Clinical trials: Common Mental Disorders
Schizophrenia, Schizotypal Disorder
Feasibility of a Novel Process-based Treatment for Patients With Psychosis
The purpose of this single-arm feasibility study is to develop and pilot test a novel process-based and modular group therapy approach for patients with acute psychotic symptoms in an inpatient setting.
- Conditions
- Schizophrenia, Schizotypal Disorder, Delusional Disorder, Brief Psychotic Disorder
- Trial name
- PROBAS (NCT04874974)
- Testing
- Metacognitive and Defusion Training
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Schizophrenia, Autism Spectrum Disorder
A Computational Neuroscience Perspective on the Shared Social Cognitive Deficits of Autism and Schizophrenia
This retrospective cohort study will examine shared neural mechanisms of social cognitive deficits in adults with autism spectrum disorder and adults with schizophrenia using existing clinical, behavioral, and neuroimaging data…
- Trial name
- NCT07618767
- Where
- Taiwan
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
HIV/AIDS, Alcohol-Related Disorders
Common Elements Treatment Approach HIV Alcohol Reduction Trial in Zambia
This study, which is part of the Zambia Alabama HIV Alcohol Comorbidities Program funded by NIH-NIAAA, is designed to examine the efficacy of brief and in-depth cognitive behavioral therapy-based interventions to address…
- Conditions
- HIV/AIDS, Alcohol-Related Disorders, Mental Illness
- Trial name
- CHARTZ (NCT05121064)
- Testing
- Alcohol Brief Intervention, Common Elements Treatment Approach, Standard of Care
- Where
- 5 sites in Zambia
- Volunteers
- 680 people
- Sponsor
- University of Alabama at Birmingham
Speech Sound Disorder
Sharing Books With Children
The promotion of language and communicative development in the early years is extremely important. Children who enter school with good language skills have better educational and economic success.
- Trial name
- NCT03006744
- Testing
- Phonological awareness training, Reading enjoyment training
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Manchester
Depressive Symptoms, Anxiety
Digital Mental Health and Wellness Intervention for Adults: A Randomized Control Trial of COMET
The investigators are evaluating the acceptability and effectiveness of brief online wellness modules. Participants will be randomly assigned to the intervention condition, an active control condition, or a wait-list control…
- Trial name
- COMET (NCT04586192)
- Testing
- Common Elements Toolbox- Adult version (COMET-A), Self-awareness Control
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Mental Illness, Shared Decision Making
Goal Elicitation, Treatment Prioritization, & Electronically-Practiced Discussion for Psychiatry
GET PrEPD-Psychiatry is a mixed-methods, developmental study to adapt a shared decision making (SDM) intervention to be specific for psychiatry decisions (Aim 1, previously completed), evaluate its feasibility and acceptability…
- Trial name
- GET-PrEPD (NCT04601194)
- Testing
- Coaching and Virtual Provider Program Practice
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Indiana University
Schizophrenia, Bipolar Disorder
Person-Centered Versus Measurement-Based Care in Mental Health
Fifteen minutes is the typical length of an outpatient medication management appointment for people with serious mental health conditions.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depression
- Trial name
- PCORI-SDM (NCT02507349)
- Testing
- Person-Centered Care, Measurement-Based Care
- Where
- 2 sites in United States
- Volunteers
- 2,443 people
- Sponsor
- University of Pittsburgh
Alcoholism
Chicago Social Drinking Project
This study attempts to elucidate the factors that contribute to escalation and maintenance of excessive ethanol drinking in young adults by: 1.
- Trial name
- CSDP (NCT00961792)
- Testing
- Ethanol, Diphenhydramine, Caffeine
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Chicago
Autism Spectrum Disorders
Pilot Study on Collaborative, Comprehensive, Multidimensional and Quality of Life Tools for Priority Definition, Shared Decision Making, Outcome Evaluation and Quality of Care Improvement in ASD Individuals and Programs in the Real World.
ASD is a very complex and lifelong disorder. Patients' functioning is influenced by multiple factors, including treatments, inclusion and life contexts.
- Trial name
- ASD Outcome (NCT07393152)
- Testing
- DD-CGAS (Wagner et al. 2007), Pediatric Quality of Life Inventory (PedsQL)., Child and Adolescent Needs and Strengths (CANS) (Lyons 2022)
- Where
- 3 sites in Italy
- Volunteers
- 400 people
- Sponsor
- Antonella Costantino
Depression, Anxiety
An Online Guided Self-help Intervention to Improve Common Mental Health Problems Among Medical Professionals
This randomized controlled trial (RCT) aims to evaluate the effectiveness of an online guided self-help intervention developed based on Problem Solving Therapy (PST) and Acceptance and Commitment Therapy (ACT), which are both…
- Trial name
- EMPOWER (NCT06910748)
- Testing
- E-training for Medical Professionals On Wellbeing and Effective Resolutions (E.M.P.O.W.E.R.), Education Materials
- Where
- Hong Kong
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Dementia, Staff Attitude
Pilot Testing Decision Making in Aging and Dementia for Autonomy Program in Nursing Homes
The purpose of this study is to adapt, pilot test, and evaluate the feasibility, acceptability, and preliminary effectiveness of DIGNITY (Decision-making In aGing and demeNtIa for auTonomY) for Preference-Based Care in Nursing…
- Conditions
- Dementia, Staff Attitude, Nurse's Role, Nursing Homes
- Trial name
- DIGNITY (NCT05618678)
- Testing
- DIGNITY, Infection Control
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Penn State University
Depression, Anxiety
A Transdiagnostic Course for Common Mental Health Problems in Primary Care
This study investigates the feasibility of a transdiagnostic course that is intended to work for a large variety of patient groups with clinically significant depression or anxiety in primary care.
