Clinical trials: Cognitive Reserve, active
Stroke, Ischemic Stroke
Detecting and Predicting Post-stroke Cognitive Impairment Using the Oxford Cognitive Screen
Cognitive problems are common after a stroke and must be identified early so that rehabilitation can be initiated to improve outcome.
- Conditions
- Stroke, Ischemic Stroke, Hemorrhagic Stroke, Intracerebral, Cognitive Dysfunction
- Trial name
- OCS-PRECISE (NCT07897916)
- Where
- 2 sites in Denmark
- Volunteers
- 180 people
- Sponsor
- University of Copenhagen
Mild Cognitive Impairment, Cognitive Dysfunction
Effects of a Computerized Cognitive Stimulation Intervention Adapted to the Level of Cognitive Reserve
Normal ageing presents subtle cognitive changes that can be detected before meeting the criteria for Mild cognitive impairment (MCI).
- Trial name
- NCT06279325
- Testing
- Computerized cognitive stimulation program, Face-to-face training-explanatory session
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
First-ever Ischemic Stroke, Cognitive Performance
Post-stroke Cognitive Impairment
Present study aims to track the post-stroke cognitive trajectories and to investigate its inter-individual variability.
- Trial name
- CogStroke (NCT05653141)
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- Roza Umarova
Primary Progressive Aphasia, Dementia
Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
Difficulties with speech and language are the first and most notable symptoms of primary progressive aphasia (PPA). While there is evidence that demonstrates positive effects of speech-language treatment for individuals with PPA…
- Conditions
- Primary Progressive Aphasia, Dementia, Dementia, Frontotemporal, Alzheimer Disease
- Trial name
- NCT05741853
- Testing
- Video-Implemented Script Training for Aphasia (VISTA), Lexical Retrieval Training (LRT)
- Where
- 3 sites in United States, Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stephanie Grasso
Frailty at Older Adults
Enhancing Physical Reserve to Promote Resilience in Physically Frail Older Adults
The goal of this clinical trial is to assess the efficacy of combined aerobic and resistance training in enhancing physical reserve in older adults with physical frailty.
- Trial name
- MRI exercise (NCT07513701)
- Testing
- Aerobic and resistance training, Usual Care
- Where
- Hong Kong
- Volunteers
- 224 people
- Sponsor
- The Hong Kong Polytechnic University
Surgery Complications
The ACCELERATE Pilot Trial
The Advancing Cognition and Cognitive reserve before ELective surgery to Enhance cognitive Recovery And TrajEctories (ACCELERATE) Pilot Trial estimates whether our novel, coach-supported cognitive prehabilitation strategy will…
- Trial name
- NCT07655414
- Testing
- Cognitive Prehabilitation
- Where
- Canada
- Volunteers
- 103 people
- Sponsor
- Ottawa Hospital Research Institute
Heart Failure (HF)
A Study on the Correlation Between Cardiac-Cerebral Oxygenation Reserve and Cognitive Function Changes in Heart Failure Patients
At different stages of heart failure (HF), the cardiac and cerebral oxygen reserve exhibits varying degrees of decline due to chronic hypoxia and microvascular dysfunction caused by reduced cardiac output, leading to cognitive…
- Trial name
- NCT07485816
- Testing
- breathing training
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University
ADHD, BD
A Novel Psychological Intervention for Adults With Bipolar Disorder and Attention Deficit Hyperactivity Disorder Comorbidity (VECTOR)
Cognitive dysfunctions are present in Bipolar Disorder (BD) and Attention Deficit Hyperactivity Disorder (ADHD) and may negatively impact psychosocial functioning.
- Trial name
- VECTOR (NCT07039903)
- Testing
- Cognitive behavioral therapy (CBT) + Functional Remediation (FR)
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Post-Intensive Care Syndrome (PICS), Critical Illness
Inflammatory and Genetic Predictors of Cognitive and Emotional Recovery After Critical Illness
Survivors of critical illness frequently develop persistent cognitive and emotional impairments, known as post-intensive care syndrome (PICS), which substantially impact quality of life and long-term recovery.
- Trial name
- CORE-ICU (NCT07659431)
- Volunteers
- 114 people
- Sponsor
- Corporacion Parc Tauli
Alzheimer Disease, Transcranial Magnetic Stimulation
Advantage of Cerebellar Transcranial Magnetic Stimulation in Alzheimer's Diseases （ACT-AD）
Alzheimer's Disease (AD) is the primary cause of dementia, with its prominent feature being cognitive decline. The cerebellum plays a crucial role in cognitive processing, making it a potential target for therapeutic…
- Conditions
- Alzheimer Disease, Transcranial Magnetic Stimulation, Cerebellum
- Trial name
- NCT06669182
- Testing
- Intermittent Theta-Burst Transcranial Magnetic Stimulation
- Where
- 4 sites in China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Mild Cognitive Impairment (MCI)
Enhancing Attention in Elderly Using a Brain-Computer-Interface
Cognitive reserve refers to the brain's ability to maintain cognitive performance despite age-related changes or neuropathology.
- Trial name
- NCT07441122
- Testing
- transcranial electrical stimulation, Mindfulness Meditation
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Mild Cognitive Impairment (MCI)
Assessment of Motor Reserve in the Preclinical Stages of Dementia
Mild Cognitive Impairment (MCI) is a clinical condition associated with an increased risk of progression to dementia. Although cognitive alterations have traditionally been the main focus of investigation, growing evidence…
- Trial name
- NCT07634055
- Testing
- Sensor-based medical device for kinematic assessment: Hand Test System (HTS)
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Postoperative Cognitive Decline, Postoperative Delirium
Increasing Preoperative Cognitive Reserve to Prevent Postoperative Cognitive Dysfunction in Cardiac Surgical Patients
Postoperative delirium (POD) and postoperative cognitive decline (POCD) can be observed after cardiosurgical interventions. Taken together, these postoperative neurocognitive dysfunctions contribute to increased morbidity and…
- Conditions
- Postoperative Cognitive Decline, Postoperative Delirium, Postoperative Cognitive Dysfunction
- Trial name
- INCORE (NCT04493996)
- Testing
- Cognitive training
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heart and Brain Research Group, Germany
Multiple Sclerosis
Sociocognitive Intervention and Rehabilitation Program in Multiple Sclerosis
Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system, involving inflammation, demyelination, and neurodegeneration. It is the most common non-traumatic disabling disease affecting young adults.
- Trial name
- REACT-MS (NCT07734675)
- Testing
- Sociocognitive rehabilitation via COGWEB platform combined with an emotional processing intervention.
- Where
- 2 sites in Portugal
- Volunteers
- 130 people
- Sponsor
- Sonia Batista
Terminal Illness, End-of-Life Care
Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence
Background: Recent electroencephalography (EEG) data indicate that the transition from clinical death to cellular death is marked by highly organized neurophysiological events, including significant surges in gamma-band power…
- Conditions
- Terminal Illness, End-of-Life Care, Death, Brain Death
- Trial name
- NeuroCogPresv (NCT07477028)
- Volunteers
- 20 people
- Sponsor
- Noah Tech, Corp.
Active Aging Individuals Aged 65 and Over, Aging
Italian Validation of the dNA Scale and Its Correlation With Neurocognitive Variables
The goal of this experimental multicentric intervention study is to validate, in Italian, the dynamic Neurocognitive Adaptation (dNA) Scale, which has already been validated in English, among a healthy elderly population (aged 65…
- Conditions
- Active Aging Individuals Aged 65 and Over, Aging, Mild Cognitive Impairment (MCI), Dementia
- Trial name
- NCT07533084
- Where
- 8 sites in Italy
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS