Clinical trials: Cold Exposure
Healthy Adult Male, Appetite
Effects of Cold-Water and Cold-Air Exercise on Appetite, Energy Intake, and Food Preference
This study investigated whether exercising in cold environments affects appetite, energy intake, and food preference compared with exercising in thermoneutral conditions.
- Conditions
- Healthy Adult Male, Appetite, Energy Intake
- Trial name
- NCT07681011
- Testing
- Control Condition, Cold-Water Exercise, Thermoneutral Water Exercise
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Coventry University
Cold Exposure
Oxytocin on Cold Water Task Performance and Recovery
Naval Special Warfare (NSW) operators are exposed to a variety of extreme environmental conditions and intense physical demands.
- Trial name
- NCT04738838
- Testing
- Oxytocin nasal spray
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Florida Institute for Human and Machine Cognition
Cold Exposure
The Effects of Cold Adaptation on Skin Blood Flow, Hand Function, and Comfort in Healthy Adults
In cold weather environments, blood flow to the extremities is significantly reduced, which severely impairs hand function and induces thermal discomfort.
- Trial name
- NCT05464758
- Testing
- Repeated cold exposure
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
Cold-Region Exposure and Cardiac Remodeling After PCI
This multicenter prospective observational cohort study aims to investigate the association between cumulative cold-region exposure and adverse left ventricular remodeling and cardiovascular outcomes in patients with coronary…
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention (PCI), Left Ventricular Remodeling, Cold Exposure
- Trial name
- COLD-PCI (NCT07773870)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Chinese PLA General Hospital
Cold-water Immersion, High Heat Sauna
Thermodynamic Exposure and Sleep in Military Cadets
This pilot study investigates the effects of cold-water immersion, traditional sauna use, and their combination on sleep architecture and psychological health in military cadets.
- Conditions
- Cold-water Immersion, High Heat Sauna, Combination of Cold-water Immersion and High Heat Sauna
- Trial name
- NCT07201935
- Testing
- Cold Water Immersion, High Heat Sauna
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Asthma, Exercise-Induced
The Effect of Physical Exercise in a Cold Air Environment on Normal Volunteers and Asthmatic Patients
The purpose of the study is to compare airway physiologic reactions to physical exercise in a cold air environment (-5°C, 60% relative humidity) between normal volunteers and subjects with mild/moderate asthma.
- Trial name
- ALASCAIR1 (NCT03840044)
- Testing
- Cold air exercise test
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Brown Adipose Tissue (BAT) Physiology, Cold Exposure
Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity
The purpose of the study is to asses brown adipose tissue activity after a cold mild stimulus, preceded by 200mg caffeine or placebo administration.
- Trial name
- ACROBAT (NCT06978777)
- Testing
- Caffeine (200 mg)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity (Disorder)
JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity
The Joule MARS study is a single center, randomized, open label clinical trial aiming to explore the metabolic adaptations that occur in response to weight management in adolescents with obesity.
- Trial name
- JOULE-MARS (NCT06852391)
- Testing
- Semaglutide Pen Injector, Behavioural Lifestyle Program (BLP)
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- McMaster University
Cold Exposure
Comparison of the Analgesic Effects of Acupuncture and Modulated Electroanalgesia in Cold Induced Pain
Physiotherapy offers a range of therapeutic modalities for pain management including Transcutaneous Electrical Nerve Stimulation (TENS), Interferential current (IC) and Acupuncture.
- Trial name
- NCT01483885
- Testing
- Transcutaneous Electric Nerve Stimulation, Interferential Current, Manual Acupuncture
- Where
- Brazil
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Piauí
Brown Adipose Tissue, Metabolic Disease
Brown Adipose Tissue as Nutrient Buffer Through Diet Induced Thermogenesis
To test the hypothesis that active BAT improves metabolic health by buffering postprandial metabolites plasma metabolites and energy expenditure will be compared in volunteers with and without active BAT.
