Clinical trials: Cognition Improvement
Parkinson's Disease
Rasagiline as Add on to Dopamine Agonists in the Treatment of Parkinson's Disease
To assess the efficacy of rasagiline 1 mg as a first add-on treatment to dopamine agonist therapy in early Parkinson Disease (PD) patients, , not optimally controlled on dopamine agonists as compared to placebo.
- Trial name
- ANDANTE (NCT01049984)
- Testing
- Rasagiline
- Where
- 58 sites in United States
- Volunteers
- 328 people
- Sponsor
- Teva Neuroscience, Inc.
Depressive Disorder
Depressed Mood Improvement Through Nicotine Dosing 2
Deficits in cognitive control are core features of late-life depression, contributing both to emotion dysregulation and problems with inhibiting irrelevant information, conflict detection, and working memory.
- Trial name
- DepMIND2 (NCT04433767)
- Testing
- Transdermal Nicotine patch
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Vanderbilt University Medical Center
Primary Progressive Multiple Sclerosis, Exercise
The Influence of HIIT Versus MCT on Cardiorespiratory Fitness in PPMS
Endurance training revealed to be an effective means to increase cardiorespiratory fitness in persons with Multiple Sclerosis (MS), considered relevant to health-related quality of life in this population.
- Conditions
- Primary Progressive Multiple Sclerosis, Exercise, Cardiorespiratory Fitness
- Trial name
- CYPRO (NCT05229861)
- Testing
- HIIT, MCT
- Where
- Switzerland
- Volunteers
- 61 people
- Sponsor
- Klinik Valens
Cognitive Function, Cognitive Decline
Phospholipid-rich Dairy Extract for Cognitive Function
This clinical trial aims to determine whether dietary phospholipid-rich dairy milk extract improves cognitive function in adults with mild cognitive impairment and to assess its safety.
- Trial name
- NCT07011680
- Testing
- Phospholipid-rich dairy milk extract
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Depressive Disorder
Depressed Mood Improvement Through Nicotine Dosing-3 (Depressed MIND3) Extension
Deficits in cognitive control are core features of late-life depression (LLD), contributing both to emotion dysregulation and problems with inhibiting irrelevant information, conflict detection, and working memory.
- Trial name
- NCT05746546
- Testing
- Transdermal Nicotine patch
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt University Medical Center
Performance Improvement in Beginner Archers
The Effect of Imagery Exercises on Attention and Performance in Olympic Archers
The goal of this clinical trial is to for beginners in archery in to examine the effects of Imagination and breathing exercises given in addition to 8-week archery training on archery target score, postural sway, attention, hand…
- Trial name
- NCT06739681
- Testing
- Routine Intervention, Mental Imagery Intervention, Breathing Exercise Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medipol University
Chronic Sinusitis
Assessing Improvement in Cognitive Deficit in CRS in Patients Treated With Medical Vs Surgical Management
Chronic rhinosinusitis presents with a plethora of symptoms including non-rhinologic symptoms such as depression, sleep disturbances \& the more recently recognized cognitive dysfunction.
- Trial name
- NCT04291118
- Testing
- Private system endoscopic sinus surgery, Public system endoscopic sinus surgery, Budesonide
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- St. Paul's Hospital, Canada
Stroke
Multi-domain Improvements in High-TEchnology Rehabilitation Programs for Post-stroke Patients
Through a multi-method, multi-informant, and patient-centred approach, the study aims to investigate the experience of use and the effectiveness of rehabilitation technology (robotics and virtual reality - VR) in post-stroke…
- Trial name
- ITER (NCT06489145)
- Testing
- Technology-enhanced Rehabilitation, Multidisciplinary Traditional Rehabiltiation
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Milano Bicocca
Schizophrenia, Schizophreniform Disorders
Benefits of Combining MCT With CR in the Recovery of Patients With Psychotic Spectrum Disorders
The goal of this clinical trial is to compare the efficacy of combined REHACOP + MCT alone in persons with nonaffective psychotic disorder in terms of recovery.
