Clinical trials: Collagen Disorder
Epidermolysis Bullosa Dystrophica
Growth Hormone in EB
Growth is extremely affected in epidermolysis bullosa patients
- Trial name
- NCT05390073
- Testing
- growth hormone level and insulin like growth factor 1
- Volunteers
- 50 people
- Sponsor
- Cairo University
Scars, Keloids
Silicone vs Pirfenidone in the Treatment of Hypertrophic Scars and Keloids
Justification: Keloid scars are a major medical and cosmetic problem, especially in darker skin types that predominate in Mexico. It is estimated that hypertrophic scars affecting from 1.5 to 4.5% of the general population.
- Conditions
- Scars, Keloids, Hypertrophic Scar
- Trial name
- NCT06909812
- Testing
- pirfenidone 8% gel, silicon gel
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Fundación Nacional para la Enseñanza y la Investigación de la Dermatología A.C.
Breast Cancer
SurgiMend in Two-stage Implant-based Breast Reconstruction in Patients With Pre-Mastectomy Radiotherapy
This is a prospective clinical study comparing two-stage breast reconstruction following mastectomy with and without the use of SurgiMend® PRS fetal bovine collagen matrix in patients with pre-mastectomy radiation therapy.
- Trial name
- NCT01959867
- Testing
- SurgiMend® PRS, No Intervention
- Sponsor
- Integra LifeSciences Corporation
Diabetic Foot Ulcer
Safety and Efficacy of an Antibiotic Sponge in Diabetic Patients With a Mild Infection of a Foot Ulcer
The purpose of this study is to determine whether the gentamicin-collagen sponge when combined with standard of daily wound care is safe and effective in treating mildly infected skin ulcers compared to treatment with an oral…
- Trial name
- NCT00593567
- Testing
- gentamicin-collagen sponge, Levofloxacin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Innocoll
Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa
Phase 3, Open-label Clinical Trial of EB-101 for the Treatment of Recessive Dystrophic Epidermolysis Bullosa (RDEB)
The purpose of this trial is to evaluate safety and efficacy of surgical application of EB-101 (autologous, gene-corrected keratinocyte sheets) as a treatment of recessive dystrophic epidermolysis bullosa (RDEB).
- Trial name
- NCT04227106
- Testing
- EB-101
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Abeona Therapeutics, Inc
Glaucoma
Efficacy and Safety of Non-resorbable Uveoscleral Implant Versus Absorbable Collagen Matrix in Non-perforating Deep Sclerectomy
The aim of the study is to evaluate and compare the hypotensive efficacy at 24 months between non-perforating deep sclerectomy surgery with non-resorbable uveoscleral implant associated with absorbable collagen matrix versus…
- Trial name
- NCT04586738
- Testing
- non-perforating deep sclerectomy surgery
- Where
- 2 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Germans Trias i Pujol Hospital
Psoriatic Arthritis, Hand Rheumatism
Hand Exercises in Psoriatic Arthritis
This study is a randomized controlled study examining the effects of 8-week hand home exercises on grip strength, functionality, disease activity and quality of life in patients with PsA.
- Trial name
- NCT06263634
- Testing
- Hand exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Akdeniz University
Peri-implantitis
Reconstructive Treatment of Peri-implantitis With Combined Defects
The aim of this randomized clinical study is to assess the additional clinical benefit of incorporating a resorbable collagen membrane (CM) alongside a xenogeneic bone graft-specifically, deproteinized bovine bone mineral with…
- Trial name
- NCT06957652
- Testing
- DBMM-C plus Resorbable collagen membrane, DBMM-C
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Hyperkeratosis, Callus
Ultrasonographic Evaluation of Cosmetic Keratolytic Treatment of Foot Calluses and Corns
This prospective, non-randomized, controlled study evaluated the efficacy of a topical cosmetic keratolytic preparation (serum and cream containing urea, salicylic acid, and collagen) in reducing the thickness and associated pain…
- Conditions
- Hyperkeratosis, Callus, Corn (Clavus), Foot Dermatoses
- Trial name
- NCT07765225
- Testing
- Topical Keratolytic Cosmetic (Serum + Cream)
- Where
- Poland
- Volunteers
- 124 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Keratoconus
Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial
The purpose of this study is to determine whether corneal collagen crosslinking is effective in the treatment of progressive keratoconus.