- Trial name
- BANDIT (NCT06078345)
- Testing
- Carbohydrate, Fat, Protein
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy Lifestyle
BATokines as Biomarkers of Brown Fat in Humans
Brown adipose tissue (BAT) burns excess calories to produce heat in response to environmental cold. Rapidly growing evidence from rodent and human studies suggests that the presence and activation of brown fat are far more…
- Trial name
- NCT05050240
- Testing
- Cooling Vest Procedure, Fasting overnight
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Cognitive Function
Acute Effects of Cold Exposure on Cognitive Function
This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of low-temperature exposure on cognitive function and the underlying mechanisms.
- Trial name
- NCT06654167
- Testing
- Low temperature (15℃) group, Moderate temperature (22℃) group
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fudan University
Sleep Deprivation, Cold Exposure
Modafinil to Optimize the Performance of Cold-Stressed Sleep-Deprived Personnel
Environmental and workplace stressors are common and often unavoidable in military operations. Two critical stressors are cold stress and sleep loss. They both can substantially degrade operational effectiveness.
- Trial name
- NCT07830056
- Testing
- Modafinil (M), 200 mg Microcrystalline Cellulose
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Hypertension
High-Dose Quinapril Versus Low-Dose Quinapril Plus Amlodipine in the Treatment of High-Risk Hypertensive Patients
The purpose of this study is to compare the impact of two blood pressure lowering treatments (high dose quinapril versus low dose quinapril plus amlodipine) on variations in heart rate over 24 hours.
- Trial name
- NCT00313547
- Testing
- Quinapril 40 mg, Quinapril 10 mg and amlodipine 5 mg
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Montreal Heart Institute
Cold Exposure, Body Temperature Regulation
Hand Cooling With Ice Packs in Healthy Young Men
This randomized, parallel-group study looked at how a standard 15-minute ice pack applied to the back of the hand affects skin temperature and how cold and comfortable the hand feels, compared with a room-temperature water pack.
- Conditions
- Cold Exposure, Body Temperature Regulation, Thermal Comfort Perception
- Trial name
- ICEHAND (NCT07254182)
- Testing
- Ice Pack (Localized Cryotherapy), Thermoneutral Water Pack (Control)
- Where
- Poland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Cold Exposure
Effects of Winter Swimming on Blood Indicators and Oxidative Stress in Males
Exposure of the human body to cold water triggers numerous beneficial physiological changes. The study aimed to assess the impact of regular winter swimming on blood morphological, rheological, and biochemical indicators and…
- Trial name
- NCT06223087
- Testing
- winter swimming
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland
Lower Respiratory Tract Infection (LRTI)
Procalcitonin Antibiotic Consensus Trial (ProACT)
The ProACT study is a 5 year, multicenter study that will test the effect of implementation of a novel procalcitonin guideline on antibiotic use and adverse outcomes in Emergency Department (ED) patients with Lower Respiratory…
- Trial name
- ProACT (NCT02130986)
- Testing
- Procalcitonin level, Results of procalcitonin (PCT) level to treating clinician, Provide procalcitonin guideline to treating clinician
- Where
- 13 sites in United States
- Volunteers
- 1,664 people
- Sponsor
- University of Pittsburgh
Obesity
Metabolism and Thyroid Hormone Changes During Exposure to Cold Temperatures
This study will examine how body metabolism adjusts to small changes in environmental temperature and how it may be related to weight loss.
- Trial name
- NCT00521729
- Testing
- Exposure to Cold Temperature
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Deglutition Disorders, Respiratory Aspiration
Cold Liquids Fed to Preterm Infants: Efficacy and Safety After 10 Minutes of Exposure
A previous study revealed that dysphagia preterm infants show statistically significant improvements in their swallowing mechanism when fed cold liquid barium when compared to room temperature liquid barium.
- Trial name
- NCT02935946
- Testing
- Cold Liquid Barium
- Where
- United States
- Volunteers
- 4,043 people
- Sponsor
- NYU Langone Health
Healthy
Chronic Cold Exposure and Energy Metabolism in Humans
Background: Researchers are studying how metabolism and hormone levels change in response to mild changes in environmental temperature. Changes in metabolism may lessen with time because of hormonal adaptations.
- Trial name
- NCT01730105
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)