Clinical trials: Cold, open to volunteers
Open Heart Surgery
The Effect of Rapid Relaxation Exercise and Cold Application on Pain, Anxiety, and Satisfaction Before Chest Tube Removal
A chest tube is inserted to drain air, fluid, or blood from the pleural space and is vital for restoring respiratory function in the postoperative period.
- Trial name
- NCT07248085
- Testing
- Cold Application, Rapid Relaxation Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people
- Sponsor
- Ataturk University
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Kidney Failure, Chronic, Kidney Transplantation
Drone Transport of Deceased-Donor Kidney Grafts Between Two French Hospitals Before Transplantation: a Pilot Safety Study
Cold ischemia time, the period during which a donated kidney is kept cold outside the body between its removal from the donor and its transplantation into the recipient, is one of the main modifiable factors influencing how…
- Conditions
- Kidney Failure, Chronic, Kidney Transplantation, Delayed Graft Function, Cold Ischemia
- Trial name
- RAfALREIN (NCT07851571)
- Testing
- Kidney graft transport by autonomous unmanned aircraft (drone) between the procurement and transplantation centres
- Volunteers
- 5 people
- Sponsor
- Nantes University Hospital
Primary Health Care, Lower Respiratory Tract Infection
CRP and Lung Ultrasound in Respiratory Evaluation
Lower respiratory tract infections (LRTIs) are one of the most common reasons for consultation in Primary Care centres. Differentiating between viral and bacterial aetiologies can be challenging, leading to inappropriate…
- Trial name
- PLURE (NCT06294899)
- Testing
- Lung ultrasound, C-Reactive Protein Test
- Volunteers
- 202 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Benign Colon Tumors
Comparison of Cold and Hot Loop Resection Techniques for the Removal of Medium-sized Benign Colon Tumors
Widespread introduction of high-resolution videocolonoscopy into clinical practice has led to an increase in the detection of epithelial lesions of the colon, a significant portion of which are small (<10 mm) and miniature (≤5…
- Trial name
- chs (NCT07041255)
- Testing
- Cold endoscopic mucosal resection, Hot endoscopic mucosal resection
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Pirogov Russian National Research Medical University
Vaccines, Vaccines Adverse Reaction
A Multifaceted Intervention on Reducing Immunization Errors
The goal of this trial is to reduce the general error related to vaccines and immunizations (composited on secondary endpoint), after 11 moths of folow-up after cluster randomization and stepped wedge on primary care on brazilian…
- Conditions
- Vaccines, Vaccines Adverse Reaction, Vaccine Practice
- Trial name
- THEIA (NCT06745635)
- Testing
- Usual Care, Multifaceted intervention
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hospital Israelita Albert Einstein
Acute Respiratory Tract Infection
A Long-term Observational Study Evaluating the Presentation and Management of Acute Respiratory Tract Infections in Primary Care Across Europe
Acute respiratory infection (ARI) is the commonest reason for consulting in community care. Furthermore, new and re-emerging pathogens are often first noticed in primary care (PC).
- Trial name
- POS-ARI-PC (NCT06282718)
- Where
- 3 sites in Belgium, France and 1 more
- Volunteers
- 2,000 people
- Sponsor
- European Clinical Research Alliance for Infectious Diseases (ECRAID)
Autoimmune Hemolytic Anemia, Immune Thrombocytopenia
Prospective Evaluation of Diagnosis and Treatment of Patients With Autoimmune Cytopenias Including Autoimmune Hemolytic Anemia, Immune Thrombocytopenia, and Chronic Idiopathic/Autoimmune Neutropenia
The goal of this observational study is to characterize the diagnostic and therapeutic management of autoimmune cytopenias including autoimmune hemolytic anemia, immune thrombocytopenia, and chronic idiopathic/autoimmune…
- Conditions
- Autoimmune Hemolytic Anemia, Immune Thrombocytopenia, Chronic Idiopathic Neutropenia, Autoimmune Neutropenia
- Trial name
- AIHA ITP CIN (NCT05931718)
- Testing
- cytokine essays, NGS, Fecal microbiome
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic
Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury
The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect…
- Conditions
- Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal Stimulation
- Trial name
- NCT06841198
- Testing
- spinal cord transcutaneous stimulation, Ice testing
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Cold Atmospheric Plasma (CAP), J-Plasma
Effects of Cold Atmospheric Plasma (CAP) on Peritoneal Tumor Tissue
There are to date no studies available that have examined the effects of CAP on tumor tissue in patients. The aim of this study is to investigate these effects in patients undergoing surgery for peritoneal metastases.