- Trial name
- NCT04522713
- Testing
- Behavioral activation, evidence-based sleep strategies including sleep restriction, exposure-based strategies, promotion of physical activity and recuperating activities, psychoeducational material
- Where
- 2 sites in Sweden
- Volunteers
- 91 people
- Sponsor
- Karolinska Institutet
Psychological Distress, PTSD
Boosting Refugee Integration Through Psychological Intervention
Refugees and asylum seekers (RAS) face numerous stressors and adversities which put them at risk for developing mental health problems. However, access to adequate mental health care in host countries is limited.
- Conditions
- Psychological Distress, PTSD, Trauma, Common Mental Health Problems
- Trial name
- BRIGHT (NCT06776523)
- Testing
- Problem Management Plus
- Where
- Switzerland
- Volunteers
- 1,200 people
- Sponsor
- University of Zurich
Substance Abuse
A Phased-Implementation Feasibility and Proof-of-Concept Study to Assess Incorporating the NIDA CTN Common Data Elements (CDEs) Into the Electronic Health Record (EHR) in Large Primary Care Settings ("CDE-EHR-PC" Study), Phase 3
This is a 4-phase study to implement the NIDA CDEs in primary care settings. Collecting and utilizing the CDEs in clinical practice requires a strategy for implementing screening to collect substance use information that…
- Trial name
- NCT02963948
- Testing
- Meetings with implementation leader(s), the SAAS survey, Patient surveys
- Where
- 2 sites in United States
- Volunteers
- 113,123 people
- Sponsor
- NYU Langone Health
Alcohol Use Disorder, Depression
Zambia Common Elements Treatment Approach Pilot Study
This is a randomized controlled trial (RCT) evaluating the effectiveness of an alcohol brief intervention alone compared to the brief intervention plus an evidence-based psychotherapy (CETA) in reducing alcohol misuse and…
- Conditions
- Alcohol Use Disorder, Depression, Post-traumatic Stress Disorder, HIV/AIDS
- Trial name
- ZCAP (NCT03966885)
- Testing
- Brief Intervention, Common Elements Treatment Approach (CETA)
- Where
- Zambia
- Volunteers
- 160 people
- Sponsor
- Columbia University
Depression - Major Depressive Disorder, Anxiety
AtWork: The Relation Between Cognitive Functioning, Common Mental Disorders and Work Functioning
Depression and anxiety affects levels of function across different levels like work, increasing levels of sick leave and as well as cognitive functioning.
- Trial name
- AtWork (NCT07349550)
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Norwegian University of Science and Technology
Internet Gaming Disorder, Social Media Addiction
Chatbot Intervention to Reduce Common Digital Addictions, Sedentary Behaviors and Mental Distress Among Adolescents
The goal of the study is to investigate the efficacy of a secondary low-intensity stage of change (SoC) and motivational interviewing (MI)-based Chatbot-assisted intervention in reducing digital addictions in adolescents with…
- Trial name
- NCT06821373
- Testing
- Chatbot, Control
- Where
- Hong Kong
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Neurodevelopmental Disorders
Developmental Origins of Mental Health Disorders
Common mental disorders (CMD) such as Depression, contributes significantly to the global burden of disease. Fetal exposure to adverse intrauterine environment mediated by life course factors can enhance risk of non-communicable…
- Trial name
- NCT03096028
- Testing
- maternal vitamin B12 folate level during pregnancy
- Where
- India
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- Kem Hospital, Pune, India
Common Mental Health Problems, Anxiety
Trial of an Online Group Psychotherapy Intervention for Common Mental Health Disorders
The goal of this clinical trial is to understand how to deliver online group therapy for adults with common mental health problems in a personalised way.
- Conditions
- Common Mental Health Problems, Anxiety, Depression Disorders
- Trial name
- UpLift-X (NCT06722781)
- Testing
- Unified Protocol
- Where
- 2 sites in United Kingdom
- Volunteers
- 660 people
- Sponsor
- Rotherham Doncaster and South Humber NHS Foundation Trust
PTSD
Shared Decision Making for PTSD in Primary Care
PTSD is one of the most common mental health conditions affecting Veterans and is associated with significant burden. Highly effective treatments exist for PTSD, evidence-based psychotherapies, but very few Veterans receive them.
- Trial name
- PRIMED-PTSD (NCT04504149)
- Testing
- Patient Readiness for Improvement through Motivation, Engagement, and Decision-making for PTSD
- Where
- United States
- Sponsor
- VA Office of Research and Development