Clinical trials: Cognition Function
Oral Health
A Study on the Correlation Between Oral Health and Delirium in Surgical Inpatients
Delirium is a clinical syndrome characterized by acute attention deficits, altered consciousness, and fluctuating cognitive dysfunction, typically triggered by multifactorial causes such as physical illness, medication use, or…
- Trial name
- NCT06969092
- Testing
- Oral Frailty
- Where
- China
- Volunteers
- 550 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Cognitive Function
Cognition Intervention Study Dortmund- Glycemic Index (CogniDo GI)
The Cognition Intervention Study Dortmund (CogniDo) and the Cognition Intervention Study Dortmund PLUS (CogniDo PLUS) investigated the short-term effects of having school lunch versus skipping it on children's basal (CogniDo) and…
- Trial name
- CogniDo-GI (NCT02763371)
- Testing
- Dietary: high GI lunch, Dietary: low GI lunch
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Research Institute of Child Nutrition, Dortmund
Major Depressive Disorder, Bipolar Disorder
Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
The purpose of this research is to measure brain activity in individuals with mood disorders and memory problems using a simple, safe, and noninvasive method called functional near-infrared spectroscopy (fNIRS).
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Mild Cognitive Impairment
- Trial name
- NCT06897670
- Testing
- Observational assessment using functional near-infrared spectroscopy (fNIRS), a noninvasive, portable brain imaging tool that measures changes in brain blood flow and oxygen levels.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Healthy Aging, Cognitive Decline
Cognitively Enriched Walking Program
Dementia currently affects more than 47 million people worldwide, its prevalence is forecasted to triple by 2050, and it has been reported to be one of the most costly disorders in Belgium.
- Conditions
- Healthy Aging, Cognitive Decline, Physical Inactivity
- Trial name
- NCT05500183
- Testing
- Cognitively enriched walking program, walking program
- Where
- 2 sites in Belgium
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University Ghent
Stroke
Comparative Effects of Dual Task and PNF on Balance ,Cognition and Motor Function in Chronic Stroke Patients .
The aim of this study is to compare the effect of dual tasking and proprioceptive neuromuscular facilitation on balance, cognition and motor function in chronic stroke patients. It will be randomized clinical trial.
- Trial name
- NCT05931172
- Testing
- Dual tasking, PNF(proprioceptive neuromuscular facilitation exercises)
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Stroke
Cognitive-motor Exercise for Stroke Patients in Function, Cognition and Related Brain Changes.
The purpose of this study is to evaluate a cognitive-motor exercise on dual-task interference during dual-task ankle movement and the corresponding alterations of brain activity.
- Trial name
- COGMOTION (NCT06362512)
- Testing
- Dual-task training, Single-task training, Upper limb strengthening exercise
- Where
- China
- Volunteers
- 84 people
- Sponsor
- The Hong Kong Polytechnic University
Conditions or Focus of Study: Cognitive Function Loneliness Aging Physical Activity
Wearable-Assisted Walking for Cognitive Function and Loneliness in Older Adults
Participants in the wearable-assisted walking group were asked to walk five days per week for approximately 30 minutes per session at moderate intensity.
- Trial name
- WAW-CogLon (NCT07650292)
- Testing
- Wearable-Assisted Walking Program
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan College of Performing Arts
Sleep Initiation and Maintenance Disorders, Insomnia
Evaluation of A Morning Dosing Of A New Medicine And Its Effects On Sleep At Bedtime In Subjects With Primary Insomnia
This study is designed to determine whether morning doses of GW679769, taken daily for 1 to 9 days, will promote sleep during the following night without significant post-dose thinking impairment and drowsiness in subjects with…
- Trial name
- NCT00354809
- Testing
- GW679769
- Where
- 24 sites in United States, France and 1 more
- Volunteers
- 68 people
- Sponsor
- GlaxoSmithKline
Cognitive Function, E-sports Performance
Visual Training Effects in Esports Players
This randomized controlled study aims to investigate the acute effects of a single session of web-based visual training on balance, reaction time, and cognitive function in professional e-sports players.
