Clinical trials: Colitis
Diarrhea
C. Difficile and Ursodiol
In vitro findings have established that ursodeoxycholic acid is a surrogate for deoxycholic acid in preventing the growth of C. difficile, and interrupting recurrence.
- Trial name
- NCT02748616
- Testing
- Ursodiol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- NYU Langone Health
Ulcerative Colitis
Study of the Safety and Tolerability of ALTH12 Versus Mesalamine Enema in Subjects With Left-Sided Ulcerative Colitis
This Phase I study will be a closely monitored trial of a small number of subjects to establish, preliminarily, the tolerability and safety of two ALTH12 enema formulations: ALTH12-1:4 and ALTH12-2:4.
- Trial name
- NCT01020708
- Testing
- mesalamine, ALTH12-1:4, ALTH12-2:4
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Altheus Therapeutics, Inc.
Clostridium Difficile Infection Recurrence
A Multi-center, Single-arm Trial Exploring the Safety and Clinical Effectiveness of RBX2660 Administered by Colonoscopy to Adults With Recurrent Clostridioides Difficile Infection
This trial will be initiated to explore whether RBX2660 (REBYOTA®) could be suitable for administration by the practice of colonoscopy.
- Trial name
- CDI-SCOPE (NCT05831189)
- Testing
- RBX2660
- Where
- 12 sites in United States
- Volunteers
- 41 people
- Sponsor
- Ferring Pharmaceuticals
Irritable Bowel Syndrome, Crohn Disease
Evaluation of the SIMBA Capsule for Small Intestinal Dysbiosis
The SIMBA Capsule is a small, single-use, ingestible capsule that allows for the non-invasive sampling of small bowel contents using purely mechanical means.
- Conditions
- Irritable Bowel Syndrome, Crohn Disease, Celiac Disease, Ulcerative Colitis
- Trial name
- NCT05633706
- Testing
- fluid biopsy capsule
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nimble Science Ltd.
Ulcerative Colitis Chronic Moderate, Ulcerative Colitis Chronic Severe
Autologous Platelet-rich Plasma (PRP) and Thrombin Coagulum for the Topical Treatment of Rectal Mucosal Ulcers
Ulcerative colitis (UC) is a chronic persistent inflammatory disease. The lesions are mainly confined to the large intestine and continuously affect the rectum and part or all of the colon.
- Conditions
- Ulcerative Colitis Chronic Moderate, Ulcerative Colitis Chronic Severe, Rectal Ulcer
- Trial name
- NCT05912712
- Testing
- Autologous Platelet-rich Plasma (PRP) and Thrombin Coagulum Treatment, Autologous Platelet-poor Plasma (PPP) and Thrombin Coagulum Treatment, Mesalazine Suppository Treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Ulcerative Colitis, Crohn's Disease
A Phase I Study of Etrolizumab Followed by Open-Label Extension and Safety Monitoring in Pediatric Patients With Moderate to Severe Ulcerative Colitis or Moderate to Severe Crohn's Disease
This study will evaluate pharmacokinetics, pharmacodynamics and safety of etrolizumab in pediatric patients of 4 to <18 years of age with moderate to severe ulcerative colitis (UC) or with moderate to severe Crohn's disease (CD).
- Trial name
- FENNEL (NCT03478956)
- Testing
- Etrolizumab
- Where
- 5 sites in Belgium, Poland and 2 more
- Volunteers
- 24 people
- Sponsor
- Hoffmann-La Roche
IBS - Irritable Bowel Syndrome, IBD - Inflammatory Bowel Disease
Relaxation Music for Chronic Pain
Chronic pain is a common complaint in inflammatory bowel disease (IBD). Compounding these concerns, opioid analgesics are frequently used to treat severe acute pain.
- Trial name
- NCT06993272
- Testing
- MIndful Jazz, Reggae Stereotypes, Traditional Mindfulness
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Irvine
Ulcerative Colitis
A Study of Pentasa in Patients With Ulcerative Colitis
Confirmation of safety profile of Pentasa slow release tablets 500 mg in patients with ulcerative colitis (UC).
- Trial name
- NCT01104753
- Where
- 30 sites in Czechia
- Volunteers
- 338 people
- Sponsor
- Ferring Pharmaceuticals
Ulcerative Colitis
Follow-up Study With Retarded Release Phosphatidylcholine in Ulcerative Colitis
Follow-Up Study with Retarded Release Phosphatidylcholine in Ulcerative Colitis Objectives: The objective of the study is to evaluate the follow up of patients treated with retarded release phosphatidylcholine in three…
- Trial name
- NCT00463619
- Testing
- Retarded release phosphatidylcholine
- Where
- Germany
- Volunteers
- 132 people
- Sponsor
- Heidelberg University
Clostridium Difficile-associated Diarrhea (CDAD)
IVIG Versus Placebo for the Treatment of Patients With Severe C-Diff
In this trial, eligible patients will be randomly assigned to receive a single dose of 400 mg/kg of IVIG or a normal saline infusion as placebo over 4-6 hours, in addition to their usual medications for CDAD.
