Clinical trials: Cognitive Recovery After Stroke
Stroke
Brain-computer Interface With Plantar Pneumoorthoses for Post-stroke Rehabilitation
STUDY PURPOSE The investigators are testing a new rehabilitation system that helps stroke patients recover their ability to walk and think more clearly.
- Trial name
- BRAIN-WALK (NCT07081308)
- Testing
- NIRS-BCI-pneumoorthesis
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Research Center of Neurology, Russia
Stroke Patients, Stroke
Young Stroke Service Deep Phenotyping: Exploring Recovery in Young Adult Survivors of Stroke
The Investigators are running a small, early-phase research study across several hospitals in Melbourne, Australia. The study will involve up to 100 young adults between the ages of 18 and 55 who have had a stroke.
- Conditions
- Stroke Patients, Stroke, Stroke; Sequelae, Young Adults
- Trial name
- NCT07019493
- Testing
- Observational Cohort
- Where
- 2 sites in Australia
- Volunteers
- 100 people
- Sponsor
- The Florey Institute of Neuroscience and Mental Health
Post Stroke Delirium, Cognitive Functioning After Stroke
Cognitive Recovery After Post Stroke Delirium (RECOVER)
RECOVER is a Proof-of-Concept study on cognitive functioning following a longitudinal design with three measurements (during the acute- and post-acute phases of a stroke and a 3-month follow-up) and two equally-sized stroke…
- Trial name
- RECOVER (NCT06680336)
- Testing
- Mulit-componant neuropsychological assessment, Multimodal MRI
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Tuebingen
Chronic Cerebral Ischemia
Safety and Efficacy of Sequential Therapy With Mexidol® in Patients With Chronic Cerebral Ischemia
The purpose of this study is to evaluate safety and efficacy of sequential treatment with Mexidol® in patients with chronic cerebral ischemia (CCI).
- Trial name
- MEMO (NCT06834490)
- Testing
- Mexidol
- Where
- 14 sites in Russia, Uzbekistan
- Volunteers
- 318 people
- Sponsor
- Pharmasoft
Trephined Syndrome, Sinking Skin Flap Syndrome
Prevalence of Trephined Syndrome After Decompressive Craniectomy
Decompressive craniectomy is frequently used to treat increased intracranial pressure or an intracranial mass effect. Trephined Syndrome describes a neurological deterioration, which is attributed to a large craniectomy.
- Conditions
- Trephined Syndrome, Sinking Skin Flap Syndrome, Traumatic Brain Injury, Stroke
- Trial name
- TS (NCT03186157)
- Testing
- Decompressive craniectomy, Cranioplasty
- Where
- Switzerland
- Volunteers
- 41 people
- Sponsor
- University Hospital, Geneva
Post-stroke Cognitive Impairment, Ischemic Stroke
HOPE From the Cerebellum: TMS-Induced Cognitive Recovery After Stroke
The objective of this clinical trial is to investigate the effectiveness and safety of repetitive transcranial magnetic stimulation (rTMS) in the cerebellum for individuals with post-stroke cognitive impairment.
- Trial name
- HOPE (NCT06316557)
- Testing
- iTBS group, control group
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Zi-Xiao Li
Ischemic Stroke, Post-Stroke Cognitive Impairment
MSC Secretome Therapy for Cognitive Recovery After Subacute Ischemic Stroke
Post-stroke cognitive impairment can limit rehabilitation, independence, and quality of life after ischemic stroke. This pilot randomized controlled trial evaluates whether mesenchymal stem cell-derived secretome, given in…
- Trial name
- NCT07731087
- Testing
- Umbilical Cord Mesenchymal Stem Cell-Derived Secretome, Standard Stroke Care and Rehabilitation
- Where
- Indonesia
- Volunteers
- 70 people
- Sponsor
- Jumraini Tammasse
Feasibility Study, Post-Stroke Patients With Upper Extremity Motor Deficit
Contralesional Inhibitory rTMS for Recovery of Arm Function After Stroke
The CanStim consensus working group (multidisciplinary team of experts in rTMS from institutions across Canada) developed consensus recommendations for a protocol to deliver rTMS as an adjunct to a standard behavioral…
- Conditions
- Feasibility Study, Post-Stroke Patients With Upper Extremity Motor Deficit, Post-Stroke Patients With Cognitive Deficits
- Trial name
- ConTRAstroke (NCT04205526)
- Testing
- Active rTMS
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- Thiel, Alexander, M.D.
Stroke (CVA) or TIA, Stroke/Brain Attack
Music Therapy After Stroke (Subacute Phase)
The goal of this longitudinal, single-subject study is to investigate the role of motivation in music therapy for stroke patients within the subacute phase, who experience upper limb and/or attention deficits.