- Conditions
- Schizophrenia, Schizophreniform Disorders, Delusional Disorder, Brief Psychotic Disorder
- Trial name
- CR+MCTp (NCT06423651)
- Testing
- Cognitive Remediation (REHACOP), Metacognitive Training (MCT)
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- Universitat Autonoma de Barcelona
Alzheimer Disease and Related Dementias, Cognition
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
The objective of this study is to determine the effects of a 6-month, home-based personalized transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on cognitive function…
- Conditions
- Alzheimer Disease and Related Dementias, Cognition, Mobility Disability
- Trial name
- TDCS4MCR (NCT06821568)
- Testing
- Personalized Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States, Israel
- Volunteers
- 128 people
- Sponsor
- Hebrew SeniorLife
Schizophrenia, Schizoaffective Disorder
Cognitive Improvement With Aripiprazole (Abilify) in Patients With Schizophrenia (BMS)
Evaluation of cognitive ability in patients with schizophrenia or schizoaffective disorder both before and after a switch from risperidone to aripiprazole may reveal some of the cognitive changes that correlate with the improved…
- Trial name
- NCT00211302
- Testing
- aripiprazole
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Major Depressive Disorder
Depressed Mood Improvement Through Nicotine Dosing (Depressed MIND Study)
Late-life depression is characterized by both affective (mood) symptoms and cognitive deficits. There is currently no intervention that may provide consistent benefits to both mood and cognitive performance.
- Trial name
- NCT02816138
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University Medical Center
Sclerosis, Multiple
The Efficacy of Tele Rehabilitation- Based Task-Specific Training for Cognitive Function Improvement
"This study investigates the feasibility of tele-rehabilitation combined with targeted training for cognitive enhancement in individuals with Multiple Sclerosis (MS).
- Trial name
- NCT06428201
- Testing
- Control Group, Experimental Group
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Superior University
Cognitive Decline
A Home-based e-Health Intervention in the Elderly: MOVI-ageing
This protocol study aims to evaluate the efficacy of the MOVI-ageing intervention, a complex home-based eHealth intervention of cognitive-demanding exercise for the elderly, in improving: global cognitive function and basic…
- Trial name
- MOVI-ageing (NCT05928078)
- Testing
- intervention
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Aging, Cognition Improvement
Westlake Aging Cohort (WeAC)
The Westlake Ageing Cohort (WeAC) is a longitudinal cohort study conducted in Hangzhou, Zhejiang Province, China. The investigators aim to enroll 2,800 participants aged 55 years and older for long-term follow-up.
- Conditions
- Aging, Cognition Improvement, Cognition Disorders, Cognition
- Trial name
- NCT07373444
- Where
- 2 sites in China
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Westlake University
Mild Cognitive Impairment
NEUROFEEDBACK TRAINING FOR OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT: A PILOT STUDY
The purpose of this study is to evaluate the effects of SMR neurofeedback training on cognitive performance and electrical brain activity in elderly with cognitive impairment.
- Trial name
- NEUROFEEDEL (NCT04027725)
- Testing
- Neurofeedback
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Delirium
Lemborexant Use for Cognition Improvement in Postoperative Delirium in Elderly Patients: A Randomized Controlled Trial
This prospective, randomized controlled trial aims to investigate the perioperative use of lemborexant, an orexin receptor antagonist, for reducing postoperative delirium (POD) in elderly patients undergoing general anesthesia.
- Trial name
- NCT07695285
- Testing
- Lemborexant Pill
- Volunteers
- 992 people
- Sponsor
- Beijing Tiantan Hospital
Subclinical Hypothyroidism
Subclinical Hypothyroidism and Mind in the Elderly
Some recommendations of expert consensus on subclinical hypothyroidism (SH) are controversial in those areas with not enough information to reach a conclusion, such as not recommending treatment with thyrotrophic hormone of 4-10…
- Trial name
- NCT00921050
- Testing
- levothyroxine sodium
- Where
- 2 sites in Mexico
- Volunteers
- 70 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Hepatic Encephalopathy.
Efficacy of Sildenafil in the Improvement of Cognition and Quality of Life in Patients With Cirrhosis of Liver. A Proof of Concept Study.
The study is being conducted to evaluate the efficacy of Sildenafil (a 5-phosphodiesterase inhibitor) as a means to improve the cognitive impairment encountered in patients of minimal hepatic encephalopathy (MHE) as proposed in…
- Trial name
- NCT02028429
- Testing
- Sildenafil.
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Depression
The Preventive Effect of Escitalopram on Depression and Related Emotional Disorders in Acute Stroke Patients
Through this study, the investigators are to demonstrate the superiority of Escitalopram over placebo for the prevention of poststroke depression in patients with acute stroke The primary hypothesis of this study is; This study…
- Trial name
- EMOTION (NCT01278498)
- Testing
- Escitalopram, sugar pill
- Where
- 16 sites in South Korea
- Volunteers
- 444 people
- Sponsor
- Asan Medical Center