- Trial name
- NCT00177970
- Testing
- intravenous immunoglobulin G (IVIG)
- Where
- 4 sites in United States
- Volunteers
- 14 people
- Sponsor
- University of Pittsburgh
Ulcerative Colitis
Hydrogen Sulfide Detoxification and Butyrate Metabolism in Ulcerative Colitis
The purpose of this study is to evaluate the relation between sulphide detoxification and butyrate metabolism at the level of gene expression and enzyme activity in ulcerative colitis patients and healthy controls.
- Trial name
- NCT01282905
- Where
- Belgium
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Ulcerative Colitis, Inflammatory Bowel Disease
Study Evaluating rhIL-11 in Left-Sided Ulcerative Colitis
To explore the safety of orally delivered rhIL-11 in patients with mild to moderate left-sided ulcerative colitis. To explore the effects of orally administered rhIL-11 on pharmacogenomics in blood samples and in colonic biopsy…
- Trial name
- NCT00038922
- Testing
- rhIL-11
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Inflammatory Bowel Diseases, Crohn Disease
Inflammatory Biomarkers and Disease Activity in Inflammatory Bowel Disease
This study aims to evaluate the diagnostic accuracy and clinical utility of routine blood-derived inflammatory biomarker ratios in assessing disease activity among adult patients with inflammatory bowel disease (IBD), including…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis (UC)
- Trial name
- NCT07788131
- Volunteers
- 120 people
- Sponsor
- Assiut University
Inflammatory Bowel Diseases, Periodontitis
Oral Health-related Quality of Life (OHRQoL) in Patients With Inflammatory Bowel Disease (IBD)
IBD patients have a higher risk of oral diseases that affect the oral mucosa, the teeth and the tooth supporting tissues. These conditions are often associated with pain, bleeding and impaired masticatory function which may have…
- Conditions
- Inflammatory Bowel Diseases, Periodontitis, Dental Caries, Tooth Loss
- Trial name
- OQal-MICI (NCT05096897)
- Testing
- Self-administrated questionnaires
- Where
- France
- Volunteers
- 138 people
- Sponsor
- University Hospital, Lille
Ulcerative Colitis
The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis
The purpose of this study is to investigate if circadian malalignment (unusual sleeping patterns), such as night shifts (sleeping during the day and being awake during the night time), worsens the inflammation of the gut.
- Trial name
- NCT05180279
- Testing
- 7-day sleep lab
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Pouchitis, Ulcerative Colitis
Assessment of Patients With Acute Pouchitis Treated With Antibiotics
The purpose of this study is to evaluate the reliability and responsiveness of symptoms, endoscopic, and histological items for assessing pouchitis disease activity in patients undergoing standard of care (SOC) antibiotic therapy…
- Trial name
- NCT05252273
- Testing
- Observational, No intervention
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 43 people
- Sponsor
- Alimentiv Inc.
Quality of Life, Ulcerative Colitis
Association Between Self-reported Web-based SCCAI and Health-related Quality of Life Index in UC Patients
An accurate assessment of disease activity is crucial for the treatment of patients with ulcerative colitis (UC). Recent studies have reported that the Simple Clinical Colitis Activity Index (SCCAI) correlates well with Mayo…
- Trial name
- UC (NCT04197973)
- Where
- South Korea
- Volunteers
- 225 people
- Sponsor
- YooJin Lee
Ulcerative Colitis
Etrasimod Dose-Ranging Versus Placebo as Induction Therapy Study in Adult Japanese Subjects With Moderately to Severely Active Ulcerative Colitis
The purpose of this Japan-only study is to assess the safety and efficacy of etrasimod at 2 doses in Japanese subjects with moderately to severely active ulcerative colitis (UC) when administered for 12 weeks.
- Trial name
- NCT05061446
- Testing
- Etrasimod
- Where
- 80 sites in Japan
- Volunteers
- 54 people
- Sponsor
- Pfizer
Ulcerative Colitis
(CB-01-02/04) Extension Study of Budesonide Multi-Matrix System (MMX) 6 mg in Maintenance Of Remission In Patients With Ulcerative Colitis.
Randomized, double-blind, comparative study versus placebo performed in patients from studies CB-01-02/01 (NCT00679432), CB-01-02/02 (NCT00679380), or CB-01-02/06 (NCT01100112) who achieved ulcerative colitis disease activity…
- Trial name
- NCT00801723
- Testing
- Budesonide MMX 6 mg Tablet
- Where
- 58 sites in United States, Canada
- Volunteers
- 123 people
- Sponsor
- Bausch Health Americas, Inc.
Inflamatory Bowel Disease, Crohn Disease (CD)
Safety and Efficiency of the Universal CNK-UT009 in Difficult-to-treat Inflammatory Bowel Disease Patients
Inflammatory bowel disease patients who failed from at least two types of biologics or suffered refractory after at least twice surgery are defiened as difficult-to-treat IBD.
- Conditions
- Inflamatory Bowel Disease, Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- NCT07416383
- Testing
- injection of CNK-UT009
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine