Clinical trials: Cognitive Frailty
Cognitive Change, Physical Performance
Coginitve and Physical Functions in Geriatric İndividuals
The aim of this study is to investigate the relationship between cognitive functions with physical performance, grip strength, walking speed, mobility, and frailty in geriatric individuals.
- Conditions
- Cognitive Change, Physical Performance, Frailty, Mobility
- Trial name
- NCT06400134
- Testing
- Cognitive Function, Physical Performance, Grip Strength
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Physical Disability, Cognitive Dysfunction
Study on Cardiovascular Health, Nutrition and Physical Functioning in Older Adults in Spain
Population aging makes it necessary to identify factors related to unhealthy aging. The purpose of this study is to examine the association between ideal cardiovascular health, diet and other lifestyles and biological risk…
- Trial name
- Sen-ENRICAII (NCT03541135)
- Where
- Spain
- Volunteers
- 4,000 people
- Sponsor
- Universidad Autonoma de Madrid
Frailty, Physical Activity
VIVIFRAIL Program in Improving the Frailty and Physical Function in the Elderly
The global population is aging, and Taiwan has become an aging society. The aging population continues to rise. When the physical function and mental state of the elderly gradually decline, it is easy for the elderly to enter a…
- Conditions
- Frailty, Physical Activity, Cognitive Function
- Trial name
- NCT05935319
- Testing
- Vivifrail
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Frailty, Motoric Cognitive Risk Syndrome
Cognitive Prefrail and Frailty, and Motoric Cognitive Risk Syndrome: Prevalence and Association With Incident Adverse Health Events
We defined a new and early condition in the spectrum of cognitive frailty: the "cognitive-prefrailty" which is a combination of prefrailty stage and subjective cognitive impairment (SCI).
- Conditions
- Frailty, Motoric Cognitive Risk Syndrome, Cognitive-prefrailty
- Trial name
- NCT04275817
- Testing
- Data collection
- Where
- Canada
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Cardiovascular Diseases
Impact of Preoperative Frailty and Cognitive Impairment on Postoperative Outcomes in Elderly Cardiac Surgery Patients
This is a retrospective study of patients aged 65 years and older who underwent cardiac and aortic surgery between March 5, 2021 and October 12, 2022 in the operating room of Severance Cardiovascular Hospital to determine the…
- Trial name
- NCT06330532
- Where
- South Korea
- Volunteers
- 447 people
- Sponsor
- Yonsei University
Alzheimer Disease, Sarcopenia
Silkworm Pupa Powder Improves Alzheimer's Disease
The goal of this clinical trial is to learn if silkworm pupa powder works to treat Alzheimer's disease in patients. It will also learn about the safety of silkworm pupa powder, and its effect on patients' nutritional and frailty…
- Conditions
- Alzheimer Disease, Sarcopenia, Asthenia, Frailty
- Trial name
- NCT07638449
- Testing
- Silkworm pupa powder
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhejiang Provincial Tongde Hospital
Health Services Accessibility, Rural Health
Health Ahead Comparative Effectiveness Study
The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening…
- Conditions
- Health Services Accessibility, Rural Health, Medically Underserved Area, Preventive Health Services
- Trial name
- HACE (NCT07669168)
- Testing
- AI-Assisted Screening Interpretation (AI Reads), Human-Only Screening Interpretation
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- William Brandenburg, MD
Critical Illness
Cortisol Levels as a Measure of Accumulated Physiological Stress in ICU Patients Undergoing Mechanical Ventilation
Critical illness is a situation of severe and prolonged stress for patients with mechanical ventilation (MV). Between 40-80% of these patients present the Post-ICU syndrome, a set of physical, cognitive, psychological alterations…
- Trial name
- Corti-COG (NCT03736135)
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Corporacion Parc Tauli
Perioperative Risk Assessment
Frailty Assessment Reveals Cognitive Differences in ASA Classification: Anesthesiologists vs Large Language Models
The American Society of Anesthesiologists (ASA) Physical Status Classification System is widely used to assess perioperative risk, but it does not explicitly include frailty as a standardized variable.
- Trial name
- ASA-AI (NCT07399938)
- Testing
- Observational Assessment Only
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Cognition Disorders in Old Age, Cognitive Function
Impact of Nutrition, Sleep, and Physical Activity on Intellectual Function and Muscle Mass in Older Adults
The goal of this prospective, single site, interventional randomized control trial is to treat age related health conditions in adults older than 65 years and functional independence.