- Conditions
- Cold Atmospheric Plasma (CAP), J-Plasma, Peritoneal Tumor
- Trial name
- NCT06796634
- Testing
- J-plasma
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- University Hospital, Ghent
Acute Respiratory Tract Infection, Ear Infection
Enhanced Telemedicine in Primary Care for Acute Respiratory Tract Infections Study
Young children often receive antibiotics for pediatric acute respiratory tract infections (ARTIs) - common childhood diagnoses like ear infections, strep throat, sinusitis, and colds - but many of these antibiotics are prescribed…
- Conditions
- Acute Respiratory Tract Infection, Ear Infection, Throat Infection, Acute Respiratory Tract Infections
- Trial name
- Tele-PARTI (NCT07845526)
- Testing
- Tele-Otoscope Enabled Primary Care, eBook-supported primary care
- Where
- 2 sites in United States
- Volunteers
- 450 people
- Sponsor
- University of Pittsburgh
Intrauterine Adhesion
Investigating the Association Between Diagnostic and Therapeutic Management Models and Prognosis of Intrauterine Adhesions Based on a Large-Scale Prospective Cohort Study
This research plan aims to explore a new diagnosis and treatment management model for intrauterine adhesions and verify its efficacy and feasibility through a multicenter real-world study.
- Trial name
- NCT07421908
- Testing
- Transcervical resection of adhesion, Uterine cavity stent, Traditional Chinese medicine for tonifying the kidney
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Muscle Soreness
Cold Vs Warm Water Immersion for DOMS Recovery
The study investigates the effectiveness of physical strategies in addressing Delayed Onset Muscle Soreness (DOMS) in physically active individuals.
- Trial name
- NCT06804564
- Testing
- Cold Water Immersion (CWI), Hot Water Immersion (HWI), Simulated Laser Therapy
- Where
- Poland
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Józef Piłsudski University of Physical Education
Polyp of Colon, Endoscopic Mucosal Resection
Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.
The goal of this randomized clinical trial is to learn if a combination of hot and cold EMR technique is associated with a lower risk of polyp recurrence without increasing the risk of complication when removing large polyps.
- Trial name
- NCT06937671
- Testing
- Cold EMR, Hybrid EMR
- Where
- 2 sites in United States
- Volunteers
- 194 people
- Sponsor
- The Cleveland Clinic
Asthma in Children, Atopy
Omalizumab Before Onset of Exacerbations
OBOE is a prospective, pilot, parallel group RCT with the overall aim of examining the effect of a single dose of anti-IgE (omalizumab) vs.
- Conditions
- Asthma in Children, Atopy, Viral Upper Respiratory Infection
- Trial name
- OBOE (NCT05332067)
- Testing
- Omalizumab
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Children's National Research Institute
Hamstring Injuries, Hamstring Muscle Repair
Thermal Therapies in the Treatment of Muscle Injuries
Muscle strain injuries represent one of the most prevalent injuries in athletes. Despite this high injury prevalence, there is no evidence to support some of the currently used therapeutic strategies.
- Conditions
- Hamstring Injuries, Hamstring Muscle Repair, Hamstring Muscles, Hamstring Rupture
- Trial name
- NCT07045129
- Testing
- Cold water immersion, Hot water immersion, Physiotherapy only
- Where
- Qatar
- Volunteers
- 135 people
- Sponsor
- Aspetar
Acute Respiratory Tract Infection
PCOT for Outpatients With Acute Respiratory Tract Infection at Risk of Severe Disease in Primary Healthcare
This study aims to evaluate the clinical value of point-of-care multiplex PCR testing (POCT) in guiding early diagnosis and target treatment for acute respiratory infections in primary healthcare settings.
- Trial name
- NCT07159230
- Testing
- point-of-care multiplex PCR test
- Where
- China
- Volunteers
- 16,868 people
- Sponsor
- Capital Medical University
AIHA - Warm Autoimmune Hemolytic Anemia, AIHA - Cold Autoimmune Hemolytic Anemia
A Multicenter Prospective Study of Iptacopan in the Treatment of Refractory/Relapsed Autoimmune Hemolytic Anemia (AIHA)
To evaluate the efficacy and safety of ipecopam in the treatment of refractory/relapsed AIHA.
- Trial name
- NCT06847607
- Testing
- Iptacopan
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Bing Han
Non-Prescription Drug Misuse, Acute Respiratory Tract Infection
Interventions on Non-prescription Dispensing of Antibiotics in Community Pharmacies
This study was a randomized controlled trial conducted in community pharmacies. Empirical data were collected primarily using standardized patient methods.
- Trial name
- NCT06521892
- Testing
- social surveillance and health education interventions
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Huazhong University of Science and Technology
Obesity (Disorder)
Mechanisms of Weight Loss: Tirzepatide vs Semaglutide
The goal of this clinical trial is to determine if there are differences in the effect of 12 weeks of tirzepatide versus semaglutide on energy balance in adults with obesity and without known diabetes.
- Trial name
- JOULE3 (NCT07900074)
- Testing
- Tirzepatide, Semaglutide
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University