- Conditions
- Cognitive Function, E-sports Performance, Reaction Time, Balance
- Trial name
- NCT07570693
- Testing
- Web-Based Visual Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Structural Imaging and Cognitive Functions in Adult Stem Cell Transplant Recipients Treated With Chemotherapy Alone or in Combination With Radiotherapy
The purpose of this study is to learn about possible changes in brain anatomy and in thinking abilities, such as memory skills, in patients with cancer who receive treatment with chemotherapy alone or in combination with total…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Acute Undifferentiated Leukemia, Biphenotypic Leukemia
- Trial name
- NCT00606216
- Testing
- MRI and cognitive evaluation, brain MRI study and a brief neuropsychological evaluation
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Frail Older Adults
CogXergaming to Promote Physical Activity and Cognitive Function in Frail Older Adults
Due to the age associated sarcopenia and reduced cardiovascular fitness, frail older adults experience significant decrease in physical function which comprises of mobility, endurance, muscle strength and balance control.
- Trial name
- NCT04534686
- Testing
- CogXergaming, Matter of Balance Training
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Illinois at Chicago
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female
Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes
The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.
- Conditions
- Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female, Adult, Endothelial Function (Reactive Hyperemia)
- Trial name
- NCT06735651
- Testing
- Wild Blueberry
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Georgia State University
Cognition, Affect (Mental Function)
PRECOG Pilot Project
This pilot study aims to investigate the chronic effects of a prebiotic blend on cognitive, affective and gut microbiome outcomes in healthy adults aged 60-75 years.
- Conditions
- Cognition, Affect (Mental Function), Gut Microbiome
- Trial name
- NCT06911957
- Testing
- Prebiotic blend
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Reading
Schizophrenia Patients
Effect of Ashwagandha as Adjunct Therapy on BDNF and Cognitive Function in Schizophrenia Patients
This study aims to evaluate the effectiveness of Ashwagandha (Withania somnifera) as an adjunctive therapy in improving serum brain-derived neurotrophic factor (BDNF) levels and cognitive function in patients with schizophrenia…
- Trial name
- ASH-BDNF (NCT07541157)
- Testing
- Risperidone 4mg/day, Ashwagandha
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Hasanuddin University
Diabetes Mellitus Type 2
Impact of Dual vs. Single Task Exercise on Cognitive Function, Balance, and Functionality in Type 2 Diabetes
Diabetes Mellitus is defined as a carbohydrate mechanism disorder in which glucose cannot be used as an adequate energy source and is produced excessively, causing hyperglycemia.
- Trial name
- NCT06819371
- Testing
- Single Task Exercise, Dual Task Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Izmir Democracy University
Schizophrenia, Schizoaffective Disorder
Oxytocin Treatment of Social Cognitive and Functional Deficits in Schizophrenia
Purpose: Test whether intranasal administration of the neuropeptide, oxytocin, improves social cognition, psychotic symptoms and social functioning in schizophrenia.
- Trial name
- OTS-12WK (NCT01394471)
- Testing
- Intranasal Oxytocin Spray
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of North Carolina, Chapel Hill
Cognitively Normal Older Adults, Hypertension
Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)
The purpose of this study is to determine if intensive lowering of systolic blood pressure (SBP), using FDA approved medications (antihypertensive), reduces Alzheimer's Disease pathology (i.e., excessive brain amyloid and tau…
- Conditions
- Cognitively Normal Older Adults, Hypertension, Subjective Cognitive Decline, Family History of Dementia
- Trial name
- IPAT (NCT05331144)
- Testing
- Angiotensin II Receptor Blockers (ARBs, losartan) and Calcium Channel Blockers (CCB, amlodipine), PCP
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Rong Zhang
Aging, Cognitive Dysfunction
Physical Activity and Cognitive Function in Older Adults: A Novel Role for GPLD1
The investigators are conducting a cross-sectional, observational study to investigate whether plasma GPLD1 concentrations are associated with higher cognitive function and better brain structure and function in two groups of…
- Trial name
- BrainFit (NCT04645134)
- Testing
- Brain Health Assessments
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Healthy
Assessment Of The Effects Of Single Doses Of An Investigational Drug, Given Alone Or With Donepezil, On Scopolamine-Induced Changes In Memory And Learning In Healthy Adults
This study is designed to look at the potential for an investigational drug (PF-04995274, under development by Pfizer, Inc. as a potential treatment for Alzheimer's disease) to reverse changes in memory and learning/problem…
- Trial name
- NCT01345864
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Pfizer
Attention Deficit Hyperactivity Disorder (ADHD)
Experimental Medicine in ADHD - Cannabinoids
Adult patients with ADHD commonly report an improvement in behavioural symptoms when using cannabis with some reporting a preference towards cannabis over their ADHD stimulant medication.
- Trial name
- EMA-C (NCT02249299)
- Testing
- Sativex Oromucosal Spray
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College London
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