- Trial name
- NCT06291480
- Testing
- Neurologic Music Therapy
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Universiteit Leiden
Stroke, Stroke Rehabilitation
Personalised Health Motor and Cognitive Assistance System for RehAbilitation (PHRASE)
This study is a multicentric randomized controlled trial evaluating the effectiveness of digital technology, specifically a smartphone with integrated VR-and AR-based intervention, for at-home rehabilitation after stroke.
- Conditions
- Stroke, Stroke Rehabilitation, Chronic Stroke Patients, Post Stroke Recovery
- Trial name
- PHRASE-2024 (NCT06885502)
- Testing
- RGS
- Where
- 2 sites in Romania, Spain
- Volunteers
- 70 people
- Sponsor
- Eodyne Systems SL
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Stroke, Cerebrovascular Accident
Cardiac Rehabilitation of Stroke Survivors (SRP-CROSS)
This study examines the effectiveness of the cardiac rehabilitation program for stroke patients. The study will examine if patients with stroke, who receive cardiac rehabilitation in addition to their standard of care treatments…
- Trial name
- SRP-CROSS (NCT05651945)
- Testing
- Cardiac rehabilitation program
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Hackensack Meridian Health
Stroke
Post-stroke Psychosocial Recovery
Stroke is a neurological injury that adversely impacts psychosocial functioning and quality of life. This may occur due to direct insult to the brain circuits integral to adaptive psychosocial functioning, and/or indirectly via…
- Trial name
- NCT05380037
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Acute Stroke Intervention, Rehabilitation Exercise
Virtual Reality-Enhanced Rehabilitation for Cognitive Recovery in Acute Post-Stroke Patients: Pilot Study
Post-stroke rehabilitation is essential for maximising the recovery of cognitive function. Virtual reality (VR) has emerged as a promising adjunct to conventional rehabilitation therapy (CRT), with the potential to enhance…
- Conditions
- Acute Stroke Intervention, Rehabilitation Exercise, Cognitive Assessment
- Trial name
- VR (NCT07381452)
- Testing
- Virtual reality-enhanced rehabilitation, Conventional rehabilitation therapy (CRT)
- Where
- Slovenia
- Volunteers
- 36 people
- Sponsor
- Tadeja Hernja Rumpf
Ictus, Stroke
Motor and Cognitive Telerehabilitation in a Virtual Environment in Patients With Post-stroke Sequelae and Parkinson's Disease
The goal of this interventional pilot trial is to evaluate whether a telerehabilitation protocol based on immersive virtual reality (VR) is effective and feasible for the recovery of cognitive and/or motor functions in patients…
- Conditions
- Ictus, Stroke, Parkinson Disease
- Trial name
- HOME VR REHAB (NCT07582497)
- Testing
- VR-based Telerehabilitation with Home Kit, Standard Rehabilitation (Conventional Care)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Usl di Bologna
Stroke, Stroke Sequelae
Imaging Post-Stroke Recovery: Using MEG to Evaluate Cognition
This is a study using magnetoencephalography (MEG) to look at recovery in those with minor stroke. The investigators know that these individuals report difficulties in attention, concentration, multi-tasking, energy level, and…
- Conditions
- Stroke, Stroke Sequelae, Stroke/Brain Attack
- Trial name
- NCT04188522
- Testing
- Magnetoencephalography (MEG)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Johns Hopkins University
Stroke
Individualized Magnetic Stimulation for Post-stroke Cognitive Recovery: Optimization, Validation & Efficacy
Rationale: 75% of all stroke survivors suffer from cognitive deficits in the acute phase, with serious implications for their long-term quality of life and societal participation.
- Trial name
- IMPROVE (NCT07150169)
- Testing
- Active TMS disruption
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Jord Vink
Aphasia, Stroke
Brain Correlates of Multimodal Rehabilitation in Chronic Post-stroke Aphasia
Post-stroke aphasia (PSA), the partial or total loss of the ability to produce and/or understand language associated with stroke, is a highly prevalent and disabling disorder that negatively impacts the personal, social and…
- Trial name
- NCT04134416
- Testing
- Donepezil, Intensive-Language Action Therapy, Transcranial direct current stimulation
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- University of Malaga
Stroke Sequelae, Motor Skills Disorders
Cognitive-motor Training Post-stroke - a Pilot Randomized Controlled Trial
Stroke is a leading and growing cause of long-term adult disability. Up to 80% of stroke patients have impaired manual dexterity reducing their independence, return to work and quality of life.
- Trial name
- Cogmos (NCT06112574)
- Testing
- Visuomotor force control training
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Danderyd Hospital
Cerebrovascular Disorders, Memory
Roflumilast to Treat Cognitive Sequela After Stroke
The aim of the current project is to validate the effects of chronic rolflumilast treatment (12 weeks) on cognitive functions (i.e.
- Conditions
- Cerebrovascular Disorders, Memory, Functional Recovery, Drug Intervention
- Trial name
- ROSTMEMA (NCT04854811)
- Testing
- Roflumilast Oral Tablet
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Maastricht University