- Trial name
- CXL-RCT (NCT01604135)
- Testing
- Corneal Collagen Crosslinking
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Sahlgrenska University Hospital
Keratoconus, Ectasia
Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2)
To evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional cross-links within or…
- Conditions
- Keratoconus, Ectasia, Degeneration
- Trial name
- NCT01097447
- Where
- 5 sites in United States
- Volunteers
- 2,619 people
- Sponsor
- Cxlusa
Keratoconus, Corneal Ectasia
Clinical and Structural Outcome of Conventional Versus Accelerated Corneal Collagen Cross-linking (CXL).
Compare different corneal parameters and visual outcome of corneal collagen cross-linking (CXL) with conventional versus accelerated ultraviolet-A irradiation using riboflavin with hydroxypropyl methylcellulose.
- Trial name
- CXL (NCT02883478)
- Testing
- UV-X 1000 (3 mW/cm²), UV-X 2000 (9 mW/cm²), riboflavin with hydroxypropyl methylcellulose
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Still's Disease Adult Onset
An Efficacy and Safety Study of GNR-086 (Canakinumab Biosimilar) and Ilaris® in Patients With Adult-onset Still's Disease
This is a randomized single-blind comparative parallel group study of the efficacy and safety of canakinumab biosimilar GNR-086 (JSC \"GENERIUM\", Russia) and Ilaris® (Novartis Pharma Stein AG, Switzerland) in the…
- Trial name
- NCT06497491
- Testing
- GNR-086, Ilaris®
- Where
- 17 sites in Russia
- Volunteers
- 118 people
- Sponsor
- AO GENERIUM
Osteogenesis Imperfecta
Safety of Fresolimumab in the Treatment of Osteogenesis Imperfecta
Osteogenesis Imperfecta (OI) is a rare disorder that causes bones to break easily. People with OI may have broken bones with little or no trauma, dentinogenesis imperfecta (DI), and, in adult years, hearing loss.
- Trial name
- NCT03064074
- Testing
- Fresolimumab
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Baylor College of Medicine
Rheumatologic Disorder
Identifying Novel Biomarkers in Early Rheumatology Patients
Patients new to a rheumatology practice will be asked if they want to consent to their blood sample, medical records, and hand/foot x-rays (with sharp scores) for the analysis and correlation with the diagnosis they will receive…
- Trial name
- NCT03843658
- Testing
- There is no intervention, but a diagnosis.
- Volunteers
- 300 people
- Sponsor
- Arthritis Northwest PLLC
Joint Hypermobility, Ehlers-Danlos Syndrome
Gait Retraining in Patients With Joint Hypermobility Syndrome/Hypermobile Ehlers Danlos Syndrome
This study evaluates the efficacy of gait retraining with biofeedback in the treatment of neuromusculoskeletal symptoms in patients with Joint Hypermobility Syndrome/Hypermobile Ehlers Danlos Syndrome.
- Conditions
- Joint Hypermobility, Ehlers-Danlos Syndrome, Hyperextension Knees
- Trial name
- NCT03575182
- Testing
- Gait retraining program
- Volunteers
- 12 people
- Sponsor
- University of South Florida
Alport Syndrome
Genotype-Phenotype Correlations in Patients With Alport Syndrome
Alport syndrome (AS) is caused by pathogenic variants in the type IV collagen genes COL4A3, COL4A4, and COL4A5. This study aims to enroll families and patients with a history of renal hematuria in 27 hospitals and detect these…
- Trial name
- NCT04947813
- Where
- China
- Volunteers
- 8,165 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Breast Cancer
Incorporation of AlloMaxTM in Breast Reconstruction Ver8-15-12
The purpose of this study is to measure the level of AlloMax™ incorporation (cellular infiltration, collagen production, and neovascularization) in human breast reconstruction.
- Trial name
- NCT01679223
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Nevada, Las Vegas
Osteogenesis Imperfecta, Rare Bone Disorders
Morphology in Oral Rare Syndromes & Artificial Intelligence for Clinical Diagnosis
MOSAIC aims to determine whether oro-dental morphological anomalies, particularly palatal morphology, associated with rare bone and cartilage diseases can be precisely characterized using 3D digital models analysed through…
- Conditions
- Osteogenesis Imperfecta, Rare Bone Disorders, Hypophosphatemia, X-Linked
- Trial name
- MOSAIC (NCT07666269)
- Testing
- intra-oral 3D optical impression
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Keratoconus
Collagen Cross-linking in Keratoconus
Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus.
- Trial name
- NCT03760432
- Testing
- Laser Custom Corneal Collagen Cross-Linking
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Oregon Health and Science University
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