- Conditions
- Cognition Disorders in Old Age, Cognitive Function, Frailty/Sarcopenia, MCI
- Trial name
- INSPIOR (NCT06135740)
- Testing
- Fitbit wearing, with notification for sleep, activity and nutrition based fitbit data, Routine care
- Where
- Japan
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Tokyo University
Healthy Aging, Sarcopenia
Plant-based Diets and Healthy Aging
This prospective study investigates the health effects of vegetarian and plant-based diets in middle-aged and older adults in Taiwan, specifically, recruiting 5000 Tzu Chi volunteers.
- Conditions
- Healthy Aging, Sarcopenia, Frailty, Cognitive Decline
- Trial name
- TCAS (NCT07151365)
- Where
- Taiwan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Falls, Frailty
Preventing Falls in Older Adults With Cognitive Frailty
The Problem: The proposed trial will address the problem of how to effectively prevent subsequent falls in community-dwelling cognitively frail older adults with a history of falls.
- Conditions
- Falls, Frailty, Mild Cognitive Impairment
- Trial name
- ACTIVE (NCT06854731)
- Testing
- Balance and Strength Training Exercises with Health Coaching, Education Session
- Where
- Canada
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Aging, Frailty
Cognitive-Motor Exergame Training in Frail Adults
This international multicentre pragmatic randomized controlled trial (RCT) aims to evaluate the effectiveness of personalized, home-based cognitive-motor training using exergames in improving cognitive and motor functions in…
- Trial name
- SMART (NCT07074639)
- Testing
- Personalized, home-based motor-cognitive exergame training, Otago Exercise Program
- Where
- Switzerland
- Volunteers
- 344 people
- Sponsor
- Eleftheria Giannouli
Physical Activity
Training Intervention in a Controlled Population of Frail Elderly
Exercise has a beneficial role in geriatric patients categorized as frail. Nevertheless, it is not known physical training pattern more beneficial for these patients.
- Trial name
- EMTIFE (NCT02331459)
- Testing
- Multicomponent training intervention, Nutritional intervention
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital de la Ribera
Dementia, Aerobic Exercise
Investigation of the Effects of Aerobic Exercise, Balance Exercise and Combined Exercise Practices on Frailty, Balance, Fall Risk, Reaction Time, Cognitive Functions and Quality of Life in Dementia Patients
Dementia is a clinical disorder characterized by progressive and permanent loss of multiple cognitive functions, especially memory, at a level that affects activities of daily living.
- Conditions
- Dementia, Aerobic Exercise, Balance Exercise, Cognitive Function
- Trial name
- NCT05839743
- Testing
- Aerobic Exercise, Balance Exercise, Combined Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Yuksek Ihtisas University
Chronic Heart Failure, Chronic Obstructive Pulmonary Disease
Cognitive Impairment, Frailty and Rehabilitative Outcome in Older Patients Affected by Cardiorespiratory Disease
A consistent number of studies in the last few years highlighted that the functional and clinical worsening in patients with cardiac and/or respiratory disease/s increase the risk of cognitive decline.
- Trial name
- NCT05230927
- Testing
- Multidisciplinary Rehabilitation
- Where
- Italy
- Volunteers
- 240 people
- Sponsor
- Antonia Pierobon
Frailty
South Korean Study to Prevent Frailty and Aging-related Diseases Through Lifestyle Intervention
The goal of this feasibility randomized controlled trial is to investigate the applicability of software that aims to improve symptoms of frailty by implementing customized interventions such as physical exercise and cognitive…
- Trial name
- SUPERAGING (NCT06891573)
- Testing
- Lifestyle Management
- Where
- 3 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- Seong Hye Choi, MD
Frail Elderly Syndrome, Mood
FOCUS Guidelines and Adherence to Physical Activity in Ageing Women.
The study aimed at assessing whether the guidelines from the European project FOCUS had an effect on adherence to a physical activity program in older women.
- Conditions
- Frail Elderly Syndrome, Mood, Quality of Life, Cognitive Decline
- Trial name
- NCT03981965
- Testing
- Physical activity
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Old Age; Debility
Puzzle Game Strategy on Older Adults
One innovative approach uses puzzle game strategies, including crosswords, Sudoku, and other brain-teasing activities. These strategies have been shown to help maintain attention, improve memory, and keep older adults' thoughts…
- Trial name
- PUZZLEOLDER (NCT06459492)
- Testing
- puzzle game strategies
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Stroke, Frailty
Pilot of Cognitive Stimulation Therapy for Pre-frail Stroke Survivors
Frailty is described as a type of vulnerability where one can struggle to recover fully from things that can put stress on one\'s body, e.g., cold weather or bronchitis.
- Conditions
- Stroke, Frailty, Carers
- Trial name
- NCT06733103
- Testing
- Stroke Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of East Anglia