial aims to compare the efficacy and safety of high-velocity nasal insufflation (HVNI) versus standard noninvasive ventilation (NIV) in adult patients experiencing acute exacerbations of…
- Trial name
- NCT06996834
- Testing
- Non-Invasive ventilation (NIV), High Velocity Nasal Insufflation
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Community Acquired Pneumonia in Children, Antibiotic Stewardship
Antibiotic Prescription in Children Hospitalized for Community-acquired Pneumonia
A study to observe how often antibiotics are prescribed in children hospitalized for pneumonia and how doctors decide if a child needs antibiotics or not. Parent satisfaction will also be recorded.
- Trial name
- NCT04681339
- Testing
- Antibiotic treatment, No antibiotic treatment
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
Community-acquired Pneumonia
Clinical Reassessment Versus Procalcitonin in Order to Shorten Antibiotic Duration in Community-acquired Pneumonia
CLINPCT study is a prospective, randomized, controlled, open intervention clinical trial including adult patients admitted in the emergency department with community-acquired pneumonia.
- Trial name
- CLINPCT (NCT01723644)
- Testing
- the clinical reassessment arm, the procalcitonin arm
- Where
- 15 sites in France
- Volunteers
- 286 people
- Sponsor
- Nantes University Hospital
Community-acquired Pneumonia
Efficacy and Safety of Trimodulin (BT588) in Subjects With Severe Community-acquired Pneumonia (sCAP)
The main objective of the trial is to assess the efficacy and safety of trimodulin as adjunctive treatment to standard of care (SoC) compared to placebo plus SoC in hospitalized subjects with sCAP on invasive mechanical…
- Trial name
- ESsCAPE (NCT05722938)
- Testing
- Trimodulin
- Where
- 170 sites in United States, Argentina and 16 more
- Volunteers
- 590 people
- Sponsor
- Biotest
Community Acquired Pneumonia (CAP)
Ceftriaxone Dosage for Non-Critical Community-Acquired Pneumonia
Aim: Demonstrate the equivalent efficacy and superior safety of Ceftriaxone 1 gram daily compared with Ceftriaxone 2 grams daily among hospitalized patients with community-acquired pneumonia who are not admitted to the intensive…
- Trial name
- DC-CAP (NCT07537413)
- Testing
- Ceftriaxone 1 gram daily, Ceftriaxone 2 grams daily
- Where
- 4 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Maryland, Baltimore
Community-acquired Pneumonia (CAP)
TCM Cohort for Elderly CAP
This study evaluates the real-world clinical efficacy of traditional Chinese medicine (TCM) in elderly Community-acquired pneumonia (CAP) patients and explores syndrome characteristics and their associations with biomarkers.
- Trial name
- NCT07797686
- Testing
- Traditional Chinese medicine (TCM), Non-traditional Chinese medicine (non-TCM)
- Where
- China
- Volunteers
- 2,234 people, healthy volunteers welcome
- Sponsor
- Henan University of Traditional Chinese Medicine
Community-Acquired Pneumonia (CAP)
A Study to Learn How Effective is PCV20 to Help Stop Adults Who Have a Higher Chance of Getting Pneumonia
The purpose of this study is to learn how well PCV20 stops adults from getting community-acquired pneumonia. Pneumonia is an infection of the lungs that can be caused by germs like bacteria, virus, or fungi.
- Trial name
- NCT07251465
- Testing
- Receipt of PCV20
- Where
- United States
- Volunteers
- 846,279 people
- Sponsor
- Pfizer
Community-Acquired Pneumonia (CAP)
Lefamulin Post-Market Surveillance Study
Community-acquired pneumonia (CAP) refers to infectious parenchymal lung inflammation acquired outside hospital settings. In China, its incidence is 7.13 per 1000 person-years, with over 10 million new cases annually.
- Trial name
- NCT07697885
- Testing
- This is a multicenter, single-arm, non-interventional study. No interventional measures will be adopted.
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Marubeni Pharmaceuticals (Suzhou) Co., Ltd.
Influenza, Community-acquired Pneumonia
Fluad vs. Fluzone High-Dose Vaccine Effectiveness Among Adults ≥65 Years
This study will evaluate the relative vaccine effectiveness of quadrivalent adjuvanted inactivated influenza vaccine (aIIV4) versus quadrivalent high-dose inactivated influenza vaccine (HD-IIV4) in preventing polymerase chain…
- Conditions
- Influenza, Community-acquired Pneumonia, Cardiovascular Events
- Trial name
- NCT06029933
- Testing
- Adjuvanted Quadrivalent Inactivated Influenza Vaccine (aIIV4), High-Dose Quadrivalent Inactivated Influenza Vaccine (HD-IIV4)
- Where
- United States
- Volunteers
- 1,500,000 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Pneumonia, Community-Acquired, Bacterial Pneumonia
Efficacy and Safety of Faropenem in Bangladeshi Adult Patients With Community-Acquired Bacterial Pneumonia (CABP)
The goal of this clinical trial is to evaluate the efficacy and safety of faropenem in comparison to co-amoxiclav and clarithromycin in Bangladeshi adults diagnosed with community-acquired bacterial pneumonia (CABP).
- Trial name
- NCT06804096
- Testing
- Faropenem, Co-amoxiclav, Clarithromycin 500 mg
- Where
- 2 sites in Bangladesh
- Volunteers
- 129 people
- Sponsor
- Dr. Md. Alimur Reza
Nosocomial Pneumonia, Community-acquired Pneumonia
High-dose Inhalations of Nitric Oxide in the Treatment of Pneumonia
This is a multicenter, prospective randomized controlled trial. At least 2 but no more than 5 centers are expected to participate in the study.
- Trial name
- NO PNEUMONIA (NCT06170372)
- Testing
- 200 ppm Nitric Oxide
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences